Marine sulfated polysaccharides as potential antiviral drug candidates to treat Corona Virus disease (COVID-19)

Efficacy of favipiravir in COVID-19 treatment: a multi-center randomized study

(2021) Hany M. Dabbous et al.   ARCHIVES OF VIROLOGY

Cytoplasmic short linear motifs in ACE2 and integrin β3 link SARS-CoV-2 host cell receptors to mediators of endocytosis and autophagy

(2021) Johanna Kliche et al.   Science Signaling

Structural Insight Into the SARS-CoV-2 Nucleocapsid Protein C-Terminal Domain Reveals a Novel Recognition Mechanism for Viral Transcriptional Regulatory Sequences

(2021) Mei Yang et al.   Frontiers in Chemistry

Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20–28 January 2020

(2020) Jantien A Backer et al.   Eurosurveillance

The neuroinvasive potential of SARS‐CoV2 may be at least partially responsible for the respiratory failure of COVID‐19 patients

(2020) Yan‐Chao Li et al.   JOURNAL OF MEDICAL VIROLOGY

Antitumour Potential of Gigartina pistillata Carrageenans against Colorectal Cancer Stem Cell-Enriched Tumourspheres

(2020) João Cotas et al.   Marine Drugs

Extraction and Modification of Macroalgal Polysaccharides for Current and Next-Generation Applications

(2020) Madeleine Jönsson et al.   MOLECULES

A pneumonia outbreak associated with a new coronavirus of probable bat origin

(2020) Peng Zhou et al.   NATURE

Coronavirus puts drug repurposing on the fast track

(2020) Charlotte Harrison   NATURE BIOTECHNOLOGY

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

(2020) Qihui Wang et al.   CELL

Understanding novel COVID-19: Its impact on organ failure and risk assessment for diabetic and cancer patients

(2020) Begum Dariya et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Teicoplanin: an alternative drug for the treatment of COVID-19?

(2020) Sophie Alexandra Baron et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Severe acute respiratory syndrome (SARS) and coronavirus disease-2019 (COVID-19): From causes to preventions in Hong Kong

(2020) Siukan Law et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Lack of Antiviral Activity of Darunavir against SARS-CoV-2

(2020) Sandra De Meyer et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

(2020) Calvin J. Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel coronavirus treatment with ribavirin: Groundwork for an evaluation concerning COVID-19

(2020) Jahan S. Khalili et al.   JOURNAL OF MEDICAL VIROLOGY

Comorbidities and multi-organ injuries in the treatment of COVID-19

(2020) Tianbing Wang et al.   LANCET

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

(2020) Tommy Tsan-Yuk Lam et al.   NATURE

Remdesivir for the Treatment of Covid-19 — Preliminary Report

(2020) John H. Beigel et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Trial of Lopinavir–Ritonavir in Adults Hospitalized with Severe Covid-19

(2020) Bin Cao et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cell entry mechanisms of SARS-CoV-2

(2020) Jian Shang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repurposing Antiviral Protease Inhibitors Using Extracellular Vesicles for Potential Therapy of COVID-19

(2020) Santosh Kumar et al.   Viruses-Basel

Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV

(2020) Xiuyuan Ou et al.   Nature Communications

The hallmarks of COVID-19 disease

(2020) Daolin Tang et al.   PLoS Pathogens

Interferon-α2b Treatment for COVID-19

(2020) Qiong Zhou et al.   Frontiers in Immunology

Potential Effects of Coronaviruses on the Cardiovascular System

(2020) Mohammad Madjid et al.   JAMA Cardiology

A Structural View of SARS-CoV-2 RNA Replication Machinery: RNA Synthesis, Proofreading and Final Capping

(2020) Maria Romano et al.   Cells

SARS-CoV-2 and COVID-19 in older adults: what we may expect regarding pathogenesis, immune responses, and outcomes

(2020) Janko Nikolich-Zugich et al.   GeroScience

Marine Algal Antioxidants as Potential Vectors for Controlling Viral Diseases

(2020) Clementina Sansone et al.   Antioxidants

Structural basis of SARS-CoV-2 3CLpro and anti-COVID-19 drug discovery from medicinal plants

(2020) Muhammad Tahir ul Qamar et al.   Journal of Pharmaceutical Analysis

Structural and functional properties of SARS-CoV-2 spike protein: potential antivirus drug development for COVID-19

