Clozapine Regulates Microglia and Is Effective in Chronic Experimental Autoimmune Encephalomyelitis

Nitric Oxide, Iron and Neurodegeneration

(2019) Chao Liu et al.   Frontiers in Neuroscience

Clozapine administration enhanced functional recovery after cuprizone demyelination

(2019) Nikki Templeton et al.   PLoS One

Clozapine-associated secondary antibody deficiency

(2019) Mark J. Ponsford et al.   Current Opinion in Allergy and Clinical Immunology

Progressive multiple sclerosis: from pathophysiology to therapeutic strategies

(2019) Simon Faissner et al.   NATURE REVIEWS DRUG DISCOVERY

DMT1 Expression and Iron Levels at the Crossroads Between Aging and Neurodegeneration

(2019) Rosaria Ingrassia et al.   Frontiers in Neuroscience

Smad7 in intestinal CD4+T cells determines autoimmunity in a spontaneous model of multiple sclerosis

(2019) Steffen Haupeltshofer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy and Safety of the Newer Multiple Sclerosis Drugs Approved Since 2010

(2018) Simon Faissner et al.   CNS DRUGS

Clozapine reduces Toll-like receptor 4/NF-κB-mediated inflammatory responses through inhibition of calcium/calmodulin-dependent Akt activation in microglia

(2018) Seunghyun Jeon et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Multiple Sclerosis Pathology

(2018) Hans Lassmann   Cold Spring Harbor Perspectives in Medicine

Mechanisms and Disease Pathogenesis Underlying Metal-Induced Oxidative Stress

(2018) Pan Chen et al.   Oxidative Medicine and Cellular Longevity

Teriflunomide and monomethylfumarate target HIV-induced neuroinflammation and neurotoxicity

(2017) Björn Ambrosius et al.   Journal of Neuroinflammation

Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?

(2017) Simon Faissner et al.   Multiple Sclerosis Journal

Systematic screening of generic drugs for progressive multiple sclerosis identifies clomipramine as a promising therapeutic

(2017) Simon Faissner et al.   Nature Communications

Unexpected additive effects of minocycline and hydroxychloroquine in models of multiple sclerosis: Prospective combination treatment for progressive disease?

(2017) Simon Faissner et al.   Multiple Sclerosis Journal

Multiple sclerosis: experimental models and reality

(2016) Hans Lassmann et al.   ACTA NEUROPATHOLOGICA

Oligodendroglial TNFR2 Mediates Membrane TNF-Dependent Repair in Experimental Autoimmune Encephalomyelitis by Promoting Oligodendrocyte Differentiation and Remyelination

(2016) Pernille M. Madsen et al.   JOURNAL OF NEUROSCIENCE

Cytoplasmic HIV-RNA in monocytes determines microglial activation and neuronal cell death in HIV-associated neurodegeneration

(2014) Simon Faissner et al.   EXPERIMENTAL NEUROLOGY

Micropillar arrays as a high-throughput screening platform for therapeutics in multiple sclerosis

(2014) Feng Mei et al.   NATURE MEDICINE

Mechanisms of neurodegeneration and axonal dysfunction in multiple sclerosis

(2014) Manuel A. Friese et al.   Nature Reviews Neurology

Iron in multiple sclerosis: roles in neurodegeneration and repair

(2014) Erin Stephenson et al.   Nature Reviews Neurology

Treatment with the Antipsychotic Agent, Risperidone, Reduces Disease Severity in Experimental Autoimmune Encephalomyelitis

(2014) David O'Sullivan et al.   PLoS One

Classics in Chemical Neuroscience: Clozapine

(2013) Cody J. Wenthur et al.   ACS Chemical Neuroscience

Brain Iron Homeostasis: From Molecular Mechanisms To Clinical Significance and Therapeutic Opportunities

(2013) Neena Singh et al.   ANTIOXIDANTS & REDOX SIGNALING

Inflammation alters the expression of DMT1, FPN1 and hepcidin, and it causes iron accumulation in central nervous system cells

(2013) Pamela Urrutia et al.   JOURNAL OF NEUROCHEMISTRY

Progressive multiple sclerosis: pathology and pathogenesis

(2012) Hans Lassmann et al.   Nature Reviews Neurology

H-ferritin is the major source of iron for oligodendrocytes

(2011) Bozho Todorich et al.   GLIA

Immunosuppression with FTY720 is insufficient to prevent secondary progressive neurodegeneration in experimental autoimmune encephalomyelitis

(2011) Sarah Al-Izki et al.   Multiple Sclerosis Journal

Ferritin as an important player in neurodegeneration

(2011) Andrzej Friedman et al.   PARKINSONISM & RELATED DISORDERS

NOX4 Expression in Human Microglia Leads to Constitutive Generation of Reactive Oxygen Species and to Constitutive IL-6 Expression

(2009) Bin Li et al.   Journal of Innate Immunity

Anti-inflammatory effects of tumour necrosis factor (TNF)-α are mediated via TNF-R2 (p75) in tolerogenic transforming growth factor-β-treated antigen-presenting cells

(2008) Sharmila Masli et al.   IMMUNOLOGY