Oral delivery of natural active small molecules by polymeric nanoparticles for the treatment of inflammatory bowel diseases

Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine

(2021) Lingzhi Zhang et al.   MOLECULAR PHARMACEUTICS

Neoteric solvents for the pharmaceutical industry: an update

(2021) Thenrajan Raja Sekharan et al.   DRUG DISCOVERY TODAY

Macrophage-based nanotherapeutic strategies in ulcerative colitis

(2020) Jiaxin Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

(2020) Frank Yeung et al.   Cell Host & Microbe

Orally delivered targeted nanotherapeutics for the treatment of colorectal cancer

(2020) Xueqing Zhang et al.   Expert Opinion on Drug Delivery

Biological properties and clinical applications of berberine

(2020) Danyang Song et al.   Frontiers of Medicine

Advanced nanomedicines for the treatment of inflammatory diseases

(2020) Romain Brusini et al.   ADVANCED DRUG DELIVERY REVIEWS

Dietary Quercetin Alleviated DSS-induced Colitis in Mice through Several Possible Pathways by Transcriptome Analysis

(2020) Yuanyang Dong et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Alpha-MSH targeted liposomal nanoparticle for imaging in Inflammatory Bowel Disease (IBD)

(2020) Tuula Peñate Medina et al.   CURRENT PHARMACEUTICAL DESIGN

Natural-lipid nanoparticle-based therapeutic approach to deliver 6-shogaol and its metabolites M2 and M13 to the colon to treat ulcerative colitis

(2020) Chunhua Yang et al.   JOURNAL OF CONTROLLED RELEASE

The Use of Curcumin as a Complementary Therapy in Ulcerative Colitis: A Systematic Review of Randomized Controlled Clinical Trials

(2020) Mariana Roque Coelho et al.   Nutrients

Modular design of a hybrid hydrogel for protease-triggered enhancement of drug delivery to regulate TNF-α production by pro-inflammatory macrophages

(2020) Dang T. Nguyen et al.   Acta Biomaterialia

A Review of the Pharmacological Properties of Psoralen

(2020) Yali Ren et al.   Frontiers in Pharmacology

Oral delivery of folate-targeted resveratrol-loaded nanoparticles for inflammatory bowel disease therapy in rats

(2020) Mahshid Naserifar et al.   LIFE SCIENCES

Inflammatory Bowel Disease: The Emergence of New Trends in Lifestyle and Nanomedicine as the Modern Tool for Pharmacotherapy

(2020) Eden Mariam Jacob et al.   Nanomaterials

Challenges in the diagnosis and management of inflammatory bowel disease in resource-limited settings in Asia

(2020) Rupa Banerjee et al.   Lancet Gastroenterology & Hepatology

Dietary Quercetin Increases Colonic Microbial Diversity and Attenuates Colitis Severity in Citrobacter rodentium-Infected Mice

(2019) Rui Lin et al.   Frontiers in Microbiology

Silk fibroin-based nanotherapeutics: application in the treatment of colonic diseases

(2019) Shuangquan Gou et al.   Nanomedicine

Delivery of Nanoparticles across the Intestinal Epithelium via the Transferrin Transport Pathway

(2019) Jing M. Yong et al.   Pharmaceutics

Multi-bioresponsive silk fibroin-based nanoparticles with on-demand cytoplasmic drug release capacity for CD44-targeted alleviation of ulcerative colitis

(2019) Shuangquan Gou et al.   BIOMATERIALS

Mucus-penetrating polymeric nanoparticles for oral delivery of curcumin to inflamed colon tissue

(2019) Xin Zhou et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Hyaluronic acid–bilirubin nanomedicine for targeted modulation of dysregulated intestinal barrier, microbiome and immune responses in colitis

(2019) Yonghyun Lee et al.   NATURE MATERIALS

Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome

(2019) Israr Khan et al.   Pathogens

Nanoparticle-Mediated Drug Delivery Systems For The Treatment Of IBD: Current Perspectives

(2019) Chunhua Yang et al.   International Journal of Nanomedicine

BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration

(2019) Min Liu et al.   Nature Communications

Drug delivery to macrophages: A review of targeting drugs and drug carriers to macrophages for inflammatory diseases

(2019) Wei He et al.   ADVANCED DRUG DELIVERY REVIEWS

Silencing of Intestinal Glycoprotein CD98 by Orally Targeted Nanoparticles Enhances Chemosensitization of Colon Cancer

(2018) Bo Xiao et al.   ACS Nano

Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors

(2018) Jingjing Gan et al.   BIOMATERIALS

Redox-sensitive nanoparticles based on 4-aminothiophenol-carboxymethyl inulin conjugate for budesonide delivery in inflammatory bowel diseases

(2018) Qijuan Sun et al.   CARBOHYDRATE POLYMERS

Current, experimental, and future treatments in inflammatory bowel disease: a clinical review

(2018) Christian L. Hvas et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Nanoparticle-Based Oral Drug Delivery Systems Targeting the Colon for Treatment of Ulcerative Colitis

(2018) Mingzhen Zhang et al.   INFLAMMATORY BOWEL DISEASES

Galactosylated PLGA nanoparticles for the oral delivery of resveratrol: enhanced bioavailability and in vitro anti-inflammatory activity

(2018) Frederick Siu et al.   International Journal of Nanomedicine

Natural deep eutectic solvents as eco-friendly and sustainable dilution medium for the determination of residual organic solvents in pharmaceuticals with static headspace-gas chromatography

(2018) Meilian Wang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Selective liposome targeting of folate receptor positive immune cells in inflammatory diseases

(2018) Scott Poh et al.   Nanomedicine-Nanotechnology Biology and Medicine

TNFα gene silencing mediated by orally targeted nanoparticles combined with interleukin-22 for synergistic combination therapy of ulcerative colitis

(2018) Bo Xiao et al.   JOURNAL OF CONTROLLED RELEASE

Preparation and characterization of pH-sensitive nanoparticles of budesonide for the treatment of ulcerative colitis

(2018) Hong Zhou et al.   Drug Design Development and Therapy

Oral Drug Delivery Systems for Ulcerative Colitis Therapy: A Comparative Study with Microparticles and Nanoparticles

(2018) Panpan Ma et al.   CURRENT CANCER DRUG TARGETS

Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections

(2018) Xufeng Tao et al.   PHARMACOLOGICAL RESEARCH

A systematic review of nano formulation of natural products for the treatment of inflammatory bowel disease: drug delivery and pharmacological targets

(2018) Yasamin Davatgaran Taghipour et al.   DARU-Journal of Pharmaceutical Sciences

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction

(2017) Emilie Catry et al.   GUT

In vitro study on anti-inflammatory effects of epigallocatechin-3-gallate-loaded nano- and microscale particles

(2017) Yan Ru Wu et al.   International Journal of Nanomedicine

Silk fibroin nanoparticles: Efficient vehicles for the natural antioxidant quercetin

(2017) Antonio Abel Lozano-Pérez et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Folate-mediated chemotherapy and diagnostics: An updated review and outlook

(2017) Leyuan Xu et al.   JOURNAL OF CONTROLLED RELEASE

Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century: a systematic review of population-based studies

(2017) Siew C Ng et al.   LANCET

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

(2017) Bo Xiao et al.   MOLECULAR THERAPY

Preparation and Bioactivity Assessment of Chitosan-1-Acetic Acid-5-Flurouracil Conjugates as Cancer Prodrugs

(2017) Mohsin Mohammed et al.   MOLECULES

Nanoparticulate drug delivery systems targeting inflammation for treatment of inflammatory bowel disease

(2017) Sufeng Zhang et al.   Nano Today

Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks

(2017) Rui Xue Zhang et al.   Nanoscale

Functionalized materials for multistage platforms in the oral delivery of biopharmaceuticals

(2017) Francisca Araújo et al.   PROGRESS IN MATERIALS SCIENCE

Berberine alleviates dextran sodium sulfate-induced colitis by improving intestinal barrier function and reducing inflammation and oxidative stress

(2017) Li-Chao Zhang et al.   Experimental and Therapeutic Medicine

Conjugation of metronidazole with dextran: a potential pharmaceutical strategy to control colonic distribution of the anti-amebic drug susceptible to metabolism by colonic microbes

(2017) Wooseong Kim et al.   Drug Design Development and Therapy

Nanotherapeutics for the treatment of inflammatory bowel disease

(2017) Qiubing Chen et al.   Expert Review of Gastroenterology & Hepatology

Evolution of macromolecular complexity in drug delivery systems

(2017) Ashok Kakkar et al.   Nature Reviews Chemistry

Risk of invasive melanoma in patients with rheumatoid arthritis treated with biologics: results from a collaborative project of 11 European biologic registers

(2016) Louise K Mercer et al.   ANNALS OF THE RHEUMATIC DISEASES

Edible ginger-derived nanoparticles: A novel therapeutic approach for the prevention and treatment of inflammatory bowel disease and colitis-associated cancer

(2016) Mingzhen Zhang et al.   BIOMATERIALS

Self assembled hyaluronic acid nanoparticles as a potential carrier for targeting the inflamed intestinal mucosa

(2016) Seyed Yaser Vafaei et al.   CARBOHYDRATE POLYMERS

Controlled local drug delivery strategies from chitosan hydrogels for wound healing

(2016) Lisa Elviri et al.   Expert Opinion on Drug Delivery

Development and performance evaluation of novel nanoparticles of a grafted copolymer loaded with curcumin

(2016) Srinivas Mutalik et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Intestinal anti-inflammatory effects of RGD-functionalized silk fibroin nanoparticles in trinitrobenzenesulfonic acid-induced experimental colitis in rats

(2016) Alba Rodriguez-Nogales et al.   International Journal of Nanomedicine

RNA interference-based nanosystems for inflammatory bowel disease therapy

(2016) Jian Guo et al.   International Journal of Nanomedicine

Effect of aqueous and particulate silk fibroin in a rat model of experimental colitis

(2016) A. Rodriguez-Nogales et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of nanoparticle size, shape and surface chemistry in oral drug delivery

(2016) Amrita Banerjee et al.   JOURNAL OF CONTROLLED RELEASE

Natural Products as Sources of New Drugs from 1981 to 2014

(2016) David J. Newman et al.   JOURNAL OF NATURAL PRODUCTS

Berberine and inflammatory bowel disease: A concise review

(2016) Solomon Habtemariam   PHARMACOLOGICAL RESEARCH

Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

(2016) Vipul Yadav et al.   Translational Research

Quercetin, Inflammation and Immunity

(2016) Yao Li et al.   Nutrients

Combination Therapy for Ulcerative Colitis: Orally Targeted Nanoparticles Prevent Mucosal Damage and Relieve Inflammation

(2016) Bo Xiao et al.   Theranostics

Colon-Targeted Oral Drug Delivery Systems: Design Trends and Approaches

(2015) Seth Amidon et al.   AAPS PHARMSCITECH

Characteristics of Skin Lesions Associated With Anti–Tumor Necrosis Factor Therapy in Patients With Inflammatory Bowel Disease

(2015) Isabelle Cleynen et al.   ANNALS OF INTERNAL MEDICINE

Berberine as a therapy for type 2 diabetes and its complications: From mechanism of action to clinical studies

(2015) Wenguang Chang et al.   Biochemistry and Cell Biology

An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease

(2015) Zhen Huang et al.   BIOMATERIALS

Inflammatory Bowel Disease: Pathogenesis, Causative Factors, Issues, Drug Treatment Strategies, and Delivery Approaches

(2015) Deependra Singh et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

In vivo anti-apoptosis activity of novel berberine-loaded chitosan nanoparticles effectively ameliorates osteoarthritis

(2015) Yan Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Nanomedicine in cancer therapy: Challenges, opportunities, and clinical applications

(2015) Andreas Wicki et al.   JOURNAL OF CONTROLLED RELEASE

Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue

(2015) Susan Hua et al.   Nanomedicine-Nanotechnology Biology and Medicine

An inflammation-targeting hydrogel for local drug delivery in inflammatory bowel disease

(2015) Sufeng Zhang et al.   Science Translational Medicine

Biased and unbiased strategies to identify biologically active small molecules

(2014) Valentina Abet et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Enzyme/pH dual sensitive polymeric nanoparticles for targeted drug delivery to the inflamed colon

(2014) Muhammad Naeem et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Overview of the preparation of organic polymeric nanoparticles for drug delivery based on gelatine, chitosan, poly(d,l-lactide-co-glycolic acid) and polyalkylcyanoacrylate

(2014) Patrick Lai et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Pulverized konjac glucomannan ameliorates oxazolone-induced colitis in mice

(2014) Toshiko Onitake et al.   EUROPEAN JOURNAL OF NUTRITION

Carboxymethylcellulose–tetrahydrocurcumin conjugates for colon-specific delivery of a novel anti-cancer agent, 4-amino tetrahydrocurcumin

(2014) Thipapun Plyduang et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Nanoparticles With Surface Antibody Against CD98 and Carrying CD98 Small Interfering RNA Reduce Colitis in Mice

(2014) Bo Xiao et al.   GASTROENTEROLOGY

pH-sensitive nanoparticles for colonic delivery of curcumin in inflammatory bowel disease

(2014) Ana Beloqui et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fab'-bearing siRNA TNFα-loaded nanoparticles targeted to colonic macrophages offer an effective therapy for experimental colitis

(2014) Hamed Laroui et al.   JOURNAL OF CONTROLLED RELEASE

Regulation of Alternative Macrophage Activation by Galectin-3

(2014) A. C. MacKinnon et al.   JOURNAL OF IMMUNOLOGY

Berberine derivatives reduce atherosclerotic plaque size and vulnerability in apoE−/− mice

(2014) Junwen Chen et al.   Journal of Translational Medicine

Delivery of Berberine Using Chitosan/Fucoidan-Taurine Conjugate Nanoparticles for Treatment of Defective Intestinal Epithelial Tight Junction Barrier

(2014) Shao-Jung Wu et al.   Marine Drugs

Glycoprotein CD98 as a receptor for colitis-targeted delivery of nanoparticles

(2014) Bo Xiao et al.   Journal of Materials Chemistry B

Galactosylated trimethyl chitosan–cysteine nanoparticles loaded with Map4k4 siRNA for targeting activated macrophages

(2013) Jing Zhang et al.   BIOMATERIALS

Mannosylated bioreducible nanoparticle-mediated macrophage-specific TNF-α RNA interference for IBD therapy

(2013) Bo Xiao et al.   BIOMATERIALS

Effects of Immunosuppression and Liver Transplantation on Inflammatory Bowel Disease in Patients With Primary Sclerosing Cholangitis

(2013) Udayakumar Navaneethan et al.   Clinical Gastroenterology and Hepatology

Intestinal Epithelial CD98 Directly Modulates the Innate Host Response to Enteric Bacterial Pathogens

(2013) Moiz A. Charania et al.   INFECTION AND IMMUNITY

Curcumin ameliorates dextran sulfate sodium-induced experimental colitis by blocking STAT3 signaling pathway

(2013) Liu Liu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Berberine potently attenuates intestinal polyps growth in ApcMin mice and familial adenomatous polyposis patients through inhibition of Wnt signalling

(2013) Junfang Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

pH-Sensitive Nanoparticles of Curcumin–Celecoxib Combination: Evaluating Drug Synergy in Ulcerative Colitis Model

(2013) Dalapathi Gugulothu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

pH-Dependent Anticancer Drug Release from Silk Nanoparticles

(2013) F. Philipp Seib et al.   Advanced Healthcare Materials

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

(2012) Subash C. Gupta et al.   AAPS Journal

Lipid-Based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic

(2012) Anu Puri et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Oral colon-specific therapeutic approaches toward treatment of inflammatory bowel disease

(2012) Bo Xiao et al.   Expert Opinion on Drug Delivery

In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin

(2012) Feng Li et al.   FOOD CHEMISTRY

An Orally Administered Redox Nanoparticle That Accumulates in the Colonic Mucosa and Reduces Colitis in Mice

(2012) Long Binh Vong et al.   GASTROENTEROLOGY

Oral drug delivery with polymeric nanoparticles: The gastrointestinal mucus barriers

(2011) Laura M. Ensign et al.   ADVANCED DRUG DELIVERY REVIEWS

The role and pathophysiological relevance of membrane transporter PepT1 in intestinal inflammation and inflammatory bowel disease

(2011) Sarah A. Ingersoll et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Berberine promotes recovery of colitis and inhibits inflammatory responses in colonic macrophages and epithelial cells in DSS-treated mice

(2011) Fang Yan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Host genetic susceptibility, dysbiosis, and viral triggers in inflammatory bowel disease

(2011) Lulu Sun et al.   CURRENT OPINION IN GASTROENTEROLOGY

Prodrugs - An Efficient Way to Breach Delivery and Targeting Barriers

(2011) Kristiina M. Huttunen et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction

(2011) Sehwan Shim et al.   FOOD AND CHEMICAL TOXICOLOGY

Enhanced Transferrin Receptor Expression by Proinflammatory Cytokines in Enterocytes as a Means for Local Delivery of Drugs to Inflamed Gut Mucosa

(2011) Efrat Harel et al.   PLoS One

Biodegradable synthetic polymers: Preparation, functionalization and biomedical application

(2011) Huayu Tian et al.   PROGRESS IN POLYMER SCIENCE

Nanoparticles: Emerging carriers for drug delivery

(2011) Sagar R. Mudshinge et al.   SAUDI PHARMACEUTICAL JOURNAL

Anti-oxidant Effects of Resveratrol on Mice with DSS-induced Ulcerative Colitis

(2010) Jun Yao et al.   ARCHIVES OF MEDICAL RESEARCH

Small molecules from natural sources, targeting signaling pathways in diabetes

(2010) Qiong Liu et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Development of biodegradable nanoparticles for delivery of quercetin

(2010) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Berberine ameliorates TNBS-induced colitis by inhibiting lipid peroxidation, enterobacterial growth and NF-κB activation

(2010) In-Ah Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

What should be considered on design of a colon-specific prodrug?

(2010) Yunjin Jung et al.   Expert Opinion on Drug Delivery

Infliximab and adalimumab-induced psoriasis in Crohn's disease: A paradoxical side effect

(2010) Marisa Iborra et al.   Journal of Crohns & Colitis

Solubility and solution thermodynamic properties of quercetin and quercetin dihydrate in subcritical water

(2010) Keerthi Srinivas et al.   JOURNAL OF FOOD ENGINEERING

Orally delivered thioketal nanoparticles loaded with TNF-α–siRNA target inflammation and inhibit gene expression in the intestines

(2010) D. Scott Wilson et al.   NATURE MATERIALS

Future biologic targets for IBD: potentials and pitfalls

(2010) Gil Y. Melmed et al.   Nature Reviews Gastroenterology & Hepatology

Selective nanoparticle adhesion can enhance colitis therapy

(2010) Alf Lamprecht   Nature Reviews Gastroenterology & Hepatology

Biodegradable polymeric nanoparticles based drug delivery systems

(2009) Avnesh Kumari et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Resveratrol inhibits prostaglandin formation in IL-1β-stimulated SK-N-SH neuronal cells

(2009) Lena Wendeburg et al.   Journal of Neuroinflammation

Importance of nutrition in inflammatory bowel disease

(2009) Alfredo José Lucendo et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Poly(ethylene glycol)-mesalazine conjugate for colon specific delivery

(2008) M. Canevari et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Role of HIF-1 and NF-κB Transcription Factors in the Modulation of Transferrin Receptor by Inflammatory and Anti-inflammatory Signals

(2008) Lorenza Tacchini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New opportunities for biocatalysis: making pharmaceutical processes greener

(2008) John M. Woodley   TRENDS IN BIOTECHNOLOGY