Advances in the Role of Leucine-Sensing in the Regulation of Protein Synthesis in Aging Skeletal Muscle

Differential regulation of mTORC1 activation by leucine and β-hydroxy-β-methylbutyrate in skeletal muscle of neonatal pigs

(2020) Agus Suryawan et al.   JOURNAL OF APPLIED PHYSIOLOGY

Asian Working Group for Sarcopenia: 2019 Consensus Update on Sarcopenia Diagnosis and Treatment

(2020) Liang-Kung Chen et al.   Journal of the American Medical Directors Association

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

(2020) Gommaar D’Hulst et al.   Nature Communications

Recent developments in the field of cachexia, sarcopenia, and muscle wasting: highlights from the 12th Cachexia Conference

(2020) Nicole Ebner et al.   Journal of Cachexia Sarcopenia and Muscle

The mechanisms and treatments for sarcopenia: could exosomes be a perspective research strategy in the future?

(2020) Shuang Rong et al.   Journal of Cachexia Sarcopenia and Muscle

Basic Science of Frailty—Biological Mechanisms of Age-Related Sarcopenia

(2020) Marie E. Csete   ANESTHESIA AND ANALGESIA

The neuromuscular junction is a focal point of mTORC1 signaling in sarcopenia

(2020) Daniel J. Ham et al.   Nature Communications

Skeletal Muscle Specific Knockout of DEP Domain-Containing 5 Increases mTORC1 Signaling, Muscle Cell Hypertrophy, and Mitochondrial Respiration

(2019) Ted G. Graber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dose-Dependent Increases in Whole-Body Net Protein Balance and Dietary Protein-Derived Amino Acid Incorporation into Myofibrillar Protein During Recovery from Resistance Exercise in Older Men

(2019) Andrew M Holwerda et al.   JOURNAL OF NUTRITION

Evidence for a Role for Sestrin1 in Mediating Leucine-Induced Activation of mTORC1 in Skeletal Muscle

(2019) Dandan Xu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Partial inhibition of mTORC1 in aged rats counteracts the decline in muscle mass and reverses molecular signaling associated with sarcopenia

(2019) Giselle A. Joseph et al.   MOLECULAR AND CELLULAR BIOLOGY

AMPK promotes induction of the tumor suppressor FLCN through activation of TFEB independently of mTOR

(2019) Caterina Collodet et al.   FASEB JOURNAL

Nutrient regulation of mTORC1 at a glance

(2019) Kendall J. Condon et al.   JOURNAL OF CELL SCIENCE

Glucose-dependent control of leucine metabolism by leucyl-tRNA synthetase 1

(2019) Ina Yoon et al.   SCIENCE

Regulation of mTORC1 by Small GTPases in Response to Nutrients

(2019) Min Zhu et al.   JOURNAL OF NUTRITION

The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle

(2018) Nina Zeng et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

Leucyl-tRNA synthetase is required for the myogenic differentiation of C2C12 myoblasts, but not for hypertrophy or metabolic alteration of myotubes

(2018) Yoriko Sato et al.   EXPERIMENTAL CELL RESEARCH

GATOR1-dependent recruitment of FLCN–FNIP to lysosomes coordinates Rag GTPase heterodimer nucleotide status in response to amino acids

(2018) Jin Meng et al.   JOURNAL OF CELL BIOLOGY

Leucine, Not Total Protein, Content of a Supplement Is the Primary Determinant of Muscle Protein Anabolic Responses in Healthy Older Women

(2018) Michaela C Devries et al.   JOURNAL OF NUTRITION

The role of physical exercise on Sestrin1 and 2 accumulations in the skeletal muscle of mice

(2018) Barbara M. Crisol et al.   LIFE SCIENCES

Coordination of the leucine-sensing Rag GTPase cycle by leucyl-tRNA synthetase in the mTORC1 signaling pathway

(2018) Minji Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aging Hallmarks: The Benefits of Physical Exercise

(2018) Alexandre Rebelo-Marques et al.   Frontiers in Endocrinology

OUP accepted manuscript

(2018)   AGE AND AGEING

Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins

(2018) Tianyi Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

OUP accepted manuscript

(2018)   NUTRITION REVIEWS

Ragulator and SLC38A9 activate the Rag GTPases through noncanonical GEF mechanisms

(2018) Kuang Shen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Importance of mTOR Trafficking for Human Skeletal Muscle Translational Control

(2018) Nathan Hodson et al.   EXERCISE AND SPORT SCIENCES REVIEWS

Src regulates amino acid-mediated mTORC1 activation by disrupting GATOR1-Rag GTPase interaction

(2018) Rituraj Pal et al.   Nature Communications

Physical exercise increases Sestrin 2 protein levels and induces autophagy in the skeletal muscle of old mice

(2017) Luciene Lenhare et al.   EXPERIMENTAL GERONTOLOGY

Sestrin2 prevents age-related intolerance to ischemia and reperfusion injury by modulating substrate metabolism

(2017) Nanhu Quan et al.   FASEB JOURNAL

SZT2 dictates GATOR control of mTORC1 signalling

(2017) Min Peng et al.   NATURE

Mechanisms of mTORC1 activation by RHEB and inhibition by PRAS40

(2017) Haijuan Yang et al.   NATURE

KICSTOR recruits GATOR1 to the lysosome and is necessary for nutrients to regulate mTORC1

(2017) Rachel L. Wolfson et al.   NATURE

Twenty-five years of mTOR: Uncovering the link from nutrients to growth

(2017) David M. Sabatini   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling

(2017) Mariana E. G. de Araujo et al.   SCIENCE

A potential strategy for counteracting age-related sarcopenia: preliminary evidence of combined exercise training and leucine supplementation

(2017) Z. Xia et al.   Food & Function

Targeting Inflammation and Downstream Protein Metabolism in Sarcopenia: A Brief Up-Dated Description of Concurrent Exercise and Leucine-Based Multimodal Intervention

(2017) Zhi Xia et al.   Frontiers in Physiology

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle

(2017) Zhe Song et al.   Scientific Reports

Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation

(2016) Scot R. Kimball et al.   CELLULAR SIGNALLING

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

(2016) Jun Hee Lee et al.   Science Signaling

Skeletal Muscle Hypertrophy with Concurrent Exercise Training: Contrary Evidence for an Interference Effect

(2016) Kevin A. Murach et al.   SPORTS MEDICINE

Control of TSC2-Rheb signaling axis by arginine regulates mTORC1 activity

(2016) Bernadette Carroll et al.   eLife

Sestrin regulation of TORC1: Is Sestrin a leucine sensor?

(2016) Jun Hee Lee et al.   Science Signaling

AMPK binds to Sestrins and mediates the effect of exercise to increase insulin-sensitivity through autophagy

(2015) Xiaolei Liu et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

(2015) R. A. Saxton et al.   SCIENCE

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Sestrin2 inhibits mTORC1 through modulation of GATOR complexes

(2015) Jeong Sig Kim et al.   Scientific Reports

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

Skeletal Muscle Ras-Related GTP Binding B mRNA and Protein Expression Is Increased after Essential Amino Acid Ingestion in Healthy Humans

(2014) Matthew B. Carlin et al.   JOURNAL OF NUTRITION

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

(2014) Anita Parmigiani et al.   Cell Reports

Recruitment of folliculin to lysosomes supports the amino acid–dependent activation of Rag GTPases

(2013) Constance S. Petit et al.   JOURNAL OF CELL BIOLOGY

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1

(2013) Zhi-Yang Tsun et al.   MOLECULAR CELL

Regulation of Small GTPases by GEFs, GAPs, and GDIs

(2013) Jacqueline Cherfils et al.   PHYSIOLOGICAL REVIEWS

A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1

(2013) L. Bar-Peled et al.   SCIENCE

Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels to mTORC1

(2012) Liron Bar-Peled et al.   CELL

Leucyl-tRNA Synthetase Is an Intracellular Leucine Sensor for the mTORC1-Signaling Pathway

(2012) Jung Min Han et al.   CELL

Hijacking Leucyl-tRNA Synthetase for Amino Acid-Dependent Regulation of TORC1

(2012) Nava Segev et al.   MOLECULAR CELL

Leucyl-tRNA Synthetase Controls TORC1 via the EGO Complex

(2012) Grégory Bonfils et al.   MOLECULAR CELL

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

(2008) Dana M. Gwinn et al.   MOLECULAR CELL

Regulation of TORC1 by Rag GTPases in nutrient response

(2008) Eunjung Kim et al.   NATURE CELL BIOLOGY

Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies

(2008) Nelo E Zanchi et al.   Nutrition & Metabolism

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE