Protein kinase C pharmacology: refining the toolbox

Adenosine-binding motif mimicry and cellular effects of a thieno[2,3-d]pyrimidine-based chemical inhibitor of atypical protein kinase C isoenzymes

(2013) Svend Kjær et al.   BIOCHEMICAL JOURNAL

Prkcz null mice show normal learning and memory

(2013) Anna M. Lee et al.   NATURE

PKM-ζ is not required for hippocampal synaptic plasticity, learning and memory

(2013) Lenora J. Volk et al.   NATURE

Shedding light on local kinase activation

(2012) John D Scott et al.   BMC BIOLOGY

Isozyme-specific Interaction of Protein Kinase Cδ with Mitochondria Dissected Using Live Cell Fluorescence Imaging

(2012) Alyssa X. Wu-Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular Pharmacology of Protein Kinase Mζ (PKMζ) Contrasts with Itsin VitroProfile

(2012) Alyssa X. Wu-Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peptidyl-prolyl Isomerase Pin1 Controls Down-regulation of Conventional Protein Kinase C Isozymes

(2012) Hilde Abrahamsen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

In Vivo Conditions to Identify Prkci Phosphorylation Targets Using the Analog-Sensitive Kinase Method in Zebrafish

(2012) Elena Cibrián Uhalte et al.   PLoS One

Simultaneous Detection of Ca2+ and Diacylglycerol Signaling in Living Cells

(2012) Paul Tewson et al.   PLoS One

An ATP-Site On-Off Switch That Restricts Phosphatase Accessibility of Akt

(2012) K. Lin et al.   Science Signaling

A novel mouse PKCδ splice variant, PKCδIX, inhibits etoposide-induced apoptosis

(2011) Jung D. Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Some Phorbol Esters Might Partially Resemble Bryostatin 1 in their Actions on LNCaP Prostate Cancer Cells and U937 Leukemia Cells

(2011) Noemi Kedei et al.   CHEMBIOCHEM

Allosteric Regulation of Protein Kinase PKCζ by the N-Terminal C1 Domain and Small Compounds to the PIF-Pocket

(2011) Laura A. Lopez-Garcia et al.   CHEMISTRY & BIOLOGY

Active Site Inhibitors Protect Protein Kinase C from Dephosphorylation and Stabilize Its Mature Form

(2011) Christine M. Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase Cα Promotes Cell Migration through a PDZ-Dependent Interaction with its Novel Substrate Discs Large Homolog 1 (DLG1)

(2011) Audrey K. O'Neill et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sequestration of phosphoinositides by mutated MARCKS effector domain inhibits stimulated Ca2+ mobilization and degranulation in mast cells

(2011) Deepti Gadi et al.   MOLECULAR BIOLOGY OF THE CELL

Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity

(2011) Theonie Anastassiadis et al.   NATURE BIOTECHNOLOGY

Comprehensive analysis of kinase inhibitor selectivity

(2011) Mindy I Davis et al.   NATURE BIOTECHNOLOGY

Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity

(2011) T. O. Chan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

(2011) J. Hu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms

(2011) Xiaokun Shu et al.   PLOS BIOLOGY

Calcium Transduces Plasma Membrane Receptor Signals to Produce Diacylglycerol at Golgi Membranes

(2010) Maya T. Kunkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C δ-specific Activity Reporter Reveals Agonist-evoked Nuclear Activity Controlled by Src Family of Kinases

(2010) Taketoshi Kajimoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oncogenic Activity of Ect2 Is Regulated through Protein Kinase Cι-mediated Phosphorylation

(2010) Verline Justilien et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interaction with AKAP79 Modifies the Cellular Pharmacology of PKC

(2010) Naoto Hoshi et al.   MOLECULAR CELL

Bryostatin 1 Inhibits Phorbol Ester-Induced Apoptosis in Prostate Cancer Cells by Differentially Modulating Protein Kinase C (PKC)   Translocation and Preventing PKC -Mediated Release of Tumor Necrosis Factor- 

(2010) V. A. von Burstin et al.   MOLECULAR PHARMACOLOGY

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

(2010) Paola Virginia Migues et al.   NATURE NEUROSCIENCE

PKC and the control of localized signal dynamics

(2010) Carine Rosse et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The odyssey of marine pharmaceuticals: a current pipeline perspective

(2010) Alejandro M.S. Mayer et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Guidelines for the effective use of chemical inhibitors of protein function to understand their roles in cell regulation: Table 1

(2009) Philip Cohen   BIOCHEMICAL JOURNAL

Protein kinase C in heart failure: a therapeutic target?

(2009) S. S. Palaniyandi et al.   CARDIOVASCULAR RESEARCH

Protein kinase C intervention—the state of play

(2009) Jon Roffey et al.   CURRENT OPINION IN CELL BIOLOGY

Protein kinase C isoforms: Multi-functional regulators of cell life and death

(2009) Mary et al.   Frontiers in Bioscience-Landmark

The Protein Scaffold NHERF-1 Controls the Amplitude and Duration of Localized Protein Kinase D Activity

(2009) Maya T. Kunkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of 3-(1H-Indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a Potent and Selective Inhibitor of Protein Kinase C Isotypes

(2009) Jürgen Wagner et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Potent Protein Kinase C-Selective Inhibitor AEB071 (Sotrastaurin) Represents a New Class of Immunosuppressive Agents Affecting Early T-Cell Activation

(2009) J.-P. Evenou et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Inhibitor hijacking of Akt activation

(2009) Tatsuya Okuzumi et al.   Nature Chemical Biology

PKC maturation is promoted by nucleotide pocket occupation independently of intrinsic kinase activity

(2009) Angus J M Cameron et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Pharmacology of mTOR Inhibition

(2009) D. A. Guertin et al.   Science Signaling

TOR regulation of AGC kinases in yeast and mammals

(2008) Estela Jacinto et al.   BIOCHEMICAL JOURNAL

The Life and Death of Protein Kinase C

(2008) Christine Gould et al.   CURRENT DRUG TARGETS

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

(2008) Tsuneo Ikenoue et al.   EMBO JOURNAL

The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C

(2008) Valeria Facchinetti et al.   EMBO JOURNAL

PKC alpha protein but not kinase activity is critical for glioma cell proliferation and survival

(2008) Angus J. Cameron et al.   INTERNATIONAL JOURNAL OF CANCER

Spatiotemporal dynamics of lipid signaling: Protein kinase C as a paradigm

(2008) Lisa L. Gallegos et al.   IUBMB LIFE

Kinetic Analysis of the Interaction of the C1 Domain of Protein Kinase C with Lipid Membranes by Stopped-flow Spectroscopy

(2008) Daniel R. Dries et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chaperones Hsp90 and Cdc37 Mediate the Maturation and Stabilization of Protein Kinase C through a Conserved PXXP Motif in the C-terminal Tail

(2008) Christine M. Gould et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The PKC inhibitor AEB071 may be a therapeutic option for psoriasis

(2008) Hans Skvara et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid activation of protein kinases

(2008) Alexandra C. Newton   JOURNAL OF LIPID RESEARCH

Convergent Assembly of Highly Potent Analogues of Bryostatin 1 via Pyran Annulation: Bryostatin Look-Alikes That Mimic Phorbol Ester Function

(2008) Gary E. Keck et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A quantitative analysis of kinase inhibitor selectivity

(2008) Mazen W Karaman et al.   NATURE BIOTECHNOLOGY

Substitution on the A-Ring Confers to Bryopyran Analogues the Unique Biological Activity Characteristic of Bryostatins and Distinct From That of the Phorbol Esters

(2008) Gary E. Keck et al.   ORGANIC LETTERS

Structural Basis of Protein Kinase C Isoform Function

(2008) Susan F. Steinberg   PHYSIOLOGICAL REVIEWS

Rationally designed peptide regulators of protein kinase C

(2008) Eric N. Churchill et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

PKMζ Maintains Spatial, Instrumental, and Classically Conditioned Long-Term Memories

(2008) Peter Serrano et al.   PLOS BIOLOGY

Function-Oriented Synthesis, Step Economy, and Drug Design

(2007) Paul A. Wender et al.   ACCOUNTS OF CHEMICAL RESEARCH

Identification of a Novel Antiapoptotic Human Protein Kinase C δ Isoform, PKCδVIII in NT2 Cells†

(2007) Kun Jiang et al.   BIOCHEMISTRY