Prostaglandin E2 breaks down pericyte–endothelial cell interaction via EP1 and EP4-dependent downregulation of pericyte N-cadherin, connexin-43, and R-Ras

Prolonged activation of cAMP signaling leads to endothelial barrier disruption via transcriptional repression of RRAS

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Pericyte degeneration causes white matter dysfunction in the mouse central nervous system

(2018) Axel Montagne et al.   NATURE MEDICINE

GRC 27864, novel, microsomal prostaglandin E synthase-1 enzyme inhibitor: phase 1 study to evaluate safety, PK and biomarkers in healthy, adult subjects

(2018) S. Sant et al.   OSTEOARTHRITIS AND CARTILAGE

Cyclooxygenase‑2 induces angiogenesis in pancreatic cancer mediated by prostaglandin E2

(2018) Chuangao Xie et al.   Oncology Letters

NSAID Exposure and Risk of Alzheimer's Disease: An Updated Meta-Analysis From Cohort Studies

(2018) Caixia Zhang et al.   Frontiers in Aging Neuroscience

Inhibition of Microsomal Prostaglandin E Synthase-1 in Cancer-Associated Fibroblasts Suppresses Neuroblastoma Tumor Growth

(2018) Anna Kock et al.   EBioMedicine

N-cadherin signaling via Trio assembles adherens junctions to restrict endothelial permeability

(2018) Kevin Kruse et al.   JOURNAL OF CELL BIOLOGY

Cyclooxygenase-2 in cancer: A review

(2018) Nasser Hashemi Goradel et al.   JOURNAL OF CELLULAR PHYSIOLOGY

EP 2 and EP 4 receptor antagonists: Impact on cytokine production and β 2 ‐adrenergic receptor desensitization in human airway smooth muscle

(2018) Peta Bradbury et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Pericyte degeneration leads to neurovascular uncoupling and limits oxygen supply to brain

(2017) Kassandra Kisler et al.   NATURE NEUROSCIENCE

Pericytes, an overlooked player in vascular pathobiology

(2017) David Ferland-McCollough et al.   PHARMACOLOGY & THERAPEUTICS

R-Ras-Akt axis induces endothelial lumenogenesis and regulates the patency of regenerating vasculature

(2017) Fangfei Li et al.   Nature Communications

Tumor-induced loss of mural Connexin 43 gap junction activity promotes endothelial proliferation

(2015) Mayur Choudhary et al.   BMC CANCER

Establishment and Dysfunction of the Blood-Brain Barrier

(2015) Zhen Zhao et al.   CELL

Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity

(2015) Santiago Zelenay et al.   CELL

Pharmacodynamic comparison of LY3023703, a novel microsomal prostaglandin e synthase 1 inhibitor, with celecoxib

(2015) Y Jin et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

The complex mural cell: Pericyte function in health and disease

(2015) Christian G.M. van Dijk et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

R-Ras Protein Inhibits Autophosphorylation of Vascular Endothelial Growth Factor Receptor 2 in Endothelial Cells and Suppresses Receptor Activation in Tumor Vasculature

(2015) Junko Sawada et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

R-Ras Inhibits VEGF-Induced p38MAPK Activation and HSP27 Phosphorylation in Endothelial Cells

(2015) Junko Sawada et al.   JOURNAL OF VASCULAR RESEARCH

COX/mPGES-1/PGE2pathway depicts an inflammatory-dependent high-risk neuroblastoma subset

(2015) Karin Larsson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined Effects of Pericytes in the Tumor Microenvironment

(2015) Aline Lopes Ribeiro et al.   Stem Cells International

The Pericyte: A Forgotten Cell Type with Important Implications for Alzheimer's Disease?

(2014) Ethan A. Winkler et al.   BRAIN PATHOLOGY

Multiple roles of the PGE2-EP receptor signal in vascular permeability

(2014) K Omori et al.   BRITISH JOURNAL OF PHARMACOLOGY

An EP4 Antagonist ONO-AE3-208 Suppresses Cell Invasion, Migration, and Metastasis of Prostate Cancer

(2014) Song Xu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Calpain-dependent Cleavage of N-cadherin Is Involved in the Progression of Post-myocardial Infarction Remodeling

(2014) Yoko Kudo-Sakamoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Capillary pericytes regulate cerebral blood flow in health and disease

(2014) Catherine N. Hall et al.   NATURE

COX-2 Inhibition Potentiates Antiangiogenic Cancer Therapy and Prevents Metastasis in Preclinical Models

(2014) L. Xu et al.   Science Translational Medicine

Phosphodiesterase-4 Inhibition Augments Human Lung Fibroblast Vascular Endothelial Growth Factor Production Induced by Prostaglandin E2

(2013) Jun Ikari et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pericyte loss influences Alzheimer-like neurodegeneration in mice

(2013) Abhay P. Sagare et al.   Nature Communications

Deficiency in Mural Vascular Cells Coincides with Blood-Brain Barrier Disruption in Alzheimer's Disease

(2012) Jesse D. Sengillo et al.   BRAIN PATHOLOGY

PGE2maintains the tone of the guinea pig trachea through a balance between activation of contractile EP1receptors and relaxant EP2receptors

(2012) J Säfholm et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels

(2012) Junko Sawada et al.   CANCER CELL

Prostaglandin E2 Regulates Pancreatic Stellate Cell Activity Via the EP4 Receptor

(2012) Chantale Charo et al.   PANCREAS

Multifaceted roles of PGE2 in inflammation and cancer

(2012) Masako Nakanishi et al.   Seminars in Immunopathology

Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2

(2012) M. Dolores Salvado et al.   TRENDS IN MOLECULAR MEDICINE

Prostaglandin E2Stimulates the Production of Vascular Endothelial Growth Factor through the E-Prostanoid–2 Receptor in Cultured Human Lung Fibroblasts

(2011) Masanori Nakanishi et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Pericyte-Derived Sphinogosine 1-Phosphate Induces the Expression of Adhesion Proteins and Modulates the Retinal Endothelial Cell Barrier

(2011) Paul G. McGuire et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Notch promotes vascular maturation by inducing integrin-mediated smooth muscle cell adhesion to the endothelial basement membrane

(2011) L. Scheppke et al.   BLOOD

PGE2 promotes angiogenesis through EP4 and PKA C  pathway

(2011) Y. Zhang et al.   BLOOD

In vitro and in vivo characterization of PF-04418948, a novel, potent and selective prostaglandin EP2 receptor antagonist

(2011) KJ af Forselles et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hepatocellular carcinoma-associated fibroblasts trigger NK cell dysfunction via PGE2 and IDO

(2011) Tuanjie Li et al.   CANCER LETTERS

Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises

(2011) Annika Armulik et al.   DEVELOPMENTAL CELL

Central nervous system pericytes in health and disease

(2011) Ethan A Winkler et al.   NATURE NEUROSCIENCE

Regulation of Smooth Muscle Contraction by the Epithelium: Role of Prostaglandins

(2011) Ye Chun Ruan et al.   PHYSIOLOGY

A Computational Tool for Quantitative Analysis of Vascular Networks

(2011) Enrique Zudaire et al.   PLoS One

Pericytes and vessel maturation during tumor angiogenesis and metastasis

(2010) Ahmad Raza et al.   AMERICAN JOURNAL OF HEMATOLOGY

The Prostaglandin E 2 Receptor EP4 Is Expressed by Human Platelets and Potently Inhibits Platelet Aggregation and Thrombus Formation

(2010) Sonia Philipose et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Misoprostol elevates intracellular calcium in Neuro-2a cells via protein kinase A

(2010) Javaneh Tamiji et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification of EP4 as a Potential Target for the Treatment of Castration-Resistant Prostate Cancer Using a Novel Xenograft Model

(2010) N. Terada et al.   CANCER RESEARCH

Structure of the gap junction channel and its implications for its biological functions

(2010) Shoji Maeda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Modulation of Stretch Evoked Adenosine Triphosphate Release From Bladder Epithelium by Prostaglandin E2

(2010) Ippei Tanaka et al.   JOURNAL OF UROLOGY

Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis

(2009) Konstantin Gaengel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment

(2009) A. Greenhough et al.   CARCINOGENESIS

Calpain-Mediated N-Cadherin Proteolytic Processing in Brain Injury

(2009) Y.-N. Jang et al.   JOURNAL OF NEUROSCIENCE

Prostaglandin E2 Regulates Tumor Angiogenesis in Prostate Cancer

(2008) S. Jain et al.   CANCER RESEARCH

Vascular normalization in Rgs5-deficient tumours promotes immune destruction

(2008) Juliana Hamzah et al.   NATURE

Pericyte coverage decreases invasion of tumour cells into blood vessels in prostate cancer xenografts

(2008) K Welén et al.   PROSTATE CANCER AND PROSTATIC DISEASES