Journal
OPEN BIOLOGY
Volume 9, Issue 1, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsob.180212
Keywords
microRNAs; colorectal cancer; biomarkers; diagnosis and prognosis
Categories
Funding
- National 863 High Tech Foundation [2014AA020608]
- National Key Basic Research Program of China [2013CB911303, 2011CB910703]
- National Natural Science Foundation of China [31470810]
- Science & Technology Department of Sichuan Province [2017JY0232]
- Health and Family Planning Commission of Sichuan Province [17ZD045]
- Chengdu Science and Technology Program [2017-GH02-00062-HZ]
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MicroRNAs (miRNAs) are one abundant class of small, endogenous non-coding RNAs, which regulate various biological processes by inhibiting expression of target genes. miRNAs have important functional roles in carcinogenesis and development of colorectal cancer (CRC), and emerging evidence has indicated the feasibility of miRNAs as robust cancer biomarkers. This review summarizes the progress in miRNA-related research, including study of its oncogene or tumour-suppressor roles and the advantages of miRNA-biomarkers for CRC diagnosis, treatment and recurrence prediction. Along with analytical technique improvements in miRNA research, use of the emerging extracellular miRNAs is feasible for CRC diagnosis and prognosis.
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