Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors

New 1,2,4-triazole/pyrazole hybrids linked to oxime moiety as nitric oxide donor celecoxib analogs: Synthesis, cyclooxygenase inhibition anti-inflammatory, ulcerogenicity, anti-proliferative activities, apoptosis, molecular modeling and nitric oxide release studies

(2020) Wael A.A. Fadaly et al.   BIOORGANIC CHEMISTRY

Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo

(2020) Yang Sheng Hu et al.   BIOORGANIC CHEMISTRY

Synthesis and anti-inflammatory evaluation of new chalcone derivatives bearing bispiperazine linker as IL-1β inhibitors

(2020) Yan-Ling Tang et al.   BIOORGANIC CHEMISTRY

Synthetic approaches, anticancer potential, HSP90 inhibition, multitarget evaluation, molecular modeling and apoptosis mechanistic study of thioquinazolinone skeleton: Promising antibreast cancer agent

(2020) Hamed W. El-Shafey et al.   BIOORGANIC CHEMISTRY

Design, synthesis and anticancer activity of novel valproic acid conjugates with improved histone deacetylase (HDAC) inhibitory activity

(2020) Tarek S. Ibrahim et al.   BIOORGANIC CHEMISTRY

Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies

(2019) Bahaa G.M. Youssif et al.   BIOORGANIC CHEMISTRY

Inducible nitric oxide synthase inhibitors: A comprehensive update

(2019) Richa Minhas et al.   MEDICINAL RESEARCH REVIEWS

Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors

(2019) Mamdouh F.A. Mohamed et al.   BIOORGANIC CHEMISTRY

Anti-inflammatory flavonoids from root bark of Broussonetia papyrifera in LPS-stimulated RAW264.7 cells

(2019) Hyung Won Ryu et al.   BIOORGANIC CHEMISTRY

The anti-inflammatory effects of jiangrines from Jiangella alba through inhibition of p38 and NF-κB signaling pathways

(2019) Peipei Guan et al.   BIOORGANIC CHEMISTRY

Anti-inflammatory effect of Calycosin glycoside on lipopolysaccharide-induced inflammatory responses in RAW 264.7 cells

(2018) Lin Dong et al.   GENE

Attenuation of inflammatory responses by (+)-syringaresinol via MAP-Kinase-mediated suppression of NF-κB signaling in vitro and in vivo

(2018) Vivek K. Bajpai et al.   Scientific Reports

Bioactivity-based analysis and chemical characterization of anti-inflammatory compounds from Curcuma zedoaria rhizomes using LPS-stimulated RAW264.7 cells

(2018) Tae Kyoung Lee et al.   BIOORGANIC CHEMISTRY

Synthesis and biological screening of novel 2-morpholinoquinoline nucleus clubbed with 1,2,4-oxadiazole motifs

(2017) Sharad C. Karad et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Optimizing Oral Bioavailability in Drug Discovery: An Overview of Design and Testing Strategies and Formulation Options

(2017) Bruce J. Aungst   JOURNAL OF PHARMACEUTICAL SCIENCES

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases

(2015) Liang Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

How drug-like are ‘ugly’ drugs: do drug-likeness metrics predict ADME behaviour in humans?

(2014) Timothy J. Ritchie et al.   DRUG DISCOVERY TODAY

Novel pyrazolopyrimidine derivatives targeting COXs and iNOS enzymes; design, synthesis and biological evaluation as potential anti-inflammatory agents

(2014) Ahmed H. Abdelazeem et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

[1, 2, 4]-Oxadiazoles: Synthesis and Biological Applications

(2014) Rajesh Bora et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

New nitric oxide donating 1,2,4-triazole/oxime hybrids: Synthesis, investigation of anti-inflammatory, ulceroginic liability and antiproliferative activities

(2013) Mohamed Abdel-Aziz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Novel pyrazoline amidoxime and their 1,2,4-oxadiazole analogues: Synthesis and pharmacological screening

(2013) Srikantamurthy Ningaiah et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, synthesis and anti-inflammatory evaluation of novel 5-benzylidene-3,4-dihalo-furan-2-one derivatives

(2013) Fang Wang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Biological Evaluation of Novel 5-Benzylidenethiazolidine-2,4-dione Derivatives for the Treatment of Inflammatory Diseases

(2011) Liang Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Inflammation 2010: New Adventures of an Old Flame

(2010) Ruslan Medzhitov   CELL

Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives

(2010) Xian-Yu Sun et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular properties prediction, synthesis and antimicrobial activity of some newer oxadiazole derivatives

(2010) Mohammed Afroz Bakht et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation

(2010) Yoshiro Kobayashi   JOURNAL OF LEUKOCYTE BIOLOGY

Potent anti-inflammatory effects of two quinolinedione compounds, OQ1 and OQ21, mediated by dual inhibition of inducible NO synthase and cyclooxygenase-2

(2009) Kyung-Min Lim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Recent Developments in the Chemistry and in the Biological Applications of Amidoximes

(2008) K. Fylaktakidou et al.   CURRENT PHARMACEUTICAL DESIGN

Cyclooxygenase-1-Selective Inhibitors Are Attractive Candidates for Analgesics That Do Not Cause Gastric Damage. Design and in Vitro/in Vivo Evaluation of a Benzamide-Type Cyclooxygenase-1 Selective Inhibitor

(2008) Hiroki Kakuta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE