Microsatellite Instability in Colorectal Cancer Liquid Biopsy—Current Updates on Its Potential in Non-Invasive Detection, Prognosis and as a Predictive Marker

Liquid biopsy enters the clinic — implementation issues and future challenges

(2021) Michail Ignatiadis et al.   Nature Reviews Clinical Oncology

Cancer statistics, 2020

(2020) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Microsatellite instability: a review of what the oncologist should know

(2020) Kai Li et al.   Cancer Cell International

Single Cell Transcriptome in Colorectal Cancer—Current Updates on Its Application in Metastasis, Chemoresistance and the Roles of Circulating Tumor Cells

(2020) Francis Yew Fu Tieng et al.   Frontiers in Pharmacology

Epigenetics of SFRP1: The Dual Roles in Human Cancers

(2020) Rashidah Baharudin et al.   Cancers

Association between Microsatellite Instability Status and Peri-Operative Release of Circulating Tumour Cells in Colorectal Cancer

(2020) James W. T. Toh et al.   Cells

Biomarkers for detecting colorectal cancer non-invasively: DNA, RNA or proteins?

(2020) Alexandre Loktionov   World Journal of Gastrointestinal Oncology

High-Accuracy Determination of Microsatellite Instability Compatible with Liquid Biopsies

(2020) Amanda Bortolini Silveira et al.   CLINICAL CHEMISTRY

Perspectives of the Application of Liquid Biopsy in Colorectal Cancer

(2020) Yuhan Ding et al.   Biomed Research International

Liquid Biopsy in Colorectal Carcinoma: Clinical Applications and Challenges

(2020) Drahomír Kolenčík et al.   Cancers

Actionable Potentials of Less Frequently Mutated Genes in Colorectal Cancer and Their Roles in Precision Medicine

(2020) Ryia Illani Mohd Yunos et al.   Biomolecules

Pre-analytical issues in liquid biopsy – where do we stand?

(2020) Michael Fleischhacker et al.   Journal of Laboratory Medicine

L1CAM, CA9, KLK6, HPN, and ALDH1A1 as Potential Serum Markers in Primary and Metastatic Colorectal Cancer Screening

(2020) Francis Yew Fu Tieng et al.   Diagnostics

Discovery of Targetable Genetic Alterations in NSCLC Patients with Different Metastatic Patterns Using a MassARRAY-Based Circulating Tumor DNA Assay

(2020) Yassine Belloum et al.   Cells

MSIsensor-ct: microsatellite instability detection using cfDNA sequencing data

(2020) Xinyin Han et al.   BRIEFINGS IN BIOINFORMATICS

A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenoma

(2019) Rongbin Liu et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Emerging microRNA biomarkers for colorectal cancer diagnosis and prognosis

(2019) Bing Chen et al.   Open Biology

Clinical utility of circulating tumor DNA for colorectal cancer

(2019) Hiroki Osumi et al.   CANCER SCIENCE

Expression analysis of circulating plasma long noncoding RNAs in colorectal cancer: The relevance of lncRNAs ATB and CCAT1 as potential clinical hallmarks

(2019) Paria Abedini et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Blood-based genomic profiling of cell-free DNA (cfDNA) to identify microsatellite instability (MSI-H), tumor mutational burden (TMB) and Wnt/B-Catenin pathway alterations in patients with gastrointestinal (GI) tract cancers.

(2019) James Isaacs et al.   JOURNAL OF CLINICAL ONCOLOGY

Technologies for circulating tumor cell separation from whole blood

(2019) Petra Bankó et al.   Journal of Hematology & Oncology

Detection of circulating tumor cells in colorectal cancer patients using the Gilupi CellCollector: Results from a prospective, single center study

(2019) Levent Dizdar et al.   Molecular Oncology

Potential Utility of Liquid Biopsy as a Diagnostic and Prognostic Tool for the Assessment of Solid Tumors: Implications in the Precision Oncology

(2019) Roshni Mathai et al.   Journal of Clinical Medicine

P-079Circulating tumor cell detection and microsatellite instability status in predicting outcomes of advanced CRC patients

(2019) I Messaritakis et al.   ANNALS OF ONCOLOGY

Subtyping of microsatellite instability-high colorectal cancer

(2019) Wangxiong Hu et al.   Cell Communication and Signaling

New approaches for detecting cancer with circulating cell-free DNA

(2019) Clare Fiala et al.   BMC Medicine

Ushering in Liquid Biopsy for the Microsatellite Status: Advantages and Caveats

(2019) Linghua Wang et al.   CLINICAL CANCER RESEARCH

Noninvasive Detection of Microsatellite Instability and High Tumor Mutation Burden in Cancer Patients Treated with PD-1 Blockade

(2019) Andrew Georgiadis et al.   CLINICAL CANCER RESEARCH

Sensitive Detection of Microsatellite Instability (MSI) in Liquid Biopsies from Early Stage Colon Cancer Patients using Nuclease-based Enrichment and Standard-Marker or NGS based approaches

(2019) G. Makrigiorgos et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

NCCN Guidelines Insights: Genetic/Familial High-Risk Assessment: Colorectal, Version 2.2019

(2019) Samir Gupta et al.   Journal of the National Comprehensive Cancer Network

THE PRE-ANALYTICAL PHASE OF THE LIQUID BIOPSY

(2019) Francesca Salvianti et al.   New Biotechnology

Potential early clinical stage colorectal cancer diagnosis using a proteomics blood test panel

(2019) Seong Beom Ahn et al.   Clinical Proteomics

Circulating tumour DNA (ctDNA) as a biomarker in metachronous melanoma and colorectal cancer- a case report

(2019) Leslie Calapre et al.   BMC CANCER

Phase II Open-Label Study of Pembrolizumab in Treatment-Refractory, Microsatellite Instability–High/Mismatch Repair–Deficient Metastatic Colorectal Cancer: KEYNOTE-164

(2019) Dung T. Le et al.   JOURNAL OF CLINICAL ONCOLOGY

Single-Cell Analysis of Circulating Tumor Cells: Why Heterogeneity Matters

(2019) Su Bin Lim et al.   Cancers

Microsatellite Instability: Diagnosis, Heterogeneity, Discordance, and Clinical Impact in Colorectal Cancer

(2019) Evrard et al.   Cancers

Colorectal cancer liver metastases – a population-based study on incidence, management and survival

(2018) Jennie Engstrand et al.   BMC CANCER

Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies

(2018) Justin I. Odegaard et al.   CLINICAL CANCER RESEARCH

Review of Blood-Based Colorectal Cancer Screening: How Far Are Circulating Cell-Free DNA Methylation Markers From Clinical Implementation?

(2018) Mai-Britt Worm Ørntoft   Clinical Colorectal Cancer

Gene expression differences among different MSI statuses in colorectal cancer

(2018) Lei Chen et al.   INTERNATIONAL JOURNAL OF CANCER

Circulating Tumor DNA Analysis in Patients With Cancer: American Society of Clinical Oncology and College of American Pathologists Joint Review

(2018) Jason D. Merker et al.   JOURNAL OF CLINICAL ONCOLOGY

The value of cell-free DNA for molecular pathology

(2018) Caitlin M Stewart et al.   JOURNAL OF PATHOLOGY

Prospective patient stratification into robust cancer-cell intrinsic subtypes from colorectal cancer biopsies

(2018) Matthew Alderdice et al.   JOURNAL OF PATHOLOGY

Enhanced detection of microsatellite instability using pre-PCR elimination of wild-type DNA homo-polymers in tissue and liquid biopsies

(2018) Ioannis Ladas et al.   NUCLEIC ACIDS RESEARCH

Optically-induced-dielectrophoresis (ODEP)-based cell manipulation in a microfluidic system for high-purity isolation of integral circulating tumor cell (CTC) clusters based on their size characteristics

(2018) Tzu-Keng Chiu et al.   SENSORS AND ACTUATORS B-CHEMICAL

Circulating tumor cells in clinical research and monitoring patients with colorectal cancer

(2018) Claudia Burz et al.   Oncotarget

Liquid Biopsy in Colorectal Cancer-Current Status and Potential Clinical Applications

(2018) Gregor Norcic   Micromachines

Microsatellite instability status determined by next-generation sequencing and compared with PD-L1 and tumor mutational burden in 11,348 patients

(2018) Ari Vanderwalde et al.   Cancer Medicine

ctDNA and CTCs in Liquid Biopsy – Current Status and Where We Need to Progress

(2018) Martin H.D. Neumann et al.   Computational and Structural Biotechnology Journal

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Monitoring microsatellite instability (MSI) in circulating tumor DNA by next-generation DNA-seq.

(2018) Adam Deng et al.   JOURNAL OF CLINICAL ONCOLOGY

Current and future perspectives of liquid biopsies in genomics-driven oncology

(2018) Ellen Heitzer et al.   NATURE REVIEWS GENETICS

Molecular and Computational Methods for the Detection of Microsatellite Instability in Cancer

(2018) Laura G. Baudrin et al.   Frontiers in Oncology

Diagnostic and prognostic role of cell-free DNA testing for colorectal cancer patients

(2017) Chiara Bedin et al.   INTERNATIONAL JOURNAL OF CANCER

Molecular Biomarkers for the Evaluation of Colorectal Cancer: Guideline From the American Society for Clinical Pathology, College of American Pathologists, Association for Molecular Pathology, and the American Society of Clinical Oncology

(2017) Antonia R. Sepulveda et al.   JOURNAL OF CLINICAL ONCOLOGY

Integrating liquid biopsies into the management of cancer

(2017) Giulia Siravegna et al.   Nature Reviews Clinical Oncology

Hypermethylated DNA, a circulating biomarker for colorectal cancer detection

(2017) Simon Ladefoged Rasmussen et al.   PLoS One

DNA damage is a pervasive cause of sequencing errors, directly confounding variant identification

(2017) Lixin Chen et al.   SCIENCE

A molecular portrait of microsatellite instability across multiple cancers

(2017) Isidro Cortes-Ciriano et al.   Nature Communications

Molecular characterization of circulating colorectal tumor cells defines genetic signatures for individualized cancer care

(2017) Say Li Kong et al.   Oncotarget

Implementing liquid biopsies into clinical decision making for cancer immunotherapy

(2017) Dagmar Quandt et al.   Oncotarget

Proteins are potent biomarkers to detect colon cancer progression

(2017) Palaniselvam Kuppusamy et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Pharmacogenomics DNA Biomarkers in Colorectal Cancer: Current Update

(2017) Nurul-Syakima Ab Mutalib et al.   Frontiers in Pharmacology

Blood-Based Protein Signatures for Early Detection of Colorectal Cancer: A Systematic Review

(2017) Megha Bhardwaj et al.   Clinical and Translational Gastroenterology

Droplet Digital PCR versus qPCR for gene expression analysis with low abundant targets: from variable nonsense to publication quality data

(2017) Sean C. Taylor et al.   Scientific Reports

Era of universal testing of microsatellite instability in colorectal cancer

(2017) Xuchen Zhang et al.   World Journal of Gastrointestinal Oncology

Genetic traits for hematogeneous tumor cell dissemination in cancer patients

(2016) Simon A. Joosse et al.   CANCER AND METASTASIS REVIEWS

Analysis of Base-Position Error Rate of Next-Generation Sequencing to Detect Tumor Mutations in Circulating DNA

(2016) Nicolas Pécuchet et al.   CLINICAL CHEMISTRY

Global patterns and trends in colorectal cancer incidence and mortality

(2016) Melina Arnold et al.   GUT

Circulating tumor cell technologies

(2016) Meghaan M. Ferreira et al.   Molecular Oncology

Clinical Applications of Circulating Tumor Cells and Circulating Tumor DNA as Liquid Biopsy

(2016) C. Alix-Panabieres et al.   Cancer Discovery

Technical challenges in the isolation and analysis of circulating tumor cells

(2016) Emma E. van der Toom et al.   Oncotarget

Targeted next-generation sequencing of 22 mismatch repair genes identifies Lynch syndrome families

(2016) Bente A. Talseth-Palmer et al.   Cancer Medicine

Early detection of colorectal cancer: from conventional methods to novel biomarkers

(2015) Nasimeh Vatandoost et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Challenges in circulating tumor cell detection by the CellSearch system

(2015) Kiki C. Andree et al.   Molecular Oncology

Non-invasive sensitive detection of KRAS and BRAF mutation in circulating tumor cells of colorectal cancer patients

(2015) Nur-Afidah Mohamed Suhaimi et al.   Molecular Oncology

The consensus molecular subtypes of colorectal cancer

(2015) Justin Guinney et al.   NATURE MEDICINE

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

Microsatellite instability in colorectal cancer: clinicopathological significance

(2015) Lisa Setaffy et al.   POLISH JOURNAL OF PATHOLOGY

Immune Escape and Survival Mechanisms in Circulating Tumor Cells of Colorectal Cancer

(2014) Gunnar Steinert et al.   CANCER RESEARCH

Tests and investigations for colorectal cancer screening

(2014) Magdalen R.R. Carroll et al.   CLINICAL BIOCHEMISTRY

A Systematic Review and Meta-Analysis of Diagnostic and Prognostic Serum Biomarkers of Colorectal Cancer

(2014) Zhongyu Liu et al.   PLoS One

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

(2014) C. Bettegowda et al.   Science Translational Medicine

Colorectal cancer intrinsic subtypes predict chemotherapy benefit, deficient mismatch repair and epithelial-to-mesenchymal transition

(2013) Paul Roepman et al.   INTERNATIONAL JOURNAL OF CANCER

Poor-prognosis colon cancer is defined by a molecularly distinct subtype and develops from serrated precursor lesions

(2013) Felipe De Sousa E Melo et al.   NATURE MEDICINE

Discovery and characterization of artifactual mutations in deep coverage targeted capture sequencing data due to oxidative DNA damage during sample preparation

(2013) Maura Costello et al.   NUCLEIC ACIDS RESEARCH

Gene Expression Classification of Colon Cancer into Molecular Subtypes: Characterization, Validation, and Prognostic Value

(2013) Laetitia Marisa et al.   PLOS MEDICINE

Efficacy of a Nationwide Screening Colonoscopy Program for Colorectal Cancer

(2012) Christian P. Pox et al.   GASTROENTEROLOGY

Comprehensive molecular characterization of human colon and rectal cancer

(2012)   NATURE

Molecular Characterization of Circulating Tumor Cells in Human Metastatic Colorectal Cancer

(2012) Jorge Barbazán et al.   PLoS One

High-Throughput Droplet Digital PCR System for Absolute Quantitation of DNA Copy Number

(2011) Benjamin J. Hindson et al.   ANALYTICAL CHEMISTRY

MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?

(2011) X. Luo et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Value of Mismatch Repair, KRAS, and BRAF Mutations in Predicting Recurrence and Benefits From Chemotherapy in Colorectal Cancer

(2011) Gordon Hutchins et al.   JOURNAL OF CLINICAL ONCOLOGY

Quality Assessment and Correlation of Microsatellite Instability and Immunohistochemical Markers among Population- and Clinic-Based Colorectal Tumors

(2011) Mine S. Cicek et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Stool DNA screening for colorectal neoplasia: biological and technical basis for high detection rates

(2011) Barry M. Berger et al.   PATHOLOGY

Tumours with loss of MSH6 expression are MSI-H when screened with a pentaplex of five mononucleotide repeats

(2010) J-F You et al.   BRITISH JOURNAL OF CANCER

Microsatellite instability as a marker of prognosis and response to therapy: A meta-analysis of colorectal cancer survival data

(2010) Cecilia Guastadisegni et al.   EUROPEAN JOURNAL OF CANCER

Microsatellite Instability in Colorectal Cancer

(2010) C. Richard Boland et al.   GASTROENTEROLOGY

Defective Mismatch Repair As a Predictive Marker for Lack of Efficacy of Fluorouracil-Based Adjuvant Therapy in Colon Cancer

(2010) Daniel J. Sargent et al.   JOURNAL OF CLINICAL ONCOLOGY

Microsatellite instability in colorectal cancer—the stable evidence

(2010) Eduardo Vilar et al.   Nature Reviews Clinical Oncology

Circulating tumour cells: their utility in cancer management and predicting outcomes

(2010) Matthew G. Krebs et al.   Therapeutic Advances in Medical Oncology

Colorectal Cancer Due to Deficiency in DNA Mismatch Repair Function

(2009) Andrew M. Bellizzi et al.   ADVANCES IN ANATOMIC PATHOLOGY

Quantitative Immunochemical Fecal Occult Blood Testing for Colorectal Adenoma Detection: Evaluation in the Target Population of Screening and Comparison With Qualitative Tests

(2009) Ulrike Haug et al.   AMERICAN JOURNAL OF GASTROENTEROLOGY

Does microsatellite instability predict the efficacy of adjuvant chemotherapy in colorectal cancer? A systematic review with meta-analysis

(2009) Gaëtan Des Guetz et al.   EUROPEAN JOURNAL OF CANCER

Plasma microRNAs are promising novel biomarkers for early detection of colorectal cancer

(2009) Zhaohui Huang et al.   INTERNATIONAL JOURNAL OF CANCER

Protection From Right- and Left-Sided Colorectal Neoplasms After Colonoscopy: Population-Based Study

(2009) H. Brenner et al.   JNCI-Journal of the National Cancer Institute

Significance of Circulating Tumor Cells Detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer

(2009) M. Craig Miller et al.   Journal of Oncology

Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

(2008) Steven J. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

Immunohistochemistry versus Microsatellite Instability Testing for Screening Colorectal Cancer Patients at Risk for Hereditary Nonpolyposis Colorectal Cancer Syndrome

(2008) Liying Zhang   JOURNAL OF MOLECULAR DIAGNOSTICS

Immunohistochemistry versus Microsatellite Instability Testing For Screening Colorectal Cancer Patients at Risk For Hereditary Nonpolyposis Colorectal Cancer Syndrome

(2008) Jinru Shia   JOURNAL OF MOLECULAR DIAGNOSTICS

Molecular Classification and Correlates in Colorectal Cancer

(2007) Shuji Ogino et al.   JOURNAL OF MOLECULAR DIAGNOSTICS