Remdesivir is a direct-acting antiviral that inhibits RNA-dependent RNA polymerase from severe acute respiratory syndrome coronavirus 2 with high potency

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

The antiviral compound remdesivir potently inhibits RNA-dependent RNA polymerase from Middle East respiratory syndrome coronavirus

(2020) Calvin J Gordon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection

(2020) Emmie de Wit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative therapeutic efficacy of remdesivir and combination lopinavir, ritonavir, and interferon beta against MERS-CoV

(2020) Timothy P. Sheahan et al.   Nature Communications

Updated Approaches against SARS-CoV-2

(2020) Haiou Li et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Remdesivir (GS-5734) protects African green monkeys from Nipah virus challenge

(2019) Michael K. Lo et al.   Science Translational Medicine

Mechanism of Inhibition of Ebola Virus RNA-Dependent RNA Polymerase by Remdesivir

(2019) Egor Tchesnokov et al.   Viruses-Basel

Nucleoside analogues for the treatment of coronavirus infections

(2019) Andrea J Pruijssers et al.   Current Opinion in Virology

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors

(2019) Robert N. Kirchdoerfer et al.   Nature Communications

Broad spectrum antiviral remdesivir inhibits human endemic and zoonotic deltacoronaviruses with a highly divergent RNA dependent RNA polymerase

(2019) Ariane J. Brown et al.   ANTIVIRAL RESEARCH

A Randomized, Controlled Trial of Ebola Virus Disease Therapeutics

(2019) Sabue Mulangu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Favipiravir (T-705) but not ribavirin is effective against two distinct strains of Crimean-Congo hemorrhagic fever virus in mice

(2018) David W. Hawman et al.   ANTIVIRAL RESEARCH

Favipiravir as a potential countermeasure against neglected and emerging RNA viruses

(2018) Leen Delang et al.   ANTIVIRAL RESEARCH

Coronavirus Susceptibility to the Antiviral Remdesivir (GS-5734) Is Mediated by the Viral Polymerase and the Proofreading Exoribonuclease

(2018) Maria L. Agostini et al.   mBio

Recombinant RNA-Dependent RNA Polymerase Complex of Ebola Virus

(2018) Egor P. Tchesnokov et al.   Scientific Reports

Initiation, extension, and termination of RNA synthesis by a paramyxovirus polymerase

(2018) Paul C. Jordan et al.   PLoS Pathogens

Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses

(2017) Dustin Siegel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Favipiravir (T-705), a broad spectrum inhibitor of viral RNA polymerase

(2017) Yousuke FURUTA et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

(2017) François Ferron et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral GS-5734 inhibits both epidemic and zoonotic coronaviruses

(2017) Timothy P. Sheahan et al.   Science Translational Medicine

Nidovirus RNA polymerases: Complex enzymes handling exceptional RNA genomes

(2017) Clara C. Posthuma et al.   VIRUS RESEARCH

GS-5734 and its parent nucleoside analog inhibit Filo-, Pneumo- and Paramyxoviruses

(2017) Michael K. Lo et al.   Scientific Reports

Lassa and Ebola virus inhibitors identified using minigenome and recombinant virus reporter systems

(2016) Stephen R. Welch et al.   ANTIVIRAL RESEARCH

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys

(2016) Travis K. Warren et al.   NATURE

Structural basis for RNA replication by the hepatitis C virus polymerase

(2015) T. C. Appleby et al.   SCIENCE

High-throughput, luciferase-based reverse genetics systems for identifying inhibitors of Marburg and Ebola viruses

(2014) Luke S. Uebelhoer et al.   ANTIVIRAL RESEARCH

One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

(2014) Lorenzo Subissi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evaluation of Antiviral Efficacy of Ribavirin, Arbidol, and T-705 (Favipiravir) in a Mouse Model for Crimean-Congo Hemorrhagic Fever

(2014) Lisa Oestereich et al.   PLoS Neglected Tropical Diseases

HCV direct-acting antiviral agents: the best interferon-free combinations

(2013) Raymond Schinazi et al.   LIVER INTERNATIONAL

The Ambiguous Base-Pairing and High Substrate Efficiency of T-705 (Favipiravir) Ribofuranosyl 5′-Triphosphate towards Influenza A Virus Polymerase

(2013) Zhinan Jin et al.   PLoS One

RNA 3'-end mismatch excision by the severe acute respiratory syndrome coronavirus nonstructural protein nsp10/nsp14 exoribonuclease complex

(2012) M. Bouvet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vitro and in vivo efficacy of fluorodeoxycytidine analogs against highly pathogenic avian influenza H5N1, seasonal, and pandemic H1N1 virus infections

(2011) Yohichi Kumaki et al.   ANTIVIRAL RESEARCH

Ribonucleoside Triphosphates as Substrate of Human Immunodeficiency Virus Type 1 Reverse Transcriptase in Human Macrophages

(2010) Edward M. Kennedy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural basis for active site closure by the poliovirus RNA-dependent RNA polymerase

(2010) P. Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase

(2008) Egor P. Tchesnokov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Insights into Mechanisms of Catalysis and Inhibition in Norwalk Virus Polymerase

(2008) Dmitry F. Zamyatkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY