Design, Synthesis andIn VitroAntiproliferative Activity of Novel Isatin-Quinazoline Hybrids

Chloroquine synergizes sunitinib cytotoxicity via modulating autophagic, apoptotic and angiogenic machineries

(2014) Amal Kamal Abdel-Aziz et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Analogue-based design, synthesis and biological evaluation of 3-substituted-(methylenehydrazono)indolin-2-ones as anticancer agents

(2014) Haytham E. Dweedar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Recent advances in the structural library of functionalized quinazoline and quinazolinone scaffolds: Synthetic approaches and multifarious applications

(2014) Imtiaz Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2)

(2013) Kapil Juvale et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Cancer statistics, 2013

(2013) Rebecca Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Synthesis and anticancer potential of certain novel 2-oxo-N'-(2-oxoindolin-3-ylidene)-2H-chromene-3-carbohydrazides

(2013) Hatem A. Abdel-Aziz et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, in vitro and in vivo antitumor activity of symmetrical bis-Schiff base derivatives of isatin

(2013) Chengyuan Liang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isatin inhibits proliferation and induces apoptosis of SH-SY5Y neuroblastoma cells in vitro and in vivo

(2013) Jinlian Song et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytotoxic and Anticancer Activities of Isatin and Its Derivatives: A Comprehensive Review from 2000-2008

(2012) K. Vine et al.   Anti-Cancer Agents in Medicinal Chemistry

Molecular docking and synthesis of novel quinazoline analogues as inhibitors of transcription factors NF-κB activation and their anti-cancer activities

(2012) Lu Xu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

2-Anilino-4-(benzimidazol-2-yl)pyrimidines – A multikinase inhibitor scaffold with antiproliferative activity toward cancer cell lines

(2012) Renate Determann et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

2-Hydroxybenzaldehyde (2-phenylquinazolin-4-yl)hydrazones and their ZnII complexes: synthesis and photophysical properties

(2012) T. V. Trashakhova et al.   RUSSIAN CHEMICAL BULLETIN

Identification and synthesis of N′-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase

(2011) Zhongjie Liang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Novel quinazoline HMJ-30 induces U-2 OS human osteogenic sarcoma cell apoptosis through induction of oxidative stress and up-regulation of ATM/p53 signaling pathway

(2011) Yu-Jen Chiu et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Design, synthesis and biological evaluation of novel quinazoline derivatives as potential antitumor agents: Molecular docking study

(2010) Adel S. El-Azab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Rhodium-catalysed hydroboration employing new Quinazolinap ligands; an investigation into electronic effects

(2010) Aoife C. Maxwell et al.   TETRAHEDRON-ASYMMETRY

Hybrid pharmacophore design and synthesis of isatin–benzothiazole analogs for their anti-breast cancer activity

(2009) V. Raja Solomon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of substituted N′-(2-oxoindolin-3-ylidene)benzohydrazides as new apoptosis inducers using a cell- and caspase-based HTS assay

(2009) Nilantha Sirisoma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor

(2009) Teresa Sardon et al.   CHEMBIOCHEM

Design of New Drug Molecules to be Used in Reversing Multidrug Resistance in Cancer Cells

(2009) Y. Mayur et al.   CURRENT CANCER DRUG TARGETS

A 4-aminoquinoline derivative that markedly sensitizes tumor cell killing by Akt inhibitors with a minimum cytotoxicity to non-cancer cells

(2009) Changkun Hu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Identification ofN,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor

(2009) Maria Gabriella Brasca et al.   JOURNAL OF MEDICINAL CHEMISTRY

Paclitaxel, Estramustine and Carboplatin Combination Chemotherapy after Initial Docetaxel-Based Chemotherapy in Castration-Resistant Prostate Cancer

(2009) A. Sella et al.   ONCOLOGY

The efficacy and selectivity of tumor cell killing by Akt inhibitors are substantially increased by chloroquine

(2008) Changkun Hu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Inhibitors of Src Homology-2 Domain Containing Protein Tyrosine Phosphatase-2 (Shp2) Based on Oxindole Scaffolds

(2008) Harshani R. Lawrence et al.   JOURNAL OF MEDICINAL CHEMISTRY

Hybrid Molecules with a Dual Mode of Action: Dream or Reality?†

(2007) Bernard Meunier   ACCOUNTS OF CHEMICAL RESEARCH