PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

Inflammation and stem markers association to PIM1/PIM2 kinase-induced tumors in breast and uterus

(2017) Manuel-Pedro Jiménez-García et al.   Oncotarget

Pim kinase isoforms: devils defending cancer cells from therapeutic and immune attacks

(2016) Goodwin G. Jinesh et al.   APOPTOSIS

PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells

(2016) Zhenhai Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The control of inflammation via the phosphorylation and dephosphorylation of tristetraprolin: a tale of two phosphatases

(2016) Andrew R. Clark et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tristetraprolin mediates the anti-proliferative effects of metformin in breast cancer cells

(2016) Indira Pandiri et al.   BREAST CANCER RESEARCH AND TREATMENT

The Novel Pan-PIM Kinase Inhibitor, PIM447, Displays Dual Antimyeloma and Bone-Protective Effects, and Potently Synergizes with Current Standards of Care

(2016) Teresa Paíno et al.   CLINICAL CANCER RESEARCH

PIM1 kinase inhibition as a targeted therapy against triple-negative breast tumors with elevated MYC expression

(2016) Dai Horiuchi et al.   NATURE MEDICINE

PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer

(2016) Fara Brasó-Maristany et al.   NATURE MEDICINE

Tristetraprolin as a Therapeutic Target in Inflammatory Disease

(2016) Sonika Patial et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Hallmarks of cancer and AU-rich elements

(2016) Khalid S. A. Khabar   Wiley Interdisciplinary Reviews-RNA

Activation of Pim Kinases Is Sufficient to Promote Resistance to MET Small-Molecule Inhibitors

(2015) N. An et al.   CANCER RESEARCH

Targeting Pim kinases for cancer treatment: opportunities and challenges

(2015) Bich Thuy Le et al.   Future Medicinal Chemistry

Pim-2 Kinase Influences Regulatory T Cell Function and Stability by Mediating Foxp3 Protein N-terminal Phosphorylation

(2015) Guoping Deng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells

(2014) Zhenhai Yu et al.   CELLULAR SIGNALLING

Tristetraprolin Represses Estrogen Receptor α Transactivation in Breast Cancer Cells

(2014) Tonatiuh Barrios-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of Pro-Angiogenic Cytokine mRNA Half-Life in Cancer: The Role of AU-Rich Elements and Associated Proteins

(2014) Paola Griseri et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Pim-2 kinase is an important target of treatment for tumor progression and bone loss in myeloma

(2014) M Hiasa et al.   LEUKEMIA

Rapid Proteasomal Degradation of Posttranscriptional Regulators of the TIS11/Tristetraprolin Family Is Induced by an Intrinsically Unstructured Region Independently of Ubiquitination

(2014) L. V. Ngoc et al.   MOLECULAR AND CELLULAR BIOLOGY

A Regulatory Feedback Loop between HIF-1α and PIM2 in HepG2 Cells

(2014) Zhenhai Yu et al.   PLoS One

Tristetraprolin (TTP): Interactions with mRNA and proteins, and current thoughts on mechanisms of action

(2013) Seth A. Brooks et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammary differentiation induces expression of Tristetraprolin, a tumor suppressor AU-rich mRNA-binding protein

(2012) M. Victoria Goddio et al.   BREAST CANCER RESEARCH AND TREATMENT

Depletion of tristetraprolin in breast cancer cells increases interleukin-16 expression and promotes tumor infiltration with monocytes/macrophages

(2012) Larissa Milke et al.   CARCINOGENESIS

ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways

(2012) Tommaso Selmi et al.   CELL CYCLE

Expression of Proviral Integration Site for Moloney Murine Leukemia Virus 1 (Pim-1) Is Post-transcriptionally Regulated by Tristetraprolin in Cancer Cells

(2012) Hong Kyeung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordinated Expression of Tristetraprolin Post-Transcriptionally Attenuates Mitogenic Induction of the Oncogenic Ser/Thr Kinase Pim-1

(2012) Dig B. Mahat et al.   PLoS One

The Pim Kinases: New Targets for Drug Development

(2011) Ronan Swords et al.   CURRENT DRUG TARGETS

Hypoxia-inducible factor-1α mRNA: a new target for destabilization by tristetraprolin in endothelial cells

(2011) Sandrine Chamboredon et al.   MOLECULAR BIOLOGY OF THE CELL

Tristetraprolin Impairs NF-κB/p65 Nuclear Translocation

(2009) Yvonne M. Schichl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY