Resolution-Based Therapies: The Potential of Lipoxins to Treat Human Diseases

Idiopathic Pulmonary Fibrosis (IPF) and pulmonary hypertension: Heracles meets the Hydra

(2020) Keshava Rajagopal et al.   BRITISH JOURNAL OF PHARMACOLOGY

Re-Imagining Cystic Fibrosis Care: Next Generation Thinking

(2020) Catherine Rang et al.   EUROPEAN RESPIRATORY JOURNAL

BML‐111 treatment prevents cardiac apoptosis and oxidative stress in a mouse model of autoimmune myocarditis

(2020) Rafael I. Jaén et al.   FASEB JOURNAL

Lipoxins, RevD1 and 9, 13 HODE as the most important derivatives after an early incident of ischemic stroke

(2020) Małgorzata Szczuko et al.   Scientific Reports

The Atlas of Inflammation Resolution (AIR)

(2020) Charles N. Serhan et al.   MOLECULAR ASPECTS OF MEDICINE

Myocarditis and inflammatory cardiomyopathy: current evidence and future directions

(2020) Carsten Tschöpe et al.   Nature Reviews Cardiology

The Protectin Family of Specialized Pro-resolving Mediators: Potent Immunoresolvents Enabling Innovative Approaches to Target Obesity and Diabetes

(2019) Trond Vidar Hansen et al.   Frontiers in Pharmacology

Salivary levels of specialized pro‐resolving lipid mediators as indicators of periodontal health/disease status

(2019) S I Tobón‐Arroyave et al.   JOURNAL OF CLINICAL PERIODONTOLOGY

Plasma Eicosanoid Levels in Tuberculosis and Tuberculosis-Diabetes Co-morbidity Are Associated With Lung Pathology and Bacterial Burden

(2019) Nathella Pavan Kumar et al.   Frontiers in Cellular and Infection Microbiology

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Cystic Fibrosis Lung Disease: An Overview

(2019) Nelson L Turcios   Respiratory Care

Lipoxin suppresses inflammation via the TLR4/MyD88/NF‐κB pathway in periodontal ligament cells

(2019) Muhanad Ali et al.   ORAL DISEASES

BML-111 alleviates acute lung injury through regulating the expression of lncRNA MALAT1

(2018) Hongbin Li et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Current Mechanistic Concepts in Ischemia and Reperfusion Injury

(2018) Meng-Yu Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Endoplasmic Reticulum Chaperone GRP78 Protects Heart From Ischemia/Reperfusion Injury Through Akt ActivationNovelty and Significance

(2018) Xukun Bi et al.   CIRCULATION RESEARCH

Combined administration of resolvin E1 and lipoxin A4 resolves inflammation in a murine model of Alzheimer's disease

(2018) Alpdogan Kantarci et al.   EXPERIMENTAL NEUROLOGY

Lipoxin A4 attenuates LPS-induced acute lung injury via activation of the ACE2-Ang-(1-7)-Mas axis

(2018) Qiong-Feng Chen et al.   Innate Immunity

Lipoxins Regulate the Early Growth Response–1 Network and Reverse Diabetic Kidney Disease

(2018) Eoin P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Asthma

(2018) Alberto Papi et al.   LANCET

Lipoxin A4 Attenuates the Inflammatory Response in Stem Cells of the Apical Papilla via ALX/FPR2

(2018) A. Gaudin et al.   Scientific Reports

The atheroprotective role of lipoxin A4 prevents oxLDL-induced apoptotic signaling in macrophages via JNK pathway

(2018) Jingting Mai et al.   ATHEROSCLEROSIS

Lipoxins Protect Against Inflammation in Diabetes-Associated Atherosclerosis

(2018) E. P. Brennan et al.   DIABETES

Restoration of Lipoxin A4 Signaling Reduces Alzheimer's Disease-Like Pathology in the 3xTg-AD Mouse Model

