Review
Chemistry, Multidisciplinary
Manuela Curcio, Orazio Vittorio, Jessica Lilian Bell, Francesca Iemma, Fiore Pasquale Nicoletta, Giuseppe Cirillo
Summary: This review focuses on the unique application of self-assembling nanoparticles (SANPs) based on hyaluronic acid (HA) in cancer therapy. By combining the targeting activity of HA towards cancer cells with the advantages of self-assembling nanosystems, these SANPs can be used to fabricate delivery devices. The review analyzes the pros and cons of different nanosystems based on HA and discusses the most promising strategies for further research and therapeutic protocol development.
Review
Chemistry, Physical
Yue Jiang, Xueting Pan, Tao Yu, Hai Wang
Summary: The existence of the blood-brain barrier (BBB) poses challenges for drug delivery to the central nervous system (CNS). Intranasal administration has emerged as an alternative method for delivering drugs to the brain by bypassing the BBB. This review focuses on the mechanisms, properties, and strategies of intranasal nanosystems for brain-targeted drug delivery. Despite promising results in animal models and clinical applications, significant challenges need to be overcome for the translation of these nanosystems into clinics. The future prospects of intranasal drug delivery nanosystems are discussed, aiming to provide insights and guidance for effective neurological disease treatment.
Article
Chemistry, Multidisciplinary
Xiunan Yu, Hao Wang, Xin Liu, Le Huang, Na Song, Yanqiu Song, Xiaowei Mo, Shaofeng Lou, Linqi Shi, Zhilin Yu
Summary: This study reports the assembly of synergistic peptide-drug conjugates for the treatment of cancer metastasis. The conjugates were created by co-assembling a protein-derived therapeutic peptide with paclitaxel, resulting in remarkable therapeutic effects and tumor-targeting properties.
Review
Pharmacology & Pharmacy
Francesca Garello, Yulia Svenskaya, Bogdan Parakhonskiy, Miriam Filippi
Summary: Targeted delivery of pharmaceuticals using magnetic carriers has great potential for efficient and controlled drug delivery. This review discusses different types of magnetic carriers and their applications in magnetic targeted delivery of bioagents. The integration of magnetic targeting with tissue engineering and imaging technologies is also highlighted.
Article
Engineering, Biomedical
Niranjan G. Kotla, Rajbir Singh, Becca Baby, Swetha Rasala, Jawad Rasool, Sean O. Hynes, Darrell Martin, Laurence J. Egan, Praveen K. Vemula, Venkatakrishna R. Jala, Yury Rochev, Abhay Pandit
Summary: Delivering drugs directly to inflamed intestinal sites to treat inflammatory bowel disease (IBD) is a challenge, but the development of targeted carrier systems such as IT-NCs shows promising therapeutic potential in improving treatment efficacy.
Review
Chemistry, Multidisciplinary
Fazhan Wang, Jia Lou, Xiaoke Gao, Lijing Zhang, Feifei Sun, Zhaoqing Wang, Tianjiao Ji, Zhihai Qin
Summary: The spleen plays a crucial role in regulating immune responses and holds great potential for preventing and treating immune-related diseases. Novel nanosystems designed for spleen-targeted delivery of immunoregulators have shown promising therapeutic effects in diseases such as cancers, infectious diseases, autoimmune diseases, and pathogenic inflammatory disorders. This review discusses the architecture of the spleen, principles for designing spleen-targeted nanosystems, and their applications in enhancing or suppressing immune responses for disease treatment or prevention.
Review
Chemistry, Medicinal
Siavash Iravani, Rajender S. Varma
Summary: Alginate has been extensively studied for its hydrophilicity, biocompatibility, and bioavailability, making it a promising material for controlled drug delivery and cancer therapy. Future research should focus on developing novel alginate-based systems using advanced drug delivery techniques for non-invasive and targeted cancer treatment.
Review
Pharmacology & Pharmacy
Daniela Placha, Josef Jampilek
Summary: Inflammatory diseases are becoming a significant issue, causing damage to affected tissues as a physiological response to harmful agents. There is ongoing research to develop new drugs to modulate inflammatory responses, as well as exploring the use of nanodrug delivery systems for targeted treatment.
Review
Chemistry, Multidisciplinary
J. Zajda, A. Wroblewska, L. Ruzik, M. Matczuk
Summary: Conventional platinum-based anticancer therapies face challenges in drug distribution and severe side effects, highlighting the need for targeted delivery systems. Utilizing nanomaterials to develop Pt-based drug targeted delivery systems offers enhanced and selective delivery to cancer cells, paving the way for safer and more effective treatments. Experimental techniques and analytical methodologies are crucial for the characterization and development of novel therapies utilizing Pt-based DTDSs.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Jialin Chen, Wujun Wang, Yue Wang, Xiushuang Yuan, Chengzhi He, Pengfei Pei, Shengdi Su, Weihong Zhao, Shi-Zhong Luo, Long Chen
Summary: Water insolubility is a significant challenge for many small molecule drugs in clinical applications. Two branched amphiphilic peptides (BAPs) were designed using computer-aided methods for drug-loading through peptide self-assembly. The BAPs could self-assemble into nano-fibrils or bilayer delimited nano-vesicles, and showed high drug-loading efficiency and entrapment efficiency. The carriers could prolong drug release and exhibit pH-triggered release. Moreover, they demonstrated increased cytotoxicity against cancer cells, possibly due to their targeting ability towards cancer overexpressed integrins. The designed BAP carriers represent a promising approach for targeted drug delivery and can improve the clinical use of small molecule drugs with poor water solubility.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Eman Elhassan, Nikita Devnarain, Mahir Mohammed, Thirumala Govender, Calvin A. Omolo
Summary: Hybrid nanoparticles are considered superior alternatives for delivering antibiotics and targeting infections, resulting in eradication of bacterial infections and overcoming antimicrobial resistance. This review provides an up-to-date overview of various types of hybrid nanoparticles and their design approaches, nanomaterial construction, drug release mechanisms, and enhanced antibacterial efficacy. Future strategies to improve hybrid nanosystems for treating bacterial infections and overcoming antibiotic resistance are also highlighted.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Engineering, Biomedical
Chong Zhang, Fen Zeng, Zhengyang Fan, Zhen He, Liang Tai, Qiang Peng, Yixin Zhang, Zhenhua Chao, Wenning Jiang, Lingyun Jia, Lulu Han
Summary: Inflammatory bowel disease (IBD) is a global public health challenge. Current medical treatments are not fully effective and may cause side effects. Researchers have developed a nanoparticle-based treatment strategy for IBD, which can target inflamed colon tissues and reduce systemic exposure of the drug. The nanoparticles also possess reactive oxygen species (ROS)-scavenging ability, which can alleviate inflammation and improve IBD symptoms.
ACTA BIOMATERIALIA
(2023)
Article
Chemistry, Physical
Ke Yan, Yecheng Feng, Ke Gao, Xiaojing Shi, Xubo Zhao
Summary: A novel drug delivery system based on hyaluronic acid-tetraphenyl ethylene conjugate (HA-SS-TPE) with glutathione (GSH) responsiveness is designed for targeted drug delivery, showing potential therapeutic effects on CD44-overexpressing cancer cells in in vivo studies.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Pharmacology & Pharmacy
Prashant Kesharwani, Rahul Chadar, Afsana Sheikh, Waleed Y. Rizg, Awaji Y. Safhi
Summary: Cluster of differentiation 44 (CD44) is a cell surface glycoprotein overexpressed in various solid tumors. It plays a significant role in cell proliferation, cell-to-cell interaction, cellular migration, inflammation, and immune responses. Nanocarriers have been developed to target the CD44 receptor and improve the efficacy of chemotherapy. Hyaluronic acid (HA) also plays a crucial role in cancer therapy and interacts with CD44, providing a potential approach for targeted therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Environmental
Xin Li, Sha Fang, Yang Yu, Hongyu Yang, Yuefeng Rao, Dongsheng Hong, Chao Lu, Mengli Yu, Xiaoyang Lu, Chaohui Yu, Qingwei Zhao
Summary: In this study, an inflammatory microenvironment-responsive nanocomplex was developed for oral administration of Infliximab for inflammatory bowel disease (IBD) treatment. The nanocomplex showed high drug loading, inflammation targeting, and bioresponsive controlled release, and exhibited great efficacy in reducing intestinal inflammation and systemic exposure.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biophysics
Sareh Aghajanpour, Mehdi Esfandyari-Manesh, Tahmineh Ghahri, Mohammad Hossein Ghahremani, Fatemeh Atyabi, Mostafa Heydari, Hamidreza Motasadizadeh, Rassoul Dinarvand
Summary: This study developed a 3D bio-printed osteogenic scaffold using alginate hydrogel, human bone marrow-derived mesenchymal stem cells (hBM-MSCs), calcium peroxide nanoparticles (CPO NPs) for oxygen generation, and bone morphogenic protein-2 nanoparticles (BMP2 NPs) as an osteoinductive growth factor. The scaffold with 3% CPO NPs showed improved viability of embedded hBM-MSCs and upregulated osteogenic gene expression. This research contributes to the advancement of stem cell therapy and tissue healing in low oxygen pressure conditions.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Pharmacology & Pharmacy
Solmaz Mojarad-Jabali, Somayeh Mahdinloo, Masoud Farshbaf, Muhammad Sarfraz, Yousef Fatahi, Fatemeh Atyabi, Hadi Valizadeh
Summary: TfR serves as a valuable target for cancer therapy, with potential for TfR-targeted liposomes as promising drug delivery vehicles. Despite the attention gained, the full assessment of TfR ligands applied for liposomal targeted delivery still needs to be accomplished.
EXPERT OPINION ON DRUG DELIVERY
(2022)
Article
Biochemistry & Molecular Biology
Armina Shirangi, Fatemeh Mottaghitalab, Sajad Dinarvand, Fatemeh Atyabi
Summary: A nanoparticle system for targeted delivery of ROR1 siRNA in the treatment of triple-negative breast cancer was designed and tested. The nanoparticles showed good properties and effectively suppressed tumor cell growth both in vitro and in vivo. The accumulation of nanoparticles in breast tumors was increased by magnetic field guidance. This therapeutic strategy has potential in the treatment of triple-negative breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Correction
Pharmacology & Pharmacy
Hosniyeh Hosseinzadeh, Fatemeh Atyabi, Behrang Shiri Varnamkhasti, Reza Hosseinzadeh, Seyed Nasser Ostad, Mohammad Hossein Ghahremani, Rassoul Dinarvand
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Summary: Infectious diseases pose serious threats to global health and socio-economic conditions. Vaccination is crucial for disease prevention, but challenges such as inadequate efficiency and immunogenicity exist. Advanced vaccine delivery systems, with suitable efficiency, safety, and immune-modulatory activity, could be helpful, but their capabilities to cover various types of pathogens have not been systematically reviewed. The rise of antibiotic-resistant strains and limitations in antibiotic testing have increased the need for more accurate and specific treatment strategies, including nanotechnology-based ones. Nanobionics, based on charge storage and transport in molecular structures, could play a key role in molecular diagnostics and highly-specific electro-analytical methods or devices. Early disease diagnostics using such devices could be critically significant against various diseases.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Abbas Ali Hosseinpour Feizi, Sajjad Vakili-Samiani, Vahid Karpisheh, Ali Masjedi, Sepideh Izadi, Sara Adibfar, Afshin Nikkhoo, Mohammad Hojjat-Farsangi, Fatemeh Atyabi, Omid Joodi Khanghah, Ali Akbar Movassaghpour, Saeed Solali, Mehdi Yousefi, Farhad Jadidi-Niaragh
Summary: This study used TAT-PEG-CCMD nanoparticles to deliver anti-WEE1 siRNA and Dox to ALL cells, which effectively inhibited WEE1 kinase overexpression and enhanced the apoptotic effects of Dox. These findings suggest that this combination therapy could be a promising approach for treating ALL.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Seyed Yaser Vafaei, Amir Hossein Abdolghaffari, Reza Mahjub, Seyyed Majid Eslami, Motahareh Esmaeili, Mohammad Abdollahi, Fatemeh Atyabi, Rassoul Dinarvand
Summary: This study investigated the therapeutic potential of budesonide-loaded hyaluronic acid nanoparticles (BDS-HANPs) for inflammatory bowel disease (IBD). The results showed that BDS-HANPs significantly improved the symptoms of colitis and had a better therapeutic effect than the same dose of the free drug.
BIOMED RESEARCH INTERNATIONAL
(2022)
Review
Chemistry, Multidisciplinary
Parichehr Hassanzadeh, Fatemeh Atyabi, Rassoul Dinarvand
Summary: The emerging pathological conditions and growing drug resistance call for the application of advanced technologies to discover therapeutic candidates and gain comprehensive understanding about their targets, action mechanisms, and interactions within the body. Physics- and chemistry-based techniques can be used for theranostic purposes, including preparing smart carriers, local drug or gene delivery, and enhancing pharmaceutical bioavailability. Crystal engineering and other techniques such as artificial intelligence and quantum-based methods can play a crucial role in manufacturing efficient pharmaceuticals and reducing adverse events.
JOURNAL OF CONTROLLED RELEASE
(2023)
Correction
Pharmacology & Pharmacy
Farhad Alvandifar, Baharnaz Ghaffari, Navid Goodarzi, Nazanin Shabani Ravari, Fahimeh Karami, Mohsen Amini, Effat Souri, Mohammad Reza Khoshayand, Mehdi Esfandyari-Manesh, Razieh Mohammad Jafari, Fatemeh Atyabi, Shiva Irani, Rassoul Dinarvand
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Retraction
Chemistry, Multidisciplinary
Armin Mahmoud Salehi, Farnaz Kheshti, Farnaz Hajizadeh, Asal Barshidi, Bentolhoda Rashidi, Farbod Ebrahimi, Simin Bahmanpour, Vahid Karpisheh, Fatemeh Karimian Noukabadi, Fariba Karoon Kiani, Hadi Hassannia, Fatemeh Atyabi, Seyed Hossein Kiaie, Fatah Kashanchi, Jamshid Gholizadeh Navashenaq, Hamed Mohammadi, Rafieh Bagherifar, Reza Jafari, Naime Majidi Zolbanin, Farhad Jadidi-Niaragh
PHARMACEUTICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Soha Habibi, Toraj Mohammadi, Romina HMTShirazi, Fatemeh Atyabi, Melika Kiani, Amir Atabak Asadi
Summary: In this study, double-layer CS/PVA/mupirocin (CPM) + CS/PVA/bupivacaine (CPB) electrospun nanofiber mats were prepared and crosslinked to optimize their water-resistant and biodegradation properties. The mats exhibited defect-free and interconnected nanofibers, providing a moist environment for efficient wound breathing and repairing. The highly porous mat absorbed wound exudates and allowed air permeability, reducing the chance of bacterial infections.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pharmacology & Pharmacy
Seyed Reza Heydari, Mahnoush Samadi, Armina Shirangi, Mehdi Farokhi, Ayda Moradi, Reza Bafkary, Fatemeh Atyabi, Fatemeh Mottaghitalab, Rassoul Dinarvand
Summary: In this study, dual responsive mesoporous silica nanoparticles (MSNs) were designed to effectively deliver PB to osteosarcoma cancer cells. PB loaded MSNs showed higher drug release in the tumor microenvironment and enhanced cytotoxicity against cancer cells. This study provides a promising method for osteosarcoma treatment using PB loaded MSNs.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nazanin Shabani Ravari, Maryam Ghareh Sheikhlou, Navid Goodarzi, Bahar Kharazian, Mohsen Amini, Fatemeh Atyabi, Saman A. A. Nasrollahi, Rassoul Dinarvand
Summary: Researchers used CPP as a carrier to create CPP-BoNT/A nanocomplexes by PEC method, aiming to increase toxin entrapment, reduce diffusion, and prolong the effect. The nanocomplexes showed higher cellular toxicity than the toxin and had a slower onset and longer duration of action on muscles.
DARU-JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sepideh Nezhadi, Parisa Norouzi, Azadeh Rasouli, Hamid Akbari Javar, Seyed Nasser Ostad, Farid Dorkoosh
Summary: This study aims to design a co-delivery system to suppress the growth and migration of triple negative breast cancer (TNBC) cells. The co-loaded mixed micelles of paclitaxel (PTX) and regorafenib (REG) showed promising potential in inhibiting proliferation and migration of TNBC cells and enhancing the therapeutic efficacy of PTX.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Ophthalmology
Elham Delrish, Mahmoud Jabbarvand, Fariba Ghassemi, Fahimeh Asadi Amoli, Fatemeh Atyabi, Saeed Heidari Keshel, Alireza Lashay, Farnaz Sadat Mirzazadeh Tekie, Masoud Soleimani, Rassoul Dinarvand
Summary: This study aimed to evaluate the efficacy of thiolated chitosan-dextran nanoparticles (TPH-CMD-TCS-NPs) in improving intravitreal chemotherapy of retinoblastoma in a rabbit xenograft model. The results showed that the NPs had a mean diameter of 30 +/- 4 nm, a polydispersity index of 0.24 +/- 0.03, and a zeta potential of +10 +/- 3 mV. The TPH-CMD-TCS-NPs group showed a significant decrease in tumor volume compared to the control group (P = 0.039).
JOURNAL OF OPHTHALMIC & VISION RESEARCH
(2023)
Review
Chemistry, Applied
Xingran Kou, Dongdong Su, Fei Pan, Xiwei Xu, Qingran Meng, Qinfei Ke
Summary: This review provides a systematic discussion of the application of molecular dynamics (MD) simulations in aroma compounds (ACs)/cyclodextrins (CDs) inclusion complexes (ICs). It covers the establishment of the simulation process, parameter selection, model evaluation, and various application cases, summarizing the major achievements and challenges of this method.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Haoyu Yu, Quanbin Zhang, Ammad Ahmad Farooqi, Jing Wang, Yang Yue, Lihua Geng, Ning Wu
Summary: Brown algae are rich in fucoidan, which has been found to have anti-cancer and anti-metastasis effects. Fucoidan inhibits tumor cell growth, proliferation, and metastasis, and also promotes immune responses in the tumor microenvironment.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Liang Dong, Yanan Li, Hailin Cong, Bing Yu, Youqing Shen
Summary: Gene therapy is a revolutionary treatment that requires suitable vectors for protecting and releasing exogenous nucleic acids in target cells. Chitosan, as a non-viral vector, has gained attention due to its good biocompatibility and ability to load large amounts of nucleic acids. This paper summarizes the potential of chitosan and its derivatives as gene delivery vector materials, discusses factors influencing transfection efficiency, performance evaluation, ways to optimize infectious efficiency, and current research development directions. It also provides an outlook on the future prospects of chitosan.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ana Iglesias-Mejuto, Beatriz Magarinos, Tania Ferreira-Goncalves, Ricardo Starbird-Perez, Carmen Alvarez-Lorenzo, Catarina Pinto Reis, Ines Ardao, Carlos A. Garcia-Gonzalez
Summary: This study developed a novel processing strategy to manufacture drug-loaded and personalized aerogels with nanostructures. The aerogels demonstrated bioactivity and antimicrobial effects, promoting bone regeneration and preventing infections in bone tissue engineering.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Zhenxu Shi, Dimei Yang, Yan Zhou, Xinyu Chen, Lin Gan, Jin Huang
Summary: This study proposes a micro-assembly method to improve the photoluminescent properties of crystalline cellulose nanocrystals (CNCs) by organizing them within a sub-micrometer-sized metal-organic framework and coating with TiO2. The TiO2 coating prevents CNC assembly breakdown and allows information to be revealed using screenprinted labels for anti-counterfeiting purposes.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Xuejiao Liu, Bin Fu, Jierong Chen, Zhenyu Sun, Dongdong Zheng, Zhonghua Li, Bing Gu, Ying Zhang, Haojie Lu
Summary: Liver disease is a major cause of global mortality, and identifying biomarkers for diagnosing its progression is crucial for improving outcomes. Targeted mass spectrometry is a powerful tool for verifying biomarker candidates and clinical applications, particularly for glycoproteins translation. However, the limitation of analyzing only one sample per run has become apparent. In this study, a high-throughput intact N-glycopeptides quantification strategy was developed, allowing the validation of 20 samples per run with an average analysis time of 3 minutes per sample. The strategy was applied in a cohort of 461 serum samples and identified a panel of 10 IgG N-glycopeptides that have strong clinical utility in evaluating the severity of liver disease.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Qian Wang, Hao Jiang, Hongli Zhang, Weiqiao Lu, Xiao Wang, Wenfeng Xu, Jia Li, Youjing Lv, Guoyun Li, Chao Cai, Guangli Yu
Summary: This study proposes a novel strategy of antibody-beta-glucan conjugates (AGC) to enhance the antitumor immune response to immune checkpoint blockade (ICB) therapy. AGC demonstrated powerful tumor suppression and promoted interaction between tumor cells and dendritic cells (DCs), thereby enhancing immunotherapeutic benefits.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Chaeyeon Lee, Sojeong Lee, Sang Wook Kang
Summary: The study aims to enhance the properties of porous membranes by addressing the limitations associated with phase separation. By using cellulose acetate and citric acid, the researchers were able to fabricate membranes with improved mechanical strength and thermal stability. The cross-linking effect of citric acid resulted in a more uniform pore structure and higher porosity.
CARBOHYDRATE POLYMERS
(2024)
Review
Chemistry, Applied
Tejaswini Kolipaka, Giriraj Pandey, Noella Abraham, Dadi A. Srinivasarao, Rajeev Singh Raghuvanshi, P. S. Rajinikanth, Vidya Tickoo, Saurabh Srivastava
Summary: This review focuses on the design and application of polysaccharide-based hydrogel wound dressings, highlighting aspects such as biocompatibility, biodegradability, drug entrapment, moisturizing ability, swelling, and mechanical properties. Additionally, various crosslinking methods and recent developments in stimuli-responsive hydrogels are discussed.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Anqi Xu, Nan Zhang, Shixing Su, Hongyu Shi, Daoqiang Lu, Xifeng Li, Xin Zhang, Xin Feng, Zhuohua Wen, Gengwu Ma, Mengshi Huang, Chi Huang, Yuqi Hu, Hao Yuan, Qinwen Liu, Daogang Guan, Jun Wang, Chuanzhi Duan
Summary: The study presents a one-pot radical polymerization method to fabricate a hydrogel with adhesive properties, which can effectively treat bacterial-infected diabetic wounds and accelerate wound healing.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Montarop Yamabhai, Munthipha Khamphio, Thae Thae Min, Chai Noy Soem, Nguyen Cao Cuong, Waheni Rizki Aprilia, Krisanai Luesukprasert, Karsidete Teeranitayatarn, Atthaphon Maneedaeng, Tina R. Tuveng, Silje B. Lorentzen, Simen Antonsen, Paiboon Jitprasertwong, Vincent G. H. Eijsink
Summary: The study investigates the bioconversion of chitosan into soluble anti-inflammatory chitosan oligosaccharides (CHOS) using an enzyme. The results show that the generated CHOS have anti-inflammatory activity, but the magnitude of the activity depends on the substrate and production process. Different methods of dissolving chitosan also affect the properties of CHOS. The study highlights the importance of quality assurance in CHOS preparations.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Wen Cao, Jiangping Wu, Xinya Zhao, Zixu Li, Jie Yu, Taili Shao, Xuefeng Hou, Lutan Zhou, Chunfei Wang, Guodong Wang, Jun Han
Summary: In this study, a water-soluble polysaccharide (PLP1) was successfully isolated and purified from Pueraria lobata. It was found that PLP1 was composed of specific glycosidic units and exhibited a better free radical-scavenging ability. Moreover, PLP1 effectively protected the liver against acute alcoholic liver disease (ALD) in mice.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ya Su, Yaqian Liu, Xueyan Hu, Yueqi Lu, Jinyuan Zhang, Wenbo Jin, Wang Liu, Yan Shu, Yuen Yee Cheng, Wenfang Li, Yi Nie, Bo Pan, Kedong Song
Summary: A 3D printed scaffold based on carbon dots-curcumin nano-drug release has been developed for drug delivery after breast cancer surgery. The scaffold showed effective inhibition of tumor growth, antibacterial activity, and promotion of wound healing, making it a promising approach for preventing tumor recurrence.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Ekaterina Sokolova, Diane Jouanneau, Antonin Chevenier, Murielle Jam, Nathalie Desban, Pierre Colas, Elizabeth Ficko-Blean, Gurvan Michel
Summary: Carrageenans, a compound synthesized in red algae, have various biological properties and are valuable in the pharmaceutical and cosmetic industries. Their fine structure affects wound healing, oxidative processes, hemostasis, and inflammation. Enzymatic modification of carrageenans produces oligosaccharides that bind to natural human serum antibodies and specific antibodies, showing potential for therapeutic applications.
CARBOHYDRATE POLYMERS
(2024)
Article
Chemistry, Applied
Yan Shi, Miao Yu, Kaijin Qiu, Tiantian Kong, Chunjing Guo, Wenxue Zhang, Daquan Chen, Ming Kong
Summary: In this study, functionalized transfersomes were developed to co-deliver doxorubicin and 1MT towards primary tumors and tumor draining lymph nodes via transdermal administration using microneedles. The results showed that the nano-complexed microneedles exhibited a stronger suppression in tumor growth compared to the intravenous group.
CARBOHYDRATE POLYMERS
(2024)