Positive regulation of PFKFB3 by PIM2 promotes glycolysis and paclitaxel resistance in breast cancer

Phosphoglycerate kinase 1 (PGK1) in cancer: A promising target for diagnosis and therapy

(2020) Qi Fu et al.   LIFE SCIENCES

PIM2 promotes hepatocellular carcinoma tumorigenesis and progression through activating NF-κB signaling pathway

(2020) Xuming Tang et al.   Cell Death & Disease

Targeting Glucose Metabolism to Overcome Resistance to Anticancer Chemotherapy in Breast Cancer

(2020) Elizabeth Varghese et al.   Cancers

Elucidating cancer metabolic plasticity by coupling gene regulation with metabolic pathways

(2019) Dongya Jia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increased 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 activity in response to EGFR signaling contributes to non-small cell lung cancer cell survival

(2019) Nadiia Lypova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer

(2019) Xue Han et al.   ONCOGENE

Phosphorylation of HSF1 by PIM2 induces PD-L1 expression and promotes tumor growth in breast cancer

(2019) Tingting Yang et al.   CANCER RESEARCH

Autophagy inhibition elicits emergence from metastatic dormancy by inducing and stabilizing Pfkfb3 expression

(2019) Alyssa La Belle Flynn et al.   Nature Communications

Global burden of breast cancer and attributable risk factors in 195 countries and territories, from 1990 to 2017: results from the Global Burden of Disease Study 2017

(2019) Na Li et al.   Journal of Hematology & Oncology

Expression of long non-coding RNA YIYA promotes glycolysis in breast cancer

(2018) Zhen Xing et al.   CANCER RESEARCH

The potential utility of PFKFB3 as a therapeutic target

(2018) Ramon Bartrons et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

(2018) Chune Ren et al.   Molecular Oncology

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

(2018) Tingting Yang et al.   ONCOGENE

Acetylation accumulates PFKFB3 in cytoplasm to promote glycolysis and protects cells from cisplatin-induced apoptosis

(2018) Fu-Long Li et al.   Nature Communications

Therapeutic targeting of PFKFB3 with a novel glycolytic inhibitor PFK158 promotes lipophagy and chemosensitivity in gynecologic cancers

(2018) Susmita Mondal et al.   INTERNATIONAL JOURNAL OF CANCER

6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 and 4: A pair of valves for fine-tuning of glucose metabolism in human cancer

(2018) Mei Yi et al.   Molecular Metabolism

The Glycolytic Enzyme PFKFB3 Is Involved in Estrogen-Mediated Angiogenesis via GPER1

(2017) Annalisa Trenti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Breast cancer

(2017) Nadia Harbeck et al.   LANCET

Proteasome inhibitors in cancer therapy

(2017) Elisabet E. Manasanch et al.   Nature Reviews Clinical Oncology

Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer

(2016) Julie O’Neal et al.   BREAST CANCER RESEARCH AND TREATMENT

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Targeting Pim kinases for cancer treatment: opportunities and challenges

(2015) Bich Thuy Le et al.   Future Medicinal Chemistry

AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest

(2015) Elena Doménech et al.   NATURE CELL BIOLOGY

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

HO-1/CO system in tumor growth, angiogenesis and metabolism — Targeting HO-1 as an anti-tumor therapy

(2015) Agnieszka Loboda et al.   VASCULAR PHARMACOLOGY

Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

(2014) Oleksandr H Minchenko   WORLD JOURNAL OF GASTROENTEROLOGY

Reduced methylation of PFKFB3 in cancer cells shunts glucose towards the pentose phosphate pathway

(2014) Takehiro Yamamoto et al.   Nature Communications

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

PFKFB3 Regulates Oxidative Stress Homeostasis via Its S-Glutathionylation in Cancer

(2013) Minsuh Seo et al.   JOURNAL OF MOLECULAR BIOLOGY

PIM2 inhibition as a rational therapeutic approach in B-cell lymphoma

(2011) C. Gomez-Abad et al.   BLOOD

Warburg effect in chemosensitivity: Targeting lactate dehydrogenase-A re-sensitizes Taxol-resistant cancer cells to Taxol

(2010) Ming Zhou et al.   Molecular Cancer