Cross-talk between PKA-Cβ and p65 mediates synergistic induction of PDE4B by roflumilast and NTHi

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(2013) Donald P Tashkin   EXPERT OPINION ON PHARMACOTHERAPY

Anchored PDE4 regulates chloride conductance in wild-type and ΔF508-CFTR human airway epithelia

(2013) Elise Blanchard et al.   FASEB JOURNAL

Protein Kinase A Regulates MYC Protein through Transcriptional and Post-translational Mechanisms in a Catalytic Subunit Isoform-specific Manner

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Cyclic AMP compartments and signaling specificity: Role of cyclic nucleotide phosphodiesterases

(2013) Marco Conti et al.   JOURNAL OF GENERAL PHYSIOLOGY

Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD

(2013) Kensei Komatsu et al.   Nature Communications

Novel Antiinflammatory Therapies for COPD

(2012) Nicholas J. Gross   CHEST

Anti-Inflammatory Role of the cAMP Effectors Epac and PKA: Implications in Chronic Obstructive Pulmonary Disease

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NCS 613, a potent and specific PDE4 inhibitor, displays anti-inflammatory effects on human lung tissues

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S-Adenosylmethionine Decreases Lipopolysaccharide-Induced Phosphodiesterase 4B2 and Attenuates Tumor Necrosis Factor Expression via cAMP/Protein Kinase A Pathway

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(2011) Marion Frankenberger et al.   MOLECULAR MEDICINE

ERK and PDE4 cooperate to induce RAF isoform switching in melanoma

(2011) Amélie Marquette et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Combined anti-inflammatory effects of β2-adrenergic agonists and PDE4 inhibitors on astrocytes by upregulation of intracellular cAMP

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The Rate of NF-κB Nuclear Translocation Is Regulated by PKA and A Kinase Interacting Protein 1

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A-kinase-interacting Protein 1 (AKIP1) Acts as a Molecular Determinant of PKA in NF-κB Signaling

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(2010) David Price et al.   Primary Care Respiratory Journal

Nuclear NF- B p65 Phosphorylation at Serine 276 by Protein Kinase A Contributes to the Malignant Phenotype of Head and Neck Cancer

(2009) P. Arun et al.   CLINICAL CANCER RESEARCH

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

A controlled trial of 6-weeks' treatment with a novel inhaled phosphodiesterase type-4 inhibitor in COPD

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Phosphodiesterase 4B2 gene is an effector of Toll-like receptor signaling in astrocytes

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Ser276 Phosphorylation of NF-kB p65 by MSK1 Controls SCF Expression in Inflammation

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Elevated cyclic AMP and PDE4 inhibition induce chemokine expression in human monocyte-derived macrophages

(2009) A. L. Hertz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The NF- B Family of Transcription Factors and Its Regulation

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Epac and PKA: a tale of two intracellular cAMP receptors

(2008) Xiaodong Cheng et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

Enhanced PDE4B expression augments LPS-inducible TNF expression in ethanol-primed monocytes: relevance to alcoholic liver disease

(2008) Leila Gobejishvili et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Short-term or long-term treatments with a phosphodiesterase-4 (PDE4) inhibitor result in opposing agonist-induced Ca2+responses in endothelial cells

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Relations between the mitogen-activated protein kinase and the cAMP-dependent protein kinase pathways: Comradeship and hostility

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NF-κB-dependent Transcriptional Activation in Lung Carcinoma Cells by Farnesol Involves p65/RelA(Ser276) Phosphorylation via the MEK-MSK1 Signaling Pathway

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Haemophilus influenzae Lysate Induces Aspects of the Chronic Obstructive Pulmonary Disease Phenotype

(2007) Seyed Javad Moghaddam et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

CXCR3 and CCR5 Chemokines in Induced Sputum From Patients With COPD

(2007) Claudia Costa et al.   CHEST