PKA Cβ: a forgotten catalytic subunit of cAMP-dependent protein kinase opens new windows for PKA signaling and disease pathologies

Defective internal allosteric network imparts dysfunctional ATP/substrate-binding cooperativity in oncogenic chimera of protein kinase A

(2021) Cristina Olivieri et al.   Communications Biology

Myristoylation alone is sufficient for PKA catalytic subunits to associate with the plasma membrane to regulate neuronal functions

(2021) Wei-Hong Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Germline and Mosaic Variants in PRKACA and PRKACB Cause a Multiple Congenital Malformation Syndrome

(2020) Adrian Palencia-Campos et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling

(2020) Jason Z. Zhang et al.   CELL

Structural analyses of the PKA RIIβ holoenzyme containing the oncogenic DnaJB1-PKAc fusion protein reveal protomer asymmetry and fusion-induced allosteric perturbations in fibrolamellar hepatocellular carcinoma

(2020) Tsan-Wen Lu et al.   PLOS BIOLOGY

Structures of the PKA RIα Holoenzyme with the FLHCC Driver J-PKAcα or Wild-Type PKAcα

(2019) Baohua Cao et al.   STRUCTURE

Tuning the “violin” of protein kinases: The role of dynamics‐based allostery

(2019) Lalima G. Ahuja et al.   IUBMB LIFE

An acquired scaffolding function of the DNAJ-PKAc fusion contributes to oncogenic signaling in fibrolamellar carcinoma

(2019) Rigney E Turnham et al.   eLife

Recurrent Rearrangements in PRKACA and PRKACB in Intraductal Oncocytic Papillary Neoplasms of the Pancreas and Bile Duct

(2019) Aatur D. Singhi et al.   GASTROENTEROLOGY

Evolution of the cAMP-dependent protein kinase (PKA) catalytic subunit isoforms

(2017) Kristoffer Søberg et al.   PLoS One

Mechanisms for restraining cAMP-dependent protein kinase revealed by subunit quantitation and cross-linking approaches

(2017) Ryan Walker-Gray et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A dynamic hydrophobic core orchestrates allostery in protein kinases

(2017) Jonggul Kim et al.   Science Advances

Protein kinase A is a target for aging and the aging heart

(2016) Linda C Enns et al.   Aging-US

Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi

(2015) Seiko Susuki-Miyata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural insights into mis-regulation of protein kinase A in human tumors

(2015) Jonah Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

(2015) Ping Zhang et al.   STRUCTURE

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

PRKACB and Carney Complex

(2014) Antonella Forlino et al.   NEW ENGLAND JOURNAL OF MEDICINE

Constitutive Activation of PKA Catalytic Subunit in Adrenal Cushing's Syndrome

(2014) Felix Beuschlein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Dynamic architecture of a protein kinase

(2014) C. L. McClendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome

(2014) Y. Cao et al.   SCIENCE

Detection of a Recurrent DNAJB1-PRKACA Chimeric Transcript in Fibrolamellar Hepatocellular Carcinoma

(2014) J. N. Honeyman et al.   SCIENCE

Stimulation of Proglucagon Gene Expression by Human GPR119 in Enteroendocrine L-cell Line GLUTag

(2013) Oleg G. Chepurny et al.   MOLECULAR ENDOCRINOLOGY

The Genotype-Tissue Expression (GTEx) project

(2013) John Lonsdale et al.   NATURE GENETICS

Evolutionary Paths of the cAMP-Dependent Protein Kinase (PKA) Catalytic Subunits

(2013) Kristoffer Søberg et al.   PLoS One

Conformational Equilibrium of N-Myristoylated cAMP-Dependent Protein Kinase A by Molecular Dynamics Simulations

(2012) Alessandro Cembran et al.   BIOCHEMISTRY

Role of N-Terminal Myristylation in the Structure and Regulation of cAMP-Dependent Protein Kinase

(2012) Adam C. Bastidas et al.   JOURNAL OF MOLECULAR BIOLOGY

The testis-specific Cα2 subunit of PKA is kinetically indistinguishable from the common Cα1 subunit of PKA

(2011) Maike M Vetter et al.   BMC BIOCHEMISTRY

A Myristoyl/Phosphoserine Switch Controls cAMP-Dependent Protein Kinase Association to Membranes

(2011) Ece C. Gaffarogullari et al.   JOURNAL OF MOLECULAR BIOLOGY

A conserved deamidation site at asn 2 in the catalytic subunit of mammalian cAMP-dependent protein kinase detected by capillary LC-MS and tandem mass spectrometry

(2010) Paul T. Jedrzejewski et al.   PROTEIN SCIENCE

Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface

(2010) Friedrich W. Herberg et al.   PROTEIN SCIENCE

Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A

(2009) Jie Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identifying Critical Non-Catalytic Residues that Modulate Protein Kinase A Activity

(2009) Eileen J. Kennedy et al.   PLoS One

A chimeric mechanism for polyvalenttrans-phosphorylation of PKA by PDK1

(2009) Robert A. Romano et al.   PROTEIN SCIENCE

Isoform-specific regulation of immune cell reactivity by the catalytic subunit of protein kinase A (PKA)

(2008) Ane Funderud et al.   CELLULAR SIGNALLING