Mechanisms of regulation of PFKFB expression in pancreatic and gastric cancer cells

Adapting glycolysis to cancer cell proliferation: the MAPK pathway focuses on PFKFB3: Figure 1

(2013) Juan P. Bolaños   BIOCHEMICAL JOURNAL

PFKFB3 activation in cancer cells by the p38/MK2 pathway in response to stress stimuli

(2013) Laura Novellasdemunt et al.   BIOCHEMICAL JOURNAL

High epiregulin expression in human U87 glioma cells relies on IRE1α and promotes autocrine growth through EGF receptor

(2013) Gregor Auf et al.   BMC CANCER

Excess glucose induces hypoxia-inducible factor-1α in pancreatic cancer cells and stimulates glucose metabolism and cell migration

(2013) Zhiwen Liu et al.   CANCER BIOLOGY & THERAPY

Role of PFKFB3-Driven Glycolysis in Vessel Sprouting

(2013) Katrien De Bock et al.   CELL

Partial and Transient Reduction of Glycolysis by PFKFB3 Blockade Reduces Pathological Angiogenesis

(2013) Sandra Schoors et al.   Cell Metabolism

HIF1 Contributes to Hypoxia-Induced Pancreatic Cancer Cells Invasion via Promoting QSOX1 Expression

(2013) Chen-Ye Shi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased Concentrations of Fructose 2,6-Bisphosphate Contribute to the Warburg Effect in Phosphatase and Tensin Homolog (PTEN)-deficient Cells

(2013) Lucía Cordero-Espinoza et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Akt-dependent Activation of the Heart 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase (PFKFB2) Isoenzyme by Amino Acids

(2013) Laura Novellasdemunt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia induces the overexpression of microRNA-21 in pancreatic cancer cells

(2013) Thomas A. Mace et al.   JOURNAL OF SURGICAL RESEARCH

Targeting 6-Phosphofructo-2-Kinase (PFKFB3) as a Therapeutic Strategy against Cancer

(2013) B. F. Clem et al.   MOLECULAR CANCER THERAPEUTICS

The Transcriptional Co-Repressor Myeloid Translocation Gene 16 Inhibits Glycolysis and Stimulates Mitochondrial Respiration

(2013) Parveen Kumar et al.   PLoS One

Control of vessel sprouting by genetic and metabolic determinants

(2013) Guy Eelen et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

c-Myc enhances colon cancer cell-mediated angiogenesis through the regulation of HIF-1α

(2012) Cheng Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CHC promotes tumor growth and angiogenesis through regulation of HIF-1α and VEGF signaling

(2012) Kuo-Hua Tung et al.   CANCER LETTERS

The real face of HIF1α in the tumor process

(2012) Matthias Kappler et al.   CELL CYCLE

Molecular and Genetic Bases of Pancreatic Cancer

(2012) Vanja Vaccaro et al.   CURRENT DRUG TARGETS

δ-catenin overexpression promotes angiogenic potential of CWR22Rv-1 prostate cancer cells via HIF-1α and VEGF

(2012) Yongfeng He et al.   FEBS LETTERS

Links between metabolism and cancer

(2012) C. V. Dang   GENES & DEVELOPMENT

The impact of the unfolded protein response on human disease

(2012) Shiyu Wang et al.   JOURNAL OF CELL BIOLOGY

MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors

(2012) S Kitamoto et al.   ONCOGENE

MUC1 regulates PDGFA expression during pancreatic cancer progression

(2012) M Sahraei et al.   ONCOGENE

Cancer Cell Metabolism: There Is No ROS for the Weary: Figure 1.

(2012) Chi V. Dang   Cancer Discovery

Functional Metabolic Screen Identifies 6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase 4 as an Important Regulator of Prostate Cancer Cell Survival

(2012) Susana Ros et al.   Cancer Discovery

Sulforaphane induces apoptosis in human hepatic cancer cells through inhibition of 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase4, mediated by hypoxia inducible factor-1-dependent pathway

(2011) Young Keul Jeon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Advances in pancreatic cancer

(2011) Edward J. Kim et al.   CURRENT OPINION IN GASTROENTEROLOGY

Cooperation of Adenosine with Macrophage Toll-4 Receptor Agonists Leads to Increased Glycolytic Flux through the Enhanced Expression ofPFKFB3Gene

(2011) Almudena Ruiz-García et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme

(2011) Amparo Wolf et al.   JOURNAL OF EXPERIMENTAL MEDICINE

RNAi screening in glioma stem-like cells identifies PFKFB4 as a key molecule important for cancer cell survival

(2011) V Goidts et al.   ONCOGENE

Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect

(2011) Minsuh Seo et al.   PLoS One

Two ubiquitin ligases, APC/C-Cdh1 and SKP1-CUL1-F (SCF)- -TrCP, sequentially regulate glycolysis during the cell cycle

(2011) S. Tudzarova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PFKFB4 as a prognostic marker in non-muscle-invasive bladder cancer

(2011) Seok Joong Yun et al.   UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS

Androgen stimulates glycolysis forde novolipid synthesis by increasing the activities of hexokinase 2 and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 in prostate cancer cells

(2010) Jong-Seok Moon et al.   BIOCHEMICAL JOURNAL

Inositol-requiring enzyme 1  is a key regulator of angiogenesis and invasion in malignant glioma

(2010) G. Auf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of glucose metabolism by 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases in cancer

(2009) Abdullah Yalcin et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Nuclear Targeting of 6-Phosphofructo-2-kinase (PFKFB3) Increases Proliferation via Cyclin-dependent Kinases

(2009) Abdullah Yalcin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of hypoxia in the hallmarks of human cancer

(2009) Kai Ruan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Hypoxic enlarged mitochondria protect cancer cells from apoptotic stimuli

(2009) Johanna Chiche et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hypoxia-Inducible mir-210 Regulates Normoxic Gene Expression Involved in Tumor Initiation

(2009) Xin Huang et al.   MOLECULAR CELL

The PFKFB3 splice variant UBI2K4 is downregulated in high-grade astrocytomas and impedes the growth of U87 glioblastoma cells

(2009) K. Zscharnack et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

E3 ubiquitin ligase APC/C-Cdh1 accounts for the Warburg effect by linking glycolysis to cell proliferation

(2009) A. Almeida et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA