Stroma Involvement in Pancreatic Ductal Adenocarcinoma: An Overview Focusing on Extracellular Matrix Proteins

Cancer Cell–Derived Matrisome Proteins Promote Metastasis in Pancreatic Ductal Adenocarcinoma

(2020) Chenxi Tian et al.   CANCER RESEARCH

Neoadjuvant Treatment in Pancreatic Cancer

(2020) Atsushi Oba et al.   Frontiers in Oncology

Engineering protein therapeutics for cancer based on the natural matrix metalloproteinase inhibitor TIMP‐1

(2020) Maryam Raeeszadeh-Sarmazdeh et al.   FASEB JOURNAL

Antifibrotic therapy to normalize the tumor microenvironment

(2020) Anette Hauge et al.   Journal of Translational Medicine

The tumour microenvironment in pancreatic cancer — clinical challenges and opportunities

(2020) Won Jin Ho et al.   Nature Reviews Clinical Oncology

Pancreatic cancer stroma: an update on therapeutic targeting strategies

(2020) Abdel N. Hosein et al.   Nature Reviews Gastroenterology & Hepatology

Tenascin C in the Tumor-Nerve Microenvironment Enhances Perineural Invasion and Correlates With Locoregional Recurrence in Pancreatic Ductal Adenocarcinoma

(2020) Satoru Furuhashi et al.   PANCREAS

Pancreatic Cancer Associated Fibroblasts (CAF): Under-Explored Target for Pancreatic Cancer Treatment

(2020) Jeffrey Norton et al.   Cancers

The Galectin Family as Molecular Targets: Hopes for Defeating Pancreatic Cancer

(2020) Noemí Manero-Rupérez et al.   Cells

Protective effects and mechanisms of bilirubin nanomedicine against acute pancreatitis

(2020) Qing Yao et al.   JOURNAL OF CONTROLLED RELEASE

Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression?

(2020) Etienne J. Slapak et al.   Biology-Basel

Pancreatic Cancer (PDAC): Introduction of Evidence-Based Complementary Measures into Integrative Clinical Management

(2020) Valerie Jentzsch et al.   Cancers

Stroma-Targeting Therapy in Pancreatic Cancer: One Coin With Two Sides?

(2020) Bolun Jiang et al.   Frontiers in Oncology

Blocking CXCLs–CXCR2 axis in tumor–stromal interactions contributes to survival in a mouse model of pancreatic ductal adenocarcinoma through reduced cell invasion/migration and a shift of immune-inflammatory microenvironment

(2019) Makoto Sano et al.   Oncogenesis

Pancreatic adenocarcinomas with mature blood vessels have better overall survival

(2019) Eriko Katsuta et al.   Scientific Reports

LAMB3 mediates apoptotic, proliferative, invasive, and metastatic behaviors in pancreatic cancer by regulating the PI3K/Akt signaling pathway

(2019) Hong Zhang et al.   Cell Death & Disease

Stromal fibronectin expression in patients with resected pancreatic ductal adenocarcinoma

(2019) Dingyuan Hu et al.   World Journal of Surgical Oncology

Inflammation and Pancreatic Cancer: Focus on Metabolism, Cytokines, and Immunity

(2019) Andrea Padoan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Transforming growth factor beta‐induced, an extracellular matrix interacting protein, enhances glycolysis and promotes pancreatic cancer cell migration

(2019) Brunella Costanza et al.   INTERNATIONAL JOURNAL OF CANCER

Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases

(2019) Yuan Cheng et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Therapeutic efficacy of anti‐MMP9 antibody in combination with nab‐paclitaxel‐based chemotherapy in pre‐clinical models of pancreatic cancer

(2019) Niranjan Awasthi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosomal Tenascin-c induces proliferation and invasion of pancreatic cancer cells by WNT signaling

(2019) Songying Qian et al.   OncoTargets and Therapy

Total Neoadjuvant Therapy With FOLFIRINOX in Combination With Losartan Followed by Chemoradiotherapy for Locally Advanced Pancreatic Cancer

(2019) Janet E. Murphy et al.   JAMA Oncology

Clinical Trials Targeting the Stroma in Pancreatic Cancer: A Systematic Review and Meta-Analysis

(2019) van Mackelenbergh et al.   Cancers

Evaluation of the diagnostic ability of laminin gene family for pancreatic ductal adenocarcinoma

(2019) Chengkun Yang et al.   Aging-US

Secretion of fibronectin by human pancreatic stellate cells promotes chemoresistance to gemcitabine in pancreatic cancer cells

(2019) Manoj Amrutkar et al.   BMC CANCER

Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts

(2019) Ela Elyada et al.   Cancer Discovery

A potential prognostic marker and therapeutic target: SPOCK1 promotes the proliferation, metastasis, and apoptosis of pancreatic ductal adenocarcinoma cells

(2019) Jia Li et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Cancer-associated fibroblasts: an emerging target of anti-cancer immunotherapy

(2019) Tongyan Liu et al.   Journal of Hematology & Oncology

Desmoplasia and oncogene driven acinar-to-ductal metaplasia are concurrent events during acinar cell-derived pancreatic cancer initiation in young adult mice

(2019) Benjamin L. Johnson et al.   PLoS One

Proteomic analyses of ECM during pancreatic ductal adenocarcinoma progression reveal different contributions by tumor and stromal cells

(2019) Chenxi Tian et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High expression of Annexin A2 is associated with DNA repair, metabolic alteration, and worse survival in pancreatic ductal adenocarcinoma

(2019) Hideo Takahashi et al.   SURGERY

TIMP-2 secreted by monocyte-like cells is a potent suppressor of invadopodia formation in pancreatic cancer cells

(2019) Christian Benzing et al.   BMC CANCER

Novel targets identified by integrated cancer-stromal interactome analysis of pancreatic adenocarcinoma

(2019) Yukihiko Hiroshima et al.   CANCER LETTERS

Proteome alterations in pancreatic ductal adenocarcinoma

(2019) Sheng Pan et al.   CANCER LETTERS

Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma

(2019) Rebecca L. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Collagen fragments quantified in serum as measures of desmoplasia associate with survival outcome in patients with advanced pancreatic cancer

(2019) Nicholas Willumsen et al.   Scientific Reports

Expression of annexin�II and stromal tenascin�C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer

(2018) Naoko Yoneura et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Annexins in Translational Research: Hidden Treasures to Be Found

(2018) Sebastian Schloer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

HALO 202: Randomized Phase II Study of PEGPH20 Plus Nab-Paclitaxel/Gemcitabine Versus Nab-Paclitaxel/Gemcitabine in Patients With Untreated, Metastatic Pancreatic Ductal Adenocarcinoma

(2018) Sunil R. Hingorani et al.   JOURNAL OF CLINICAL ONCOLOGY

Proteomic analyses identify prognostic biomarkers for pancreatic ductal adenocarcinoma

(2018) Dingyuan Hu et al.   Oncotarget

Angiogenesis in pancreatic cancer: current research status and clinical implications

(2018) Shuo Li et al.   ANGIOGENESIS

Identification and characterization of transforming growth factor beta-induced in circulating tumor cell subline from pancreatic cancer cell line

(2018) Taku Sato et al.   CANCER SCIENCE

The Role of CXC Chemokine Receptors 1–4 on Immune Cells in the Tumor Microenvironment

(2018) Katharina Helene Susek et al.   Frontiers in Immunology

The Extracellular Matrix and Pancreatic Cancer: A Complex Relationship

(2018) Maximilian Weniger et al.   Cancers

Stromal protein βig-h3 reprogrammes tumour microenvironment in pancreatic cancer

(2018) Delphine Goehrig et al.   GUT

Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods

(2018) J. Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Inter- and intra-tumoral heterogeneity in cancer-associated fibroblasts of human pancreatic ductal adenocarcinoma

(2018) Cindy Neuzillet et al.   JOURNAL OF PATHOLOGY

TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell Mediated Regression of Pancreatic Cancer

(2018) Daniel R Principe et al.   MOLECULAR CANCER THERAPEUTICS

ADAM9 contributes to vascular invasion in pancreatic ductal adenocarcinoma

(2018) Victor O. Oria et al.   Molecular Oncology

Tenascin C, Fibronectin, and Tumor-Stroma Ratio in Pancreatic Ductal Adenocarcinoma

(2018) Joni Leppänen et al.   PANCREAS

SERPINB7 Expression Predicts Poor Pancreatic Cancer Survival Upon Gemcitabine Treatment

(2018) Daniela Bianconi et al.   Translational Oncology

ADAM12 is a circulating marker for stromal activation in pancreatic cancer and predicts response to chemotherapy

(2018) V. L. Veenstra et al.   Oncogenesis

Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer

(2017) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Stromal SPOCK1 supports invasive pancreatic cancer growth

(2017) Veronique L. Veenstra et al.   Molecular Oncology

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

Prolonged exposure to extracellular lumican restrains pancreatic adenocarcinoma growth

(2017) X Li et al.   ONCOGENE

SerpinB2 regulates stromal remodelling and local invasion in pancreatic cancer

(2017) N L E Harris et al.   ONCOGENE

Microenvironment in determining chemo-resistance in pancreatic cancer: Neighborhood matters

(2017) Patricia Dauer et al.   PANCREATOLOGY

Annexin A10 is a candidate marker associated with the progression of pancreatic precursor lesions to adenocarcinoma

(2017) Jianhui Zhu et al.   PLoS One

Collagen-derived proline promotes pancreatic ductal adenocarcinoma cell survival under nutrient limited conditions

(2017) Orianne Olivares et al.   Nature Communications

TGF-β in pancreatic cancer initiation and progression: two sides of the same coin

(2017) Wei Shen et al.   Cell and Bioscience

The TGF-β/Smad4 Signaling Pathway in Pancreatic Carcinogenesis and Its Clinical Significance

(2017) Sunjida Ahmed et al.   Journal of Clinical Medicine

Human pancreatic stellate cells modulate 3D collagen alignment to promote the migration of pancreatic ductal adenocarcinoma cells

(2016) Cole R. Drifka et al.   BIOMEDICAL MICRODEVICES

Matrix control of pancreatic cancer: New insights into fibronectin signaling

(2016) Mary Topalovski et al.   CANCER LETTERS

Role of hyaluronan in pancreatic cancer biology and therapy: Once again in the spotlight

(2016) Norihiro Sato et al.   CANCER SCIENCE

ROCK signaling promotes collagen remodeling to facilitate invasive pancreatic ductal adenocarcinoma tumor cell growth

(2016) Nicola Rath et al.   EMBO Molecular Medicine

Tenascin-C at a glance

(2016) Kim S. Midwood et al.   JOURNAL OF CELL SCIENCE

The extracellular matrix: Tools and insights for the “omics” era

(2016) Alexandra Naba et al.   MATRIX BIOLOGY

SERPINB5 Promoter Hypomethylation Differentiates Pancreatic Ductal Adenocarcinoma From Pancreatitis

(2016) Wolf Arif Mardin et al.   PANCREAS

Tumor-associated fibroblasts predominantly come from local and not circulating precursors

(2016) Ainhoa Arina et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key players in pancreatic cancer-stroma interaction: Cancer-associated fibroblasts, endothelial and inflammatory cells

(2016) Michael Friberg Bruun Nielsen et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Lysyl oxidase family activity promotes resistance of pancreatic ductal adenocarcinoma to chemotherapy by limiting the intratumoral anticancer drug distribution

(2016) Benjamin Le Calvé et al.   Oncotarget

Angiogenesis in pancreatic ductal adenocarcinoma: A controversial issue

(2016) Vito Longo et al.   Oncotarget

Targeting hyaluronan for the treatment of pancreatic ductal adenocarcinoma

(2016) Norihiro Sato et al.   Acta Pharmaceutica Sinica B

The role of S100 proteins and their receptor RAGE in pancreatic cancer

(2015) Estelle Leclerc et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Impaired Synthesis of Stromal Components in Response to Minnelide Improves Vascular Function, Drug Delivery, and Survival in Pancreatic Cancer

(2015) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Desmoplasia in Primary Tumors and Metastatic Lesions of Pancreatic Cancer

(2015) C. J. Whatcott et al.   CLINICAL CANCER RESEARCH

βig-h3 Represses T-Cell Activation in Type 1 Diabetes

(2015) Maeva Patry et al.   DIABETES

The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer

(2015) Yingqiang Xu et al.   Diagnostic Pathology

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy

(2015) Bryan W Miller et al.   EMBO Molecular Medicine

Proteoglycan form and function: A comprehensive nomenclature of proteoglycans

(2015) Renato V. Iozzo et al.   MATRIX BIOLOGY

The role of pancreatic stellate cells in pancreatic cancer

(2015) John A.G. Moir et al.   SURGICAL ONCOLOGY-OXFORD

ADAM8 as a drug target in pancreatic cancer

(2015) Uwe Schlomann et al.   Nature Communications

Perspectives of TGF-β inhibition in pancreatic and hepatocellular carcinomas

(2015) Cindy Neuzillet et al.   Oncotarget

Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival

(2014) Berna C. Özdemir et al.   CANCER CELL

Stromal Elements Act to Restrain, Rather Than Support, Pancreatic Ductal Adenocarcinoma

(2014) Andrew D. Rhim et al.   CANCER CELL

Extracellular Lumican Inhibits Pancreatic Cancer Cell Growth and Is Associated with Prolonged Survival after Surgery

(2014) X. Li et al.   CLINICAL CANCER RESEARCH

Fibroblast heterogeneity in the cancer wound

(2014) Daniel Öhlund et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tenascins in stem cell niches

(2014) Ruth Chiquet-Ehrismann et al.   MATRIX BIOLOGY

Pancreatic cancer and its stroma: A conspiracy theory

(2014) Zhihong Xu   WORLD JOURNAL OF GASTROENTEROLOGY

S100P antibody-mediated therapy as a new promising strategy for the treatment of pancreatic cancer

(2014) S Dakhel et al.   Oncogenesis

Immunohistochemically Detected Expression of 3 Major Genes (CDKN2A/p16, TP53, and SMAD4/DPC4) Strongly Predicts Survival in Patients With Resectable Pancreatic Cancer

(2013) Minoru Oshima et al.   ANNALS OF SURGERY

Type IV collagen stimulates pancreatic cancer cell proliferation, migration, and inhibits apoptosis through an autocrine loop

(2013) Daniel Öhlund et al.   BMC CANCER

Designing and Developing S100P Inhibitor 5-Methyl Cromolyn for Pancreatic Cancer Therapy

(2013) T. Arumugam et al.   MOLECULAR CANCER THERAPEUTICS

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Collagen XV Inhibits Epithelial to Mesenchymal Transition in Pancreatic Adenocarcinoma Cells

(2013) Anthony G. Clementz et al.   PLoS One

Prognostic Impact of Hyaluronan and Its Regulators in Pancreatic Ductal Adenocarcinoma

(2013) Xiao-Bo Cheng et al.   PLoS One

Enzymatic Targeting of the Stroma Ablates Physical Barriers to Treatment of Pancreatic Ductal Adenocarcinoma

(2012) Paolo P. Provenzano et al.   CANCER CELL

The Pancreas Cancer Microenvironment

(2012) C. Feig et al.   CLINICAL CANCER RESEARCH

Biglycan expression and clinical outcome in patients with pancreatic adenocarcinoma

(2012) Giuseppe Aprile et al.   TUMOR BIOLOGY

Inhibiting Cxcr2 disrupts tumor-stromal interactions and improves survival in a mouse model of pancreatic ductal adenocarcinoma

(2011) Hideaki Ijichi et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Novel Accessible Proteins Bearing Diagnostic and Therapeutic Potential in Human Pancreatic Ductal Adenocarcinoma

(2011) Andrei Turtoi et al.   JOURNAL OF PROTEOME RESEARCH

Tyrosine 23 Phosphorylation-Dependent Cell-Surface Localization of Annexin A2 Is Required for Invasion and Metastases of Pancreatic Cancer

(2011) Lei Zheng et al.   PLoS One

New Markers of Pancreatic Cancer Identified Through Differential Gene Expression Analyses: Claudin 18 and Annexin A8

(2009) Zarir E. Karanjawala et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

Type IV collagen is a tumour stroma-derived biomarker for pancreas cancer

(2009) D Öhlund et al.   BRITISH JOURNAL OF CANCER

Annexin II Overexpression Predicts Rapid Recurrence after Surgery in Pancreatic Cancer Patients Undergoing Gemcitabine-Adjuvant Chemotherapy

(2008) Shigetsugu Takano et al.   ANNALS OF SURGICAL ONCOLOGY

Sonic Hedgehog Promotes Desmoplasia in Pancreatic Cancer

(2008) J. M. Bailey et al.   CLINICAL CANCER RESEARCH

The role of annexins in tumour development and progression

(2008) S Mussunoor et al.   JOURNAL OF PATHOLOGY

Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses

(2008) S. Jones et al.   SCIENCE