Viscoelasticity and Adhesion Signaling in Biomaterials Control Human Pluripotent Stem Cell Morphogenesis in 3D Culture

Single-cell and spatial transcriptomics reveal somitogenesis in gastruloids

(2020) Susanne C. van den Brink et al.   NATURE

Basement membrane remodelling regulates mouse embryogenesis

(2020) Christos Kyprianou et al.   NATURE

Mechanisms of human embryo development: from cell fate to tissue shape and back

(2020) Marta N. Shahbazi   DEVELOPMENT

An in vitro model of early anteroposterior organization during human development

(2020) Naomi Moris et al.   NATURE

Mechano-modulatory synthetic niches for liver organoid derivation

(2020) Giovanni Sorrentino et al.   Nature Communications

Pluripotent Stem Cell-Based Cell Therapy—Promise and Challenges

(2020) Shinya Yamanaka   Cell Stem Cell

Pluripotent stem cell models of early mammalian development

(2020) Peter Baillie-Benson et al.   CURRENT OPINION IN CELL BIOLOGY

Homeostatic mini-intestines through scaffold-guided organoid morphogenesis

(2020) Mikhail Nikolaev et al.   NATURE

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Extracellular matrix plasticity as a driver of cell spreading

(2020) Joshua M. Grolman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bioengineered pluripotent stem cell models: new approaches to explore early human embryo development

(2020) Agnes M Resto Irizarry et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mouse embryonic stem cells self-organize into trunk-like structures with neural tube and somites

(2020) Jesse V. Veenvliet et al.   SCIENCE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Nonadhesive Alginate Hydrogels Support Growth of Pluripotent Stem Cell-Derived Intestinal Organoids

(2019) Meghan M. Capeling et al.   Stem Cell Reports

Volume expansion and TRPV4 activation regulate stem cell fate in three-dimensional microenvironments

(2019) Hong-pyo Lee et al.   Nature Communications

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

(2019) Stefano Vianello et al.   DEVELOPMENTAL CELL

Self-organization and symmetry breaking in intestinal organoid development

(2019) Denise Serra et al.   NATURE

YAP-independent mechanotransduction drives breast cancer progression

(2019) Joanna Y. Lee et al.   Nature Communications

Engineering Stem Cell Self-organization to Build Better Organoids

(2019) Jonathan A. Brassard et al.   Cell Stem Cell

A 3D model of a human epiblast reveals BMP4-driven symmetry breaking

(2019) Mijo Simunovic et al.   NATURE CELL BIOLOGY

Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst

(2019) Julien G. Dumortier et al.   SCIENCE

Self-organization of stem cells into embryos: A window on early mammalian development

(2019) Marta N. Shahbazi et al.   SCIENCE

Controlled modelling of human epiblast and amnion development using stem cells

(2019) Yi Zheng et al.   NATURE

Engineered materials for organoid systems

(2019) Michael J. Kratochvil et al.   Nature Reviews Materials

Cell cycle progression in confining microenvironments is regulated by a growth-responsive TRPV4-PI3K/Akt-p27Kip1 signaling axis

(2019) Sungmin Nam et al.   Science Advances

Mouse embryo geometry drives formation of robust signaling gradients through receptor localization

(2019) Zhechun Zhang et al.   Nature Communications

Leveraging Biomaterial Mechanics to Improve Pluripotent Stem Cell Applications for Tissue Engineering

(2019) Stephen Lenzini et al.   Frontiers in Bioengineering and Biotechnology

How cells sense their own shape – mechanisms to probe cell geometry and their implications in cellular organization and function

(2018) Armin Haupt et al.   JOURNAL OF CELL SCIENCE

Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures

(2018) Berna Sozen et al.   NATURE CELL BIOLOGY

Deconstructing and reconstructing the mouse and human early embryo

(2018) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Multi-axial self-organization properties of mouse embryonic stem cells into gastruloids

(2018) Leonardo Beccari et al.   NATURE

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

An apicosome initiates self-organizing morphogenesis of human pluripotent stem cells

(2017) Kenichiro Taniguchi et al.   JOURNAL OF CELL BIOLOGY

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos

(2017) Marta N. Shahbazi et al.   NATURE

Revisiting the Warnock rule

(2017) J Benjamin Hurlbut et al.   NATURE BIOTECHNOLOGY

Mechanobiology of YAP and TAZ in physiology and disease

(2017) Tito Panciera et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro

(2017) Sarah Ellys Harrison et al.   SCIENCE

Mechanotransductive cascade of Myo-II-dependent mesoderm and endoderm invaginations in embryo gastrulation

