The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

Citrus fruits intake and oral cancer risk: A systematic review and meta-analysis

(2018) Santa Cirmi et al.   PHARMACOLOGICAL RESEARCH

Sirtuin activators and inhibitors: Promises, achievements, and challenges

(2018) Han Dai et al.   PHARMACOLOGY & THERAPEUTICS

Naringin Activates AMPK Resulting in Altered Expression of SREBPs, PCSK9, and LDLR To Reduce Body Weight in Obese C57BL/6J Mice

(2018) Guo-Guang Sui et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chronic Silymarin, Quercetin and Naringenin Treatments Increase Monoamines Synthesis and Hippocampal Sirt1 Levels Improving Cognition in Aged Rats

(2017) F. Sarubbo et al.   Journal of Neuroimmune Pharmacology

Neohesperidin Exerts Lipid-Regulating Effects in vitro and in vivo via Fibroblast Growth Factor 21 and AMP-Activated Protein Kinase/Sirtuin Type 1/Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1α Signaling Axis

(2017) Haoshu Wu et al.   PHARMACOLOGY

Anticancer Potential of Citrus Juices and Their Extracts: A Systematic Review of Both Preclinical and Clinical Studies

(2017) Santa Cirmi et al.   Frontiers in Pharmacology

Natural iron chelators: Protective role in A549 cells of flavonoids-rich extracts of Citrus juices in Fe 3+ -induced oxidative stress

(2016) Nadia Ferlazzo et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

NF-κB mediates the antiproliferative and proapoptotic effects of bergamot juice in HepG2 cells

(2016) Nadia Ferlazzo et al.   LIFE SCIENCES

Anti-Inflammatory Activity of Citrus bergamia Derivatives: Where Do We Stand?

(2016) Nadia Ferlazzo et al.   MOLECULES

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

(2016) Santa Cirmi et al.   MOLECULES

Clinical Pharmacology ofCitrus bergamia: A Systematic Review

(2016) Carmen Mannucci et al.   PHYTOTHERAPY RESEARCH

Anti-infective potential ofCitrus bergamiaRisso et Poiteau (bergamot) derivatives: a systematic review

(2016) Santa Cirmi et al.   PHYTOTHERAPY RESEARCH

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

(2016) Santa Cirmi et al.   Nutrients

Citrus bergamia Juice Extract Attenuates β-Amyloid-Induced Pro-Inflammatory Activation of THP-1 Cells Through MAPK and AP-1 Pathways

(2016) Monica Currò et al.   Scientific Reports

Anti-inflammatory and Antioxidant Effects of Flavonoid-Rich Fraction of Bergamot Juice (BJe) in a Mouse Model of Intestinal Ischemia/Reperfusion Injury

(2016) Daniela Impellizzeri et al.   Frontiers in Pharmacology

In vitro effect of bergamot (Citrus bergamia) juice against cagA-positive and-negative clinical isolates of Helicobacter pylori

(2015) Angela Filocamo et al.   BMC Complementary and Alternative Medicine

Citrus fruits as a treasure trove of active natural metabolites that potentially provide benefits for human health

(2015) Xinmiao Lv et al.   Chemistry Central Journal

The anti-inflammatory and antioxidant effects of bergamot juice extract (BJe) in an experimental model of inflammatory bowel disease

(2015) Daniela Impellizzeri et al.   CLINICAL NUTRITION

Flavonoid Fraction of Orange and Bergamot Juices Protect Human Lung Epithelial Cells from Hydrogen Peroxide-Induced Oxidative Stress

(2015) Nadia Ferlazzo et al.   Evidence-based Complementary and Alternative Medicine

Effects of bergamot essential oil and its extractive fractions on SH-SY5Y human neuroblastoma cell growth

(2015) Michele Navarra et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Bergamot Juice Extract Inhibits Proliferation by Inducing Apoptosis in Human Colon Cancer Cells

(2014) Giuseppa Visalli et al.   Anti-Cancer Agents in Medicinal Chemistry

Flavonoid Fraction of Bergamot Juice Reduces LPS-Induced Inflammatory Response through SIRT1-Mediated NF-κB Inhibition in THP-1 Monocytes

(2014) Roberto Risitano et al.   PLoS One

The 2.5 Å Crystal Structure of the SIRT1 Catalytic Domain Bound to Nicotinamide Adenine Dinucleotide (NAD+) and an Indole (EX527 Analogue) Reveals a Novel Mechanism of Histone Deacetylase Inhibition

(2013) Xun Zhao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mechanisms Underlying the Anti-Tumoral Effects of Citrus bergamia Juice

(2013) Simona Delle Monache et al.   PLoS One

Chemistry and Biological Activities of Flavonoids: An Overview

(2013) Shashank Kumar et al.   TheScientificWorldJOURNAL

Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase

(2012) Veronica Nin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LigPlot+: Multiple Ligand–Protein Interaction Diagrams for Drug Discovery

(2011) Roman A. Laskowski et al.   Journal of Chemical Information and Modeling

Naringenin, a citrus flavonoid, increases muscle cell glucose uptake via AMPK

(2010) Katarzyna Zygmunt et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Sirt1 is involved in energy metabolism: The role of chronic ethanol feeding and resveratrol

(2008) Joan Oliva et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY