New nitric oxide-releasing indomethacin derivatives with 1,3-thiazolidine-4-one scaffold: Design, synthesis, in silico and in vitro studies

From inflammation to colitis-associated colorectal cancer in inflammatory bowel disease: Pathogenesis and impact of current therapies

(2021) Massimo Claudio Fantini et al.   DIGESTIVE AND LIVER DISEASE

Antitubercular properties of thiazolidin-4-ones – A review

(2021) Nazar Trotsko   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Toxic effects of NSAIDs in non-target species: a review from the perspective of the aquatic environment

(2020) Klaudia Świacka et al.   ENVIRONMENTAL POLLUTION

Combatting Inflammation in Cardiovascular Disease

(2020) Anver M. Sethwala et al.   Heart Lung and Circulation

A novel role of nifuroxazide in attenuation of sepsis-associated acute lung and myocardial injuries; role of TLR4/NLPR3/IL-1β signaling interruption

(2020) Ahmed E. Khodir et al.   LIFE SCIENCES

The Atlas of Inflammation Resolution (AIR)

(2020) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Carcinogenesis: Failure of resolution of inflammation?

(2020) Anna Fishbein et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis, molecular docking, and in silico ADME/Tox profiling studies of new 1-aryl-5-(3-azidopropyl)indol-4-ones: Potential inhibitors of SARS CoV-2 main protease

(2020) Francisco Xavier Domínguez-Villa et al.   BIOORGANIC CHEMISTRY

Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors

(2020) Mamdouh F.A. Mohamed et al.   BIOORGANIC CHEMISTRY

Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice

(2020) Katarzyna Stachowicz   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigation of (S)-(–)-acidomycin: A selective antimycobacterial natural product that inhibits biotin synthase

(2019) Matthew R Bockman et al.   ACS Infectious Diseases

Targeting nitric oxide as a key modulator of sepsis, arthritis and pain

(2019) Fernando Spiller et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Discovery of Orexant and Anorexant Agents with Indazole Scaffold Endowed with Peripheral Antiedema Activity

(2019) Dimmito et al.   Biomolecules

Visible-light-promoted C N and C S bonds formation: A catalyst and solvent-free photochemical approach for the synthesis of 1,3-thiazolidin-4-ones

(2019) Mohd Nazeef et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY

New hydrazide-hydrazones and 1,3-thiazolidin-4-ones with 3-hydroxy-2-naphthoic moiety: Synthesis, in vitro and in vivo studies

(2018) Łukasz Popiołek et al.   BIOMEDICINE & PHARMACOTHERAPY

N -Acylhydrazones as drugs

(2018) Sreekanth Thota et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Incorporation of nitric oxide donor into 1,3-dioxyxanthones leads to synergistic anticancer activity

(2018) Jie Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, characterization, antioxidant and antimicrobial activity of novel 5-arylidene-2-ferrocenyl-1,3-thiazolidin-4-ones

(2018) Anka Pejović et al.   JOURNAL OF ORGANOMETALLIC CHEMISTRY

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

(2018) Supakanya Wongrakpanich et al.   Aging and Disease

Novel Fubinaca/Rimonabant hybrids as endocannabinoid system modulators

(2018) Azzurra Stefanucci et al.   AMINO ACIDS

Metabolic disorders and inflammation are associated with familial combined hyperlipemia

(2018) María Díaz-Ruiz et al.   CLINICA CHIMICA ACTA

Pharmacoepidemiology of non-steroidal anti-inflammatory drugs

(2018) Nicholas Moore et al.   THERAPIE

Relevance and Standardization of In Vitro Antioxidant Assays: ABTS, DPPH, and Folin–Ciocalteu

(2018) Helena Abramovič et al.   Journal of Chemistry

Discovery of new indomethacin-based analogs with potentially selective cyclooxygenase-2 inhibition and observed diminishing to PGE2 activities

(2017) Shaymaa E. Kassab et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of novel α-hederagenin derivatives with anticancer activity

(2017) Xian-xuan Liu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Multiple target-centric strategy to tame inflammation

(2017) Gaganpreet Kaur et al.   Future Medicinal Chemistry

Exploring the first Rimonabant analog-opioid peptide hybrid compound, as bivalent ligand for CB1 and opioid receptors

(2017) Adriano Mollica et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

COX Inhibition Profile and Molecular Docking Studies of Some 2-(Trimethoxyphenyl)-Thiazoles

(2017) Smaranda Oniga et al.   MOLECULES

Validation of Structures in the Protein Data Bank

(2017) Swanand Gore et al.   STRUCTURE

Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)

(2017) G. Carullo et al.   MedChemComm

SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules

(2017) Antoine Daina et al.   Scientific Reports

Crystal Structure of Aspirin-Acetylated Human Cyclooxygenase-2: Insight into the Formation of Products with Reversed Stereochemistry

(2016) Michael J. Lucido et al.   BIOCHEMISTRY

2-(Thienothiazolylimino)-1,3-thiazolidin-4-ones inhibit cell division cycle 25 A phosphatase

(2016) Sophie Huber-Villaume et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile

(2016) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

A BOILED-Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

(2016) Antoine Daina et al.   ChemMedChem

2-Aryl-3-(2-morpholinoethyl)thiazolidin-4-ones: Synthesis, anti-inflammatory in vivo, cytotoxicity in vitro and molecular docking studies

(2016) Daniela Pires Gouvea et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Pharmacology of Indomethacin

(2016) Sylvia Lucas   HEADACHE

A concise review on advances in development of small molecule anti-inflammatory therapeutics emphasising AMPK: An emerging target

(2016) Chethan Gejjalagere Honnappa et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

A Proteomic Approach to Analyze the Aspirin-mediated Lysine Acetylome

(2016) Michael H. Tatham et al.   MOLECULAR & CELLULAR PROTEOMICS

Resolution of inflammation: a new therapeutic frontier

(2016) James N. Fullerton et al.   NATURE REVIEWS DRUG DISCOVERY

FDA labeling of NSAIDs: Review of nonsteroidal anti-inflammatory drugs in cardiovascular disease

(2016) Preethi Pirlamarla et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Nitric oxide-releasing indomethacin enhances susceptibility to Trypanosoma cruzi infection acting in the cell invasion and oxidative stress associated with anemia

(2015) Vera Lucia Hideko Tatakihara et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Molecular basis for nonspecificity of nonsteroidal anti-inflammatory drugs (NSAIDs)

(2015) Avaneesh K. Dwivedi et al.   DRUG DISCOVERY TODAY

pkCSM: Predicting Small-Molecule Pharmacokinetic and Toxicity Properties Using Graph-Based Signatures

(2015) Douglas E. V. Pires et al.   JOURNAL OF MEDICINAL CHEMISTRY

The nitric oxide donor cis-[Ru(bpy)2(SO3)NO](PF6) increases gastric mucosa protection in mice – Involvement of the soluble guanylate cyclase/KATP pathway

(2015) Ana Paula M. Santana et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Synthesis, biological evaluation and molecular docking studies of N-acylheteroaryl hydrazone derivatives as antioxidant and anti-inflammatory agents

(2015) Pravin S. Mahajan et al.   RESEARCH ON CHEMICAL INTERMEDIATES

Applicability of the DPPH Assay for Evaluating the Antioxidant Capacity of Food Additives ^|^ndash; Inter-laboratory Evaluation Study ^|^ndash;

(2014) Tomoko SHIMAMURA et al.   ANALYTICAL SCIENCES

Molecular targets of aspirin and cancer prevention

(2014) L Alfonso et al.   BRITISH JOURNAL OF CANCER

Investigation of DMSO-Induced Conformational Transitions in Human Serum Albumin Using Two-Dimensional Raman Optical Activity Spectroscopy

(2014) Andrea N. L. Batista et al.   CHIRALITY

Development of GI-safe NSAID; progression from the bark of willow tree to modern pharmacology

(2014) Napapan Kangwan et al.   CURRENT OPINION IN PHARMACOLOGY

Multi-target approach for natural products in inflammation

(2014) Andreas Koeberle et al.   DRUG DISCOVERY TODAY

Mechanistic Insights into a Classic Wonder Drug—Aspirin

(2014) Jinping Lei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and anticancer properties of RGD peptides conjugated to nitric oxide releasing functional groups and abiraterone

(2014) Andrew Nortcliffe et al.   TETRAHEDRON

An insight into synthetic Schiff bases revealing antiproliferative activities in vitro

(2013) Krzysztof Sztanke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structural Transformation of Bovine Serum Albumin Induced by Dimethyl Sulfoxide and Probed by Fluorescence Correlation Spectroscopy and Additional Methods

(2013) Ashok Pabbathi et al.   CHEMPHYSCHEM

Angiogenesis inhibitors identified by cell-based high-throughput screening: Synthesis, structure–activity relationships and biological evaluation of 3-[(E)-styryl]benzamides that specifically inhibit endothelial cell proliferation

(2012) Kihito Hada et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Contributions of central and systemic inflammation to the pathophysiology of Parkinson's disease

(2012) Louise M. Collins et al.   NEUROPHARMACOLOGY

Functionalized Fullerenes in Self-Assembled Monolayers

(2011) Maria del Carmen Gimenez-Lopez et al.   LANGMUIR

A turbulent decade for NSAIDs: update on current concepts of classification, epidemiology, comparative efficacy, and toxicity

(2011) Philip G. Conaghan   RHEUMATOLOGY INTERNATIONAL

Molecular Basis for Cyclooxygenase Inhibition by the Non-steroidal Anti-inflammatory Drug Naproxen

(2010) Kelsey C. Duggan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defining the COX inhibitor selectivity of NSAIDs: implications for understanding toxicity

(2010) Kathleen M Knights et al.   Expert Review of Clinical Pharmacology

Design, synthesis and biological investigation of certain pyrazole-3-carboxylic acid derivatives as novel carriers for nitric oxide

(2009) El-Shimaa M.N. Abdel-Hafez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Does aspirin acetylate multiple cellular proteins? (Review)

(2009) Bhat   Molecular Medicine Reports

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Role of nitric oxide in the gastrointestinal tract

(2008) Angel Lanas   ARTHRITIS RESEARCH & THERAPY