DNA Metalating-Intercalating Hybrid Agents for the Treatment of Chemoresistant Cancers

Next-Generation Anticancer Metallodrugs

(2012) Seiji Komeda et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Analysis of the DNA damage produced by a platinum–acridine antitumor agent and its effects in NCI-H460 lung cancer cells

(2012) Xin Qiao et al.   Metallomics

Metal Complexes as DNA Intercalators

(2011) Hong-Ke Liu et al.   ACCOUNTS OF CHEMICAL RESEARCH

Targeted Delivery of Cisplatin to Lung Cancer Using ScFvEGFR-Heparin-Cisplatin Nanoparticles

(2011) Xiang-Hong Peng et al.   ACS Nano

Monofunctional Platinum-DNA Adducts Are Strong Inhibitors of Transcription and Substrates for Nucleotide Excision Repair in Live Mammalian Cells

(2011) G. Zhu et al.   CANCER RESEARCH

A Tetrazolato-Bridged Dinuclear Platinum(II) Complex Exhibits Markedly High in vivo Antitumor Activity against Pancreatic Cancer

(2011) Seiji Komeda et al.   ChemMedChem

Spectrum of Cellular Responses to Pyriplatin, a Monofunctional Cationic Antineoplastic Platinum(II) Compound, in Human Cancer Cells

(2011) K. S. Lovejoy et al.   MOLECULAR CANCER THERAPEUTICS

Replacement of a Thiourea with an Amidine Group in a Monofunctional Platinum–Acridine Antitumor Agent. Effect on DNA Interactions, DNA Adduct Recognition and Repair

(2011) Hana Kostrhunova et al.   MOLECULAR PHARMACEUTICS

Molecular mechanisms of cisplatin resistance

(2011) L Galluzzi et al.   ONCOGENE

Unusual Reactivity of a Potent Platinum–Acridine Hybrid Antitumor Agent

(2011) Leigh A. Graham et al.   ACS Medicinal Chemistry Letters

Inhibition of DNA Synthesis by a Platinum–Acridine Hybrid Agent Leads to Potent Cell Kill in Nonsmall Cell Lung Cancer

(2011) Christopher L. Smyre et al.   ACS Medicinal Chemistry Letters

Probing Platinum−Adenine-N3 Adduct Formation with DNA Minor-Groove Binding Agents

(2010) Lu Rao et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Antibody–drug conjugates: targeted drug delivery for cancer

(2010) Stephen C Alley et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

The status of platinum anticancer drugs in the clinic and in clinical trials

(2010) Nial J. Wheate et al.   DALTON TRANSACTIONS

Rates of intercalator-driven platination of DNA determined by a restriction enzyme cleavage inhibition assay

(2010) Jayati Roy Choudhury et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Characteristic effect of an anticancer dinuclear platinum(II) complex on the higher-order structure of DNA

(2010) Naoko Kida et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Transcription Inhibition by Platinum−DNA Cross-Links in Live Mammalian Cells

(2010) Wee Han Ang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells

(2010) Takashi Shingu et al.   NEURO-ONCOLOGY

Unusual DNA binding modes for metal anticancer complexes

(2009) Ana M. Pizarro et al.   BIOCHIMIE

Non-traditional platinum compounds for improved accumulation, oral bioavailability, and tumor targeting

(2009) Katherine S. Lovejoy et al.   DALTON TRANSACTIONS

Targeted therapies for non-small cell lung cancer

(2009) Wolfram C.M. Dempke et al.   LUNG CANCER

Effect of linkage geometry on biological activity in thiourea- and guanidine-substituted acridines and platinum–acridines

(2008) Zhidong Ma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Non-Cross-Linking Platinum−Acridine Agent with Potent Activity in Non-Small-Cell Lung Cancer

(2008) Zhidong Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects

(2008) Katherine S. Lovejoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer

(2007) Tetsuya Fujii et al.   LUNG CANCER