Tuning the “violin” of protein kinases: The role of dynamics‐based allostery

Allostery in Its Many Disguises: From Theory to Applications

(2019) Shoshana J. Wodak et al.   STRUCTURE

Self-organization, entropy and allostery

(2018) Alexandr P. Kornev   BIOCHEMICAL SOCIETY TRANSACTIONS

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation

(2018) Yilin Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Corrigendum to “A Catalytically-Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.” J. Mol. Biol. 430(6) (Mar 16 2018), 881–889

(2018) Yilin Meng et al.   JOURNAL OF MOLECULAR BIOLOGY

Long-Range Changes in Neurolysin Dynamics Upon Inhibitor Binding

(2017) A. Uyar et al.   Journal of Chemical Theory and Computation

Structures of the inactive and active states of RIP2 kinase inform on the mechanism of activation

(2017) Erika Pellegrini et al.   PLoS One

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

(2017) Lalima G. Ahuja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Entropy redistribution controls allostery in a metalloregulatory protein

(2017) Daiana A. Capdevila et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Long-range allosteric signaling in red light–regulated diguanylyl cyclases

(2017) Geoffrey Gourinchas et al.   Science Advances

Unidirectional allostery in the regulatory subunit RIα facilitates efficient deactivation of protein kinase A

(2016) Cong Guo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transition path theory analysis of c-Src kinase activation

(2016) Yilin Meng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

(2016) Nikita Chopra et al.   PLoS Computational Biology

On the relationship between low-frequency normal modes and the large-scale conformational changes of proteins

(2015) Swapnil Mahajan et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Disorder-to-Order Transition of an Active-Site Loop Mediates the Allosteric Activation of Sortase A

(2015) Xiaodong Pang et al.   BIOPHYSICAL JOURNAL

Allostery without a conformational change? Revisiting the paradigm

(2015) Ruth Nussinov et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A violin shell model: Vibrational modes and acoustics

(2015) Colin E. Gough   JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA

Cofactor-Mediated Conformational Dynamics Promote Product Release From Escherichia coli Dihydrofolate Reductase via an Allosteric Pathway

(2015) David Oyen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Two Pathways Mediate Interdomain Allosteric Regulation in Pin1

(2015) Jingjing Guo et al.   STRUCTURE

Dynamics-Driven Allostery in Protein Kinases

(2015) Alexandr P. Kornev et al.   TRENDS IN BIOCHEMICAL SCIENCES

A network of molecular switches controls the activation of the two-component response regulator NtrC

(2015) Dan K. Vanatta et al.   Nature Communications

Allostery through the computational microscope: cAMP activation of a canonical signalling domain

(2015) Robert D. Malmstrom et al.   Nature Communications

Kinase Regulation by Hydrophobic Spine Assembly in Cancer

(2014) Jiancheng Hu et al.   MOLECULAR AND CELLULAR BIOLOGY

Kinases and Pseudokinases: Lessons from RAF

(2014) A. S. Shaw et al.   MOLECULAR AND CELLULAR BIOLOGY

Dynamic architecture of a protein kinase

(2014) C. L. McClendon et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synchronous Opening and Closing Motions Are Essential for cAMP-Dependent Protein Kinase A Signaling

(2014) Atul K. Srivastava et al.   STRUCTURE

Activation pathway of Src kinase reveals intermediate states as targets for drug design

(2014) Diwakar Shukla et al.   Nature Communications

Allostery in Disease and in Drug Discovery

(2013) Ruth Nussinov et al.   CELL

Signalling from disordered proteins

(2013) Vincent J. Hilser   NATURE

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

(2013) Hiruy S. Meharena et al.   PLOS BIOLOGY

The Structural Basis for Control of Eukaryotic Protein Kinases

(2012) Jane A. Endicott et al.   Annual Review of Biochemistry

Evolution of the eukaryotic protein kinases as dynamic molecular switches

(2012) S. S. Taylor et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The binding mechanism, multiple binding modes, and allosteric regulation ofStaphylococcus aureusSortase A probed by molecular dynamics simulations

(2012) Kalli Kappel et al.   PROTEIN SCIENCE

Discovery of a Potential Allosteric Ligand Binding Site in CDK2

(2011) Stephane Betzi et al.   ACS Chemical Biology

Catalytic Contributions from Remote Regions of Enzyme Structure

(2011) Jeeyeon Lee et al.   CHEMICAL REVIEWS

cAMP-Dependent Protein Kinase A Selects the Excited State of the Membrane Substrate Phospholamban

(2011) Larry R. Masterson et al.   JOURNAL OF MOLECULAR BIOLOGY

Dynamic Cross-Talk among Remote Binding Sites: The Molecular Basis for Unusual Synergistic Allostery

(2011) Wanting Jiao et al.   JOURNAL OF MOLECULAR BIOLOGY

50th anniversary of the word “allosteric”

(2011) Jean-Pierre Changeux   PROTEIN SCIENCE

Protein dynamics and allostery: an NMR view

(2010) Shiou-Ru Tzeng et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Allosteric Communication between cAMP Binding Sites in the RI Subunit of Protein Kinase A Revealed by NMR

(2010) In-Ja L. Byeon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanometer Propagation of Millisecond Motions in V-Type Allostery

(2010) James M. Lipchock et al.   STRUCTURE

During Transitions Proteins Make Fleeting Bonds

(2009) David D. Boehr   CELL

BlockMaster: Partitioning Protein Kinase Structures Using Normal-Mode Analysis†

(2009) Marina Shudler et al.   JOURNAL OF PHYSICAL CHEMISTRY A

Conformational selection or induced fit: A flux description of reaction mechanism

(2009) G. G. Hammes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamical networks in tRNA:protein complexes

(2009) A. Sethi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Activation of tyrosine kinases by mutation of the gatekeeper threonine

(2008) Mohammad Azam et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A helix scaffold for the assembly of active protein kinases

(2008) A. P. Kornev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allosteric cooperativity in protein kinase A

(2008) L. R. Masterson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Allostery and cooperativity revisited

(2008) Qiang Cui et al.   PROTEIN SCIENCE