Mouse models for studying angiogenesis and lymphangiogenesis in cancer

Knockout mice created by TALEN-mediated gene targeting

(2013) Young Hoon Sung et al.   NATURE BIOTECHNOLOGY

The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling Pathway

(2013) G. Thurston et al.   Cold Spring Harbor Perspectives in Medicine

ProxTom Lymphatic Vessel Reporter Mice Reveal Prox1 Expression in the Adrenal Medulla, Megakaryocytes, and Platelets

(2012) Lucy A. Truman et al.   AMERICAN JOURNAL OF PATHOLOGY

Matrix metalloproteinase-2 governs lymphatic vessel formation as an interstitial collagenase

(2012) B. Detry et al.   BLOOD

Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth

(2012) M. A. Abengozar et al.   BLOOD

VEGF-A recruits a proangiogenic MMP-9-delivering neutrophil subset that induces angiogenesis in transplanted hypoxic tissue

(2012) G. Christoffersson et al.   BLOOD

VEGF-D Promotes Tumor Metastasis by Regulating Prostaglandins Produced by the Collecting Lymphatic Endothelium

(2012) Tara Karnezis et al.   CANCER CELL

Anti-angiogenesis therapy in cancer: Current challenges and future perspectives

(2012) Farbod Shojaei   CANCER LETTERS

Genetic Ablation of SOX18 Function Suppresses Tumor Lymphangiogenesis and Metastasis of Melanoma in Mice

(2012) T. Duong et al.   CANCER RESEARCH

Genetically Engineered Mouse Models: Closing the Gap between Preclinical Data and Trial Outcomes

(2012) M. Singh et al.   CANCER RESEARCH

Angiopoietin-2 Functions as a Tie2 Agonist in Tumor Models, Where It Limits the Effects of VEGF Inhibition

(2012) C. Daly et al.   CANCER RESEARCH

SnapShot: Lung Cancer Models

(2012) Anna F. Farago et al.   CELL

Molecular Pathways: The Hedgehog Signaling Pathway in Cancer

(2012) R. McMillan et al.   CLINICAL CANCER RESEARCH

Using genetically engineered mouse models to validate candidate cancer genes and test new therapeutic approaches

(2012) Martine H van Miltenburg et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

What We Have Learned About Pancreatic Cancer From Mouse Models

(2012) Pedro A. Pérez–Mancera et al.   GASTROENTEROLOGY

Glioblastoma-derived Tumor Cells Induce Vasculogenic Mimicry through Flk-1 Protein Activation

(2012) Ralph Francescone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In vivo preclinical photoacoustic imaging of tumor vasculature development and therapy

(2012) Jan Laufer et al.   JOURNAL OF BIOMEDICAL OPTICS

Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice

(2012) Federica Maione et al.   JOURNAL OF CLINICAL INVESTIGATION

SIX1 induces lymphangiogenesis and metastasis via upregulation of VEGF-C in mouse models of breast cancer

(2012) Chu-An Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

(2012) Natalie Cook et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transdifferentiation of Glioblastoma Stem-Like Cells into Mural Cells Drives Vasculogenic Mimicry in Glioblastomas

(2012) S. Scully et al.   JOURNAL OF NEUROSCIENCE

Differential drug class-specific metastatic effects following treatment with a panel of angiogenesis inhibitors

(2012) Alicia S Chung et al.   JOURNAL OF PATHOLOGY

Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models

(2012) Mallika Singh et al.   JOURNAL OF PATHOLOGY

Effects of Angiopoietin-2-Blocking Antibody on Endothelial Cell–Cell Junctions and Lung Metastasis

(2012) Tanja Holopainen et al.   JNCI-Journal of the National Cancer Institute

Distinct types of tumors exhibit differential grade of inflammation and angiogenesis in mice

(2012) C.T.R. Viana et al.   MICROVASCULAR RESEARCH

Heterogeneity among RIP-Tag2 insulinomas allows vascular endothelial growth factor-A independent tumor expansion as revealed by studies in Shb mutant mice: Implications for tumor angiogenesis

(2012) Björn Åkerblom et al.   Molecular Oncology

Modeling and predicting clinical efficacy for drugs targeting the tumor milieu

(2012) Mallika Singh et al.   NATURE BIOTECHNOLOGY

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

In vivo imaging of lymphatic vessels in development, wound healing, inflammation, and tumor metastasis

(2012) I. Martinez-Corral et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photoacoustic Tomography: In Vivo Imaging from Organelles to Organs

(2012) L. V. Wang et al.   SCIENCE

Human Melanoma Metastasis in NSG Mice Correlates with Clinical Outcome in Patients

