Targeting peripheral immune organs with self‐assembling prodrug nanoparticles ameliorates allogeneic heart transplant rejection

New approaches in viraemic organ transplantation and antiviral therapies

(2020) Jacinta A. Holmes et al.   Nature Reviews Gastroenterology & Hepatology

Polyglycerol Grafting Shields Nanoparticles from Protein Corona Formation to Avoid Macrophage Uptake

(2020) Yajuan Zou et al.   ACS Nano

Target-oriented delivery of self-assembled immunosuppressant cocktails prolongs allogeneic orthotopic liver transplant survival

(2020) Haiyang Xie et al.   JOURNAL OF CONTROLLED RELEASE

Post-transplant diabetes mellitus in patients with solid organ transplants

(2019) Trond Jenssen et al.   Nature Reviews Endocrinology

A maresin 1/RORα/12-lipoxygenase autoregulatory circuit prevents inflammation and progression of nonalcoholic steatohepatitis

(2019) Yong-Hyun Han et al.   JOURNAL OF CLINICAL INVESTIGATION

Tailoring Nanomaterials for Targeting Tumor‐Associated Macrophages

(2019) Muhammad Ovais et al.   ADVANCED MATERIALS

Ceria Nanoparticles Meet Hepatic Ischemia‐Reperfusion Injury: The Perfect Imperfection

(2019) Dalong Ni et al.   ADVANCED MATERIALS

ZNNT1 long noncoding RNA induces autophagy to inhibit tumorigenesis of uveal melanoma by regulating key autophagy gene expression

(2019) Peng Li et al.   Autophagy

A Diet Rich in Fish Oil and Leucine Ameliorates Hypercalcemia in Tumour-Induced Cachectic Mice

(2019) Rogier L.C. Plas et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells

(2019) Ritesh K. Srivastava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolite identification and pharmacokinetic profiling of PP242, an ATP-competitive inhibitor of mTOR using ultra high-performance liquid chromatography and mass spectrometry

(2018) Md. Mamunur Rashid et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Flavonoids as Th1/Th2 cytokines immunomodulators: A systematic review of studies on animal models

(2018) Gopalsamy Rajiv Gandhi et al.   PHYTOMEDICINE

Reprogramming axial ligands facilitates the self-assembly of a platinum(iv) prodrug: overcoming drug resistance and safer in vivo delivery of cisplatin

(2018) Tao Fang et al.   CHEMICAL COMMUNICATIONS

Hypercholesterolemia after conversion to sirolimus as primary immunosuppression and cardiac allograft vasculopathy in heart transplant recipients

(2018) Rabea Asleh et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Monocyte-Derived Macrophages: The Missing Link in Organ Transplantation

(2018) Simon Pascual-Gil et al.   IMMUNITY

Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival

(2018) Baharak Bahmani et al.   JOURNAL OF CLINICAL INVESTIGATION

T cell Allorecognition Pathways in Solid Organ Transplantation

(2018) Jacqueline H. Y. Siu et al.   Frontiers in Immunology

Elements of cancer immunity and the cancer–immune set point

(2017) Daniel S. Chen et al.   NATURE

Evidence of the immunomodulatory role of dual PI3K/mTOR inhibitors in transplantation: an experimental study in mice

(2017) Valery Vilchez et al.   TRANSPLANT INTERNATIONAL

Influence of the Novel ATP-Competitive Dual mTORC1/2 Inhibitor AZD2014 on Immune Cell Populations and Heart Allograft Rejection

(2017) Daniel Fantus et al.   TRANSPLANTATION

T Cell Cosignaling Molecules in Transplantation

(2016) Mandy L. Ford   IMMUNITY

Role of memory T cell subsets for adoptive immunotherapy

(2016) Dirk H. Busch et al.   SEMINARS IN IMMUNOLOGY

Graft-infiltrating host dendritic cells play a key role in organ transplant rejection

(2016) Quan Zhuang et al.   Nature Communications

Membrane Tension Acts Through PLD2 and mTORC2 to Limit Actin Network Assembly During Neutrophil Migration

(2016) Alba Diz-Muñoz et al.   PLOS BIOLOGY

Allorecognition by T Lymphocytes and Allograft Rejection

(2016) Jose Marino et al.   Frontiers in Immunology

Self-Assembling Prodrugs by Precise Programming of Molecular Structures that Contribute Distinct Stability, Pharmacokinetics, and Antitumor Efficacy

(2015) Hangxiang Wang et al.   ADVANCED FUNCTIONAL MATERIALS

Target of Rapamycin Complex 2 Regulates Actin Polarization and Endocytosis via Multiple Pathways

(2015) Delphine Rispal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

Exosome-mediated microRNA signaling from breast cancer cells is altered by the anti-angiogenesis agent docosahexaenoic acid (DHA)

(2015) Bethany N. Hannafon et al.   Molecular Cancer

From sewer to saviour — targeting the lymphatic system to promote drug exposure and activity

(2015) Natalie L. Trevaskis et al.   NATURE REVIEWS DRUG DISCOVERY

Adenosine Triphosphate-Competitive mTOR Inhibitors: A New Class of Immunosuppressive Agents That Inhibit Allograft Rejection

(2014) B. R. Rosborough et al.   AMERICAN JOURNAL OF TRANSPLANTATION

IL-15 is decreased upon CsA and FK506 treatment of acute rejection following heart transplantation in mice

(2014) ZHIYONG YU et al.   Molecular Medicine Reports

mTOR kinase structure, mechanism and regulation

(2013) Haijuan Yang et al.   NATURE

Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma

(2012) A Naing et al.   BRITISH JOURNAL OF CANCER

Sirolimus for calcineurin inhibitors in organ transplantation: contra

(2010) Paolo Cravedi et al.   KIDNEY INTERNATIONAL

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

(2010) Matthew R Janes et al.   NATURE MEDICINE

Arsenic Trioxide Attenuated the Rejection of Major Histocompatibility Complex Fully-Mismatched Cardiac Allografts in Mice

(2009) S. Yan et al.   TRANSPLANTATION PROCEEDINGS