(2020) Yuan Huang et al.   ACTA PHARMACOLOGICA SINICA

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

Remdesivir, lopinavir, emetine, and homoharringtonine inhibit SARS-CoV-2 replication in vitro

(2020) Ka-Tim Choy et al.   ANTIVIRAL RESEARCH

Structural Basis for Helicase-Polymerase Coupling in the SARS-CoV-2 Replication-Transcription Complex

(2020) James Chen et al.   CELL

Challenges and issues about organizing a hospital to respond to the COVID-19 outbreak: experience from a French reference centre

(2020) N. Peiffer-Smadja et al.   CLINICAL MICROBIOLOGY AND INFECTION

The broad-spectrum antiviral recommendations for drug discovery against COVID-19

(2020) Abu Hazafa et al.   DRUG METABOLISM REVIEWS

Ulvan lyase assisted structural characterization of ulvan from Ulva pertusa and its antiviral activity against vesicular stomatitis virus

(2020) Yongzhou Chi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

In vitro testing of combined hydroxychloroquine and azithromycin on SARS-CoV-2 shows synergistic effect

(2020) Julien Andreani et al.   MICROBIAL PATHOGENESIS

The experiences of health-care providers during the COVID-19 crisis in China: a qualitative study

(2020) Qian Liu et al.   Lancet Global Health

Ulvan, a Polysaccharide from Macroalga Ulva sp.: A Review of Chemistry, Biological Activities and Potential for Food and Biomedical Applications

(2020) Faradila Ratu Cindana Mo’o et al.   Applied Sciences-Basel

COVID-19, Renin-Angiotensin System and Endothelial Dysfunction

(2020) Razie Amraei et al.   Cells

Sulfated polysaccharides effectively inhibit SARS-CoV-2 in vitro

(2020) Paul S. Kwon et al.   Cell Discovery

Cytokine storm induced by SARS-CoV-2

(2020) Peipei Song et al.   CLINICA CHIMICA ACTA

Sulfated polysaccharide from the red algae Gelidiella acerosa: Anticoagulant, antiplatelet and antithrombotic effects

(2020) Francisco Diêgo da Silva Chagas et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression

(2020) Rubens Cecchini et al.   MEDICAL HYPOTHESES

Receptor binding and priming of the spike protein of SARS-CoV-2 for membrane fusion

(2020) Donald J. Benton et al.   NATURE

Antibody-independent and dependent infection of human myeloid cells with dengue virus is inhibited by carrageenan

(2020) Luana E. Piccini et al.   VIRUS RESEARCH

Repurposed Antiviral Drugs for Covid-19 — Interim WHO Solidarity Trial Results

(2020)   NEW ENGLAND JOURNAL OF MEDICINE

Cytokine storm induced by SARS-CoV-2 infection: The spectrum of its neurological manifestations

(2020) Parisorn Thepmankorn et al.   CYTOKINE

Interferon-inducer antivirals: Potential candidates to combat COVID-19

(2020) Ashkan Bagheri et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Antithrombotics from the Sea: Polysaccharides and Beyond

(2019) Francisca Carvalhal et al.   Marine Drugs

Chemistry and immunostimulatory activity of a polysaccharide from Undaria pinnatifida

(2019) Yongyi Yu et al.   FOOD AND CHEMICAL TOXICOLOGY

Have marine natural product drug discovery efforts been productive and how can we improve their efficiency?

(2019) Florbela Pereira   Expert Opinion on Drug Discovery

Anticoagulant and Antithrombotic Properties in Vitro and in Vivo of a Novel Sulfated Polysaccharide from Marine Green Alga Monostroma nitidum

(2019) Sujian Cao et al.   Marine Drugs

Coronavirus envelope protein: current knowledge

(2019) Dewald Schoeman et al.   Virology Journal

Ulvan: A systematic review of extraction, composition and function

(2019) Joel T. Kidgell et al.   Algal Research-Biomass Biofuels and Bioproducts

Advances in Exploring the Therapeutic Potential of Marine Natural Products

(2019) Xiao Liang et al.   PHARMACOLOGICAL RESEARCH

Chitosan alters inactivated respiratory syncytial virus vaccine elicited immune responses without affecting lung histopathology in mice

(2019) Abenaya Muralidharan et al.   VACCINE

Pharmacologic Application Potentials of Sulfated Polysaccharide from Marine Algae

(2019) Joanne Katherine Talens Manlusoc et al.   Polymers

Assessment of antiherpetic activity of nonsulfated and sulfated polysaccharides from Azadirachta indica

(2019) Ligia Carla Faccin-Galhardi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Chemically sulfated polysaccharides from natural sources: Assessment of extraction-sulfation efficiencies, structural features and antiviral activities

(2019) Shuvam Mukherjee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Vaccine Adjuvants Derived from Marine Organisms

(2019) Nina Sanina   Biomolecules

Physicochemical characterization and antioxidant activity of sulphated polysaccharides derived from Porphyra haitanensis

(2019) Bilal Muhammad Khan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Sulfated polysaccharides: Immunomodulation and signaling mechanisms

(2019) Lixin Huang et al.   TRENDS IN FOOD SCIENCE & TECHNOLOGY

In vitro anti-HIV-1 activity of the bioactive compound extracted and purified from two different marine macroalgae (seaweeds) (Dictyota bartayesiana J.V.Lamouroux and Turbinaria decurrens Bory)

(2019) Elumalai Sanniyasi et al.   Scientific Reports

A sulfated glucuronorhamnan from the green seaweed Monostroma nitidum: Characteristics of its structure and antiviral activity

(2019) Shuyao Wang et al.   CARBOHYDRATE POLYMERS

Structural features of microbial exopolysaccharides in relation to their antioxidant activity

(2019) Monic Andrew et al.   CARBOHYDRATE RESEARCH

Marine Pharmacology in 2014–2015: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, Antiviral, and Anthelmintic Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

(2019) Alejandro M. S. Mayer et al.   Marine Drugs

Influence of sulfated polysaccharides from Ulva lactuca L. upon Xa and IIa coagulation factors and on venous blood clot formation

(2019) Samara E. Reis et al.   Algal Research-Biomass Biofuels and Bioproducts

The inhibitory effects and mechanisms of 3,6- O -sulfated chitosan against human papillomavirus infection

(2018) Yanyun Gao et al.   CARBOHYDRATE POLYMERS

Insight into carrageenases: major review of sources, category, property, purification method, structure, and applications

(2018) Benwei Zhu et al.   CRITICAL REVIEWS IN BIOTECHNOLOGY

Chemical characterization and antioxidant activity of sulfated polysaccharides from Navicula sp.

(2018) Diana Fimbres-Olivarria et al.   FOOD HYDROCOLLOIDS

Purification, structural features and immunostimulatory activity of novel polysaccharides from Caulerpa lentillifera

(2018) Yujiao Sun et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

The antiviral activity of polysaccharides and their derivatives

(2018) Ling Chen et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Virus Entry: Looking Back and Moving Forward

(2018) Ari Helenius   JOURNAL OF MOLECULAR BIOLOGY

Chemical Modification of Chitosan for Efficient Vaccine Delivery

(2018) Lei Xing et al.   MOLECULES

Anti-hydroxyl radical activity, redox potential and anti-AChE activity of Amanita strobiliformis polysaccharide extract

(2018) Maja Karaman et al.   NATURAL PRODUCT RESEARCH

Antiviral activity against enterovirus 71 of sulfated rhamnan isolated from the green alga Monostroma latissimum

(2018) Shuyao Wang et al.   CARBOHYDRATE POLYMERS

Polysaccharides as vaccine adjuvants

(2018) Beini Sun et al.   VACCINE

Synthesized sulfated and acetylated derivatives of polysaccharide extracted from Gracilariopsis lemaneiformis and their potential antioxidant and immunological activity

(2018) Xiaomei Wang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Acidic polysaccharides isolated from marine algae inhibit the early step of viral infection

(2018) Mikinori Ueno et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

A novel antioxidant sulfated polysaccharide from the algae Gracilaria caudata: In vitro and in vivo activities

(2018) Poliana O. Cavalcante Alencar et al.   FOOD HYDROCOLLOIDS

Green seaweed Enteromorpha compressa ( Chlorophyta , Ulvaceae ) derived sulphated polysaccharides inhibit herpes simplex virus

(2017) Nayara Lopes et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Milestone 8: Targeting the Xa factor

(2017) Shimona Starling   Nature Reviews Cardiology

Macromolecular Antiviral Agents against Zika, Ebola, SARS, and Other Pathogenic Viruses

(2017) Franziska Schandock et al.   Advanced Healthcare Materials

FTIR characterization and antioxidant activity of water soluble crude polysaccharides of Sri Lankan marine algae

(2017) I. P. Shanura Fernando et al.   ALGAE

Sulfated polysaccharide fraction from marine algae Solieria filiformis : Structural characterization, gastroprotective and antioxidant effects

(2016) Willer M. Sousa et al.   CARBOHYDRATE POLYMERS

Structural characterization and antiviral activity of a novel heteropolysaccharide isolated from Grifola frondosa against enterovirus 71

(2016) Chao Zhao et al.   CARBOHYDRATE POLYMERS

Anti-HBV activity and mechanism of marine-derived polyguluronate sulfate (PGS) in vitro

(2016) Lijuan Wu et al.   CARBOHYDRATE POLYMERS

In vitro inhibition of human papillomavirus following use of a carrageenan-containing vaginal gel

(2016) Akiva P. Novetsky et al.   GYNECOLOGIC ONCOLOGY

In vitro anti-HIV-1 activity of fucoidan from Sargassum swartzii

(2016) Subramaniam Dinesh et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Polysaccharides from the Marine Environment with Pharmacological, Cosmeceutical and Nutraceutical Potential

(2016) Nadia Ruocco et al.   MOLECULES

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Prospects for the use of sulfated polysaccharides from brown seaweeds as vaccine adjuvants

(2016) T. A. Kuznetsova et al.   Russian Journal of Marine Biology

Synergistic Effects of Sulfated Polysaccharides from Mexican Seaweeds against Measles Virus

(2016) Karla Morán-Santibañez et al.   Biomed Research International

Vaccination with Astragalus and Ginseng Polysaccharides Improves Immune Response of Chickens against H5N1 Avian Influenza Virus

(2016) Auwalu Yusuf Abdullahi et al.   Biomed Research International

Role of Marine Natural Products in the Genesis of Antiviral Agents

(2015) Vedanjali Gogineni et al.   CHEMICAL REVIEWS

Coxsackievirus B3 replication and pathogenesis

(2015) Farshid S Garmaroudi et al.   Future Microbiology

Sulphated Polysaccharides from Ulva clathrata and Cladosiphon okamuranus Seaweeds both Inhibit Viral Attachment/Entry and Cell-Cell Fusion, in NDV Infection

(2015) José Aguilar-Briseño et al.   Marine Drugs

Characterization and Comparison of the Structural Features, Immune-Modulatory and Anti-Avian Influenza Virus Activities Conferred by Three Algal Sulfated Polysaccharides

(2015) Lin Song et al.   Marine Drugs

Antitumor and Adjuvant Activity of λ-carrageenan by Stimulating Immune Response in Cancer Immunotherapy

(2015) Min Luo et al.   Scientific Reports

Chemical characterization and antiherpes activity of sulfated polysaccharides from Lithothamnion muelleri

(2014) Bruna G. Malagoli et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Influence of sulphate on the composition and antibacterial and antiviral properties of the exopolysaccharide from Porphyridium cruentum

(2014) Maria Filomena de Jesus Raposo et al.   LIFE SCIENCES

A comprehensive map of the influenza A virus replication cycle

(2013) Yukiko Matsuoka et al.   BMC Systems Biology

Structure and anti-metapneumovirus activity of sulfated galactans from the red seaweed Cryptonemia seminervis

(2013) Gabriella S. Mendes et al.   CARBOHYDRATE POLYMERS

The depolymerized fucosylated chondroitin sulfate from sea cucumber potently inhibits HIV replication via interfering with virus entry

(2013) Ning Huang et al.   CARBOHYDRATE RESEARCH

Antiviral and immunomodulatory effects of a novel bacterial exopolysaccharide of shallow marine vent origin

(2013) C. Gugliandolo et al.   JOURNAL OF APPLIED MICROBIOLOGY

Concepts of papillomavirus entry into host cells

(2013) Patricia M. Day et al.   Current Opinion in Virology

Sulfated Polysaccharide, Curdlan Sulfate, Efficiently Prevents Entry/Fusion and Restricts Antibody-Dependent Enhancement of Dengue Virus Infection In Vitro: A Possible Candidate for Clinical Application

(2013) Koji Ichiyama et al.   PLoS Neglected Tropical Diseases

Novel polymeric inhibitors of HCoV-NL63

(2012) Aleksandra Milewska et al.   ANTIVIRAL RESEARCH

A sulfated polysaccharide, fucans, isolated from brown algae Sargassum vulgare with anticoagulant, antithrombotic, antioxidant and anti-inflammatory effects

(2012) Celina Maria P. Guerra Dore et al.   CARBOHYDRATE POLYMERS

Antiviral activity against dengue virus of diverse classes of algal sulfated polysaccharides

(2012) Carlos A. Pujol et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Nutritional and Chemical Composition and Antiviral Activity of Cultivated Seaweed Sargassum naozhouense Tseng et Lu

(2012) Yan Peng et al.   Marine Drugs

The Antiviral Activities and Mechanisms of Marine Polysaccharides: An Overview

(2012) Wei Wang et al.   Marine Drugs

In vitro characterization of the antiviral activity of fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus

(2012) Regina Elizondo-Gonzalez et al.   Virology Journal

Properties of polysaccharides in several seaweeds from Atlantic Canada and their potential anti-influenza viral activities

(2012) Guangling Jiao et al.   Journal of Ocean University of China

In vitro inhibition of influenza A virus infection by marine microalga-derived sulfated polysaccharide p-KG03

(2011) Meehyein Kim et al.   ANTIVIRAL RESEARCH

Sulfated polysaccharides from Laminaria angustata: Structural features and in vitro antiviral activities

(2011) Sudipta Saha et al.   CARBOHYDRATE POLYMERS

Biological activities and potential industrial applications of fucose rich sulfated polysaccharides and fucoidans isolated from brown seaweeds: A review

(2011) W.A.J.P. Wijesinghe et al.   CARBOHYDRATE POLYMERS

Sulfated Polysaccharides in Marine Sponges: Extraction Methods and Anti-HIV Activity

(2011) Ana I. S. Esteves et al.   Marine Drugs

Antiviral Activities of Sulfated Polysaccharides Isolated from Sphaerococcus coronopifolius (Rhodophytha, Gigartinales) and Boergeseniella thuyoides (Rhodophyta, Ceramiales)

(2011) Rhimou Bouhlal et al.   Marine Drugs

Polyanionic inhibitors of HIV adsorption

(2011) E. O. Baranova et al.   RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY

The Sulfated Polysaccharide Fucoidan Stimulates Osteogenic Differentiation of Human Adipose-Derived Stem Cells

(2011) Soo-jeong Park et al.   STEM CELLS AND DEVELOPMENT

Antiviral Lead Compounds from Marine Sponges

(2010) Sunil Sagar et al.   Marine Drugs

Structural features and in vitro antiviral activities of sulfated polysaccharides from Sphacelaria indica

(2010) Shruti S. Bandyopadhyay et al.   PHYTOCHEMISTRY

Virus assembly, allostery and antivirals

(2010) Adam Zlotnick et al.   TRENDS IN MICROBIOLOGY

Carrageenan as an adjuvant to enhance peptide-based vaccine potency

(2010) Yu-Qian Zhang et al.   VACCINE

In vitro anti-influenza virus activities of sulfated polysaccharide fractions from Gracilaria lemaneiformis

(2010) Mei-zhen Chen et al.   VIROLOGICA SINICA

Chitosan as an adjuvant for parenterally administered inactivated influenza vaccines

(2008) Y. Ghendon et al.   ARCHIVES OF VIROLOGY

Structure and anti-dengue virus activity of sulfated polysaccharide from a marine alga

(2008) Kazuya I.P.J. Hidari et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Using a 3-O-Sulfated Heparin Octasaccharide To Inhibit the Entry of Herpes Simplex Virus Type 1†

(2008) Ronald Copeland et al.   BIOCHEMISTRY

Innate immune response to viral infection

(2008) Shohei Koyama et al.   CYTOKINE

Focus on antivirally active sulfated polysaccharides: From structure–activity analysis to clinical evaluation

(2008) Tuhin Ghosh et al.   GLYCOBIOLOGY

Iota-Carrageenan is a potent inhibitor of rhinovirus infection

(2008) Andreas Grassauer et al.   Virology Journal