Zebrafish as a Useful Model to Study Oxidative Stress-Linked Disorders: Focus on Flavonoids

Antioxidant Effects of Turmeric Leaf Extract against Hydrogen Peroxide-Induced Oxidative Stress In Vitro in Vero Cells and In Vivo in Zebrafish

(2021) Sera Kim et al.   Antioxidants

A White Grape Juice Extract Reduces Fat Accumulation through the Modulation of Ghrelin and Leptin Expression in an In Vivo Model of Overfed Zebrafish

(2021) Giuseppe Montalbano et al.   MOLECULES

Nutraceuticals against Oxidative Stress in Autoimmune Disorders

(2021) Carmen Mannucci et al.   Antioxidants

Deguelin targets multiple oncogenic signaling pathways to combat human malignancies

(2021) Hardeep Singh Tuli et al.   PHARMACOLOGICAL RESEARCH

The Zebrafish Xenograft Models for Investigating Cancer and Cancer Therapeutics

(2021) John T. Gamble et al.   Biology-Basel

Anti-inflammatory effect of a flavonoid-rich extract of orange juice in adult zebrafish subjected to Vibrio anguillarum-induced enteritis

(2020) Santa Cirmi et al.   NATURAL PRODUCT RESEARCH

Neuroprotective Effect of Bergamot Juice in 6-OHDA-Induced SH-SY5Y Cell Death, an In Vitro Model of Parkinson’s Disease

(2020) Nadia Ferlazzo et al.   Pharmaceutics

Eupatilin Promotes Cell Death by Calcium Influx through ER-Mitochondria Axis with SERPINB11 Inhibition in Epithelial Ovarian Cancer

(2020) Jin-Young Lee et al.   Cancers

Treatment With a Flavonoid-Rich Fraction of Bergamot Juice Improved Lipopolysaccharide-Induced Periodontitis in Rats

(2019) Enrico Gugliandolo et al.   Frontiers in Pharmacology

Antioxidant Activities of Quercetin and Its Complexes for Medicinal Application

(2019) Dong Xu et al.   MOLECULES

A flavonoid-rich extract from bergamot juice prevents carcinogenesis in a genetic model of colorectal cancer, the Pirc rat (F344/NTac-Apcam1137)

(2019) Michele Navarra et al.   EUROPEAN JOURNAL OF NUTRITION

Citrus fruits and their flavonoids in inflammatory bowel disease: an overview

(2019) Laura Musumeci et al.   NATURAL PRODUCT RESEARCH

Agathisflavone isolated from Schinus polygamus (Cav.) Cabrera leaves prevents scopolamine-induced memory impairment and brain oxidative stress in zebrafish (Danio rerio)

(2019) Gabriela Dumitru et al.   PHYTOMEDICINE

The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

(2019) Alessandro Maugeri et al.   PHYTOTHERAPY RESEARCH

Citrus fruits and inflammaging: a systematic review

(2019) Alessandro Maugeri et al.   PHYTOCHEMISTRY REVIEWS

Polyphenol Characterization, Antioxidant and Skin Whitening Properties of Alnus cordata Stem Bark

(2019) Antonella Smeriglio et al.   CHEMISTRY & BIODIVERSITY

Ethnopharmacology, Phytochemistry, Pharmacology, Toxicology and Clinical Applications of Radix Astragali

(2019) Chun-hong Zhang et al.   Chinese Journal of Integrative Medicine

Effects of a Flavonoid-Rich Extract from Citrus sinensis Juice on a Diet-Induced Obese Zebrafish

(2019) Giuseppe Montalbano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zebrafish Models of Cancer—New Insights on Modeling Human Cancer in a Non-Mammalian Vertebrate

(2019) Hason et al.   Genes

Pharmacological basis and new insights of quercetin action in respect to its anti-cancer effects

(2019) Si-Min Tang et al.   BIOMEDICINE & PHARMACOTHERAPY

Pinostrobin exerts neuroprotective actions in neurotoxin-induced Parkinson’s disease models through Nrf2 induction

