Zebrafish Models of Cancer—New Insights on Modeling Human Cancer in a Non-Mammalian Vertebrate

Bromelain inhibits the ability of colorectal cancer cells to proliferate via activation of ROS production and autophagy

(2019) Tung-Cheng Chang et al.   PLoS One

Genotypic and Phenotypic Variables Affect Meiotic Cell Cycle Progression, Tumor Ploidy, and Cancer-Associated Mortality in a brca2-Mutant Zebrafish Model

(2019) L. Mensah et al.   Journal of Oncology

Combination Therapy of Chloroquine and C2-Ceramide Enhances Cytotoxicity in Lung Cancer H460 and H1299 Cells

(2019) Han-Lin Chou et al.   Cancers

Anti-Invasion and Antiangiogenic Effects of Stellettin B through Inhibition of the Akt/Girdin Signaling Pathway and VEGF in Glioblastoma Cells

(2019) Shu-Yu Cheng et al.   Cancers

Characterization of immune responses to anti-PD-1 mono and combination immunotherapy in hematopoietic humanized mice implanted with tumor xenografts

(2019) A. Capasso et al.   Journal for ImmunoTherapy of Cancer

CXCR4 signaling regulates metastatic onset by controlling neutrophil motility and response to malignant cells

(2019) C. Tulotta et al.   Scientific Reports

Enhanced Cas12a editing in mammalian cells and zebrafish

(2019) Pengpeng Liu et al.   NUCLEIC ACIDS RESEARCH

Engineered CRISPR–Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing

(2019) Benjamin P. Kleinstiver et al.   NATURE BIOTECHNOLOGY

Effects of sex hormones on liver tumor progression and regression in Myc/xmrk double oncogene transgenic zebrafish

(2019) Hankun Li et al.   GENERAL AND COMPARATIVE ENDOCRINOLOGY

Leptin induces muscle wasting in a zebrafish kras-driven hepatocellular carcinoma (HCC) model

(2019) Qiqi Yang et al.   Disease Models & Mechanisms

Studying the Fate of Tumor Extracellular Vesicles at High Spatiotemporal Resolution Using the Zebrafish Embryo

(2019) Vincent Hyenne et al.   DEVELOPMENTAL CELL

Visualizing Engrafted Human Cancer and Therapy Responses in Immunodeficient Zebrafish

(2019) Chuan Yan et al.   CELL

Automated in vivo screen in zebrafish identifies Clotrimazole as targeting a metabolic vulnerability in a melanoma model

(2019) Francesca Precazzini et al.   DEVELOPMENTAL BIOLOGY

Modeling Cancer with Flies and Fish

(2019) Ross L. Cagan et al.   DEVELOPMENTAL CELL

Epigenetic modifiers as new immunomodulatory therapies in solid tumours

(2018) S Aspeslagh et al.   ANNALS OF ONCOLOGY

Improving zebrafish embryo xenotransplantation conditions by increasing incubation temperature and establishing a proliferation index with ZFtool

(2018) Pablo Cabezas-Sainz et al.   BMC CANCER

A novel zebrafish intestinal tumor model reveals a role for cyp7a1 -dependent tumor–liver crosstalk in causing adverse effects on the host

(2018) Sora Enya et al.   Disease Models & Mechanisms

Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

(2018) Laura E. Schultz et al.   Disease Models & Mechanisms

Optimized CRISPR-Cpf1 system for genome editing in zebrafish

(2018) Juan P. Fernandez et al.   METHODS

Genome editing by natural and engineered CRISPR-associated nucleases

(2018) Wen Y. Wu et al.   Nature Chemical Biology

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

(2018) Lu Wang et al.   NATURE MEDICINE

An orthotopic glioblastoma animal model suitable for high-throughput screenings

(2018) Linda Pudelko et al.   NEURO-ONCOLOGY

Cancer modeling by Transgene Electroporation in Adult Zebrafish (TEAZ)

(2018) Scott J. Callahan et al.   Disease Models & Mechanisms

Humanized Mice for the Study of Immuno-Oncology

(2018) Philippe De La Rochere et al.   TRENDS IN IMMUNOLOGY

Comparison of efficacy and toxicity of bevacizumab, endostar and apatinib in transgenic and human lung cancer xenograftzebrafish model

(2018) Yinghua Jin et al.   Scientific Reports

tp53 deficiency causes a wide tumor spectrum and increases embryonal rhabdomyosarcoma metastasis in zebrafish

(2018) Myron S Ignatius et al.   eLife

Zebrafish model of KRAS-initiated pancreatic cancer

(2018) Joon Tae Park et al.   Animal Cells and Systems

Zebrafish: Speeding Up the Cancer Drug Discovery Process

(2018) Patricia Letrado et al.   CANCER RESEARCH

Ribose-5-phosphate isomerase A overexpression promotes liver cancer development in transgenic zebrafish via activation of ERK and β-catenin pathways

(2018) Yu-Ting Chou et al.   CARCINOGENESIS

The Power of Fish Models to Elucidate Skin Cancer Pathogenesis and Impact the Discovery of New Therapeutic Opportunities

(2018) Sreeja Sarasamma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sandensolide Induces Oxidative Stress-Mediated Apoptosis in Oral Cancer Cells and in Zebrafish Xenograft Model

(2018) Chung-I Yu et al.   Marine Drugs

Human tumor genomics and zebrafish modeling identify SPRED1 loss as a driver of mucosal melanoma

(2018) Julien Ablain et al.   SCIENCE

Triphala Suppresses Growth and Migration of Human Gastric Carcinoma Cells In Vitro and in a Zebrafish Xenograft Model

(2018) Jokyab Tsering et al.   Biomed Research International

Inducible Intestine-Specific Expression of kras Triggers Intestinal Tumorigenesis In Transgenic Zebrafish

(2018) Jeng-Wei Lu et al.   NEOPLASIA

Ras-Induced miR-146a and 193a Target Jmjd6 to Regulate Melanoma Progression

(2018) Viviana Anelli et al.   Frontiers in Genetics

An efficient method to generate xenograft tumor models of acute myeloid leukemia and hepatocellular carcinoma in adult zebrafish

(2018) Nusrat Khan et al.   BLOOD CELLS MOLECULES AND DISEASES

Zebrafish xenograft models of cancer and metastasis for drug discovery

(2017) Hannah K Brown et al.   Expert Opinion on Drug Discovery

Interleukin 8 mediates bcl-xL-induced enhancement of human melanoma cell dissemination and angiogenesis in a zebrafish xenograft model

(2017) Chiara Gabellini et al.   INTERNATIONAL JOURNAL OF CANCER

Roadmap for investigating epigenome deregulation and environmental origins of cancer

(2017) Zdenko Herceg et al.   INTERNATIONAL JOURNAL OF CANCER

Characterization of prostate cancer cell progression in zebrafish xenograft model

(2017) Wei Xu et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Patient-derived xenograft in zebrafish embryos: a new platform for translational research in gastric cancer

(2017) Jia-Qi Wu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Beyond mouse cancer models: Three-dimensional human-relevant in vitro and non-mammalian in vivo models for photodynamic therapy

(2017) Malgorzata Kucinska et al.   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

PRMT5 as a druggable target for glioblastoma therapy

(2017) Yeshavanth Kumar Banasavadi-Siddegowda et al.   NEURO-ONCOLOGY

Changes in tumor cell heterogeneity after chemotherapy treatment in a xenograft model of glioblastoma

(2017) Alessandra M. Welker et al.   NEUROSCIENCE

Single-cell functional and chemosensitive profiling of combinatorial colorectal therapy in zebrafish xenografts

(2017) Rita Fior et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intratumor and Intertumor Heterogeneity in Melanoma

(2017) Tomasz M. Grzywa et al.   Translational Oncology

Combination Targeted Therapy to Disrupt Aberrant Oncogenic Signaling and Reverse Epigenetic Dysfunction in IDH2 - and TET2 -Mutant Acute Myeloid Leukemia

(2017) Alan H. Shih et al.   Cancer Discovery

Development of zebrafish medulloblastoma-like PNET model by TALEN-mediated somatic gene inactivation

(2017) Jaegal Shim et al.   Oncotarget

Enzalutamide inhibits testosterone-induced growth of human prostate cancer xenografts in zebrafish and can induce bradycardia

(2017) Nicole Melong et al.   Scientific Reports

Identify a Blood-Brain Barrier Penetrating Drug-TNB using Zebrafish Orthotopic Glioblastoma Xenograft Model

(2017) Anqi Zeng et al.   Scientific Reports

Oncogenic BRAF disrupts thyroid morphogenesis and function via twist expression

(2017) Viviana Anelli et al.   eLife

Zebrafish in Translational Cancer Research: Insight into Leukemia, Melanoma, Glioma and Endocrine Tumor Biology

(2017) et al.   Genes

RECQ1 Helicase Silencing Decreases the Tumour Growth Rate of U87 Glioblastoma Cell Xenografts in Zebrafish Embryos

(2017) Miloš Vittori et al.   Genes

The Potential of Zebrafish as a Model Organism for Improving the Translation of Genetic Anticancer Nanomedicines

(2017) C Gutiérrez-Lovera et al.   Genes

Modeling Myeloid Malignancies Using Zebrafish

(2017) Kathryn S. Potts et al.   Frontiers in Oncology

Quo natas, Danio?—Recent Progress in Modeling Cancer in Zebrafish

(2017) Stefanie Kirchberger et al.   Frontiers in Oncology

Comparison of Zebrafish tmem88a mutant and morpholino knockdown phenotypes

(2017) Alexander M. J. Eve et al.   PLoS One

A clinically relevant in vivo zebrafish model of human multiple myeloma to study preclinical therapeutic efficacy

(2016) J. Lin et al.   BLOOD

The challenges of tumor genetic diversity

(2016) Edmund A. Mroz et al.   CANCER

Cancer Cell Dissemination and Homing to the Bone Marrow in a Zebrafish Model

(2016) Antonio Sacco et al.   CANCER RESEARCH

Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes

(2016) Alexa Burger et al.   DEVELOPMENT

Inhibition of signaling between human CXCR4 and zebrafish ligands by the small molecule IT1t impairs the formation of triple-negative breast cancer early metastases in a zebrafish xenograft model

(2016) Claudia Tulotta et al.   Disease Models & Mechanisms

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies

(2016) Michelle Dang et al.   Disease Models & Mechanisms

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A zebrafish melanoma model reveals emergence of neural crest identity during melanoma initiation

(2016) C. K. Kaufman et al.   SCIENCE

Imaging tumour cell heterogeneity following cell transplantation into optically clear immune-deficient zebrafish

(2016) Qin Tang et al.   Nature Communications

Marine guanidine alkaloids crambescidins inhibit tumor growth and activate intrinsic apoptotic signaling inducing tumor regression in a colorectal carcinoma zebrafish xenograft model

(2016) María Roel et al.   Oncotarget

Smad6 determines BMP-regulated invasive behaviour of breast cancer cells in a zebrafish xenograft model

(2016) Miriam de Boeck et al.   Scientific Reports

Preclinical validation of the small molecule drug quininib as a novel therapeutic for colorectal cancer

(2016) Adrian G. Murphy et al.   Scientific Reports

Molecular landscape of acute myeloid leukemia in younger adults and its clinical relevance

(2015) D. Grimwade et al.   BLOOD

A Quantitative System for Studying Metastasis Using Transparent Zebrafish

(2015) S. Heilmann et al.   CANCER RESEARCH

The melanocyte lineage in development and disease

(2015) R. L. Mort et al.   DEVELOPMENT

Making Sense of Anti-Sense Data

(2015) Didier Y.R. Stainier et al.   DEVELOPMENTAL CELL

A CRISPR/Cas9 Vector System for Tissue-Specific Gene Disruption in Zebrafish

(2015) Julien Ablain et al.   DEVELOPMENTAL CELL

Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish

(2015) Fatma O. Kok et al.   DEVELOPMENTAL CELL

Zebrafish xenotransplantation as a tool for in vivo cancer study

(2015) Beibei Zhang et al.   Familial Cancer

A fresh look at zebrafish from the perspective of cancer research

(2015) Shuai Zhao et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Zebrafish as a model for leukemia and other hematopoietic disorders

(2015) Parisa Rasighaemi et al.   Journal of Hematology & Oncology

Cross-species models of human melanoma

(2015) Louise van der Weyden et al.   JOURNAL OF PATHOLOGY

Epigenetic therapy restores normal hematopoiesis in a zebrafish model of NUP98–HOXA9-induced myeloid disease

(2015) A P Deveau et al.   LEUKEMIA

Genetic compensation induced by deleterious mutations but not gene knockdowns

(2015) Andrea Rossi et al.   NATURE

Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth

(2015) Jiajun Zhu et al.   NATURE

CRISPRscan: designing highly efficient sgRNAs for CRISPR-Cas9 targeting in vivo

(2015) Miguel A Moreno-Mateos et al.   NATURE METHODS

Molecular and functional interactions between AKT and SOX2 in breast carcinoma

(2015) Thorsten Schaefer et al.   Oncotarget

Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model

(2015) Xiaoyun Chen et al.   Scientific Reports

Rapid tumor induction in zebrafish by TALEN-mediated somatic inactivation of the retinoblastoma1 tumor suppressor rb1

(2015) Staci L. Solin et al.   Scientific Reports

Zebrafish as a Model for the Study of Human Myeloid Malignancies

(2015) Jeng-Wei Lu et al.   Biomed Research International

Current Challenges in Glioblastoma: Intratumour Heterogeneity, Residual Disease, and Models to Predict Disease Recurrence

(2015) Hayley P. Ellis et al.   Frontiers in Oncology

Expression of stemness genes in primary breast cancer tissues: the role of SOX2 as a prognostic marker for detection of early recurrence

(2015) Mauro Finicelli et al.   Oncotarget

Targeting epigenetic regulators for cancer therapy

(2014) Susan Wee et al.   Annals of the New York Academy of Sciences

Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia

(2014) B.-L. He et al.   BLOOD

Mouse Models of Human Cancer

(2014) Barbara C. Böck et al.   CANCER RESEARCH

SYK Is a Candidate Kinase Target for the Treatment of Advanced Prostate Cancer

(2014) V. P. S. Ghotra et al.   CANCER RESEARCH

The zebrafish/tumor xenograft angiogenesis assay as a tool for screening anti-angiogenic miRNAs

(2014) Elena Chiavacci et al.   CYTOTECHNOLOGY

Hooking the big one: the potential of zebrafish xenotransplantation to reform cancer drug screening in the genomic era

(2014) C. J. Veinotte et al.   Disease Models & Mechanisms

Focused chemical genomics using zebrafish xenotransplantation as a pre-clinical therapeutic platform for T-cell acute lymphoblastic leukemia

(2014) V. L. Bentley et al.   HAEMATOLOGICA

Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia

(2014) Alejandro Gutierrez et al.   JOURNAL OF CLINICAL INVESTIGATION

Ewing sarcoma inhibition by disruption of EWSR1-FLI1 transcriptional activity and reactivation of p53

(2014) Wietske van der Ent et al.   JOURNAL OF PATHOLOGY

CRISPR/Cas9 and TALEN-mediated knock-in approaches in zebrafish

(2014) Thomas O. Auer et al.   METHODS

A Zebrafish Model of Myelodysplastic Syndrome Produced throughtet2Genomic Editing

(2014) Evisa Gjini et al.   MOLECULAR AND CELLULAR BIOLOGY

An In Vivo Antilymphatic Screen in Zebrafish Identifies Novel Inhibitors of Mammalian Lymphangiogenesis and Lymphatic-Mediated Metastasis

(2014) J. W. Astin et al.   MOLECULAR CANCER THERAPEUTICS

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

 1 Integrin Inhibition Elicits a Prometastatic Switch Through the TGF -miR-200-ZEB Network in E-Cadherin-Positive Triple-Negative Breast Cancer

(2014) H. H. Truong et al.   Science Signaling

Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors

(2014) Beibei Zhang et al.   TUMOR BIOLOGY

Snail and Slug, key regulators of TGF-β-induced EMT, are sufficient for the induction of single-cell invasion

(2013) Hildegonda P.H. Naber et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Evaluating human cancer cell metastasis in zebrafish

(2013) Yong Teng et al.   BMC CANCER

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo

(2013) James A. Lister et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The zebrafish reference genome sequence and its relationship to the human genome

(2013) Kerstin Howe et al.   NATURE

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer

(2013) Christoph Plass et al.   NATURE REVIEWS GENETICS

The Histone Methyltransferase SUV39H1 Suppresses Embryonal Rhabdomyosarcoma Formation in Zebrafish

(2013) Colleen E. Albacker et al.   PLoS One

Zebrafish screen identifies novel compound with selective toxicity against leukemia

(2012) S. Ridges et al.   BLOOD

Cancer Epigenetics: From Mechanism to Therapy

(2012) Mark A. Dawson et al.   CELL

Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development

(2012) J. Shin et al.   Disease Models & Mechanisms

Alternative TEL-JAK2 fusions associated with T-cell acute lymphoblastic leukemia and atypical chronic myelogenous leukemia dissected in zebrafish

(2012) S. M. N. Onnebo et al.   HAEMATOLOGICA

Neutrophil-mediated experimental metastasis is enhanced by VEGFR inhibition in a zebrafish xenograft model

(2012) Shuning He et al.   JOURNAL OF PATHOLOGY

In vivo genome editing using a high-efficiency TALEN system

(2012) Victoria M. Bedell et al.   NATURE

Automated Whole Animal Bio-Imaging Assay for Human Cancer Dissemination

(2012) Veerander P. S. Ghotra et al.   PLoS One

Small molecule screening in zebrafish: swimming in potential drug therapies

(2012) Owen J. Tamplin et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Molecular conservation of estrogen-response associated with cell cycle regulation, hormonal carcinogenesis and cancer in zebrafish and human cancer cell lines

(2011) Siew Hong Lam et al.   BMC Medical Genomics

Leukaemia xenotransplantation in zebrafish - chemotherapy response assay in vivo

(2011) Dale P. Corkery et al.   BRITISH JOURNAL OF HAEMATOLOGY

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Xenografts in zebrafish embryos as a rapid functional assay for breast cancer stem-like cell identification

(2011) Arrate Eguiara et al.   CELL CYCLE

Leukemic cell xenograft in zebrafish embryo for investigating drug efficacy

(2011) B. Pruvot et al.   HAEMATOLOGICA

DHODH modulates transcriptional elongation in the neural crest and melanoma

(2011) Richard Mark White et al.   NATURE

The histone methyltransferase SETDB1 is recurrently amplified in melanoma and accelerates its onset

(2011) Craig J. Ceol et al.   NATURE

Heritable gene targeting in zebrafish using customized TALENs

(2011) Peng Huang et al.   NATURE BIOTECHNOLOGY

Identification of phosphorylase kinase as a novel therapeutic target through high-throughput screening for anti-angiogenesis compounds in zebrafish

(2011) S Camus et al.   ONCOGENE

A Novel Xenograft Model in Zebrafish for High-Resolution Investigating Dynamics of Neovascularization in Tumors

(2011) Chengjian Zhao et al.   PLoS One

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia

(2010) A. C. H. Smith et al.   BLOOD

Expression of the cytoplasmic NPM1 mutant (NPMc+) causes the expansion of hematopoietic cells in zebrafish

(2010) N. Bolli et al.   BLOOD

Rosuvastatin, Identified From a Zebrafish Chemical Genetic Screen for Antiangiogenic Compounds, Suppresses the Growth of Prostate Cancer

(2010) Chunyang Wang et al.   EUROPEAN UROLOGY

Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders

(2010) Thomas Ernst et al.   NATURE GENETICS

Kita Driven Expression of Oncogenic HRAS Leads to Early Onset and Highly Penetrant Melanoma in Zebrafish

(2010) Cristina Santoriello et al.   PLoS One

brca2 in zebrafish ovarian development, spermatogenesis, and tumorigenesis

(2010) H. R. Shive et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zebrafish Tumor Assays: The State of Transplantation

(2010) Alison M. Taylor et al.   Zebrafish

Metastatic behaviour of primary human tumours in a zebrafish xenotransplantation model

(2009) Ines J Marques et al.   BMC CANCER

Zebrafish modelling of leukaemias

(2009) Elspeth Payne et al.   BRITISH JOURNAL OF HAEMATOLOGY

Rb Regulates DNA Damage Response and Cellular Senescence through E2F-Dependent Suppression of N-Ras Isoprenylation

(2009) Awad Shamma et al.   CANCER CELL

Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex

(2009) M. A. King et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Characterization of zebrafish larval inflammatory macrophages

(2009) Jonathan R. Mathias et al.   DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY

Polycomb Group Protein Enhancer of Zeste 2 Is an Oncogene That Promotes the Neoplastic Transformation of a Benign Prostatic Epithelial Cell Line

(2009) B. D.W. Karanikolas et al.   MOLECULAR CANCER RESEARCH

Melanoma Biology and the Promise of Zebrafish

(2009) Craig J. Ceol et al.   Zebrafish

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival

(2008) F. Dayyani et al.   BLOOD

MOZ/TIF2-induced acute myeloid leukaemia in transgenic fish

(2008) Julia Zhuravleva et al.   BRITISH JOURNAL OF HAEMATOLOGY

Transparent Adult Zebrafish as a Tool for In Vivo Transplantation Analysis

(2008) Richard Mark White et al.   Cell Stem Cell

Expression of H-RASV12 in a zebrafish model of Costello syndrome causes cellular senescence in adult proliferating cells

(2008) C. Santoriello et al.   Disease Models & Mechanisms

Oncogenic KRAS Induces Progenitor Cell Expansion and Malignant Transformation in Zebrafish Exocrine Pancreas

(2008) Seung Woo Park et al.   GASTROENTEROLOGY

Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

(2008) Yannick Doyon et al.   NATURE BIOTECHNOLOGY

An embryonic stem cell–like gene expression signature in poorly differentiated aggressive human tumors

(2008) Ittai Ben-Porath et al.   NATURE GENETICS

Co-injection strategies to modify radiation sensitivity and tumor initiation in transgenic Zebrafish

(2008) D M Langenau et al.   ONCOGENE