Structure–activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009–2016)

Design and Synthesis of New Transient Receptor Potential Vanilloid Type-1 (TRPV1) Channel Modulators: Identification, Molecular Modeling Analysis, and Pharmacological Characterization of the N-(4-Hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl)butanamide, a Small Molecule Endowed with Agonist TRPV1 Activity and Protective Effects against Oxidative Stress

(2016) Francesca Aiello et al.   ACS Chemical Neuroscience

Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors

(2016) Khaled R.A. Abdellatif et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Structure–activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies

(2016) Baker Jawabrah Al-Hourani et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Coumarin sulfonamides derivatives as potent and selective COX-2 inhibitors with efficacy in suppressing cancer proliferation and metastasis

(2016) Xiao-Yuan Lu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

(2016) Sara Consalvi et al.   ChemMedChem

TRPV1-FAAH-COX: TheCouples Gamein Pain Treatment

(2016) Francesca Aiello et al.   ChemMedChem

Low-dose Aspirin, Nonsteroidal Anti-inflammatory Drugs, Selective COX-2 Inhibitors and Breast Cancer Recurrence

(2016) Deirdre P. Cronin-Fenton et al.   EPIDEMIOLOGY

Synthesis and biological evaluation of fluorinated 1,5-diarylpyrrole-3-alkoxyethyl ether derivatives as selective COX-2 inhibitors endowed with anti-inflammatory activity

(2016) Angela Di Capua et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Quantitative structure–activity relationships (HQSAR, CoMFA, and CoMSIA) studies for COX-2 selective inhibitors

(2016) Renan A. Gomes et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent

(2016) Palwinder Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain

(2016) Margherita Brindisi et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, synthesis and biological evaluation of new tricyclic spiroisoxazoline derivatives as selective COX-2 inhibitors and study of their COX-2 binding modes via docking studies

(2016) Hoda Abolhasani et al.   MEDICINAL CHEMISTRY RESEARCH

In vitro pharmacological evaluation of multitarget agents for thromboxane prostanoid receptor antagonism and COX-2 inhibition

(2016) Malvina Hoxha et al.   PHARMACOLOGICAL RESEARCH

Synthesis of dihydropyrazole sulphonamide derivatives that act as anti-cancer agents through COX-2 inhibition

(2016) Han-Yue Qiu et al.   PHARMACOLOGICAL RESEARCH

Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells?

(2016) Jessica Roos et al.   PHARMACOLOGY & THERAPEUTICS

Synthesis of novel thiadiazole derivatives as selective COX-2 inhibitors

(2016) Fatma A. Ragab et al.   MedChemComm

Dual-Acting Compounds Targeting Endocannabinoid and Endovanilloid Systems—A Novel Treatment Option for Chronic Pain Management

(2016) Natalia Malek et al.   Frontiers in Pharmacology

Optical imaging of COX-2: Studies on an autofluorescent 2,3-diaryl-substituted indole-based cyclooxygenase-2 inhibitor

(2015) Christoph Tondera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cyclooxygenase inhibitors: From pharmacology to clinical read-outs

(2015) Paola Patrignani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Synthesis, biological evaluation and docking study of maleimide derivatives bearing benzenesulfonamide as selective COX-2 inhibitors and anti-inflammatory agents

(2015) Sandip D. Firke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

(2015) Sara Consalvi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents

(2015) Khaled R.A. Abdellatif et al.   BIOORGANIC CHEMISTRY

ADouble Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation

(2015) Rita Scarpelli et al.   ChemMedChem

nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2

(2015) Wilma Neumann et al.   ChemMedChem

Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: Anti-inflammatory and analgesic activities

(2015) Amer M. Alanazi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

COX inhibitors: a patent review (2011 – 2014)

(2015) Sara Consalvi et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Molecular characterization, biological activity, and in silico study of 2-(3,4-dimethoxyphenyl)-3-(4-fluorophenyl)-6-methoxy-4H-chromen-4-one as a novel selective COX-2 inhibitor

(2015) Kamal Rullah et al.   JOURNAL OF MOLECULAR STRUCTURE

Diaryl-Substituted (Dihydro)pyrrolo[3,2,1-hi]indoles, a Class of Potent COX-2 Inhibitors with Tricyclic Core Structure

(2015) Markus Laube et al.   JOURNAL OF ORGANIC CHEMISTRY

Design and Synthesis of Imidazopyrazolopyridines as Novel Selective COX-2 Inhibitors

(2015) Mohamed Badrey et al.   MOLECULES

Attenuation of persistent pain-related behavior by fatty acid amide hydrolase (FAAH) inhibitors in a rat model of HIV sensory neuropathy

(2015) Farinaz Nasirinezhad et al.   NEUROPHARMACOLOGY

2,5-Diaryl-1,3,4-oxadiazoles as selective COX-2 inhibitors and anti-inflammatory agents

(2015) Jagdeep Grover et al.   RSC Advances

Hydroxycinnamic acid as a novel scaffold for the development of cyclooxygenase-2 inhibitors

(2015) T. Silva et al.   RSC Advances

Structure–affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

(2014) Antonella Brizzi et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and Evaluation of Indole Based Molecules for Treatment of Oxidative Stress Related Diseases

(2014) Francesca Aiello et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Potent, orally available, selective COX-2 inhibitors based on 2-imidazoline core

(2014) Pakornwit Sarnpitak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, bioassay studies, and molecular docking of novel 5-substituted 1H tetrazoles as cyclooxygenase-2 (COX-2) inhibitors

(2014) Baker Jawabrah Al-Hourani et al.   MEDICINAL CHEMISTRY RESEARCH

2,3-Diaryl-substituted indole based COX-2 inhibitors as leads for imaging tracer development

(2014) Markus Laube et al.   RSC Advances

A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity

(2013) Claudio Battilocchio et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2

(2013) Ibrahim A. Al-Suwaidan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fluorophore-Labeled Cyclooxygenase-2 Inhibitors for the Imaging of Cyclooxygenase-2 Overexpression in Cancer: Synthesis and Biological Studies

(2013) Atul Bhardwaj et al.   ChemMedChem

Visualization of cyclooxygenase-2 using a 2,3-diarylsubstituted indole-based inhibitor and confocal laser induced cryofluorescence microscopy at 20K in melanoma cells in vitro

(2012) Christoph Tondera et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Designing Multitarget Anti-inflammatory Agents: Chemical Modulation of the Lumiracoxib Structure toward Dual Thromboxane Antagonists-COX-2 Inhibitors

(2012) Massimo Bertinaria et al.   ChemMedChem

Prostaglandins and Inflammation

(2011) Emanuela Ricciotti et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Synthesis and biological evaluation of N-substituted-3,5-diphenyl-2-pyrazoline derivatives as cyclooxygenase (COX-2) inhibitors

(2010) Rossella Fioravanti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis, Biological Evaluation, and Molecular Modeling of Oleuropein and Its Semisynthetic Derivatives as Cyclooxygenase Inhibitors

(2009) Antonio Procopio et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Synthesis and cyclooxygenase inhibition of various (aryl-1,2,3-triazole-1-yl)-methanesulfonylphenyl derivatives

(2008) Frank Wuest et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Prostanoids in health and disease: Fig. 1.

(2008) Emer M. Smyth et al.   JOURNAL OF LIPID RESEARCH

Cyclooxygenases: structural and functional insights

(2008) Carol A. Rouzer et al.   JOURNAL OF LIPID RESEARCH