Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs

Prematurity blunts the feeding-induced stimulation of translation initiation signaling and protein synthesis in muscle of neonatal piglets

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Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation

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mTOR as a central hub of nutrient signalling and cell growth

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Beta-hydroxy-beta-methylbutyrate supplementation and skeletal muscle in healthy and muscle-wasting conditions

(2017) Milan Holeček   Journal of Cachexia Sarcopenia and Muscle

Enteral β-hydroxy-β-methylbutyrate supplementation increases protein synthesis in skeletal muscle of neonatal pigs

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Leucyl-tRNA Synthetase Activates Vps34 in Amino Acid-Sensing mTORC1 Signaling

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Sestrin2 is a leucine sensor for the mTORC1 pathway

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Conversion of leucine to β-hydroxy-β-methylbutyrate by α-keto isocaproate dioxygenase is required for a potent stimulation of protein synthesis in L6 rat myotubes

(2015) María D. Girón et al.   Journal of Cachexia Sarcopenia and Muscle

β-Hydroxy-β-Methylbutyrate (HMB) Normalizes Dexamethasone-Induced Autophagy-Lysosomal Pathway in Skeletal Muscle

(2015) María D. Girón et al.   PLoS One

β-Hydroxy-β-Methylbutyrate (HMB) Promotes Neurite Outgrowth in Neuro2a Cells

(2015) Rafael Salto et al.   PLoS One

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

(2015) Jeong Sig Kim et al.   Scientific Reports

Leucine is a major regulator of muscle protein synthesis in neonates

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Recent progress in the study of the Rheb family GTPases

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(2014) Daniel J. Ham et al.   CLINICAL NUTRITION

Protein Ingestion Induces Muscle Insulin Resistance Independent of Leucine-Mediated mTOR Activation

(2014) Gordon I. Smith et al.   DIABETES

AMPK controls exercise endurance, mitochondrial oxidative capacity, and skeletal muscle integrity

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Dietary supplementation of β-hydroxy-β-methylbutyrate in animals - a review

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Skeletal Muscle Ras-Related GTP Binding B mRNA and Protein Expression Is Increased after Essential Amino Acid Ingestion in Healthy Humans

(2014) Matthew B. Carlin et al.   JOURNAL OF NUTRITION

β-Hydroxy-β-methylbutyrate facilitates PI3K/Akt-dependent mammalian target of rapamycin and FoxO1/3a phosphorylations and alleviates tumor necrosis factor α/interferon γ–induced MuRF-1 expression in C2C12 cells

(2014) Kaoru Kimura et al.   NUTRITION RESEARCH

Synergistic Effects of Polyphenols and Methylxanthines with Leucine on AMPK/Sirtuin-Mediated Metabolism in Muscle Cells and Adipocytes

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Protein synthesis in skeletal muscle of neonatal pigs is enhanced by administration of β-hydroxy-β-methylbutyrate

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β-Hydroxy-β-methylbutyrate (HMB) enhances the proliferation of satellite cells in fast muscles of aged rats during recovery from disuse atrophy

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Effects of leucine and its metabolite β-hydroxy-β-methylbutyrate on human skeletal muscle protein metabolism

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Effect of  -hydroxy- -methylbutyrate calcium on growth, blood parameters, and carcass qualities of broiler chickens

(2013) X. Qiao et al.   POULTRY SCIENCE

Optimum feeding and growth in preterm neonates

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Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine

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Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

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Leucyl-tRNA synthetase: double duty in amino acid sensing

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SH3BP4 Is a Negative Regulator of Amino Acid-Rag GTPase-mTORC1 Signaling

(2012) Young-Mi Kim et al.   MOLECULAR CELL

Enteral leucine supplementation increases protein synthesis in skeletal and cardiac muscles and visceral tissues of neonatal pigs through mTORC1-dependent pathways

(2012) Agus Suryawan et al.   PEDIATRIC RESEARCH

Preterm Birth and Body Composition at Term Equivalent Age: A Systematic Review and Meta-analysis

(2012) M. J. Johnson et al.   PEDIATRICS

Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis

(2011) S. M. Pasiakos et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

β-Hydroxy-β-methylbutyrate (HMβ) supplementation stimulates skeletal muscle hypertrophy in rats via the mTOR pathway

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Muscle full effect after oral protein: time-dependent concordance and discordance between human muscle protein synthesis and mTORC1 signaling

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Long-term effects of leucine supplementation on body composition

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The abundance and activation of mTORC1 regulators in skeletal muscle of neonatal pigs are modulated by insulin, amino acids, and age

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Leucine Supplementation of a Low-Protein Meal Increases Skeletal Muscle and Visceral Tissue Protein Synthesis in Neonatal Pigs by Stimulating mTOR-Dependent Translation Initiation

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Leucine and α-Ketoisocaproic Acid, but Not Norleucine, Stimulate Skeletal Muscle Protein Synthesis in Neonatal Pigs

(2010) Jeffery Escobar et al.   JOURNAL OF NUTRITION

β-hydroxy-β-methylbutyrate (HMB) stimulates myogenic cell proliferation, differentiation and survival via the MAPK/ERK and PI3K/Akt pathways

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mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action

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Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation

(2008) Agus Suryawan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential regulation of protein synthesis by amino acids and insulin in peripheral and visceral tissues of neonatal pigs

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Insulin Signaling in Skeletal Muscle and Liver of Neonatal Pigs During Endotoxemia

(2008) Renán A Orellana et al.   PEDIATRIC RESEARCH

Leucine-enriched essential amino acid and carbohydrate ingestion following resistance exercise enhances mTOR signaling and protein synthesis in human muscle

(2007) Hans C. Dreyer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Insulin-like growth factor-1 (IGF-1) and leucine activate pig myogenic satellite cells through mammalian target of rapamycin (mTOR) pathway

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