(2012) Elsa Quintana et al.   Science Translational Medicine

Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors

(2012) Barbara Sennino et al.   Cancer Discovery

Generation of Functional Blood Vessels from a Single c-kit+ Adult Vascular Endothelial Stem Cell

(2012) Shentong Fang et al.   PLOS BIOLOGY

Tumor-Recruited Neutrophils and Neutrophil TIMP-Free MMP-9 Regulate Coordinately the Levels of Tumor Angiogenesis and Efficiency of Malignant Cell Intravasation

(2011) Erin M. Bekes et al.   AMERICAN JOURNAL OF PATHOLOGY

A New Mechanism for Pillar Formation during Tumor-Induced Intussusceptive Angiogenesis: Inverse Sprouting

(2011) Sándor Paku et al.   AMERICAN JOURNAL OF PATHOLOGY

Developmental and Pathological Angiogenesis

(2011) Alicia S. Chung et al.   Annual Review of Cell and Developmental Biology

Mouse Models of Cancer

(2011) Dong-Joo Cheon et al.   Annual Review of Pathology-Mechanisms of Disease

Intravital two-photon microscopy of lymphatic vessel development and function using a transgenicProx1promoter-directed mOrange2 reporter mouse

(2011) René Hägerling et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Rapid validation of cancer genes in chimeras derived from established genetically engineered mouse models

(2011) Ivo J. Huijbers et al.   BIOESSAYS

Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence

(2011) S. S. Oladipupo et al.   BLOOD

The Notch1-Dll4 signaling pathway regulates mouse postnatal lymphatic development

(2011) K. Niessen et al.   BLOOD

Multiple Effects of Angiopoietin-2 Blockade on Tumors

(2011) Claire E. Lewis et al.   CANCER CELL

Intussusceptive microvascular growth in tumors

(2011) Domenico Ribatti et al.   CANCER LETTERS

Angiopoietin-1 and -2 Exert Antagonistic Functions in Tumor Angiogenesis, yet Both Induce Lymphangiogenesis

(2011) E. Fagiani et al.   CANCER RESEARCH

VEGF and c-Met Blockade Amplify Angiogenesis Inhibition in Pancreatic Islet Cancer

(2011) W.-K. You et al.   CANCER RESEARCH

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Shedding light on the system: studying embryonic development with light sheet microscopy

(2011) Raju Tomer et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Angiopoietin-2 drives lymphatic metastasis of pancreatic cancer

(2011) Petra Schulz et al.   FASEB JOURNAL

The use of the orthotopic model to validate antivascular therapies for cancer

(2011) Monica Loi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Bevacizumab Treatment for Solid Tumors

(2011) Daniel F. Hayes   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

In vivo label-free three-dimensional imaging of zebrafish vasculature with optical projection tomography

(2011) Andrea Bassi et al.   JOURNAL OF BIOMEDICAL OPTICS

Genes regulating lymphangiogenesis control venous valve formation and maintenance in mice

(2011) Eleni Bazigou et al.   JOURNAL OF CLINICAL INVESTIGATION

Wide-field functional imaging of blood flow and hemoglobin oxygen saturation in the rodent dorsal window chamber

(2011) Austin J. Moy et al.   MICROVASCULAR RESEARCH

Inhibition of angiogenesis and suppression of colorectal cancer metastatic to the liver using the Sleeping Beauty Transposon System

(2011) Lalitha R Belur et al.   Molecular Cancer

Soluble vascular endothelial growth factor receptor-3 suppresses lymphangiogenesis and lymphatic metastasis in bladder cancer

(2011) Hanseul Yang et al.   Molecular Cancer

Cancer: The flipside of Notch

(2011) Demetrios Kalaitzidis et al.   NATURE

Germ-layer and lineage-restricted stem/progenitors regenerate the mouse digit tip

(2011) Yuval Rinkevich et al.   NATURE

The lymphatic vasculature in disease

(2011) Kari Alitalo   NATURE MEDICINE

In vivo optical molecular imaging and analysis in mice using dorsal window chamber models applied to hypoxia, vasculature and fluorescent reporters

(2011) Gregory M Palmer et al.   Nature Protocols

Antiangiogenic therapy: impact on invasion, disease progression and metastasis

(2011) John M. L. Ebos et al.   Nature Reviews Clinical Oncology

Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases

(2011) Peter Carmeliet et al.   NATURE REVIEWS DRUG DISCOVERY

Interaction of tumor cells and lymphatic vessels in cancer progression

(2011) A Alitalo et al.   ONCOGENE

In-Vivo Visualization of Tumor Microvessel Density and Response to Anti-Angiogenic Treatment by High Resolution MRI in Mice

(2011) Roland T. Ullrich et al.   PLoS One

Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma

(2011) P. Olson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expression of a functional VEGFR-1 in tumor cells is a major determinant of anti-PlGF antibodies efficacy

(2011) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting

(2011) Sunday Oladipupo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transdifferentiation of glioblastoma cells into vascular endothelial cells

(2011) Y. Soda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Photodynamic Ablation of Lymphatic Vessels and Intralymphatic Cancer Cells Prevents Metastasis

(2011) T. Tammela et al.   Science Translational Medicine

VEGF and angiopoietin signaling in tumor angiogenesis and metastasis

(2011) Pipsa Saharinen et al.   TRENDS IN MOLECULAR MEDICINE

Vascular endothelial growth factor-A and changes in a tumor-bearing mouse model with Lewis lung cancer

(2011) MENG-SHU TSAI et al.   Oncology Letters

Integrin-Mediated Cell-Matrix Interaction in Physiological and Pathological Blood Vessel Formation

(2011) Stephan Niland et al.   Journal of Oncology

Visualization of lymphatic vessels by Prox1-promoter directed GFP reporter in a bacterial artificial chromosome-based transgenic mouse

(2010) I. Choi et al.   BLOOD

CXCR4 Signaling Regulates Metastasis of Chemoresistant Melanoma Cells by a Lymphatic Metastatic Niche

(2010) M. Kim et al.   CANCER RESEARCH

PlGF Blockade Does Not Inhibit Angiogenesis during Primary Tumor Growth

(2010) Carlos Bais et al.   CELL

Further Pharmacological and Genetic Evidence for the Efficacy of PlGF Inhibition in Cancer and Eye Disease

(2010) Sara Van de Veire et al.   CELL

Lymphangiogenesis: Molecular Mechanisms and Future Promise

(2010) Tuomas Tammela et al.   CELL

Increased angiogenesis inCdk4R24C/R24C:Apc+/Minintestinal tumors

(2010) Zahidur R. Abedin et al.   CELL CYCLE

Glioblastoma cells incorporate into tumor vasculature and contribute to vascular radioresistance

(2010) Candice A. Shaifer et al.   INTERNATIONAL JOURNAL OF CANCER

Three-dimensional optical imaging of microvascular networks within intact lymph node in vivo

(2010) Yeongri Jung et al.   JOURNAL OF BIOMEDICAL OPTICS

Application of intravital microscopy in studies of tumor microcirculation

(2010) Sarah Jane Lunt et al.   JOURNAL OF BIOMEDICAL OPTICS

Neuropilin-2 mediates VEGF-C–induced lymphatic sprouting together with VEGFR3

(2010) Yunling Xu et al.   JOURNAL OF CELL BIOLOGY

The Human Cutaneous Squamous Cell Carcinoma Microenvironment Is Characterized by Increased Lymphatic Density and Enhanced Expression of Macrophage-Derived VEGF-C

(2010) Dariush Moussai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Stem cells in tumor angiogenesis

(2010) Shentong Fang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Glioma stem cells involved in tumor tissue remodeling in a xenograft model

(2010) Jun Dong et al.   JOURNAL OF NEUROSURGERY

Tumor Microvasculature and Microenvironment: Novel Insights Through Intravital Imaging in Pre-Clinical Models

(2010) DAI FUKUMURA et al.   MICROCIRCULATION

A Human Monoclonal Anti-ANG2 Antibody Leads to Broad Antitumor Activity in Combination with VEGF Inhibitors and Chemotherapy Agents in Preclinical Models

(2010) J. L. Brown et al.   MOLECULAR CANCER THERAPEUTICS

Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

(2010) Lucia Ricci-Vitiani et al.   NATURE

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Glioblastoma stem-like cells give rise to tumour endothelium

(2010) Rong Wang et al.   NATURE

Raising the bar for cancer therapy models

(2010) Giulio Francia et al.   NATURE BIOTECHNOLOGY

Assessing therapeutic responses in Kras mutant cancers using genetically engineered mouse models

(2010) Mallika Singh et al.   NATURE BIOTECHNOLOGY

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

3D-reconstruction of blood vessels by ultramicroscopy

(2010) Nina Jährling et al.   Organogenesis

Cytogenetic Abnormalities of Tumor-Associated Endothelial Cells in Human Malignant Tumors

(2009) Tomoshige Akino et al.   AMERICAN JOURNAL OF PATHOLOGY

DLL1-mediated Notch activation regulates endothelial identity in mouse fetal arteries

