HflX is a ribosome-splitting factor rescuing stalled ribosomes under stress conditions

An Integrated Approach Reveals Regulatory Controls on Bacterial Translation Elongation

(2014) Arvind R. Subramaniam et al.   CELL

Dom34 Rescues Ribosomes in 3′ Untranslated Regions

(2014) Nicholas R. Guydosh et al.   CELL

Structural and Functional Insights into the Mode of Action of a Universally Conserved Obg GTPase

(2014) Boya Feng et al.   PLOS BIOLOGY

Overcoming stalled translation in human mitochondria

(2014) Maria T. Wesolowska et al.   Frontiers in Microbiology

Biochemical aspects of bacterial strategies for handling the incomplete translation processes

(2014) Yoshihiro Shimizu   Frontiers in Microbiology

Cotranslational Response to Proteotoxic Stress by Elongation Pausing of Ribosomes

(2013) Botao Liu et al.   MOLECULAR CELL

The Ribosome as a Hub for Protein Quality Control

(2013) Sebastian Pechmann et al.   MOLECULAR CELL

Widespread Regulation of Translation by Elongation Pausing in Heat Shock

(2013) Reut Shalgi et al.   MOLECULAR CELL

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Less is more: improving proteostasis by translation slow down

(2013) Michael Y. Sherman et al.   TRENDS IN BIOCHEMICAL SCIENCES

The ribosome modulates the structural dynamics of the conserved GTPase HflX and triggers tight nucleotide binding

(2012) Jeffrey J. Fischer et al.   BIOCHIMIE

Mechanism of Elongation Factor-G-mediated Fusidic Acid Resistance and Fitness Compensation inStaphylococcus aureus

(2012) Ravi Kiran Koripella et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biology of the Heat Shock Response and Protein Chaperones: Budding Yeast (Saccharomyces cerevisiae) as a Model System

(2012) J. Verghese et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Dom34:Hbs1 Plays a General Role in Quality-Control Systems by Dissociation of a Stalled Ribosome at the 3′ End of Aberrant mRNA

(2012) Tatsuhisa Tsuboi et al.   MOLECULAR CELL

Translation drives mRNA quality control

(2012) Christopher J Shoemaker et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A suite of Switch I and Switch II mutant structures from the G-protein domain of FeoB

(2011) Miriam-Rose Ash et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Dissociation by Pelota, Hbs1 and ABCE1 of mammalian vacant 80S ribosomes and stalled elongation complexes

(2011) Vera P Pisareva et al.   EMBO JOURNAL

An HflX-Type GTPase from Sulfolobus solfataricus Binds to the 50S Ribosomal Subunit in All Nucleotide-Bound States

(2011) F. Blombach et al.   JOURNAL OF BACTERIOLOGY

A Bayesian View on Cryo-EM Structure Determination

(2011) Sjors H.W. Scheres   JOURNAL OF MOLECULAR BIOLOGY

The Universally Conserved Prokaryotic GTPases

(2011) N. Verstraeten et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Escherichia coli YaeJ protein mediates a novel ribosome-rescue pathway distinct from SsrA- and ArfA-mediated pathways

(2011) Yuhei Chadani et al.   MOLECULAR MICROBIOLOGY

Bacterial ribosome requires multiple L12 dimers for efficient initiation and elongation of protein synthesis involving IF2 and EF-G

(2011) C. S. Mandava et al.   NUCLEIC ACIDS RESEARCH

Kinetic analysis reveals the ordered coupling of translation termination and ribosome recycling in yeast

(2011) C. J. Shoemaker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structures of the Bacterial Ribosome in Classical and Hybrid States of tRNA Binding

(2011) J. A. Dunkle et al.   SCIENCE

tRNA mimicry in translation termination and beyond

(2011) Yoshikazu Nakamura et al.   Wiley Interdisciplinary Reviews-RNA

Functional study on GTP hydrolysis by the GTP-binding protein from Sulfolobus solfataricus, a member of the HflX family

(2010) Bo Huang et al.   JOURNAL OF BIOCHEMISTRY

The Ribosomal Stalk Plays a Key Role in IF2-Mediated Association of the Ribosomal Subunits

(2010) Chenhui Huang et al.   JOURNAL OF MOLECULAR BIOLOGY

The Heat Shock Response: Life on the Verge of Death

(2010) Klaus Richter et al.   MOLECULAR CELL

Translational Regulation of Gene Expression during Conditions of Cell Stress

(2010) Keith A. Spriggs et al.   MOLECULAR CELL

I-TASSER: a unified platform for automated protein structure and function prediction

(2010) Ambrish Roy et al.   Nature Protocols

YaeJ is a novel ribosome-associated protein in Escherichia coli that can hydrolyze peptidyl-tRNA on stalled ribosomes

(2010) Y. Handa et al.   NUCLEIC ACIDS RESEARCH

Translational control of bacterial heat shock and virulence genes by temperature-sensing mRNAs

(2010) Franz Narberhaus   RNA Biology

Dom34:Hbs1 Promotes Subunit Dissociation and Peptidyl-tRNA Drop-Off to Initiate No-Go Decay

(2010) C. J. Shoemaker et al.   SCIENCE

Toward Understanding the Function of the Universally Conserved GTPase HflX fromEscherichia coli: A Kinetic Approach

(2009) Michael J. Shields et al.   BIOCHEMISTRY

The A–Z of bacterial translation inhibitors

(2009) Daniel N. Wilson   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Transcriptome analysis ofEscherichia coli O157:H7 EDL933 during heat shock

(2009) Michael D. Carruthers et al.   FEMS MICROBIOLOGY LETTERS

Properties of HflX, an Enigmatic Protein from Escherichia coli

(2009) D. Dutta et al.   JOURNAL OF BACTERIOLOGY

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

(2009) Tanvir R Shaikh et al.   Nature Protocols

The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins

(2009) Günter Kramer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Converging concepts of protein folding in vitro and in vivo

(2009) F Ulrich Hartl et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome

(2009) Rebecca M Voorhees et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ribosome-induced changes in elongation factor Tu conformation control GTP hydrolysis

(2009) E. Villa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conformational flexibility and molecular interactions of an archaeal homologue of the Shwachman-Bodian-Diamond syndrome protein

(2009) C Leong Ng et al.   BMC STRUCTURAL BIOLOGY

E. coli HflX interacts with 50S ribosomal subunits in presence of nucleotides

(2008) Nikhil Jain et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Complementary roles of initiation factor 1 and ribosome recycling factor in 70S ribosome splitting

(2008) Michael Y Pavlov et al.   EMBO JOURNAL

Particle-verification for single-particle, reference-based reconstruction using multivariate data analysis and classification

(2008) Tanvir R. Shaikh et al.   JOURNAL OF STRUCTURAL BIOLOGY

Chlamydophila pneumoniae HflX belongs to an uncharacterized family of conserved GTPases and associates with the Escherichia coli 50S large ribosomal subunit

(2008) A. Polkinghorne et al.   MICROBIOLOGY-SGM

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Crystal structure of a translation termination complex formed with release factor RF2

(2008) A. Korostelev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Flexible Fitting of Atomic Structures into Electron Microscopy Maps Using Molecular Dynamics

(2008) Leonardo G. Trabuco et al.   STRUCTURE