Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 47, Issue 1, Pages 46-53Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000173
Keywords
mTORC1; lysosome; resistance exercise; amino acids; skeletal muscle
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The mechanistic target of rapamycin (mTOR) is a central regulator of muscle protein synthesis, and its activation has long been attributed to its translocation to the lysosome. Here, we present a novel model of mTOR activation in skeletal muscle where the translocation of mTOR and the lysosome toward the cell membrane is a key process in mTOR activation.
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