Let’s make microglia great again in neurodegenerative disorders

Peripheral complement interactions with amyloid β peptide in Alzheimer's disease: 2. Relationship to amyloid β immunotherapy

(2018) Andrés Crane et al.   Alzheimers & Dementia

BDNF, TNFα, HSP90, CFH, and IL-10 Serum Levels in Patients with Early or Late Onset Alzheimer's Disease or Mild Cognitive Impairment

(2018) Duygu Gezen-Ak et al.   JOURNAL OF ALZHEIMERS DISEASE

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

(2017) Ina Tesseur et al.   JOURNAL OF NEUROSCIENCE

The role of peripheral immune cells in the CNS in steady state and disease

(2017) Marco Prinz et al.   NATURE NEUROSCIENCE

Significance of aberrant glial cell phenotypes in pathophysiology of amyotrophic lateral sclerosis

(2017) Emiliano Trias et al.   NEUROSCIENCE LETTERS

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain

(2017) Anna Sznejder-Pachołek et al.   Pharmacological Reports

Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2017) Haitao A. Wang et al.   Skeletal Muscle

Identification of miRNA Changes in Alzheimer's Disease Brain and CSF Yields Putative Biomarkers and Insights into Disease Pathways

(2017) John P. Cogswell et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin-Degrading Enzyme Sorting in Exosomes: A Secretory Pathway for a Key Brain Amyloid-β Degrading Protease

(2017) Ayelén Bulloj et al.   JOURNAL OF ALZHEIMERS DISEASE

Soluble phospho-tau from Alzheimer’s disease hippocampus drives microglial degeneration

(2016) Elisabeth Sanchez-Mejias et al.   ACTA NEUROPATHOLOGICA

Toll-like receptor 2 is increased in neurons in Parkinson’s disease brain and may contribute to alpha-synuclein pathology

(2016) Nicolas Dzamko et al.   ACTA NEUROPATHOLOGICA

Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease

(2016) David C. Hondius et al.   Alzheimers & Dementia

Like prions: the propagation of aggregated tau and α-synuclein in neurodegeneration

(2016) Michel Goedert et al.   BRAIN

Microglia regulate hippocampal neurogenesis during chronic neurodegeneration

(2016) Chiara De Lucia et al.   BRAIN BEHAVIOR AND IMMUNITY

Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease

(2016) Claire L. McDonald et al.   BRAIN BEHAVIOR AND IMMUNITY

scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K/Akt pathway

(2016) Ying Wang et al.   BRAIN RESEARCH

Expression of microRNA-34a in Alzheimer's disease brain targets genes linked to synaptic plasticity, energy metabolism, and resting state network activity

(2016) S. Sarkar et al.   BRAIN RESEARCH

Inflammatory Process in Alzheimer's and Parkinson's Diseases: Central Role of Cytokines

(2016) Qamre Alam et al.   CURRENT PHARMACEUTICAL DESIGN

Toll-like receptor-mediated immune response inhibits prion propagation

(2016) Sang-Gyun Kang et al.   GLIA

Amyloid Cascade into Clarity

(2016) Tara M. Weitz et al.   IMMUNITY

Genetic and Transcriptomic Profiles of Inflammation in Neurodegenerative Diseases: Alzheimer, Parkinson, Creutzfeldt-Jakob and Tauopathies

(2016) Irene López González et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular Vesicles Isolated from the Brains of rTg4510 Mice Seed Tau Protein Aggregation in a Threshold-dependent Manner

(2016) Juan Carlos Polanco et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques

(2016) Yaming Wang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stimulation of TLR4 Attenuates Alzheimer’s Disease–Related Symptoms and Pathology in Tau-Transgenic Mice

(2016) Yiren Qin et al.   JOURNAL OF IMMUNOLOGY

Targeting innate immunity for neurodegenerative disorders of the central nervous system

(2016) Katrin I. Andreasson et al.   JOURNAL OF NEUROCHEMISTRY

Prion-like propagation as a pathogenic principle in frontotemporal dementia

(2016) Eva-Maria Hock et al.   JOURNAL OF NEUROCHEMISTRY

Balancing the immune response in the brain: IL-10 and its regulation

(2016) Diogo Lobo-Silva et al.   Journal of Neuroinflammation

Complement activation at the motor end-plates in amyotrophic lateral sclerosis

(2016) Nawal Bahia El Idrissi et al.   Journal of Neuroinflammation

Disease Progression-Dependent Effects of TREM2 Deficiency in a Mouse Model of Alzheimer's Disease

(2016) Taylor R. Jay et al.   JOURNAL OF NEUROSCIENCE

IL-10 Controls Early Microglial Phenotypes and Disease Onset in ALS Caused by Misfolded Superoxide Dismutase 1

(2016) M. Gravel et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-Microglia Cross Talk through Complement Activation Modulates Amyloid Pathology in Mouse Models of Alzheimer's Disease

(2016) H. Lian et al.   JOURNAL OF NEUROSCIENCE

TREM2 rare variant p.R47H is not associated with Parkinson's disease

(2016) David Mengel et al.   PARKINSONISM & RELATED DISORDERS

Synthetic and natural small molecule TLR4 antagonists inhibit motoneuron death in cultures from ALS mouse model

(2016) Massimiliano De Paola et al.   PHARMACOLOGICAL RESEARCH

Gut microbiome in health and disease: Linking the microbiome–gut–brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases

(2016) Shivani Ghaisas et al.   PHARMACOLOGY & THERAPEUTICS

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Potential Pathways of Abnormal Tau and α-Synuclein Dissemination in Sporadic Alzheimer's and Parkinson's Diseases

(2016) Heiko Braak et al.   Cold Spring Harbor Perspectives in Biology

Effects of pramipexole treatment on the α-synuclein content in serum exosomes of Parkinson's disease patients

(2016) He-Ting Luo et al.   Experimental and Therapeutic Medicine

Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72 -ALS/FTD

(2016) Thomas Westergard et al.   Cell Reports

Neurotransmitter receptors on microglia

(2016) Huan Liu et al.   JOURNAL OF INVESTIGATIVE MEDICINE

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

Increased tauopathy drives microglia-mediated clearance of beta-amyloid

(2016) Wesley Chen et al.   Acta Neuropathologica Communications

Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2

(2016) Changyoun Kim et al.   Experimental Neurobiology

Age-dependent defects of alpha-synuclein oligomer uptake in microglia and monocytes

(2015) Corinna Bliederhaeuser et al.   ACTA NEUROPATHOLOGICA

The role of TREM2 R47H as a risk factor for Alzheimer's disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson's disease

(2015) Christina M. Lill et al.   Alzheimers & Dementia

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

(2015) Anne Stuendl et al.   BRAIN

The role of the immune system in neurodegenerative disorders: Adaptive or maladaptive?

(2015) Kevin R. Doty et al.   BRAIN RESEARCH

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 enables amyloid β clearance by microglia

(2015) Serge Rivest   CELL RESEARCH

Non-Steroidal Anti-Inflammatory Drugs as a Treatment for Alzheimer’s Disease: A Systematic Review and Meta-Analysis of Treatment Effect

(2015) Marina Miguel-Álvarez et al.   DRUGS & AGING

Differential upregulation of the cannabinoid CB2 receptor in neurotoxic and inflammation-driven rat models of Parkinson's disease

(2015) Ruth M. Concannon et al.   EXPERIMENTAL NEUROLOGY

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Amyloid-β Activates Microglia and Regulates Protein Expression in a Manner Similar to Prions

(2015) Jian Tu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

(2015) Jia Y Lee et al.   Journal of Neuroinflammation

Cerebrospinal Fluid Particles in Alzheimer Disease and Parkinson Disease

(2015) Yue Yang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Assessment of TREM2 rs75932628 association with amyotrophic lateral sclerosis in a Chinese population

(2015) Xueping Chen et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Neuroinflammation in Alzheimer's disease

(2015) Michael T Heneka et al.   LANCET NEUROLOGY

CD33 modulates TREM2: convergence of Alzheimer loci

(2015) Gail Chan et al.   NATURE NEUROSCIENCE

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

Immune attack: the role of inflammation in Alzheimer disease

(2015) Frank L. Heppner et al.   NATURE REVIEWS NEUROSCIENCE

Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains

(2015) Caihong Zhu et al.   NEUROBIOLOGY OF AGING

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex

(2015) Douglas G. Walker et al.   NEUROBIOLOGY OF AGING

Il10 Deficiency Rebalances Innate Immunity to Mitigate Alzheimer-Like Pathology

(2015) Marie-Victoire Guillot-Sestier et al.   NEURON

Anti-inflammatory Signaling in Microglia Exacerbates Alzheimer’s Disease-Related Pathology

(2015) Jean-Philippe Michaud et al.   NEURON

IL-10 Alters Immunoproteostasis in APP Mice, Increasing Plaque Burden and Worsening Cognitive Behavior

(2015) Paramita Chakrabarty et al.   NEURON

Variation in complement protein C1q is not a major contributor to cognitive impairment in Parkinson’s disease

(2015) Sophia Carbutt et al.   NEUROSCIENCE LETTERS

Protective and Toxic Neuroinflammation in Amyotrophic Lateral Sclerosis

(2015) Kristopher G. Hooten et al.   Neurotherapeutics

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Innate Immunity Fights Alzheimer's Disease

(2015) Marie-Victoire Guillot-Sestier et al.   TRENDS IN NEUROSCIENCES

Astrocytic TGF-β1: detrimental factor in ALS

(2015) Fumito Endo et al.   Oncotarget

Exposure to ALS-FTD-CSF generates TDP-43 aggregates in glioblastoma cells through exosomes and TNTs-like structure

(2015) Xuebing Ding et al.   Oncotarget

Altered microRNA profiles in cerebrospinal fluid exosome in Parkinson disease and Alzheimer disease

(2015) YaXing Gui et al.   Oncotarget

Integrated genomic approaches identify major pathways and upstream regulators in late onset Alzheimer’s disease

(2015) Xinzhong Li et al.   Scientific Reports

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

Complex Inflammation mRNA-Related Response in ALS Is Region Dependent

(2015) Sara Berjaoui et al.   NEURAL PLASTICITY

Activation of MyD88-dependent TLR1/2 signaling by misfolded α-synuclein, a protein linked to neurodegenerative disorders

(2015) Stefano G. Daniele et al.   Science Signaling

Prion-like Mechanism in Amyotrophic Lateral Sclerosis: are Protein Aggregates the Key?

(2015) Shynrye Lee et al.   Experimental Neurobiology

Toll-Like Receptor Expression in the Blood and Brain of Patients and a Mouse Model of Parkinson's Disease

(2015) J. Drouin-Ouellet et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Exosome-dependent and independent mechanisms are involved in prion-like transmission of propagated Cu/Zn superoxide dismutase misfolding

(2015) Leslie I Grad et al.   Prion

R47H TREM2 variant increases risk of typical early-onset Alzheimer's disease but not of prion or frontotemporal dementia

(2014) Catherine F. Slattery et al.   Alzheimers & Dementia

Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice

(2014) Oleg Butovsky et al.   ANNALS OF NEUROLOGY

Microglial Aβ Receptors in Alzheimer’s Disease

(2014) Yang Yu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Parkinson's disease-linked human PARK9/ATP13A2 maintains zinc homeostasis and promotes α-Synuclein externalization via exosomes

(2014) Stephanie M.Y. Kong et al.   HUMAN MOLECULAR GENETICS

Interleukin-10-1082A/G and −592C/A Polymorphisms with risk of Parkinson's disease: a meta-analysis

(2014) Jun Jin et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Acceleration of α-Synuclein Aggregation by Exosomes

(2014) Marie Grey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Complement Factor C5a Contributes to Pathology in a Rat Model of Amyotrophic Lateral Sclerosis

(2014) T. M. Woodruff et al.   JOURNAL OF IMMUNOLOGY

Toll-Like Receptor 2 Deficiency Shifts PrP106-126-Induced Microglial Activation from a Neurotoxic to a Neuroprotective Phenotype

(2014) Jihong Wang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Elevation of the terminal complement activation products C5a and C5b-9 in ALS patient blood

(2014) S. Mantovani et al.   JOURNAL OF NEUROIMMUNOLOGY

ATP13A2/PARK9 Regulates Secretion of Exosomes and  -Synuclein

(2014) T. Tsunemi et al.   JOURNAL OF NEUROSCIENCE

Emerging Roles of Extracellular Vesicles in the Nervous System

(2014) L. Rajendran et al.   JOURNAL OF NEUROSCIENCE

Remarkable Activation of the Complement System and Aberrant Neuronal Localization of the Membrane Attack Complex in the Brain Tissues of Scrapie-Infected Rodents

(2014) Yan Lv et al.   MOLECULAR NEUROBIOLOGY

CD33 rs3865444 Polymorphism Contributes to Alzheimer’s Disease Susceptibility in Chinese, European, and North American Populations

(2014) Xingwang Li et al.   MOLECULAR NEUROBIOLOGY

Circulating miRNAs as Biomarkers for Neurodegenerative Disorders

(2014) Margherita Grasso et al.   MOLECULES

Triggering receptor expressed on myeloid cells 2 variants are rare in Parkinson's disease in a Han Chinese cohort

(2014) Shu-jun Feng et al.   NEUROBIOLOGY OF AGING

Astrogliosis as a therapeutic target for neurodegenerative diseases

(2014) Anna Maria Colangelo et al.   NEUROSCIENCE LETTERS

The influence of AAV2-mediated gene transfer of human IL-10 on neurodegeneration and immune response in a murine model of Parkinson's disease

(2014) Ilona Joniec-Maciejak et al.   Pharmacological Reports

Multifaceted effects of oligodendroglial exosomes on neurons: impact on neuronal firing rate, signal transduction and gene regulation

(2014) D. Frohlich et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

MicroRNAs: New Regulators of Toll-Like Receptor Signalling Pathways

(2014) Xiaobing He et al.   Biomed Research International

TREM2Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis

(2014) Janet Cady et al.   JAMA Neurology

Microglial phenotypes and toll-like receptor 2 in the substantia nigra and hippocampus of incidental Lewy body disease cases and Parkinson’s disease patients

(2014) Karlijn J Doorn et al.   Acta Neuropathologica Communications

Microglia actions in Alzheimer’s disease

(2013) Stefan Prokop et al.   ACTA NEUROPATHOLOGICA

Integrated Systems Approach Identifies Genetic Nodes and Networks in Late-Onset Alzheimer’s Disease

(2013) Bin Zhang et al.   CELL

The role of inflammation in sporadic and familial Parkinson’s disease

(2013) Michela Deleidi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Complement protein C3 exacerbates prion disease in a mouse model of chronic wasting disease

(2013) Brady Michel et al.   INTERNATIONAL IMMUNOLOGY

Intercellular Communication by Exosome-Derived microRNAs in Cancer

(2013) Bethany Hannafon et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD33 Alzheimer's Risk-Altering Polymorphism, CD33 Expression, and Exon 2 Splicing

(2013) M. Malik et al.   JOURNAL OF NEUROSCIENCE

Characterization and deep sequencing analysis of exosomal and non-exosomal miRNA in human urine

(2013) Lesley Cheng et al.   KIDNEY INTERNATIONAL

TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson’s disease

(2013) Sruti Rayaprolu et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

CD33 Alzheimer's disease locus: altered monocyte function and amyloid biology

(2013) Elizabeth M Bradshaw et al.   NATURE NEUROSCIENCE

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

TREM2 mutations are rare in a French cohort of patients with frontotemporal dementia