(2018) Haley C. Dunn et al.   JOURNAL OF ALZHEIMERS DISEASE

The therapeutic effects of lipoxin A4 during treadmill exercise on monosodium iodoacetate-induced osteoarthritis in rats

(2018) Yue Yang et al.   MOLECULAR IMMUNOLOGY

Resolution of chronic inflammatory disease: universal and tissue-specific concepts

(2018) Georg Schett et al.   Nature Communications

Ovulation: Parallels with Inflammatory Processes

(2018) Diane M Duffy et al.   ENDOCRINE REVIEWS

Pro-resolving mediators in the regulation of periodontal disease

(2017) Thomas E. Van Dyke   MOLECULAR ASPECTS OF MEDICINE

Signal transduction involved in lipoxin A4-induced protection of tubular epithelial cells against hypoxia/reoxygenation injury

(2017) Sheng-Hua Wu et al.   Molecular Medicine Reports

Deletion of 12/15-lipoxygenase accelerates the development of aging-associated and instability-induced osteoarthritis

(2017) L. Habouri et al.   OSTEOARTHRITIS AND CARTILAGE

BML-111 equilibrated ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis to protect hepatic fibrosis in rats

(2017) Quandong Hu et al.   PROSTAGLANDINS & OTHER LIPID MEDIATORS

Low dose aspirin increases 15-epi-lipoxin A4 levels in diabetic chronic kidney disease patients

(2017) Marian Goicoechea et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Pilot application of lipoxin A4 analog and lipoxin A4 receptor agonist in asthmatic children with acute episodes

(2017) Xia Kong et al.   Experimental and Therapeutic Medicine

Targeting resolution of neuroinflammation after ischemic stroke with a lipoxin A4 analog: Protective mechanisms and long-term effects on neurological recovery

(2017) Kimberly E. Hawkins et al.   Brain and Behavior

Pulmonary fibrosis, part I: epidemiology, pathogenesis, and diagnosis

(2017) Keith C Meyer   Expert Review of Respiratory Medicine

Periodontal diseases

(2017) Denis F. Kinane et al.   Nature Reviews Disease Primers

Lipoxin A4 prevents tight junction disruption and delays the colonization of cystic fibrosis bronchial epithelial cells by Pseudomonas aeruginosa

(2016) Gerard Higgins et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Formyl-Peptide Receptor 2/3/Lipoxin A4Receptor Regulates Neutrophil-Platelet Aggregation and Attenuates Cerebral InflammationCLINICAL PERSPECTIVE

(2016) Shantel A. Vital et al.   CIRCULATION

BML-111 attenuates acute lung injury in endotoxemic mice

(2016) Min Tang et al.   JOURNAL OF SURGICAL RESEARCH

An imbalance between specialized pro-resolving lipid mediators and pro-inflammatory leukotrienes promotes instability of atherosclerotic plaques

(2016) Gabrielle Fredman et al.   Nature Communications

Resolution of inflammation is altered in Alzheimer's disease

(2015) Xiuzhe Wang et al.   Alzheimers & Dementia

Transcellular biosynthesis of eicosanoid lipid mediators

(2015) Valérie Capra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Lipoxin A4 Attenuates Obesity-Induced Adipose Inflammation and Associated Liver and Kidney Disease

(2015) Emma Börgeson et al.   Cell Metabolism

Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein

(2015) Christoph Lehmann et al.   FASEB JOURNAL

BML-111 Attenuates Renal Ischemia/Reperfusion Injury Via Peroxisome Proliferator-Activated Receptor-α-Regulated Heme Oxygenase-1

(2015) Sheng-Hua Wu et al.   INFLAMMATION

Lipoxin A4Attenuates Constitutive and TGF-β1–Dependent Profibrotic Activity in Human Lung Myofibroblasts

(2015) Katy M. Roach et al.   JOURNAL OF IMMUNOLOGY

Lipoxin A4 Activates Nrf2 Pathway and Ameliorates Cell Damage in Cultured Cortical Astrocytes Exposed to Oxygen-Glucose Deprivation/Reperfusion Insults

(2015) Le Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Pro-Resolving Lipid Mediators Improve Neuronal Survival and Increase Aβ42 Phagocytosis

(2015) Mingqin Zhu et al.   MOLECULAR NEUROBIOLOGY

The immunology of asthma

(2015) Bart N Lambrecht et al.   NATURE IMMUNOLOGY

Lipoxin A4 and Neutrophil/Lymphocyte Ratio: A Possible Indicator in Achieved Systemic Risk Factors for Periodontitis

(2015) Burak Doğan et al.   MEDICAL SCIENCE MONITOR

Aspirin-triggered 15-epi-lipoxin A4 regulates neutrophil-platelet aggregation and attenuates acute lung injury in mice

(2014) G. Ortiz-Munoz et al.   BLOOD

Inflammation and Cardiovascular Disease: From Pathogenesis to Therapeutic Target

(2014) Enrica Golia et al.   Current Atherosclerosis Reports

Impaired resolution of inflammation in human chronic heart failure

(2014) Marta Reina-Couto et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Decreased Levels of Lipoxin A4 and Annexin A1 in Wheezy Infants

(2014) Hatice Eke Gungor et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Transcellular biosynthesis of eicosanoids

(2014) Angelo Sala et al.   Pharmacological Reports

Lipoxin A4 and Platelet Activating Factor Are Involved in E. coli or LPS-Induced Lung Inflammation in CFTR-Deficient Mice

(2014) Haiya Wu et al.   PLoS One

S102 Lipoxin A4 Improves Efferocytosis Via Inhibition Of The Hmgb1 In Human Alveolar Macrophages

(2014) Q. Wang et al.   THORAX

Aspirin-Triggered Lipoxin A4 Stimulates Alternative Activation of Microglia and Reduces Alzheimer Disease–Like Pathology in Mice

(2013) Rodrigo Medeiros et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipoxin A4-mediated KATP potassium channel activation results in cystic fibrosis airway epithelial repair

(2013) Paul J. Buchanan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Antifibrotic Mechanisms Aspirin-Triggered Lipoxin A4Synthetic Analog

(2013) Rafael F. Guilherme et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Lipoxin A4 attenuates brain damage and downregulates the production of pro-inflammatory cytokines and phosphorylated mitogen-activated protein kinases in a mouse model of traumatic brain injury

(2013) Cheng-Liang Luo et al.   BRAIN RESEARCH

Natural history, predictors and outcomes of depression after stroke: systematic review and meta-analysis

(2013) Luis Ayerbe et al.   BRITISH JOURNAL OF PSYCHIATRY

Lipoxin A4modulates adaptive immunity by decreasing memory B-cell responses via an ALX/FPR2-dependent mechanism

(2013) Sesquile Ramon et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lipoxin A4 attenuation of endothelial inflammation response mimicking pancreatitis-induced lung injury

(2013) Wanzhi Lv et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

LipoxinA4 attenuates myocardial ischemia reperfusion injury via a mechanism related to downregulation of GRP-78 and caspase-12 in rats

(2013) Qifeng Zhao et al.   HEART AND VESSELS

Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4receptor agonist, BML-111, in a rat model of ischemic stroke

(2013) Kimberly E. Hawkins et al.   JOURNAL OF NEUROCHEMISTRY

BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats

(2013) Hong-Bin Li et al.   JOURNAL OF SURGICAL RESEARCH

Lipoxins Attenuate Renal Fibrosis by Inducing let-7c and Suppressing TGF R1

(2013) E. P. Brennan et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Contribution of CFTR to Alveolar Fluid Clearance by Lipoxin A4via PI3K/Akt Pathway in LPS-Induced Acute Lung Injury

(2013) Yi Yang et al.   MEDIATORS OF INFLAMMATION

Annexin A1: potential for glucocorticoid sparing in RA

(2013) Yuan H. Yang et al.   Nature Reviews Rheumatology

Lipoxin A4 ameliorates cerebral ischaemia/reperfusion injury through upregulation of nuclear factor erythroid 2-related factor 2

(2013) Le Wu et al.   NEUROLOGICAL RESEARCH

Lipoxin A4-Induced Heme Oxygenase-1 Protects Cardiomyocytes against Hypoxia/Reoxygenation Injury via p38 MAPK Activation and Nrf2/ARE Complex

(2013) Xiao-Qing Chen et al.   PLoS One

Lipoxin A4 Regulates Natural Killer Cell and Type 2 Innate Lymphoid Cell Activation in Asthma

(2013) C. Barnig et al.   Science Translational Medicine

BML-111, a lipoxin receptor agonist, ameliorates ‘two-hit’-induced acute pancreatitis-associated lung injury in mice by the upregulation of heme oxygenase-1

(2013) Ying Zhen Wang et al.   Artificial Cells Nanomedicine and Biotechnology

Effect of Lipoxin A4 on Myocardial Ischemia Reperfusion Injury Following Cardiac Arrest in a Rabbit Model

(2012) Zhiqiao Chen et al.   INFLAMMATION

An ex vivo model of severe asthma using reconstituted human bronchial epithelium

(2012) Delphine Gras et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Lipoxin A4 Inhibits 5-Lipoxygenase Translocation and Leukotrienes Biosynthesis to Exert a Neuroprotective Effect in Cerebral Ischemia/Reperfusion Injury

(2012) Le Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The multiple facets of glucocorticoid action in rheumatoid arthritis

(2012) Ulrike Baschant et al.   Nature Reviews Rheumatology

Lipoxin A4 Stimulates Calcium-Activated Chloride Currents and Increases Airway Surface Liquid Height in Normal and Cystic Fibrosis Airway Epithelia

(2012) Valia Verrière et al.   PLoS One

Primary Human Airway Epithelial Cell-Dependent Inhibition of Human Lung Mast Cell Degranulation

(2012) Neil Martin et al.   PLoS One

Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo

(2011) Jun Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Comparative Lipidomics Profiling of Human Atherosclerotic Plaques

(2011) Christin Stegemann et al.   Circulation-Cardiovascular Genetics

Urinary concentrations of 15-epimer of lipoxin A4 are lower in patients with aspirin-intolerant compared with aspirin-tolerant asthma

(2011) H. Yamaguchi et al.   CLINICAL AND EXPERIMENTAL ALLERGY

Phosphoinositide-3 Kinase Signaling in Cardiac Hypertrophy and Heart Failure

(2011) Toshinori Aoyagi et al.   CURRENT PHARMACEUTICAL DESIGN

Lipoxin A4 and benzo-lipoxin A4 attenuate experimental renal fibrosis

(2011) Emma Börgeson et al.   FASEB JOURNAL

Lipoxin A4InhibitsPorphyromonas gingivalis-Induced Aggregation and Reactive Oxygen Species Production by Modulating Neutrophil-Platelet Interaction and CD11b Expression

(2011) Emma Börgeson et al.   INFECTION AND IMMUNITY

A Lipoxin A4 Analog Ameliorates Blood–Brain Barrier Dysfunction and Reduces MMP-9 Expression in a Rat Model of Focal Cerebral Ischemia–Reperfusion Injury

(2011) Yan Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Aspirin-triggered lipoxin A4 attenuates LPS-induced pro-inflammatory responses by inhibiting activation of NF-κB and MAPKs in BV-2 microglial cells

(2011) Yan-Ping Wang et al.   Journal of Neuroinflammation

Lipoxins as biomarkers of lupus and other inflammatory conditions

(2011) Undurti N Das   Lipids in Health and Disease

Lipoxin A4 and 8-isoprostane in the exhaled breath condensate of children hospitalized for status asthmaticus*

(2011) Rashed A. Hasan et al.   Pediatric Critical Care Medicine

Aspirin-Triggered Lipoxin and Resolvin E1 Modulate Vascular Smooth Muscle Phenotype and Correlate with Peripheral Atherosclerosis

(2010) Karen J. Ho et al.   AMERICAN JOURNAL OF PATHOLOGY

Lipoxin A 4 analogue protects brain and reduces inflammation in a rat model of focal cerebral ischemia reperfusion

(2010) Xi-Hong Ye et al.   BRAIN RESEARCH

Lipoxin A4 attenuates zymosan-induced arthritis by modulating endothelin-1 and its effects

(2010) FP Conte et al.   BRITISH JOURNAL OF PHARMACOLOGY

Atorvastatin Reduces Plaque Vulnerability in an Atherosclerotic Rabbit Model by Altering the 5-Lipoxygenase Pathway

(2010) Guangyi Zhou et al.   CARDIOLOGY

Lipoxin A4 impairment of apoptotic signaling in macrophages: implication of the PI3K/Akt and the ERK/Nrf-2 defense pathways

(2010) P Prieto et al.   CELL DEATH AND DIFFERENTIATION

Novel Lipid Mediators Promote Resolution of Acute Inflammation

(2010) Matthew Spite et al.   CIRCULATION RESEARCH

Cystic fibrosis transmembrane conductance regulator (CFTR) expression in human platelets: impact on mediators and mechanisms of the inflammatory response

(2010) Domenico Mattoscio et al.   FASEB JOURNAL

Acute Lung Injury: Epidemiology, Pathogenesis, and Treatment

(2010) Elizabeth R. Johnson et al.   Journal of Aerosol Medicine and Pulmonary Drug Delivery

Neuroprotective Effect of Lipoxin A4 Methyl Ester in a Rat Model of Permanent Focal Cerebral Ischemia

(2010) Yan Wu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Gender and Stroke Symptoms

(2010) Claudia C. Beal   JOURNAL OF NEUROSCIENCE NURSING

Amyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks

(2010) Jorge J Palop et al.   NATURE NEUROSCIENCE

Reversed changes of lipoxin A4and leukotrienes in children with asthma in different severity degree

(2010) Sheng-Hua Wu et al.   PEDIATRIC PULMONOLOGY

15-Epi-lipoxin A4Inhibits Myeloperoxidase Signaling and Enhances Resolution of Acute Lung Injury

(2009) Driss El Kebir et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

ATLa, an Aspirin-Triggered Lipoxin A4 Synthetic Analog, Prevents the Inflammatory and Fibrotic Effects of Bleomycin-Induced Pulmonary Fibrosis

(2009) V. Martins et al.   JOURNAL OF IMMUNOLOGY

12/15-Lipoxygenase Counteracts Inflammation and Tissue Damage in Arthritis

(2009) G. Kronke et al.   JOURNAL OF IMMUNOLOGY

Synthesis of Lipoxin A4 by 5-Lipoxygenase Mediates PPAR -Dependent, Neuroprotective Effects of Rosiglitazone in Experimental Stroke

(2009) M. Sobrado et al.   JOURNAL OF NEUROSCIENCE

BML-111, a lipoxin receptor agonist, modulates the immune response and reduces the severity of collagen-induced arthritis

(2008) L. Zhang et al.   INFLAMMATION RESEARCH

What is “physiological” intestinal inflammation and how does it differ from “pathological” inflammation?

(2008) Claudio Fiocchi   INFLAMMATORY BOWEL DISEASES

Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma

(2008) Anne M. Fitzpatrick et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Nonsteroidal Anti-Inflammatory Drugs: Adverse Effects and Their Prevention

(2008) Harald E. Vonkeman et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Prevention of Cardiac Hypertrophy and Heart Failure by Silencing of NF-κB

(2007) Sudhiranjan Gupta et al.   JOURNAL OF MOLECULAR BIOLOGY