Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle
Authors
Keywords
-
Journal
Frontiers in Cell and Developmental Biology
Volume 9, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2021-04-01
DOI
10.3389/fcell.2021.646482
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs
- (2020) Agus Suryawan et al. JOURNAL OF APPLIED PHYSIOLOGY
- Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment
- (2020) Liang-Kung Chen et al. Journal of the American Medical Directors Association
- PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase
- (2020) Gommaar D’Hulst et al. Nature Communications
- Recent developments in the field of cachexia, sarcopenia, and muscle wasting: highlights from the 12th Cachexia Conference
- (2020) Nicole Ebner et al. Journal of Cachexia Sarcopenia and Muscle
- The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?
- (2020) Shuang Rong et al. Journal of Cachexia Sarcopenia and Muscle
- Basic Science of Frailty—Biological Mechanisms of Age-Related Sarcopenia
- (2020) Marie E. Csete ANESTHESIA AND ANALGESIA
- The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia
- (2020) Daniel J. Ham et al. Nature Communications
- Skeletal Muscle Specific Knockout of DEP Domain-Containing 5 Increases mTORC1 Signaling, Muscle Cell Hypertrophy, and Mitochondrial Respiration
- (2019) Ted G. Graber et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Dose-Dependent Increases in Whole-Body Net Protein Balance and Dietary Protein-Derived Amino Acid Incorporation into Myofibrillar Protein During Recovery from Resistance Exercise in Older Men
- (2019) Andrew M Holwerda et al. JOURNAL OF NUTRITION
- Evidence for a Role for Sestrin1 in Mediating Leucine-Induced Activation of mTORC1 in Skeletal Muscle
- (2019) Dandan Xu et al. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
- Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia
- (2019) Giselle A. Joseph et al. MOLECULAR AND CELLULAR BIOLOGY
- AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR
- (2019) Caterina Collodet et al. FASEB JOURNAL
- Nutrient regulation of mTORC1 at a glance
- (2019) Kendall J. Condon et al. JOURNAL OF CELL SCIENCE
- Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1
- (2019) Ina Yoon et al. SCIENCE
- Regulation of mTORC1 by Small GTPases in Response to Nutrients
- (2019) Min Zhu et al. JOURNAL OF NUTRITION
- The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle
- (2018) Nina Zeng et al. EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY
- Leucyl-tRNA synthetase is required for the myogenic differentiation of C2C12 myoblasts, but not for hypertrophy or metabolic alteration of myotubes
- (2018) Yoriko Sato et al. EXPERIMENTAL CELL RESEARCH
- GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids
- (2018) Jin Meng et al. JOURNAL OF CELL BIOLOGY
- Leucine, Not Total Protein, Content of a Supplement Is the Primary Determinant of Muscle Protein Anabolic Responses in Healthy Older Women
- (2018) Michaela C Devries et al. JOURNAL OF NUTRITION
- The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice
- (2018) Barbara M. Crisol et al. LIFE SCIENCES
- Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway
- (2018) Minji Lee et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aging Hallmarks: The Benefits of Physical Exercise
- (2018) Alexandre Rebelo-Marques et al. Frontiers in Endocrinology
- OUP accepted manuscript
- (2018) AGE AND AGEING
- Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins
- (2018) Tianyi Wang et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- OUP accepted manuscript
- (2018) NUTRITION REVIEWS
- Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms
- (2018) Kuang Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control
- (2018) Nathan Hodson et al. EXERCISE AND SPORT SCIENCES REVIEWS
- Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction
- (2018) Rituraj Pal et al. Nature Communications
- Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice
- (2017) Luciene Lenhare et al. EXPERIMENTAL GERONTOLOGY
- Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism
- (2017) Nanhu Quan et al. FASEB JOURNAL
- SZT2 dictates GATOR control of mTORC1 signalling
- (2017) Min Peng et al. NATURE
- Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40
- (2017) Haijuan Yang et al. NATURE
- KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1
- (2017) Rachel L. Wolfson et al. NATURE
- Twenty-five years of mTOR: Uncovering the link from nutrients to growth
- (2017) David M. Sabatini PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
- (2017) Mariana E. G. de Araujo et al. SCIENCE
- A potential strategy for counteracting age-related sarcopenia: preliminary evidence of combined exercise training and leucine supplementation
- (2017) Z. Xia et al. Food & Function
- Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention
- (2017) Zhi Xia et al. Frontiers in Physiology
- Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle
- (2017) Zhe Song et al. Scientific Reports
- Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
- (2016) Scot R. Kimball et al. CELLULAR SIGNALLING
- Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
- (2016) Jun Hee Lee et al. Science Signaling
- Skeletal Muscle Hypertrophy with Concurrent Exercise Training: Contrary Evidence for an Interference Effect
- (2016) Kevin A. Murach et al. SPORTS MEDICINE
- Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity
- (2016) Bernadette Carroll et al. eLife
- Sestrin regulation of TORC1: Is Sestrin a leucine sensor?
- (2016) Jun Hee Lee et al. Science Signaling
- AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy
- (2015) Xiaolei Liu et al. METABOLISM-CLINICAL AND EXPERIMENTAL
- Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway
- (2015) R. A. Saxton et al. SCIENCE
- Sestrin2 is a leucine sensor for the mTORC1 pathway
- (2015) R. L. Wolfson et al. SCIENCE
- Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
- (2015) Jeong Sig Kim et al. Scientific Reports
- Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
- (2014) Suchithra Menon et al. CELL
- Skeletal Muscle Ras-Related GTP Binding B mRNA and Protein Expression Is Increased after Essential Amino Acid Ingestion in Healthy Humans
- (2014) Matthew B. Carlin et al. JOURNAL OF NUTRITION
- Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
- (2014) Anita Parmigiani et al. Cell Reports
- Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases
- (2013) Constance S. Petit et al. JOURNAL OF CELL BIOLOGY
- Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome
- (2013) Brittany L. Jacobs et al. JOURNAL OF PHYSIOLOGY-LONDON
- The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
- (2013) Zhi-Yang Tsun et al. MOLECULAR CELL
- Regulation of Small GTPases by GEFs, GAPs, and GDIs
- (2013) Jacqueline Cherfils et al. PHYSIOLOGICAL REVIEWS
- A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
- (2013) L. Bar-Peled et al. SCIENCE
- Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1
- (2012) Liron Bar-Peled et al. CELL
- Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway
- (2012) Jung Min Han et al. CELL
- Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1
- (2012) Nava Segev et al. MOLECULAR CELL
- Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex
- (2012) Grégory Bonfils et al. MOLECULAR CELL
- Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
- (2010) Yasemin Sancak et al. CELL
- AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
- (2008) Dana M. Gwinn et al. MOLECULAR CELL
- Regulation of TORC1 by Rag GTPases in nutrient response
- (2008) Eunjung Kim et al. NATURE CELL BIOLOGY
- Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies
- (2008) Nelo E Zanchi et al. Nutrition & Metabolism
- The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
- (2008) Y. Sancak et al. SCIENCE
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now