Talin and Kindlin as Integrin-Activating Proteins: Focus on the Heart

Integrin Activation: Implications for Axon Regeneration

(2018) Menghon Cheah et al.   Cells

Integrin activation by talin, kindlin and mechanical forces

(2018) Zhiqi Sun et al.   NATURE CELL BIOLOGY

Smurf1 inhibits integrin activation by controlling Kindlin-2 ubiquitination and degradation

(2017) Xiaofan Wei et al.   JOURNAL OF CELL BIOLOGY

Talin – the master of integrin adhesions

(2017) Benjamin Klapholz et al.   JOURNAL OF CELL SCIENCE

Structural basis of kindlin-mediated integrin recognition and activation

(2017) Huadong Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy

(2017) Ana Maria Manso et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphatidylinositol 4,5-Bisphosphate Modulates the Affinity of Talin-1 for Phospholipid Bilayers and Activates Its Autoinhibited Form

(2016) Xin Ye et al.   BIOCHEMISTRY

The Rap1-RIAM-talin axis of integrin activation and blood cell function

(2016) F. Lagarrigue et al.   BLOOD

Postnatal Loss of Kindlin-2 Leads to Progressive Heart FailureCLINICAL PERSPECTIVE

(2016) Zhiyuan Zhang et al.   Circulation-Heart Failure

Nuclear Localization of Integrin Cytoplasmic Domain-associated Protein-1 (ICAP1) Influences β1 Integrin Activation and Recruits Krev/Interaction Trapped-1 (KRIT1) to the Nucleus

(2016) Kyle M. Draheim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

Proximity biotinylation provides insight into the molecular composition of focal adhesions at the nanometer scale

(2016) J.-M. Dong et al.   Science Signaling

In vivo quantitative analysis of Talin turnover in response to force

(2015) Guðlaug Katrín Hákonardóttir et al.   MOLECULAR BIOLOGY OF THE CELL

Integrin activation

(2015) Mark H. Ginsberg   BMB Reports

Integrins and Integrin-Associated Proteins in the Cardiac Myocyte

(2014) Sharon Israeli-Rosenberg et al.   CIRCULATION RESEARCH

The Mechanism of Kindlin-Mediated Activation of Integrin αIIbβ3

(2013) Feng Ye et al.   CURRENT BIOLOGY

Integrins protect cardiomyocytes from ischemia/reperfusion injury

(2013) Hideshi Okada et al.   JOURNAL OF CLINICAL INVESTIGATION

β1 Integrin Gene Excision in the Adult Murine Cardiac Myocyte Causes Defective Mechanical and Signaling Responses

(2012) Ruixia Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Talin1 Has Unique ExpressionversusTalin 2 in the Heart and Modifies the Hypertrophic Response to Pressure Overload

(2012) Ana Maria Manso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spatial Coordination of Kindlin-2 with Talin Head Domain in Interaction with Integrin β Cytoplasmic Tails

(2012) Kamila Bledzka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulators of integrin activity

(2012) J. Pouwels et al.   JOURNAL OF CELL SCIENCE

Loss of the Integrin-Activating Transmembrane Protein Fam38A (Piezo1) Promotes a Switch to a Reduced Integrin-Dependent Mode of Cell Migration

(2012) Brian J. McHugh et al.   PLoS One

Regulation of Integrin Activation

(2011) Chungho Kim et al.   Annual Review of Cell and Developmental Biology

SHARPIN is an endogenous inhibitor of β1-integrin activation

(2011) Juha K. Rantala et al.   NATURE CELL BIOLOGY

Affinity of talin-1 for the  3-integrin cytosolic domain is modulated by its phospholipid bilayer environment

(2011) D. T. Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrin Structure, Activation, and Interactions

(2011) I. D. Campbell et al.   Cold Spring Harbor Perspectives in Biology

Structure of a double ubiquitin-like domain in the talin head: a role in integrin activation

(2010) Benjamin T Goult et al.   EMBO JOURNAL

Talin 1 and 2 are required for myoblast fusion, sarcomere assembly and the maintenance of myotendinous junctions

(2009) F. J. Conti et al.   DEVELOPMENT

β Integrin Tyrosine Phosphorylation Is a Conserved Mechanism for Regulating Talin-induced Integrin Activation

(2009) Nicholas J. Anthis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Integrin activation by Fam38A uses a novel mechanism of R-Ras targeting to the endoplasmic reticulum

(2009) B. J. McHugh et al.   JOURNAL OF CELL SCIENCE

Cardiac Ankyrin Repeat Protein Gene (ANKRD1) Mutations in Hypertrophic Cardiomyopathy

(2009) Takuro Arimura et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Tail of Integrins, Talin, and Kindlins

(2009) M. Moser et al.   SCIENCE

Kindlin-2 Is an Essential Component of Intercalated Discs and Is Required for Vertebrate Cardiac Structure and Function

(2008) James J. Dowling et al.   CIRCULATION RESEARCH

Kindlins: essential regulators of integrin signalling and cell–matrix adhesion

(2008) Hannu Larjava et al.   EMBO REPORTS

Structural Basis of the Migfilin-Filamin Interaction and Competition with Integrin β Tails

(2008) Yatish Lad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RIAM Activates Integrins by Linking Talin to Ras GTPase Membrane-targeting Sequences

(2008) Ho-Sup Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Migfilin, a Molecular Switch in Regulation of Integrin Activation

(2008) Sujay Subbayya Ithychanda et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Talin depletion reveals independence of initial cell spreading from integrin activation and traction

(2008) Xian Zhang et al.   NATURE CELL BIOLOGY