(2017) Démosthène Mitrossilis et al.   Nature Communications

A pluripotent stem cell-based model for post-implantation human amniotic sac development

(2017) Yue Shao et al.   Nature Communications

Morphogen interpretation: concentration, time, competence, and signaling dynamics

(2017) Andreas Sagner et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Tissue Mechanics Orchestrate Wnt-Dependent Human Embryonic Stem Cell Differentiation

(2016) Laralynne Przybyla et al.   Cell Stem Cell

Midbrain-like Organoids from Human Pluripotent Stem Cells Contain Functional Dopaminergic and Neuromelanin-Producing Neurons

(2016) Junghyun Jo et al.   Cell Stem Cell

Self-organization of the in vitro attached human embryo

(2016) Alessia Deglincerti et al.   NATURE

Designer matrices for intestinal stem cell and organoid culture

(2016) Nikolce Gjorevski et al.   NATURE

Self-organization of the human embryo in the absence of maternal tissues

(2016) Marta N. Shahbazi et al.   NATURE CELL BIOLOGY

Neural tube morphogenesis in synthetic 3D microenvironments

(2016) Adrian Ranga et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On human pluripotent stem cell control: The rise of 3D bioengineering and mechanobiology

(2015) Yue Shao et al.   BIOMATERIALS

Organoid Models of Human and Mouse Ductal Pancreatic Cancer

(2015) Sylvia F. Boj et al.   CELL

Rho-Signaling-Directed YAP/TAZ Activity Underlies the Long-Term Survival and Expansion of Human Embryonic Stem Cells

(2015) Masatoshi Ohgushi et al.   Cell Stem Cell

Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis

(2015) Nduka O. Enemchukwu et al.   JOURNAL OF CELL BIOLOGY

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Ductal pancreatic cancer modeling and drug screening using human pluripotent stem cell– and patient-derived tumor organoids

(2015) Ling Huang et al.   NATURE MEDICINE

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

Lumen Formation Is an Intrinsic Property of Isolated Human Pluripotent Stem Cells

(2015) Kenichiro Taniguchi et al.   Stem Cell Reports

Self-Organizing Properties of Mouse Pluripotent Cells Initiate Morphogenesis upon Implantation

(2014) Ivan Bedzhov et al.   CELL

Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures

(2014) Wouter R. Karthaus et al.   CELL

Modelling human development and disease in pluripotent stem-cell-derived gastric organoids

(2014) Kyle W. McCracken et al.   NATURE

A method to recapitulate early embryonic spatial patterning in human embryonic stem cells

(2014) Aryeh Warmflash et al.   NATURE METHODS

Rapid and Efficient Conversion of Integration-Free Human Induced Pluripotent Stem Cells to GMP-Grade Culture Conditions

(2014) Jens Durruthy-Durruthy et al.   PLoS One

Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells

(2014) Xiong Zhang et al.   Stem Cell Research

A novel efficient feeder-free culture system for the derivation of human induced pluripotent stem cells

(2014) Masato Nakagawa et al.   Scientific Reports

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Soft microenvironments promote the early neurogenic differentiation but not self-renewal of human pluripotent stem cells

(2012) Albert J. Keung et al.   Integrative Biology

Molecular Pathway and Cell State Responsible for Dissociation-Induced Apoptosis in Human Pluripotent Stem Cells

(2010) Masatoshi Ohgushi et al.   Cell Stem Cell

Long-term self-renewal of human pluripotent stem cells on human recombinant laminin-511

(2010) Sergey Rodin et al.   NATURE BIOTECHNOLOGY

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

(2009) Noriyuki Nishioka et al.   DEVELOPMENTAL CELL

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

(2009) Toshiro Sato et al.   NATURE

Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell niche

(2009) Akifumi Ootani et al.   NATURE MEDICINE

Wnt Signaling Mediates Self-Organization and Axis Formation in Embryoid Bodies

(2008) Derk ten Berge et al.   Cell Stem Cell

From cells to organs: building polarized tissue

(2008) David M. Bryant et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY