The constitutive activity of melanocortin‐4 receptors in cAMP pathway is allosterically modulated by zinc and copper ions

Developing a Biased Unmatched Bivalent Ligand (BUmBL) Design Strategy to Target the GPCR Homodimer Allosteric Signaling (cAMP over β-Arrestin 2 Recruitment) Within the Melanocortin Receptors

(2018) Cody J. Lensing et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assays with Detection of Fluorescence Anisotropy: Challenges and Possibilities for Characterizing Ligand Binding to GPCRs

(2018) Ago Rinken et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Characterization of ligand binding to melanocortin 4 receptors using fluorescent peptides with improved kinetic properties

(2017) Reet Link et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The biological inorganic chemistry of zinc ions

(2016) Artur Krężel et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Insights into Basal Signaling Regulation, Oligomerization, and Structural Organization of the Human G-Protein Coupled Receptor 83

(2016) Anne Müller et al.   PLoS One

Characterization of the Biological Activities of Human Luteinizing Hormone and Chorionic Gonadotropin by a Förster Resonance Energy Transfer-Based Biosensor Assay

(2015) Olga Mazina et al.   ANALYTICAL LETTERS

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

Fourth-Generation Epac-Based FRET Sensors for cAMP Feature Exceptional Brightness, Photostability and Dynamic Range: Characterization of Dedicated Sensors for FLIM, for Ratiometry and with High Affinity

(2015) Jeffrey Klarenbeek et al.   PLoS One

Characterization of 5-HT1A receptors and their complexes with G-proteins in budded baculovirus particles using fluorescence anisotropy of Bodipy-FL-NAN-190

(2014) Lauri Tõntson et al.   NEUROCHEMISTRY INTERNATIONAL

Budded baculoviruses as a tool for a homogeneous fluorescence anisotropy-based assay of ligand binding to G protein-coupled receptors: The case of melanocortin 4 receptors

(2013) Santa Veiksina et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Glutamate Mediates the Function of Melanocortin Receptor 4 on Sim1 Neurons in Body Weight Regulation

(2013) Yuanzhong Xu et al.   Cell Metabolism

“Are melanocortin receptors constitutively active in vivo?”

(2013) Anthony P. Coll   EUROPEAN JOURNAL OF PHARMACOLOGY

G-Protein Coupled Receptor 83 (GPR83) Signaling Determined by Constitutive and Zinc(II)-Induced Activity

(2013) Anne Müller et al.   PLoS One

The melanocortin 4 receptor: Oligomer formation, interaction sites and functional significance

(2012) Kathryn L. Chapman et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Cell culture and gene transcription effects of copper sulfate on Chinese hamster ovary cells

(2011) Yueming Qian et al.   BIOTECHNOLOGY PROGRESS

Pharmacological characterization of zinc and copper interaction with the human alpha1A-adrenoceptor

(2011) Justyna Ciolek et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Fluorescence anisotropy assay for pharmacological characterization of ligand binding dynamics to melanocortin 4 receptors

(2010) Santa Veiksina et al.   ANALYTICAL BIOCHEMISTRY

The Melanocortin-4 Receptor: Physiology, Pharmacology, and Pathophysiology

(2010) Ya-Xiong Tao   ENDOCRINE REVIEWS

Zinc: The brain's dark horse

(2009) Byron K.Y. Bitanihirwe et al.   SYNAPSE

Targeting melanocortin receptors: an approach to treat weight disorders and sexual dysfunction

(2008) Jarl E. S. Wikberg et al.   NATURE REVIEWS DRUG DISCOVERY

Effect of Copper Sulfate on Performance of a Serum-Free CHO Cell Culture Process and the Level of Free Thiol in the Recombinant Antibody Expressed

(2005) Wendy B. Chaderjian et al.   BIOTECHNOLOGY PROGRESS