Article
Oncology
Xia Li, Li Zha, Bo Li, Rong Sun, Jianhua Liu, Hongwei Zeng
Summary: Research indicates that MMP-9 overexpression is significantly associated with the risk, clinical features, and prognosis of endometrial cancer (EC). In Asian populations, MMP-9 overexpression is linked to tumor grade, FIGO stage, lymph node metastasis, and myometrial invasion. Overall, MMP-9 overexpression predicts a worse prognosis for EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ming Zhang, Rui Zhang, Tiansheng Zheng, Zhixi Chen, Guanglin Ji, Fang Peng, Wei Wang
Summary: Xanthohumol (XH) attenuates inflammatory responses and extracellular matrix (ECM) degradation in osteoarthritis chondrocytes by mediating HO-1 and C/EBPβ signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Cell Biology
Noritaka Tanaka, Takeharu Sakamoto
Summary: MT1-MMP is a member of the metalloproteinase family, which degrades extracellular matrix components directly and can indirectly degrade type IV collagen through the activation of MMP-2 with TIMP-2. MT1-MMP is initially expressed as an inactive form in the ER and is activated through truncation processing by furin. Upon trafficking from the ER to the cell surface membrane, MT1-MMP exhibits proteolytic activities on surrounding molecules.
Review
Chemistry, Medicinal
Sanjib Das, Sk Abdul Amin, Tarun Jha
Summary: Matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) play significant roles in solid tumor invasion, metastasis, and angiogenesis, while their role in hematological malignancies is less understood. Recent studies have shown correlations between gelatinases and hematological malignancies, leading to the development of potential inhibitors for these conditions.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Cardiac & Cardiovascular Systems
Xiaowei Zheng, Chongke Zhong, Zhengbao Zhu, Kaixin Zhang, Hao Peng, Tian Xu, Xiaoqing Bu, Bizhong Che, Tan Xu, Aili Wang, Jing Chen, Yonghong Zhang, Jiang He
Summary: This study found that the prognostic value of MMP-9 in ischemic stroke patients is modified by the patients' dyslipidemia status, suggesting that increased MMP-9 is associated with poor prognosis only in patients with dyslipidemia. Further research is needed to confirm these findings and explore potential mechanisms.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Medicine, Research & Experimental
Licen Li, Jiaolin Bao, Haitao Wang, Josh Haipeng Lei, Cheng Peng, Jianming Zeng, Wenhui Hao, Xu Zhang, Xiaoling Xu, Chundong Yu, Chu-Xia Deng, Qiang Chen
Summary: The study reveals that AIB1 plays a crucial role in the progression of PDAC through Hh and ECM signaling pathways, suggesting potential therapeutic targets for PDAC treatment.
Article
Oncology
Ughur Aghamaliyev, Kaifeng Su, Maximilian Weniger, Dominik Koch, Jan G. D'Haese, Jens Werner, Alexandr V. Bazhin
Summary: The study aims to investigate the potential role of SPOCK2 in the pathogenesis of pancreatic ductal adenocarcinoma (PDAC). SPOCK2 expression was significantly downregulated in PDAC cell lines compared to the normal pancreatic cell line. Treatment with 5-aza-dC led to an increase in SPOCK2 expression, and knockdown of SPOCK2 promoted cell growth and migration. High SPOCK2 expression was associated with longer overall survival in PDAC patients.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Soudeh Ghafouri-Fard, Mohadeseh Fathi, Tianyue Zhai, Mohammad Taheri, Peixin Dong
Summary: Pancreatic cancer is a deadly neoplasm with poor prognosis, and recent research has highlighted the impact of lncRNAs on its progression. Some lncRNAs are oncogenic while others act as tumor suppressors in pancreatic cancer. Dysregulated expression of specific lncRNAs may serve as prognostic markers in patients with this aggressive cancer.
Article
Reproductive Biology
Yunxiang Li, Yuguang Chen, Wenping Wu, Na Li, Jinlian Hua
Summary: Metalloproteinases, including matrix metalloproteinases and disintegrin metalloproteinases, play important roles in the degradation and reconstruction of the extracellular matrix (ECM). They are associated with tissue development and disease. Although their relationship with male reproduction is clear, the underlying mechanism is still unclear.
Article
Oncology
Rajalakshmi Sabanayagam, Sneha Krishnamoorthy, Jayapradha Gnanagurusamy, Bharathi Muruganatham, Sridhar Muthusami
Summary: This study aimed to investigate the effects of epigallocatechin gallate (EGCG) in preventing the actions of epidermal growth factor (EGF) in HPV positive and HPV negative cervical cancer cells. The results showed that EGCG pre-treatment blocked EGF-induced colony formation and prevented epithelial-mesenchymal transition (EMT). EGCG has the potential to act as a supplementary therapy for EGF-driven cervical cancer.
Review
Biochemistry & Molecular Biology
Il-Sup Kim, Woong-Suk Yang, Cheorl-Ho Kim
Summary: MMPs are enzymes that play a key role in promoting cell migration by degrading the extracellular matrix (ECM). They are upregulated in cancers and inflamed regions. TIMPs are highly specific inhibitors of MMPs, regulating their activity and potentially playing a role in inhibiting MMP-dependent diseases.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Oncology
Soyeon Ko, Kyung Hee Jung, Young -Chan Yoon, Beom Seok Han, Min Seok Park, Yun Ji Lee, Sang Eun Kim, Ye Jin Cho, Pureunchowon Lee, Joo Han Lim, Ji-Kan Ryu, Kewon Kim, Tae Young Kim, Sungwoo Hong, So Ha Lee, Soon-Sun Hong
Summary: In this study, a novel DDR1 inhibitor, KI-301690, was developed to enhance the delivery efficiency and improve the sensitivity of chemotherapy drugs by inhibiting the binding of tumor cells to collagen. The results showed that KI-301690 in combination with gemcitabine suppressed the growth of pancreatic cancer cells and attenuated the expression of major tumor ECM components. Additionally, this combination effectively inhibited cell migration and invasion. Mechanistically, the enhanced anticancer efficacy of the co-treatment could be attributed to the inhibition of DDR1/PYK2/FAK signaling pathway, resulting in reduced tumor growth in a pancreatic xenograft model.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Review
Medicine, Research & Experimental
Bowen Huang, Haoran Huang, Shuting Zhang, Dingyue Zhang, Qingya Shi, Jianzhou Liu, Junchao Guo
Summary: Pancreatic cancer is a deadly disease, and early diagnosis and treatment are crucial. Artificial intelligence technology can be used for early screening, predicting prognosis, and developing diagnostic systems for pancreatic cancer. It also has wide applications in health records and imaging parameters estimation.