(2013) Serena Lattante et al.   NEUROBIOLOGY OF AGING

Missense variant in TREML2 protects against Alzheimer's disease

(2013) Bruno A. Benitez et al.   NEUROBIOLOGY OF AGING

Alzheimer’s Disease Risk Gene CD33 Inhibits Microglial Uptake of Amyloid Beta

(2013) Ana Griciuc et al.   NEURON

Exosomes of BV-2 cells induced by alpha-synuclein: Important mediator of neurodegeneration in PD

(2013) Chongwang Chang et al.   NEUROSCIENCE LETTERS

Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population

(2013) Kun Nie et al.   NEUROSCIENCE LETTERS

Circulating miRNA Biomarkers for Alzheimer's Disease

(2013) Pavan Kumar et al.   PLoS One

Intricate interplay between astrocytes and motor neurons in ALS

(2013) H. P. Phatnani et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice

(2013) C. S. Lobsiger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The involvement of microRNAs in neurodegenerative diseases

(2013) Simona Maciotta et al.   Frontiers in Cellular Neuroscience

Extracellular vesicles as mediators of neuron-glia communication

(2013) Carsten Frühbeis et al.   Frontiers in Cellular Neuroscience

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Toll like receptor 4 mediates cell death in a mouse MPTP model of Parkinson disease

(2013) Carmen Noelker et al.   Scientific Reports

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains

(2013) Takashi Nonaka et al.   Cell Reports

Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication

(2013) Carsten Frühbeis et al.   PLOS BIOLOGY

Non-Steroidal Anti-Inflammatory Drugs and Alzheimers Disease: The Epidemiological Evidence

(2012) C.A. Szekely et al.   CNS & Neurological Disorders-Drug Targets

Microvesicles released from microglia stimulate synaptic activity via enhanced sphingolipid metabolism

(2012) Flavia Antonucci et al.   EMBO JOURNAL

Brain-resident microglia predominate over infiltrating myeloid cells in activation, phagocytosis and interaction with T-lymphocytes in the MPTP mouse model of Parkinson disease

(2012) Candan Depboylu et al.   EXPERIMENTAL NEUROLOGY

Prion-infected cells regulate the release of exosomes with distinct ultrastructural features

(2012) Bradley M. Coleman et al.   FASEB JOURNAL

Extracellular aggregated Cu/Zn superoxide dismutase activates microglia to give a cytotoxic phenotype

(2012) Kate Roberts et al.   GLIA

Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia

(2012) Lisa Fellner et al.   GLIA

MicroRNA-205 regulates the expression of Parkinson's disease-related leucine-rich repeat kinase 2 protein

(2012) Hyun Jin Cho et al.   HUMAN MOLECULAR GENETICS

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

(2012) Kohei Yuyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Depletion of Complement Receptors CD21/35 Prevents Terminal Prion Disease in a Mouse Model of Chronic Wasting Disease

(2012) Brady Michel et al.   JOURNAL OF IMMUNOLOGY

Loss of Interleukin Receptor-Associated Kinase 4 Signaling Suppresses Amyloid Pathology and Alters Microglial Phenotype in a Mouse Model of Alzheimer's Disease

(2012) B. Cameron et al.   JOURNAL OF NEUROSCIENCE

Identification and proteomic profiling of exosomes in human cerebrospinal fluid

(2012) Jonathan M Street et al.   Journal of Translational Medicine

Exosomal cell-to-cell transmission of alpha synuclein oligomers

(2012) Karin M Danzer et al.   Molecular Neurodegeneration

An unconventional role for miRNA: let-7 activates Toll-like receptor 7 and causes neurodegeneration

(2012) Sabrina M Lehmann et al.   NATURE NEUROSCIENCE

Activation of Transforming Growth Factor-β/Smad Signaling Reduces Aggregate Formation of Mislocalized TAR DNA-Binding Protein-43

(2012) Masataka Nakamura et al.   Neurodegenerative Diseases

Interleukin-10 promoter polymorphisms in Chinese patients with Parkinson's disease

(2012) Dequan Li et al.   NEUROSCIENCE LETTERS

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Small RNA deep sequencing reveals a distinct miRNA signature released in exosomes from prion-infected neuronal cells

(2012) Shayne A. Bellingham et al.   NUCLEIC ACIDS RESEARCH

MicroRNA 146a (miR-146a) Is Over-Expressed during Prion Disease and Modulates the Innate Immune Response and the Microglial Activation State

(2012) Reuben Saba et al.   PLoS One

Complement 3 and Factor H in Human Cerebrospinal Fluid in Parkinson's Disease, Alzheimer's Disease, and Multiple-System Atrophy

(2011) Yu Wang et al.   AMERICAN JOURNAL OF PATHOLOGY

Toll-Like Receptor 4 Promotes α-Synuclein Clearance and Survival of Nigral Dopaminergic Neurons

(2011) Nadia Stefanova et al.   AMERICAN JOURNAL OF PATHOLOGY

Assessing the contribution of inflammation in models of Alzheimer's disease: Figure 1

(2011) Hannah Johnston et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Interaction and uptake of exosomes by ovarian cancer cells

(2011) Cristina Escrevente et al.   BMC CANCER

Genetic association of TLR4/11367 polymorphism with late-onset Alzheimer's disease in a Han Chinese population

(2011) Li-Zhu Wang et al.   BRAIN RESEARCH

Self-propagation and transmission of misfolded mutant SOD1: Prion or prion-like phenomenon?

(2011) Christian Münch et al.   CELL CYCLE

Complement receptor 1 (CR1) and Alzheimer's disease

(2011) Helen Crehan et al.   IMMUNOBIOLOGY

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Complement upregulation and activation on motor neurons and neuromuscular junction in the SOD1 G93A mouse model of familial amyotrophic lateral sclerosis

(2011) Bianca Heurich et al.   JOURNAL OF NEUROIMMUNOLOGY

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Possible Involvement of Complement Factor C1q in the Clearance of Extracellular Neuromelanin From the Substantia Nigra in Parkinson Disease

(2011) Candan Depboylu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Pathological roles of α-synuclein in neurological disorders

(2011) Kostas Vekrellis et al.   LANCET NEUROLOGY

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

(2011) Lydia Alvarez-Erviti et al.   NATURE BIOTECHNOLOGY

Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease

(2011) Adam C Naj et al.   NATURE GENETICS

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Lysosomal dysfunction increases exosome-mediated alpha-synuclein release and transmission

(2011) Lydia Alvarez-Erviti et al.   NEUROBIOLOGY OF DISEASE

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Misfolded α-synuclein and toll-like receptors: therapeutic targets for Parkinson's disease

(2011) Dawn Béraud et al.   PARKINSONISM & RELATED DISORDERS

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Prion-like propagation of mutant superoxide dismutase-1 misfolding in neuronal cells

(2011) Christian Münch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

(2011) Angélique Bobrie et al.   TRAFFIC

High levels of C3c in the cerebrospinal fluid from amyotrophic lateral sclerosis patients

(2010) P. Annunziata et al.   ACTA NEUROLOGICA SCANDINAVICA

Lack of association between IL-1β, TNF-α, and IL-10 gene polymorphisms and sporadic Parkinson’s disease in an Italian cohort

(2010) E. Pascale et al.   ACTA NEUROLOGICA SCANDINAVICA

Dual Induction of TREM2 and Tolerance-Related Transcript, Tmem176b, in Amyloid Transgenic Mice: Implications for Vaccine-Based Therapies for Alzheimer's Disease

(2010) Benoit Melchior et al.   ASN Neuro

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Antiparkinsonian trophic action of glial cell line-derived neurotrophic factor and transforming growth factor β1 is enhanced after co-infusion in rats

(2010) Ramiro Gonzalez-Aparicio et al.   EXPERIMENTAL NEUROLOGY

Alzheimer’s disease beyond Aβ

(2010) Terrence Town   Expert Review of Neurotherapeutics

Statins Promote the Degradation of Extracellular Amyloid β-Peptide by Microglia via Stimulation of Exosome-associated Insulin-degrading Enzyme (IDE) Secretion

(2010) Irfan Y. Tamboli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Macrophages in Alzheimer’s disease: the blood-borne identity

(2010) David Gate et al.   JOURNAL OF NEURAL TRANSMISSION

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Overexpression of CB2 cannabinoid receptors results in neuroprotection against behavioral and neurochemical alterations induced by intracaudate administration of 6-hydroxydopamine

(2010) Alexander Ternianov et al.   NEUROBIOLOGY OF AGING

TGF-β 1 enhances neurite outgrowth via regulation of proteasome function and EFABP

(2010) Johanna Knöferle et al.   NEUROBIOLOGY OF DISEASE

Exosomal Hsp70 Induces a Pro-Inflammatory Response to Foreign Particles Including Mycobacteria

(2010) Paras K. Anand et al.   PLoS One

Locus ceruleus controls Alzheimer's disease pathology by modulating microglial functions through norepinephrine

(2010) M. T. Heneka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Decreased Clearance of CNS  -Amyloid in Alzheimer's Disease

(2010) K. G. Mawuenyega et al.   SCIENCE

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

The combinations of TNFα-308 and IL-6 -174 or IL-10 -1082 genes polymorphisms suggest an association with susceptibility to sporadic late-onset Alzheimer’s disease

(2009) P. Vural et al.   ACTA NEUROLOGICA SCANDINAVICA

Circulating interleukin-10 and interleukin-12 in Parkinson’s disease

(2009) M. Rentzos et al.   ACTA NEUROLOGICA SCANDINAVICA

Degenerating Synaptic Boutons in Prion Disease

(2009) Zuzana Šišková et al.   AMERICAN JOURNAL OF PATHOLOGY

Alternative Aβ Immunotherapy Approaches for Alzheimers Disease

(2009) Terrence Town   CNS & Neurological Disorders-Drug Targets

WIN55,212-2, a cannabinoid receptor agonist, protects against nigrostriatal cell loss in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease

(2009) David A. Price et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Extracellular mutant SOD1 induces microglial-mediated motoneuron injury

(2009) Weihua Zhao et al.   GLIA

Propagation of Tau Misfolding from the Outside to the Inside of a Cell

(2009) Bess Frost et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CNS Infiltration of Peripheral Immune Cells: D-Day for Neurodegenerative Disease?

(2009) Kavon Rezai-Zadeh et al.   Journal of Neuroimmune Pharmacology

CD14 and Toll-Like Receptors 2 and 4 Are Required for Fibrillar A -Stimulated Microglial Activation

(2009) E. G. Reed-Geaghan et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammation in Parkinson's disease: a target for neuroprotection?

(2009) Etienne C Hirsch et al.   LANCET NEUROLOGY

Upregulation of miRNA hsa-miR-342-3p in experimental and idiopathic prion disease

(2009) Judith Montag et al.   Molecular Neurodegeneration

α-Synuclein and neuronal cell death

(2009) Mark R Cookson   Molecular Neurodegeneration

Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease

(2009) Jean-Charles Lambert et al.   NATURE GENETICS

Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease

(2009) Denise Harold et al.   NATURE GENETICS

Microglial activation and amyloid deposition in mild cognitive impairment: A PET study

(2009) A. Okello et al.   NEUROLOGY

The Transcellular Spread of Cytosolic Amyloids, Prions, and Prionoids

(2009) Adriano Aguzzi et al.   NEURON

Differential regulation of toll-like receptor mRNAs in amyloid plaque-associated brain tissue of aged APP23 transgenic mice

(2009) Stefanie Frank et al.   NEUROSCIENCE LETTERS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Repression of  -synuclein expression and toxicity by microRNA-7

(2009) E. Junn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The influence of microglia on the pathogenesis of Parkinson's disease

(2009) Caitríona M. Long-Smith et al.   PROGRESS IN NEUROBIOLOGY

Phosphorylated Smad2/3 immunoreactivity in sporadic and familial amyotrophic lateral sclerosis and its mouse model

(2008) Masataka Nakamura et al.   ACTA NEUROPATHOLOGICA

Mouse neuroblastoma cells release prion infectivity associated with exosomal vesicles

(2008) Sandrine Alais et al.   BIOLOGY OF THE CELL

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

(2008) Christopher J. Henry et al.   BRAIN BEHAVIOR AND IMMUNITY

Regulation of βAPP and PrPc Cleavage by α-Secretase: Mechanistic and Therapeutic Perspectives

(2008) Bruno Vincent et al.   Current Alzheimer Research

Inflammation-related genes and the risk of Parkinson’s disease: a multilocus approach

(2008) J. Infante et al.   EUROPEAN JOURNAL OF NEUROLOGY

TREM2 is upregulated in amyloid plaque-associated microglia in aged APP23 transgenic mice

(2008) Stefanie Frank et al.   GLIA

Contextual Regulation of Inflammation: A Duet by Transforming Growth Factor-β and Interleukin-10

(2008) Ming O. Li et al.   IMMUNITY

Assembly-dependent endocytosis and clearance of extracellular a-synuclein

(2008) He-Jin Lee et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cytokines in Alzheimer's Disease and Vascular Dementia

(2008) P. Angelopoulos et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Expression of Amyotrophic Lateral Sclerosis-linked SOD1 Mutant Increases the Neurotoxic Potential of Microglia via TLR2

(2008) Yang Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Infiltration of CD4+ lymphocytes into the brain contributes to neurodegeneration in a mouse model of Parkinson disease

(2008) Vanessa Brochard et al.   JOURNAL OF CLINICAL INVESTIGATION

Plaque complement activation and cognitive loss in Alzheimer's disease

(2008) David A Loeffler et al.   Journal of Neuroinflammation

Dynamics of the Microglial/Amyloid Interaction Indicate a Role in Plaque Maintenance

(2008) T. Bolmont et al.   JOURNAL OF NEUROSCIENCE

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Accelerated Prion Disease Pathogenesis in Toll-Like Receptor 4 Signaling-Mutant Mice

(2008) D. S. Spinner et al.   JOURNAL OF VIROLOGY

Human Interleukin-10 Gene Transfer Is Protective in a Rat Model of Parkinson's Disease

(2008) Louisa C Johnston et al.   MOLECULAR THERAPY

Blocking TGF-β–Smad2/3 innate immune signaling mitigates Alzheimer-like pathology

(2008) Terrence Town et al.   NATURE MEDICINE

Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis

(2008) Koji Yamanaka et al.   NATURE NEUROSCIENCE

Th1 responses to beta-amyloid in young humans convert to regulatory IL-10 responses in Down syndrome and Alzheimer's disease

(2008) Kai F. Loewenbrueck et al.   NEUROBIOLOGY OF AGING

Microglia, amyloid, and cognition in Alzheimer's disease: An [11C](R)PK11195-PET and [11C]PIB-PET study

(2008) Paul Edison et al.   NEUROBIOLOGY OF DISEASE

Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFα, and INFγ concentrations are elevated in patients with atypical and idiopathic parkinsonism

(2008) Bogdan Brodacki et al.   NEUROSCIENCE LETTERS

Interleukin-10 (IL10) and tumor necrosis factor α (TNF) gene polymorphisms in Parkinson's disease patients

(2008) M. Bialecka et al.   PARKINSONISM & RELATED DISORDERS

A miRNA Signature of Prion Induced Neurodegeneration

(2008) Reuben Saba et al.   PLoS One

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Screening of innate immune receptors in neurodegenerative diseases: A similar pattern

(2007) Maryse Letiembre et al.   NEUROBIOLOGY OF AGING

Grafts of extra-adrenal chromaffin cells as aggregates show better survival rate and regenerative effects on parkinsonian rats than dispersed cell grafts

(2007) B. Galan-Rodriguez et al.   NEUROBIOLOGY OF DISEASE

TGF-β1 is increased in a transgenic mouse model of familial Alzheimer's disease and causes neuronal apoptosis

(2007) Pradeep Salins et al.   NEUROSCIENCE LETTERS