(2009) I. Sorensen et al.   BLOOD

Silencing or Fueling Metastasis with VEGF Inhibitors: Antiangiogenesis Revisited

(2009) Sonja Loges et al.   CANCER CELL

Accelerated Metastasis after Short-Term Treatment with a Potent Inhibitor of Tumor Angiogenesis

(2009) John M.L. Ebos et al.   CANCER CELL

Antiangiogenic Therapy Elicits Malignant Progression of Tumors to Increased Local Invasion and Distant Metastasis

(2009) Marta Pàez-Ribes et al.   CANCER CELL

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

(2009) Patrick Nasarre et al.   CANCER RESEARCH

Imaging glioma cell invasionin vivoreveals mechanisms of dissemination and peritumoral angiogenesis

(2009) Frank Winkler et al.   GLIA

Tumor metastasis and the lymphatic vasculature

(2009) Jonathan P. Sleeman et al.   INTERNATIONAL JOURNAL OF CANCER

Unraveling the mysteries of endostatin

(2009) Yan Fu et al.   IUBMB LIFE

Phase III Trial of Bevacizumab in Combination With Gemcitabine and Erlotinib in Patients With Metastatic Pancreatic Cancer

(2009) Eric Van Cutsem et al.   JOURNAL OF CLINICAL ONCOLOGY

M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis

(2009) Yoshiaki Kubota et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lymphatic endothelial cell sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning

(2009) Trung H.M. Pham et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Three-dimensional microscopy of the tumor microenvironment in vivo using optical frequency domain imaging

(2009) Benjamin J Vakoc et al.   NATURE MEDICINE

Development of a novel mouse glioma model using lentiviral vectors

(2009) Tomotoshi Marumoto et al.   NATURE MEDICINE

Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications

(2009) Erika L Abel et al.   Nature Protocols

Inhibition of Hedgehog Signaling Enhances Delivery of Chemotherapy in a Mouse Model of Pancreatic Cancer

(2009) K. P. Olive et al.   SCIENCE

Tumor and stromal pathways mediating refractoriness/resistance to anti-angiogenic therapies

(2009) Yongping Crawford et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Tumor Recovery by Angiogenic Switch from Sprouting to Intussusceptive Angiogenesis after Treatment with PTK787/ZK222584 or Ionizing Radiation

(2008) Ruslan Hlushchuk et al.   AMERICAN JOURNAL OF PATHOLOGY

Transgenic Induction of Vascular Endothelial Growth Factor-C Is Strongly Angiogenic in Mouse Embryos but Leads to Persistent Lymphatic Hyperplasia in Adult Tissues

(2008) Marja Lohela et al.   AMERICAN JOURNAL OF PATHOLOGY

Imaging angiogenesis and the microenvironment 

(2008) DAI FUKUMURA et al.   APMIS

Immunohistochemistry in the evaluation of neovascularization in tumor xenografts

(2008) D Wang et al.   BIOTECHNIC & HISTOCHEMISTRY

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis

(2008) Maresa Caunt et al.   CANCER CELL

Cancer related inflammation: The macrophage connection

(2008) Antonio Sica et al.   CANCER LETTERS

Suppression of Prostate Cancer Nodal and Systemic Metastasis by Blockade of the Lymphangiogenic Axis

(2008) J. B. Burton et al.   CANCER RESEARCH

VEGF inhibition: insights from preclinical and clinical studies

(2008) Yongping Crawford et al.   CELL AND TISSUE RESEARCH

Blocking Vascular Endothelial Growth Factor-A Inhibits the Growth of Pituitary Adenomas and Lowers Serum Prolactin Level in a Mouse Model of Multiple Endocrine Neoplasia Type 1

(2008) N. Korsisaari et al.   CLINICAL CANCER RESEARCH

Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase

(2008) J. Matsui et al.   CLINICAL CANCER RESEARCH

Efficient, inducible Cre-recombinase activation in vascular endothelium

(2008) Suzanne Claxton et al.   GENESIS

Dual inhibition of VEGFR and EGFR signaling reduces the incidence and size of intestinal adenomas in ApcMin/+ mice

(2008) D. Alferez et al.   MOLECULAR CANCER THERAPEUTICS

Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation

(2008) Tuomas Tammela et al.   NATURE

Crypt stem cells as the cells-of-origin of intestinal cancer

(2008) Nick Barker et al.   NATURE

Apc mice: Models, modifiers and mutants

(2008) Amy E. McCart et al.   PATHOLOGY RESEARCH AND PRACTICE

CANCER: A Few to Flip the Angiogenic Switch

(2008) S. Rafii et al.   SCIENCE

Endothelial Progenitor Cells Control the Angiogenic Switch in Mouse Lung Metastasis

(2008) D. Gao et al.   SCIENCE