Negative regulation of AMPKα1 by PIM2 promotes aerobic glycolysis and tumorigenesis in endometrial cancer

AMPK: Sensing Glucose as well as Cellular Energy Status

(2018) Sheng-Cai Lin et al.   Cell Metabolism

The AMPK agonist 5‐aminoimidazole‐4‐carboxamide ribonucleotide (AICAR), but not metformin, prevents inflammation‐associated cachectic muscle wasting

(2018) Derek T Hall et al.   EMBO Molecular Medicine

The AMPK inhibitor overcomes the paradoxical effect of RAF inhibitors through blocking the phospho-Ser-621 in the carboxyl-terminus of CRAF

(2018) Jimin Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity

(2018) Anusara Daenthanasanmak et al.   JOURNAL OF CLINICAL INVESTIGATION

PIM2 interacts with tristetraprolin and promotes breast cancer tumorigenesis

(2018) Chune Ren et al.   Molecular Oncology

PIM2-mediated phosphorylation of hexokinase 2 is critical for tumor growth and paclitaxel resistance in breast cancer

(2018) Tingting Yang et al.   ONCOGENE

RSK2 is a new Pim2 target with pro-survival functions in FLT3-ITD-positive acute myeloid leukemia

(2017) M-A Hospital et al.   LEUKEMIA

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Characterization of HJ-PI01 as a novel Pim-2 inhibitor that induces apoptosis and autophagic cell death in triple-negative human breast cancer

(2016) Yu-qian Zhao et al.   ACTA PHARMACOLOGICA SINICA

PKM2 Thr454 phosphorylation increases its nuclear translocation and promotes xenograft tumor growth in A549 human lung cancer cells

(2016) Zhenhai Yu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The effect of visceral obesity on clinicopathological features in patients with endometrial cancer: a retrospective analysis of 200 Chinese patients

(2016) Shuang Ye et al.   BMC CANCER

Addressing the Role of Obesity in Endometrial Cancer Risk, Prevention, and Treatment

(2016) Michaela A. Onstad et al.   JOURNAL OF CLINICAL ONCOLOGY

Novel inhibition of PIM2 kinase has significant anti-tumor efficacy in multiple myeloma

(2016) J R Nair et al.   LEUKEMIA

AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs

(2016) D. Grahame Hardie et al.   TRENDS IN CELL BIOLOGY

Loss of PIM2 enhances the anti-proliferative effect of the pan-PIM kinase inhibitor AZD1208 in non-Hodgkin lymphomas

(2015) S. Kreuz et al.   Molecular Cancer

PIM kinase (and Akt) biology and signaling in tumors

(2015) Noel A. Warfel et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation by Akt within the ST loop of AMPK-α1 down-regulates its activation in tumour cells

(2014) Simon A. Hawley et al.   BIOCHEMICAL JOURNAL

Using a yeast two-hybrid system to identify FTCD as a new regulator for HIF-1α in HepG2 cells

(2014) Zhenhai Yu et al.   CELLULAR SIGNALLING

A Regulatory Feedback Loop between HIF-1α and PIM2 in HepG2 Cells

(2014) Zhenhai Yu et al.   PLoS One

Pim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation

(2013) J. Lu et al.   BLOOD

Proviral Insertion in Murine Lymphomas 2 (PIM2) Oncogene Phosphorylates Pyruvate Kinase M2 (PKM2) and Promotes Glycolysis in Cancer Cells

(2013) Zhenhai Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PIM Family of Serine/Threonine Kinases in Cancer

(2013) Maja Narlik-Grassow et al.   MEDICINAL RESEARCH REVIEWS

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake

(2012) Yossi Dagon et al.   Cell Metabolism

AMPK Is a Negative Regulator of the Warburg Effect and Suppresses Tumor Growth In Vivo

(2012) Brandon Faubert et al.   Cell Metabolism

Pim-2 phosphorylation of p21Cip1/WAF1 enhances its stability and inhibits cell proliferation in HCT116 cells

(2010) Zeping Wang et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The Pim protein kinases regulate energy metabolism and cell growth

(2010) Z. Beharry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

(2010) D. Bungard et al.   SCIENCE

LKB1 and AMPK Family Signaling: The Intimate Link Between Cell Polarity and Energy Metabolism

(2009) Marnix Jansen et al.   PHYSIOLOGICAL REVIEWS

Pim Kinases Promote Cell Cycle Progression by Phosphorylating and Down-regulating p27Kip1 at the Transcriptional and Posttranscriptional Levels

(2008) D. Morishita et al.   CANCER RESEARCH