(2018) Chuwen Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Therapeutic evaluation of solid lipid nanoparticle of quercetin in pentylenetetrazole induced cognitive impairment of zebrafish

(2018) Narahari Rishitha et al.   LIFE SCIENCES

Naringin attenuates alcoholic liver injury by reducing lipid accumulation and oxidative stress

(2018) Chuying Zhou et al.   LIFE SCIENCES

Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

(2018) Santa Cirmi et al.   PHARMACOLOGICAL RESEARCH

Clinical Pharmacology of Citrus aurantium and Citrus sinensis for the Treatment of Anxiety

(2018) Carmen Mannucci et al.   Evidence-based Complementary and Alternative Medicine

Effectiveness ofCitrusFruits onHelicobacter pylori

(2017) Giuseppina Mandalari et al.   Evidence-based Complementary and Alternative Medicine

A flavonoid-rich extract of orange juice reduced oxidative stress in an experimental model of inflammatory bowel disease

(2017) Roberta Fusco et al.   Journal of Functional Foods

Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

(2017) Santa Cirmi et al.   Frontiers in Pharmacology

Natural iron chelators: Protective role in A549 cells of flavonoids-rich extracts of Citrus juices in Fe 3+ -induced oxidative stress

(2016) Nadia Ferlazzo et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?

(2016) Nadia Ferlazzo et al.   MOLECULES

The Anticonvulsant Activity of a Flavonoid-Rich Extract from Orange Juice Involves both NMDA and GABA-Benzodiazepine Receptor Complexes

(2016) Rita Citraro et al.   MOLECULES

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

(2016) Santa Cirmi et al.   MOLECULES

Advancements in zebrafish applications for 21st century toxicology

(2016) Gloria R. Garcia et al.   PHARMACOLOGY & THERAPEUTICS

Clinical Pharmacology ofCitrus bergamia: A Systematic Review

(2016) Carmen Mannucci et al.   PHYTOTHERAPY RESEARCH

Comparative Developmental Toxicity of Flavonoids Using an Integrative Zebrafish System

(2016) Sean M. Bugel et al.   TOXICOLOGICAL SCIENCES

Developing a Novel Embryo–Larval Zebrafish Xenograft Assay to Prioritize Human Glioblastoma Therapeutics

(2016) Leah Christine Wehmas et al.   Zebrafish

Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways

(2016) Monica Currò et al.   Scientific Reports

In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori

(2015) Angela Filocamo et al.   BMC Complementary and Alternative Medicine

Neuroprotective effects of a polyphenolic white grape juice extract in a mouse model of experimental autoimmune encephalomyelitis

(2015) Sabrina Giacoppo et al.   FITOTERAPIA

Flavonoid Fraction ofCitrus ReticulataJuice Reduces Proliferation and Migration of Anaplastic Thyroid Carcinoma Cells

(2015) Marilena Celano et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis

(2014) Masanori Hiramitsu et al.   Scientific Reports

Inhibitory effects of quercetin on angiogenesis in larval zebrafish and human umbilical vein endothelial cells

(2013) Daxian Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Evaluation of the Anti-Inflammatory Effect of Chalcone and Chalcone Analogues in a Zebrafish Model

(2013) Yau-Hung Chen et al.   MOLECULES

Flavones induce neutrophil apoptosis by down-regulation of Mcl-1 via a proteasomal-dependent pathway

(2012) Christopher D. Lucas et al.   FASEB JOURNAL

In vivo UVB-photoprotective activity of extracts from commercial marine macroalgae

(2012) María Guinea et al.   FOOD AND CHEMICAL TOXICOLOGY

Evaluation of the structure–activity relationship of flavonoids as antioxidants and toxicants of zebrafish larvae

(2012) Yau-Hung Chen et al.   FOOD CHEMISTRY

Quercitrin protects against ultraviolet B-induced cell death in vitro and in an in vivo zebrafish model

(2012) Hye-Mi Yang et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Anti-Inflammatory Trends of 1, 3-Diphenyl-2-propen-1-one Derivatives

(2012) Syed Nasir Abbas Bukhari et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

In vitro and in vivo structure and activity relationship analysis of polymethoxylated flavonoids: Identifying sinensetin as a novel antiangiogenesis agent

(2012) In Kei Lam et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Quercetin-4′-O-β-D-glucopyranoside (QODG) Inhibits Angiogenesis by Suppressing VEGFR2-Mediated Signaling in Zebrafish and Endothelial Cells

(2012) Chen Lin et al.   PLoS One

Quercetin 3-O-methyl ether protects FL83B cells from copper induced oxidative stress through the PI3K/Akt and MAPK/Erk pathway

(2012) Hsiao-Ling Tseng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Nobiletin, a polymethoxylated flavonoid from citrus, shows anti-angiogenic activity in a zebrafish in vivo model and HUVEC in vitro model

(2011) Kai Heng Lam et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Anti-tumor and anti-angiogenic effects of Macrothelypteris viridifrons and its constituents by HPLC–DAD/MS analysis

(2011) Anhua Wei et al.   JOURNAL OF ETHNOPHARMACOLOGY

Sunscreens: An overview and update

(2011) Divya R. Sambandan et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Transcriptional profiling of angiogenesis activities of calycosin in zebrafish

(2011) Shang Li et al.   Molecular BioSystems

Flavonoids from the aerial parts ofMacrothelypteris torresiana

(2011) Wei Fang et al.   NATURAL PRODUCT RESEARCH

Large Scale Zebrafish-Based In vivo Small Molecule Screen

(2011) Jijun Hao et al.   Jove-Journal of Visualized Experiments

Apoptotic effect of citrus fruit extract nobiletin on lung cancer cell line A549 in vitro and in vivo

(2010) Gang Luo et al.   CANCER BIOLOGY & THERAPY

Plant Polyphenols as Dietary Antioxidants in Human Health and Disease

(2010) Kanti Bhooshan Pandey et al.   Oxidative Medicine and Cellular Longevity

Calycosin Promotes Angiogenesis Involving Estrogen Receptor and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathway in Zebrafish and HUVEC

(2010) Jing Yan Tang et al.   PLoS One

Two new flavanone glycosides from Macrothelypteris torresiana (Gaud.) Ching

(2009) Wei Fu et al.   CHINESE CHEMICAL LETTERS

A novel flavonoid from the root of Macrothelypteris torresiana (Gaud.) Ching

(2009) Ying Tang et al.   CHINESE CHEMICAL LETTERS

Guidance of Vascular Development

(2009) Bruno Larrivée et al.   CIRCULATION RESEARCH

A Chinese Herbal Decoction, Danggui Buxue Tang, Stimulates Proliferation, Differentiation and Gene Expression of Cultured Osteosarcoma Cells: Genomic Approach to Reveal Specific Gene Activation

(2009) Roy C. Y. Choi et al.   Evidence-based Complementary and Alternative Medicine

The power of the zebrafish for disease analysis

(2009) P. W. Ingham   HUMAN MOLECULAR GENETICS

Suppressive effects of nobiletin on hyperleptinemia and colitis-related colon carcinogenesis in male ICR mice

(2008) Shingo Miyamoto et al.   CARCINOGENESIS

The latest on skin photoprotection

(2008) Salvador González et al.   CLINICS IN DERMATOLOGY

Nobiletin, a Citrus Flavonoid, Improves Memory Impairment and A  Pathology in a Transgenic Mouse Model of Alzheimer's Disease

(2008) H. Onozuka et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Skin DNA photodamage and its biological consequences

(2008) Laurent Marrot et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Development of a Whole-organism Model to Screen New Compounds for Sun Protection

(2008) Yun-Hsin Wang et al.   MARINE BIOTECHNOLOGY

Downregulation of Melanin Synthesis by Haginin A and Its Application to In Vivo Lightening Model

(2007) Jin Hee Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY