Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Combined mTORC1/mTORC2 inhibition blocks growth and induces catastrophic macropinocytosis in cancer cells
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 116, Issue 49, Pages 24583-24592
Publisher
Proceedings of the National Academy of Sciences
Online
2019-11-16
DOI
10.1073/pnas.1911393116
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide
- (2019) Margaux Colin et al. Cancers
- CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells
- (2019) Eduardo Silva-Pavez et al. Cell Death & Disease
- The molecular machinery of regulated cell death
- (2019) Daolin Tang et al. CELL RESEARCH
- Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins
- (2019) Nydia Tejeda-Muñoz et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Use of dual mTOR inhibitor MLN0128 against everolimus-resistant breast cancer
- (2018) Karineh Petrossian et al. BREAST CANCER RESEARCH AND TREATMENT
- SOX9 Transcriptionally Regulates mTOR-Induced Proliferation of Basal Cell Carcinomas
- (2018) Arianna L. Kim et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- PP242 Counteracts Glioblastoma Cell Proliferation, Migration, Invasiveness and Stemness Properties by Inhibiting mTORC2/AKT
- (2018) Carmen Mecca et al. Frontiers in Cellular Neuroscience
- Tubeimoside 1 Acts as a Chemotherapeutic Synergist via Stimulating Macropinocytosis
- (2018) Xianling Gong et al. Frontiers in Pharmacology
- Impact on Autophagy and Ultraviolet B Induced Responses of Treatment with the MTOR Inhibitors Rapamycin, Everolimus, Torin 1, and pp242 in Human Keratinocytes
- (2017) Song Xu et al. Oxidative Medicine and Cellular Longevity
- Vacquinol-1 inducible cell death in glioblastoma multiforme is counter regulated by TRPM7 activity induced by exogenous ATP
- (2017) Philip Sander et al. Oncotarget
- Macropinocytosis: A Metabolic Adaptation to Nutrient Stress in Cancer
- (2017) Maria Victoria Recouvreux et al. Frontiers in Endocrinology
- Disruption of endolysosomal trafficking pathways in glioma cells by methuosis-inducing indole-based chalcones
- (2016) Nneka E. Mbah et al. CELL BIOLOGY AND TOXICOLOGY
- Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells
- (2016) Chunhui Li et al. MOLECULAR AND CELLULAR BIOLOGY
- Dual mTORC1/2 Inhibition as a Novel Strategy for the Resensitization and Treatment of Platinum-Resistant Ovarian Cancer
- (2016) Fernanda Musa et al. MOLECULAR CANCER THERAPEUTICS
- The mTOR signalling cascade: paving new roads to cure neurological disease
- (2016) Peter B. Crino Nature Reviews Neurology
- Inhibition of JNK-mediated autophagy enhances NSCLC cell sensitivity to mTORC1/2 inhibitors
- (2016) Hyeon-Ok Jin et al. Scientific Reports
- mTOR: a pharmacologic target for autophagy regulation
- (2015) Young Chul Kim et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells
- (2015) B. W. Chen et al. MOLECULAR CANCER THERAPEUTICS
- A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation
- (2015) Guang Yang et al. Cell Reports
- Non-apoptotic cell death associated with perturbations of macropinocytosis
- (2015) William A. Maltese et al. Frontiers in Physiology
- GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis
- (2015) Ritesh K. Srivastava et al. Oncotarget
- MLN0128, an ATP-Competitive mTOR Kinase Inhibitor with Potent In Vitro and In Vivo Antitumor Activity, as Potential Therapy for Bone and Soft-Tissue Sarcoma
- (2014) E. K. Slotkin et al. MOLECULAR CANCER THERAPEUTICS
- The dual mTORC1 and mTORC2 inhibitor AZD8055 inhibits head and neck squamous cell carcinoma cell growth in vivo and in vitro
- (2013) Qiang Li et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Rapamycin targeting mTOR and hedgehog signaling pathways blocks human rhabdomyosarcoma growth in xenograft murine model
- (2013) Samer Z. Kaylani et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Platelet-derived growth factor-induced Akt phosphorylation requires mTOR/Rictor and phospholipase C-γ1, whereas S6 phosphorylation depends on mTOR/Raptor and phospholipase D
- (2013) Masoud Razmara et al. Cell Communication and Signaling
- Dissecting the roles of Rac1 activation and deactivation in macropinocytosis using microscopic photo-manipulation
- (2013) Makoto Fujii et al. Scientific Reports
- Antitumor activities of ATP-competitive inhibitors of mTOR in colon cancer cells
- (2012) Benjamin Blaser et al. BMC CANCER
- mTOR Signaling in Growth Control and Disease
- (2012) Mathieu Laplante et al. CELL
- Role of mTOR Signaling in Tumor Cell Motility, Invasion and Metastasis
- (2012) Shile Huang et al. CURRENT PROTEIN & PEPTIDE SCIENCE
- The mTOR Signalling Pathway in Human Cancer
- (2012) Helena Pópulo et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Rhabdomyosarcoma: Review of the Children's Oncology Group (COG) soft-tissue Sarcoma committee experience and rationale for current COG studies
- (2012) Suman Malempati et al. PEDIATRIC BLOOD & CANCER
- Rapamycin and mTORC1 Inhibition in the Mouse: Skin Cancer Prevention
- (2011) Mohammad Athar et al. Cancer Prevention Research
- mTORC1 and mTORC2 Regulate EMT, Motility, and Metastasis of Colorectal Cancer via RhoA and Rac1 Signaling Pathways
- (2011) P. Gulhati et al. CANCER RESEARCH
- Preclinical Characterization of OSI-027, a Potent and Selective Inhibitor of mTORC1 and mTORC2: Distinct from Rapamycin
- (2011) S. V. Bhagwat et al. MOLECULAR CANCER THERAPEUTICS
- mTOR Complex Component Rictor Interacts with PKC and Regulates Cancer Cell Metastasis
- (2010) F. Zhang et al. CANCER RESEARCH
- Novel Expression Patterns of PI3K/Akt/mTOR Signaling Pathway Components in Colorectal Cancer
- (2010) Sara M. Johnson et al. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
- An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
- (2009) Carson C. Thoreen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- mTOR signaling at a glance
- (2009) M. Laplante et al. JOURNAL OF CELL SCIENCE
- Targeting the phosphoinositide 3-kinase pathway in cancer
- (2009) Pixu Liu et al. NATURE REVIEWS DRUG DISCOVERY
- EGFR Signals to mTOR Through PKC and Independently of Akt in Glioma
- (2009) Q.-W. Fan et al. Science Signaling
- New Insights into mTOR Signaling: mTORC2 and Beyond
- (2009) D. R. Alessi et al. Science Signaling
- Active Ras Triggers Death in Glioblastoma Cells through Hyperstimulation of Macropinocytosis
- (2008) J. H. Overmeyer et al. MOLECULAR CANCER RESEARCH
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now