Ribosome-Associated Quality Control in Bacteria

Translational Control by Ribosome Pausing in Bacteria: How a Non-uniform Pace of Translation Affects Protein Production and Folding

(2021) Ekaterina Samatova et al.   Frontiers in Microbiology

trans-Translation inhibitors bind to a novel site on the ribosome and clear Neisseria gonorrhoeae in vivo

(2021) Zachary D. Aron et al.   Nature Communications

Ribosome Rescue Pathways in Bacteria

(2021) Claudia Müller et al.   Frontiers in Microbiology

ELAC1 Repairs tRNAs Cleaved during Ribosome-Associated Quality Control

(2020) Matthew C.J. Yip et al.   Cell Reports

The Science of Antibiotic Discovery

(2020) Kim Lewis   CELL

Mimicry of Canonical Translation Elongation Underlies Alanine Tail Synthesis in RQC

(2020) Sebastian Filbeck et al.   MOLECULAR CELL

Structural Basis for Bacterial Ribosome-Associated Quality Control by RqcH and RqcP

(2020) Caillan Crowe-McAuliffe et al.   MOLECULAR CELL

The Origin and Evolution of Release Factors: Implications for Translation Termination, Ribosome Rescue, and Quality Control Pathways

(2019) A. Maxwell Burroughs et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mechanisms and functions of ribosome-associated protein quality control

(2019) Claudio A. P. Joazeiro   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanism for recycling tRNAs on stalled ribosomes

(2019) Matthew C. J. Yip et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control

(2019) Iryna Lytvynenko et al.   CELL

Vms1 and ANKZF1 peptidyl-tRNA hydrolases release nascent chains from stalled ribosomes

(2018) Rati Verma et al.   NATURE

How Macrolide Antibiotics Work

(2018) Nora Vázquez-Laslop et al.   TRENDS IN BIOCHEMICAL SCIENCES

A New Mechanism for Ribosome Rescue Can Recruit RF1 or RF2 to Nonstop Ribosomes

(2018) Tyler D. P. Goralski et al.   mBio

Intrinsic Ribosome Destabilization Underlies Translation and Provides an Organism with a Strategy of Environmental Sensing

(2017) Yuhei Chadani et al.   MOLECULAR CELL

Structural Basis for Polyproline-Mediated Ribosome Stalling and Rescue by the Translation Elongation Factor EF-P

(2017) Paul Huter et al.   MOLECULAR CELL

Ribosome pausing, arrest and rescue in bacteria and eukaryotes

(2017) Allen R. Buskirk et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Reduction of translating ribosomes enables Escherichia coli to maintain elongation rates during slow growth

(2016) Xiongfeng Dai et al.   Nature Microbiology

Ribosome rescue systems in bacteria

(2015) Hyouta Himeno et al.   BIOCHIMIE

The Fibronectin-Binding Protein EfbA Contributes to Pathogenesis and Protects against Infective Endocarditis Caused by Enterococcus faecalis

(2015) Kavindra V. Singh et al.   INFECTION AND IMMUNITY

Mechanisms of ribosome rescue in bacteria

(2015) Kenneth C. Keiler   NATURE REVIEWS MICROBIOLOGY

HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

(2015) Yanqing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Precision methylome characterization ofMycobacterium tuberculosiscomplex (MTBC) using PacBio single-molecule real-time (SMRT) technology

(2015) Lingxiang Zhu et al.   NUCLEIC ACIDS RESEARCH

Rqc2p and 60S ribosomal subunits mediate mRNA-independent elongation of nascent chains

(2015) P. S. Shen et al.   SCIENCE

HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

(2015) Yanqing Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural and functional insights into peptidyl-tRNA hydrolase

(2014) Sujata Sharma et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Resolving Nonstop Translation Complexes Is a Matter of Life or Death

(2014) K. C. Keiler et al.   JOURNAL OF BACTERIOLOGY

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

(2014) Boya Feng et al.   PLOS BIOLOGY

Analysis of two domains with novel RNA-processing activities throws light on the complex evolution of ribosomal RNA biogenesis

(2014) A. Maxwell Burroughs et al.   Frontiers in Genetics

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

(2013) Reut Shalgi et al.   MOLECULAR CELL

Small molecule inhibitors of trans-translation have broad-spectrum antibiotic activity

(2013) N. S. Ramadoss et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ArfA Recruits RF2 into Stalled Ribosomes

(2012) Yoshihiro Shimizu   JOURNAL OF MOLECULAR BIOLOGY

ArfA recruits release factor 2 to rescue stalled ribosomes by peptidyl-tRNA hydrolysis inEscherichia coli

(2012) Yuhei Chadani et al.   MOLECULAR MICROBIOLOGY

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

EF-P Is Essential for Rapid Synthesis of Proteins Containing Consecutive Proline Residues

(2012) L. K. Doerfel et al.   SCIENCE

Translation Elongation Factor EF-P Alleviates Ribosome Stalling at Polyproline Stretches

(2012) S. Ude et al.   SCIENCE

Structural Basis for the Rescue of Stalled Ribosomes: Structure of YaeJ Bound to the Ribosome

(2012) M. G. Gagnon et al.   SCIENCE

Deciphering the catalytic machinery in a universally conserved ribosome binding ATPase YchF

(2011) Sushil Kumar Tomar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Birth, life and death of nascent polypeptide chains

(2011) Sujata Jha et al.   Biotechnology Journal

Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathways

(2011) Yuhei Chadani et al.   MOLECULAR MICROBIOLOGY

Elongation factor 4 (EF4/LepA) accelerates protein synthesis at increased Mg2+ concentrations

(2011) M. Pech et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of ABCE1 in Eukaryotic Posttermination Ribosomal Recycling

(2010) Andrey V. Pisarev et al.   MOLECULAR CELL

YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes

(2010) Y. Handa et al.   NUCLEIC ACIDS RESEARCH

Autoregulatory systems controlling translation factor expression: Thermostat-like control of translational accuracy

(2010) R. Betney et al.   RNA

Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

(2010) C. J. Shoemaker et al.   SCIENCE

Recycling of Aborted Ribosomal 50S Subunit-Nascent Chain-tRNA Complexes by the Heat Shock Protein Hsp15

(2008) Linhua Jiang et al.   JOURNAL OF MOLECULAR BIOLOGY