Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

Exosomes and Cell Communication: From Tumour-Derived Exosomes and Their Role in Tumour Progression to the Use of Exosomal Cargo for Cancer Treatment

(2021) Andrea Nicolini et al.   Cancers

Exosomes and cancer: from molecular mechanisms to clinical applications

(2021) Ameneh Jafari et al.   MEDICAL ONCOLOGY

Stem Cell-Derived Exosomes: a New Strategy of Neurodegenerative Disease Treatment

(2021) Nashmin Fayazi et al.   MOLECULAR NEUROBIOLOGY

A call for the standardised reporting of factors affecting the exogenous loading of extracellular vesicles with therapeutic cargos

(2021) Stephanie Rankin-Turner et al.   ADVANCED DRUG DELIVERY REVIEWS

Magnetic Resonance Lymphangiography of the Central Lymphatic System: Technique and Clinical Applications

(2020) Waleska M. Pabon‐Ramos et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

The biology, function, and biomedical applications of exosomes

(2020) Raghu Kalluri et al.   SCIENCE

Extracellular vesicles as drug delivery systems: Why and how?

(2020) Omnia M. Elsharkasy et al.   ADVANCED DRUG DELIVERY REVIEWS

In vivo Imaging Technologies to Monitor the Immune System

(2020) Claire E. McCarthy et al.   Frontiers in Immunology

Anti-CTLA-4 Antibody-Functionalized Dendritic Cell-derived Exosomes Targeting Tumor-draining Lymph Nodes for Effective Induction of Antitumor T-cell Responses

(2020) Cao Dai Phung et al.   Acta Biomaterialia

Lymphatic vessels in tumor dissemination vs. immunotherapy

(2020) Kari Vaahtomeri et al.   CANCER RESEARCH

Targeting immune cells within lymph nodes

(2020) Christopher J. H. Porter et al.   Nature Nanotechnology

Sentinel Node Imaging and Radioguided Surgery in the Era of SPECT/CT and PET/CT

(2020) Renato Alfredo Valdés Olmos et al.   CLINICAL NUCLEAR MEDICINE

Identification of Lymphatic and Hematogenous Routes of Rapidly Labeled Radioactive and Fluorescent Exosomes through Highly Sensitive Multimodal Imaging

(2020) Kyung Oh Jung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Development and aging of the lymphatic vascular system

(2020) Alejandra González-Loyola et al.   ADVANCED DRUG DELIVERY REVIEWS

Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications

(2019) Seyed Mohammadali Dadfar et al.   ADVANCED DRUG DELIVERY REVIEWS

Employment of enhanced permeability and retention effect (EPR): Nanoparticle-based precision tools for targeting of therapeutic and diagnostic agent in cancer

(2019) Dnyaneshwar Kalyane et al.   Materials Science & Engineering C-Materials for Biological Applications

Colorectal cancer exosomes induce lymphatic network remodeling in lymph nodes

(2019) Bo Sun et al.   INTERNATIONAL JOURNAL OF CANCER

Tumor-associated factors are enriched in lymphatic exudate compared to plasma in metastatic melanoma patients

(2019) Maria A.S. Broggi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Material design for lymph node drug delivery

(2019) Alex Schudel et al.   Nature Reviews Materials

Lymphangiogenesis in kidney and lymph node mediates renal inflammation and fibrosis

(2019) Guangchang Pei et al.   Science Advances

Back to the Future

(2019) Claus Christian Pieper et al.   INVESTIGATIVE RADIOLOGY

Nanoparticle Size Influences Antigen Retention and Presentation in Lymph Node Follicles for Humoral Immunity

(2019) Yi-Nan Zhang et al.   NANO LETTERS

Smart cancer nanomedicine

(2019) Roy van der Meel et al.   Nature Nanotechnology

Engineered Extracellular Vesicles as a Reliable Tool in Cancer Nanomedicine

(2019) Francesca Susa et al.   Cancers

Multiple roles of lymphatic vessels in tumor progression

(2018) Qiaoli Ma et al.   CURRENT OPINION IN IMMUNOLOGY

Indocyanine green nanoparticles undergo selective lymphatic uptake, distribution and retention and enable detailed mapping of lymph vessels, nodes and abnormalities

(2018) John C. Kraft et al.   JOURNAL OF DRUG TARGETING

Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation

(2018) Haiying Zhang et al.   NATURE CELL BIOLOGY

Exosomal PD-L1 contributes to immunosuppression and is associated with anti-PD-1 response

(2018) Gang Chen et al.   NATURE

IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin

(2018) Ryan S. Lane et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Efficient Delivery of Tyrosinase Related Protein‐2 (TRP2) Peptides to Lymph Nodes using Serum‐Derived Exosomes

(2018) Ok Park et al.   MACROMOLECULAR BIOSCIENCE

Specificities of secretion and uptake of exosomes and other extracellular vesicles for cell-to-cell communication

(2018) Mathilde Mathieu et al.   NATURE CELL BIOLOGY

Mechanisms of Tumor-Induced Lymphovascular Niche Formation in Draining Lymph Nodes

(2018) Catharina D. Commerford et al.   Cell Reports

Recent developments in penile cancer imaging

(2018) Hielke M. de Vries et al.   CURRENT OPINION IN UROLOGY

Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer

(2017) Sushrut Kamerkar et al.   NATURE

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

(2017) David Olmeda et al.   NATURE

Ultra-small superparamagnetic iron oxides for metastatic lymph node detection: back on the block

(2017) Ansje S. Fortuin et al.   Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology

Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy

(2017) Guizhi Zhu et al.   Nature Communications

Tumor-Associated Lymphatic Vessels Upregulate PDL1 to Inhibit T-Cell Activation

(2017) Lothar C. Dieterich et al.   Frontiers in Immunology

Development and Characterization of A Novel Prox1-EGFP Lymphatic and Schlemm’s Canal Reporter Rat

(2017) Eunson Jung et al.   Scientific Reports

Vegfr3-CreER T2 mouse, a new genetic tool for targeting the lymphatic system

(2016) Ines Martinez-Corral et al.   ANGIOGENESIS

Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

(2016) Annette Becker et al.   CANCER CELL

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

SPECT/CT in Melanoma Lymphoscintigraphy

(2016) Khimling Tew et al.   CLINICAL NUCLEAR MEDICINE

Genetically engineered mouse models in oncology research and cancer medicine

(2016) Kelly Kersten et al.   EMBO Molecular Medicine

Lymphatic vessels regulate immune microenvironments in human and murine melanoma

(2016) Amanda W. Lund et al.   JOURNAL OF CLINICAL INVESTIGATION

Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

(2016) Myung Soo Kim et al.   Nanomedicine-Nanotechnology Biology and Medicine

The role of fatty acid β-oxidation in lymphangiogenesis

(2016) Brian W. Wong et al.   NATURE

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

(2016) F. Pucci et al.   SCIENCE

Exosome-Mediated Metastasis: From Epithelial–Mesenchymal Transition to Escape from Immunosurveillance

(2016) Nicholas Syn et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation

(2016) Riikka Kivelä et al.   Nature Communications

Efficient Assessment of Developmental, Surgical and Pathological Lymphangiogenesis Using a Lymphatic Reporter Mouse and Its Embryonic Stem Cells

(2016) Mingu Hong et al.   PLoS One

Intravital Imaging Reveals Dynamics of Lymphangiogenesis and Valvulogenesis

(2016) Gyeong Jin Kang et al.   Scientific Reports

Lymphatic transport of exosomes as a rapid route of information dissemination to the lymph node

(2016) Swetha Srinivasan et al.   Scientific Reports

Diagnostic Accuracy of Fluorescence Microlymphography for Detecting Limb Lymphedema

(2015) H.H. Keo et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

The lymph node pre-metastatic niche

(2015) Jonathan P. Sleeman   JOURNAL OF MOLECULAR MEDICINE-JMM

USPIO-Enhanced MRI Neuroimaging: A Review

(2015) Maria Gkagkanasiou et al.   JOURNAL OF NEUROIMAGING

Lymphatic endothelial lineage assemblage during corneal lymphangiogenesis

(2015) Alicia L Connor et al.   LABORATORY INVESTIGATION

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver

(2015) Bruno Costa-Silva et al.   NATURE CELL BIOLOGY

Lymphatic system: An active pathway for immune protection

(2015) Shan Liao et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Transgenic Prox1-Cre-tdTomato Reporter Mouse for Lymphatic Vessel Research

(2015) Roberta Bianchi et al.   PLoS One

Magnetic Field-Induced T Cell Receptor Clustering by Nanoparticles Enhances T Cell Activation and Stimulates Antitumor Activity

(2014) Karlo Perica et al.   ACS Nano

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Light In and Sound Out: Emerging Translational Strategies for Photoacoustic Imaging

(2014) S. Zackrisson et al.   CANCER RESEARCH

Photoacoustic lymphatic imaging with high spatial-temporal resolution

(2014) Catherine Martel et al.   JOURNAL OF BIOMEDICAL OPTICS

Emerging lymphatic imaging technologies for mouse and man

(2014) Eva M. Sevick-Muraca et al.   JOURNAL OF CLINICAL INVESTIGATION

Mechanisms of lymphatic metastasis

(2014) Sinem Karaman et al.   JOURNAL OF CLINICAL INVESTIGATION

Magnetic resonance imaging of melanoma exosomes in lymph nodes

(2014) Lingzhi Hu et al.   MAGNETIC RESONANCE IN MEDICINE

Structure-based programming of lymph-node targeting in molecular vaccines

(2014) Haipeng Liu et al.   NATURE

In vivo albumin labeling and lymphatic imaging

(2014) Yu Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Non-invasive mapping of deep-tissue lymph nodes in live animals using a multimodal PET/MRI nanoparticle

(2014) Daniel L. J. Thorek et al.   Nature Communications

Enhancing Efficacy of Anticancer Vaccines by Targeted Delivery to Tumor-Draining Lymph Nodes

(2014) L. Jeanbart et al.   Cancer Immunology Research

Use of a PEG-conjugated bright near-infrared dye for functional imaging of rerouting of tumor lymphatic drainage after sentinel lymph node metastasis

(2013) Steven T. Proulx et al.   BIOMATERIALS

Targeting the tumor-draining lymph node with adjuvanted nanoparticles reshapes the anti-tumor immune response

(2013) Susan N. Thomas et al.   BIOMATERIALS

A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy

(2013) Yanhua Tian et al.   BIOMATERIALS

Expansion of the lymphatic vasculature in cancer and inflammation: New opportunities for in vivo imaging and drug delivery

(2013) Steven T. Proulx et al.   JOURNAL OF CONTROLLED RELEASE

Mouse models for studying angiogenesis and lymphangiogenesis in cancer

(2013) Lauri Eklund et al.   Molecular Oncology

Nanoscale artificial antigen presenting cells for T cell immunotherapy

(2013) Karlo Perica et al.   Nanomedicine-Nanotechnology Biology and Medicine

ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets

(2012) Lucy A. Truman et al.   AMERICAN JOURNAL OF PATHOLOGY

Long-term multimodal imaging of tumor draining sentinel lymph nodes using mesoporous silica-based nanoprobes

(2012) Xinglu Huang et al.   BIOMATERIALS

Lymphatic endothelial cells induce tolerance via PD-L1 and lack of costimulation leading to high-level PD-1 expression on CD8 T cells

(2012) E. F. Tewalt et al.   BLOOD

Lymph node-derived lymphatic endothelial cells express functional costimulatory molecules and impair dendritic cell-induced allogenic T-cell proliferation

(2012) Miriam Nörder et al.   FASEB JOURNAL

Systemically Injected Exosomes Targeted to EGFR Deliver Antitumor MicroRNA to Breast Cancer Cells

(2012) Shin-ichiro Ohno et al.   MOLECULAR THERAPY

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

(2012) Héctor Peinado et al.   NATURE MEDICINE

In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis

(2012) I. Martinez-Corral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF-C Promotes Immune Tolerance in B16 Melanomas and Cross-Presentation of Tumor Antigen by Lymph Node Lymphatics

(2012) Amanda W. Lund et al.   Cell Reports

Intravital two-photon microscopy of lymphatic vessel development and function using a transgenicProx1promoter-directed mOrange2 reporter mouse

(2011) René Hägerling et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Current trends and emerging future of indocyanine green usage in surgery and oncology

(2011) Karol Polom et al.   CANCER

Exosomes Released by Melanoma Cells Prepare Sentinel Lymph Nodes for Tumor Metastasis

(2011) J. L. Hood et al.   CANCER RESEARCH

Vascular endothelial growth factor receptor 3 directly regulates murine neurogenesis

(2011) C.-F. Calvo et al.   GENES & DEVELOPMENT

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulated release of nitric oxide by nonhematopoietic stroma controls expansion of the activated T cell pool in lymph nodes

(2011) Veronika Lukacs-Kornek et al.   NATURE IMMUNOLOGY

A multifunctional core–shell nanoparticle for dendritic cell-based cancer immunotherapy

(2011) Nam-Hyuk Cho et al.   Nature Nanotechnology

Interaction of tumor cells and lymphatic vessels in cancer progression

(2011) A Alitalo et al.   ONCOGENE

Impaired lymphatic contraction associated with immunosuppression

(2011) S. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Near infrared photoacoustic detection of sentinel lymph nodes with gold nanobeacons

(2010) Dipanjan Pan et al.   BIOMATERIALS

An exquisite cross-control mechanism among endothelial cell fate regulators directs the plasticity and heterogeneity of lymphatic endothelial cells

(2010) J. Kang et al.   BLOOD

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

In vivo Imaging of Inflammation- and Tumor-Induced Lymph Node Lymphangiogenesis by Immuno-Positron Emission Tomography

(2010) V. Mumprecht et al.   CANCER RESEARCH

Quantitative Imaging of Lymphatic Function with Liposomal Indocyanine Green

(2010) S. T. Proulx et al.   CANCER RESEARCH

The nuclear hormone receptor Coup-TFII is required for the initiation and early maintenance of Prox1 expression in lymphatic endothelial cells

(2010) R. S. Srinivasan et al.   GENES & DEVELOPMENT

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inflamed Lymphatic Endothelium Suppresses Dendritic Cell Maturation and Function via Mac-1/ICAM-1-Dependent Mechanism

(2009) S. Podgrabinska et al.   JOURNAL OF IMMUNOLOGY

Long-term Persistence and Spectral Blue Shifting of Quantum Dots in Vivo

(2009) James A. J. Fitzpatrick et al.   NANO LETTERS

BrafV600E cooperates with Pten loss to induce metastatic melanoma

(2009) David Dankort et al.   NATURE GENETICS

Myeloid Cells Contribute to Tumor Lymphangiogenesis

(2009) Adrian Zumsteg et al.   PLoS One

Nanoparticle-Delivered Multimeric Soluble CD40L DNA Combined with Toll-Like Receptor Agonists as a Treatment for Melanoma

(2009) Geoffrey W. Stone et al.   PLoS One

Vascular Endothelial Growth Factor-C and C-C Chemokine Receptor 7 in Tumor Cell-Lymphatic Cross-talk Promote Invasive Phenotype

(2008) A. Issa et al.   CANCER RESEARCH

Expression of the hyaluronan receptor LYVE-1 is not restricted to the lymphatic vasculature; LYVE-1 is also expressed on embryonic blood vessels

(2008) Emma J. Gordon et al.   DEVELOPMENTAL DYNAMICS

Noninvasive photoacoustic identification of sentinel lymph nodes containing methylene blue in vivo in a rat model

(2008) Kwang Hyun Song et al.   JOURNAL OF BIOMEDICAL OPTICS

Tumor lymphangiogenesis and melanoma metastasis

(2008) Matthias Rinderknecht et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Imaging of Lymph Flow in Breast Cancer Patients after Microdose Administration of a Near-Infrared Fluorophore: Feasibility Study

(2008) Eva M. Sevick-Muraca et al.   RADIOLOGY

Magnetic lymphatic targeting drug delivery system using carbon nanotubes

(2007) Feng Yang et al.   MEDICAL HYPOTHESES