Article
Biochemistry & Molecular Biology
Zhehao Shi, Yi Wang, Wen Ye, Zixia Lin, Tuo Deng, Tan Zhang, Jungang Zhao, Yifan Tong, Yunfeng Shan, Gang Chen
Summary: Studies have shown that BML-111 can enhance the expression of E-cadherin, alleviate apoptosis, and mitigate the accumulation of reactive oxygen species in intestinal epithelial cells, thereby improving anti-inflammatory efficacy in vitro and in vivo through activation of the Nrf2 antioxidant pathway.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Huimin Beng, Junhua Hu, Shanping Wang, Xinglong Liang, Haolong Qin, Wen Tan
Summary: This study investigated the effects of R-salbutamol, S-salbutamol, and their racemic mixture on a mouse model of lipopolysaccharide-induced endotoxemia. The results showed that R-salbutamol significantly improved the 7-day survival rate of endotoxic mice. It also effectively inhibited lung damage and reduced inflammatory responses, suggesting its potential benefits in regulating endotoxemia and endotoxin-induced lung injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Xiyue Zhang, Li Du, Jinrong Zhang, Chunyan Li, Jie Zhang, Xuejiao Lv
Summary: The study found that hordenine (Hor) can inhibit lipopolysaccharide-induced acute lung injury (ALI) by alleviating the disease through anti-inflammatory mechanisms. Hor can suppress the increase in inflammatory cytokine levels and exert its effects by regulating multiple signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xin Lv, Tingting Yao, Rongling He, Yijun He, Mengyu Li, Yuanyuan Han, Yan Zhang, Lingzhi Long, Guoliang Jiang, Xiaoyun Cheng, Yanyun Xie, Ling Huang, Zhangzhe Peng, Gaoyun Hu, Qianbin Li, Lijian Tao, Jie Meng
Summary: Fluorofenidone demonstrates protective effects against LPS-induced ALI by alleviating lung tissue injury, reducing inflammation, and inhibiting the activation of the MAPK/NF-κB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Agriculture, Multidisciplinary
Jingjing Guo, Ying Luo, Jingru Zuo, Jiang Teng, Bingyu Shen, Xiaoqiang Liu
Summary: Our study investigated the protective effect of Echinacea polyphenols (EPP) against LPS-induced acute lung injury (ALI) and the underlying mechanisms. We found that EPP pretreatment significantly alleviated lung tissue injury and pulmonary edema caused by LPS. EPP inhibited PANoptosis by regulating the expression of inflammasome proteins, gasdermin D, caspase-8, caspase-3, and mixed lineage kinase domain-like protein.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Immunology
Yuehong Chen, Huan Liu, Yunru Tian, Zhongling Luo, Jingjing Ran, Zhiyong Miao, Qiuping Zhang, Geng Yin, Qibing Xie
Summary: This study evaluated the therapeutic effects of FFD, a small-molecule drug that targets cPLA2, on LPS-induced ALI. FFD inhibited cPLA2 activity and the cPLA2/ERK/p65 signaling pathway, suppressed p65 translocation, and reduced the production of cytokines, chemokines, and downstream hydrolysates. These findings suggest that FFD holds promise as a therapeutic option for cPLA2-involved diseases, particularly ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yunduan Song, Chunyan Xu, Jiaoxiang Wu, Jie Shu, Huiming Sheng, Yao Shen
Summary: Palmatine (PAL) can alleviate acute lung injury (ALI) by inhibiting macrophage activation and attenuating the inflammatory response. PAL has inhibitory effects on the production of inflammatory mediators in cells and fluids. Additionally, PAL regulates macrophage function by inhibiting the activation of NF-KB and p38 MAPK signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Immunology
Cheng Wang, Yuting Yang, Chaoqi Zhou, Xianghuang Mei, Jing Liu, Kaihang Luo, Jia Zhou, Cheng Qin, Zhenguo Zeng
Summary: This study investigated the expression of WWOX in mouse lung and epithelial cells and explored its role in the LPS-induced ALI model. The researchers found that overexpressing WWOX could activate autophagy and suppress inflammatory responses, thus protecting against LPS-induced ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Cheng Wang, Xianghuang Mei, Yanrong Wu, Yuting Yang, Zhenguo Zeng
Summary: This study revealed for the first time that cinobufagin inhibited the inflammatory response in LPS-induced ALI, which lays the foundation for further understanding and development of cinobufagin as a potential new drug for ALI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Evy Goossens, Jianhui Li, Chana Callens, Nathalie Van Rysselberghe, Hannele Kettunen, Juhani Vuorenmaa, Natalia Garcia Gonzalez, Claude Libert, Richard Ducatelle, Filip Van Immerseel
Summary: The acute stage of SIRS induces dysbiosis of the small intestinal and respiratory microbiome, which are associated with systemic inflammation and organ failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ya-Xian Wu, Si Zeng, Bin-Bin Wan, Ying-Ying Wang, Hong-Xu Sun, Gang Liu, Zhi-Qi Gao, Dan Chen, Yong-Quan Chen, Mu-Dan Lu, Qing-Feng Pang
Summary: The study found that Sophoricoside (SOP) can attenuate LPS-induced acute lung injury (ALI) through modulation of the AMPK/Nrf2 signaling pathway. This suggests that SOP may be a potential therapeutic candidate for treating ALI/ARDS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Szu-Yu Liu, Chia-Chang Huang, Shiang-Fen Huang, Tsai-Ling Liao, Nai-Rong Kuo, Ying-Ying Yang, Tzu-Hao Li, Chih-Wei Liu, Ming-Chih Hou, Han-Chieh Lin
Summary: Activation of systemic, renal vessel and renal tissue levels of PPAR gamma by chronic pioglitazone treatment has beneficial effects on endotoxemia-related TNF alpha/NF kappa B-mediated acute and chronic renal inflammation in cirrhosis. This study revealed that normalization of renal and renal arterial levels of PPAR gamma effectively prevented LPS-induced acute and chronic renal dysfunction in cirrhotic ascitic rats.
Article
Cell Biology
Nursel Dikmen, Mustafa Cellat, Muhammed Etyemez, Cafer Tayer Isler, Ahmet Uyar, Tuba Aydin, Mehmet Guvenc
Summary: The study demonstrated that oleuropein, a component of olive leaf, has protective effects against LPS-induced ALI in rats, reducing inflammatory cytokines and oxidative stress, and improving the histopathological conditions of lung tissue.
Article
Biochemistry & Molecular Biology
Yifan Tu, Xiaodong Li, Yuanzheng Fu, Yunyun Chen, Hui Fang, Yuan Li, Ying Gu, Jiawei Zhang
Summary: Isocorydine (ICD), an isoquinoline alkaloid, shows potential effects in reducing IL-6 expression and protecting mice from acute lung injury by attenuating the phosphorylation of p65 and JNK in BMDMs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
Mingxing Su, Huixiu Qi, Qingzhen Huang, Lili Wang, Xueqi Guo, Qiang Wang
Summary: Inhalation of arsenic can exacerbate the development of bacterial pneumonia, but the exact mechanism remains unclear. Exposure to arsenic or lipopolysaccharide alone produced different effects, while combined exposure increased inflammatory factors and lung damage. The expression of certain proteins involved in epithelial barrier integrity was further disrupted by combined exposure.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Cell Biology
Jingyi Yang, Maohua Zhong, Ejuan Zhang, Ke Hong, Qingyu Yang, Dihan Zhou, Jianbo Xia, Yao-Qing Chen, Mingbo Sun, Bali Zhao, Jie Xiang, Ying Liu, Yang Han, Mengxin Xu, Xi Zhou, Chaolin Huang, You Shang, Huimin Yan
Summary: The study revealed significant alterations in the immune status of lymphocytes in COVID-19-recovered patients, suggesting potential dysfunction even after clinical recovery. No tendency toward recovery within 4-11 weeks post discharge was observed for phenotypes associated with reduced function.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Article
Immunology
Bing Xie, Jiancheng Zhang, Yuwen Li, Shiying Yuan, You Shang
Summary: COVID-19, caused by SARS-CoV-2, has led to high morbidity and mortality globally. While most infected individuals are asymptomatic or have mild symptoms, immunocompromised patients are at risk of progressing to severe cases. A well-coordinated immune response and understanding of the immunological processes underlying COVID-19 are crucial for effective treatment and management.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yun Tang, Xiaobo Yang, Huaqing Shu, Yuan Yu, Shangwen Pan, Jiqian Xu, You Shang
Summary: The study found that septic shock and acute kidney injury are closely related, and genes VMP1, SLPI, PTX3, TIMP1, OLFM4, LCN2, and S100A9 are significantly associated with novel biomarkers involved in the occurrence and development of SSAKI.
Editorial Material
Critical Care Medicine
Xuehui Gao, Wen Yang, Huaqing Shu, Xiaobo Yang, Yuan Yu, You Shang
Editorial Material
Medicine, General & Internal
Yue-Tian Yu, Jiao Liu, Bo Hu, Rui-Lan Wang, Xiang-Hong Yang, Xiu-Ling Shang, Gang Wang, Chang-Song Wang, Bai-Ling Li, Ye Gong, Sheng Zhang, Xin Li, Lu Wang, Min Shao, Mei Meng, Feng Zhu, You Shang, Qiang-Hong Xu, Zhi-Xiong Wu, De-Chang Chen
CHINESE MEDICAL JOURNAL
(2021)
Article
Critical Care Medicine
Yaxin Wang, Xiangzhi Fang, Yiyi Yang, Lin Chen, Wei Xiong, Limin Song, Bo Li, Ting Zhou, Yuan Yu, Xiaobo Yang, Huaqing Shu, Shiying Yuan, Shanglong Yao, You Shang
Summary: In this study, it was found that DAPK1 mediated cyclic stretch-induced alveolar epithelial cell apoptosis and ventilator-induced lung injury through the P53 pathway. Inhibition of DAPK1 or P53 can alleviate high tidal volume ventilation-induced lung injury and alveolar epithelial cell apoptosis.
Article
Cell Biology
Ruiting Li, Xuemei Hu, Huibin Chen, Yue Zhao, Xuehui Gao, Yin Yuan, Huiling Guo, Haiyan Huang, Xiaojing Zou, Hong Qi, Hong Liu, You Shang
Summary: This study suggests that the cholinergic anti-inflammatory pathway contributes to the reduction in the inflammatory response in ALI by regulating the maturation, phenotype, and quantity of DCs and conventional DCs.
MEDIATORS OF INFLAMMATION
(2022)
Review
Respiratory System
Xuehui Gao, Xiaojing Zou, Ruiting Li, Huaqing Shu, Yuan Yu, Xiaobo Yang, You Shang
Summary: COVID-19 has been a global challenge for more than two years. The recent emergence of mutant virus strains has posed even greater obstacles to disease prevention and treatment. Point-of-care ultrasound (POCUS) is recommended for regular use in COVID-19 patients, particularly in respiratory failure management. This review summarizes the ultrasound characteristics of COVID-19 patients, focusing on lung ultrasound and echocardiography, and discusses the experience of using POCUS to manage COVID-19-related acute respiratory distress syndrome (ARDS).
BMC PULMONARY MEDICINE
(2022)
Article
Medicine, General & Internal
Wei Cheng, Xu-Dong Ma, Long-Xiang Su, Yun Long, Da-Wei Liu, Bin Du, Hai-Bo Qiu, Xiang-Dong Guan, De-Chang Chen, Yan Kang, Zhao-Hui Tong, Zhi-Yong Peng, You Shang, Rui-Qiang Zheng, Shu-Sheng Li, Chun Pan, Xiao-Bo Huang, Qing-Yuan Zhan, Ren-Yu Ding, Chao-Lin Huang, Yong-Jie Yin, Sheng-Qing Li, Xu-Yan Li, Li Jiang, Ming Hu, Xin Li, Xiang Zhou, Zhi-Cheng Jing, Yan-Hong Guo, Shu-Yang Zhang
Summary: The study examined the clinical characteristics and in-hospital mortality of critically ill COVID-19 patients supported with ECMO. It found that ECMO support could reduce mortality, but its effectiveness was influenced by patient age. Factors like patient age, lymphocyte count, and medical resource availability should be fully considered when initiating ECMO therapy under significant pressure.
FRONTIERS IN MEDICINE
(2021)
Review
Medicine, General & Internal
Hongling Zhang, Jiqian Xu, Xiaobo Yang, Xiaojing Zou, Huaqing Shu, Zhengdong Liu, You Shang
Summary: ECMO is a life-saving technique used worldwide, especially during the COVID-19 pandemic, but patients undergoing ECMO have a low survival rate due to various complications. The neurological morbidity associated with ECMO has been increasingly focused on, with early recognition of neurologic injury being crucial for patient outcomes. Multimodal monitoring is advocated as an important approach for early diagnosis of devastating neurologic injuries in ECMO patients.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Shangwen Pan, Huaqing Shu, Yaxin Wang, Ruiting Li, Ting Zhou, Yuan Yu, Jiqian Xu, Wei Xiong, Xiaobo Yang, Jiancheng Zhang, Yin Yuan, Shiying Yuan, You Shang
Summary: By analyzing data from 118 confirmed SARS-CoV-2 patients, it was found that characteristics such as lymphocyte and platelet levels, as well as lesion areas on CT scans, were associated with disease severity. The study suggests that combining clinical features with specific CT levels can effectively predict severe/critical cases of SARS-CoV-2 pneumonia.
FRONTIERS IN MEDICINE
(2021)
Article
Medicine, General & Internal
Jiqian Xu, Xiaobo Yang, Zheng Lv, Ting Zhou, Hong Liu, Xiaojing Zou, Fengsheng Cao, Lu Zhang, Boyi Liu, Wei Chen, Yuan Yu, Huaqing Shu, Shiying Yuan, Ming Hu, Chaolin Huang, You Shang
Summary: This study found that thrombocytopenia, vasopressor use, and corticosteroid treatment were significantly associated with an increased risk of incident IPA in COVID-19 patients admitted to ICUs. The occurrence of CAPA may lead to longer ICU stays and higher 180-day mortality compared to those without CAPA.
FRONTIERS IN MEDICINE
(2021)
Editorial Material
Emergency Medicine
Rui-ting Li, Yue Zhao, Xiao-jing Zou, Hua-qing Shu, Ting Zhou, Shang-wen Pan, Xue-hui Gao, Hai-yan Huang, Hong Liu, You Shang
WORLD JOURNAL OF EMERGENCY MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Hong Qi, Jiancheng Zhang, You Shang, Shiying Yuan, Chunqing Meng
Summary: Argon preconditioning can inhibit the PDCD4/PTEN pathway through miR-21, reducing oxidative stress and inflammatory factor levels, protecting cardiomyocytes from MI/R injury.
Article
Obstetrics & Gynecology
Yin Zhao, Bangxing Huang, Hui Ma, You Shang, Xiu Nie, Li Zou
Summary: This study analyzed the clinical data of 5 pregnant women who were infected with COVID-19 in early pregnancy, showing that infants were healthy and asymptomatic at 3-6 months after birth, with no adverse outcomes observed. Placental pathology revealed chronic ischemia changes, suggesting that COVID-19 may cause placental injury.
MATERNAL-FETAL MEDICINE
(2021)
Editorial Material
Surgery
Meghal Shah, Tejas S. Sathe, Sukriti Bansal, Anai N. Kothari, Sophie Dream
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Zafer Turkyilmaz, Ramazan Karabulut, Kaan Sonmez
JOURNAL OF SURGICAL RESEARCH
(2024)
Letter
Surgery
Priyanka Jadhav, Gerald Gollin
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Kheira Hireche, Ludovic Canaud, Pierre Antoine Peyron, Linda Sakhri, Isabelle Serres, Sanaa Kamel, Youcef Lounes, Thomas Gandet, Pierre Alric
Summary: This study evaluated the elastic properties of commonly used vascular substitutes for pulmonary artery replacement and compared their compliance and stiffness indexes to human pulmonary artery. The results showed that allogenic arterial grafts appeared to be the most suitable vascular substitutes in terms of compliance and stiffness for PA replacement.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Margaret Siu, Aixa Perez Coulter, Heather M. Grant, Reginald Alouidor, Michael Tirabassi
Summary: There is no significant difference in adverse respiratory events between intubated, critically ill patients requiring operative intervention who are kept NPO for 6 hours or longer compared to those kept NPO for less than 6 hours. Patients commonly experience periods of fasting much longer than the recommended 6-hour period by the American Society of Anesthesiologists.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Whitney Elks, Allison G. McNickle, Matthew Kelecy, Kavita Batra, Shirley Wong, Shawn Wang, Lisa Angotti, Deborah A. Kuhls, Charles St Hill, Syed F. Saquib, Paul J. Chestovich, Douglas R. Fraser
Summary: This study aimed to compare the effects of early and late enteral feeding after PEG placement on achieving nutritional therapy goals and adverse outcomes. The results showed that patients with early initiation of feeds achieved a higher percentage of goals on day 0 without an increased rate of adverse events.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Manisha B. Bhatia, Cassandra M. Anderson, Abdiwahab N. Hussein, Brian Opondo, Nereah Aruwa, Otieno Okumu, Sarah G. Fisher, Tasha Sparks Joplin, JoAnna L. Hunter-Squires, Brian W. Gray, Peter W. Saula
Summary: This study aimed to understand postoperative pediatric nutrition practices in Kenya and the United States. The results showed that in the United States, patients initiated enteral nutrition earlier and had shorter hospital stays. However, in Kenya, patients initiated enteral nutrition earlier but had no significant difference in hospital stays.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David P. Stonko, Joseph Edwards, Hossam Abdou, Rebecca Treffalls, Patrick Walker, Jonathan J. Morrison
Summary: Raising mean arterial pressure (MAP) >90 mmHg with norepinephrine can increase gastroduodenal artery (GDA) flow and delay bowel ischemia.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
David R. Mann, Kathryn E. Engelhardt, Barry C. Gibney, Macelyn E. Batten, Eric C. Klipsch, Rupak Mukherjee, Ian C. Bostock
Summary: Pathologic upstaging is associated with decreased overall survival in cT1b esophageal cancer. Esophagectomy has better survival outcomes compared to endoscopic local tumor excision. Neoadjuvant chemoradiation therapy does not improve overall survival in cT1b lesions.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ross Mudgway, Zachary Tran, Juan C. Quispe Espiritu, Woo Bin Bong, Hayden Schultz, Vamsi Vemireddy, Aarthy Kannappan, Marcos Michelotti, Kaushik Mukherjee, Jeffrey Quigley, Keith Scharf, Daniel Srikureja, Sharon S. Lum, Esther Wu
Summary: Comparison of medium-term outcomes between robotic-assisted cholecystectomy (RC) and laparoscopic cholecystectomy (LC) using validated quality of life (QoL) and pain assessments did not show significant differences.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Ningjie Chen, Haitao Wang, Yang Shao, Jincun Yang, Guodong Song
Summary: This study aimed to compare the therapeutic effects of activated platelet-rich plasma (PRP) prepared from elderly individuals and young adults in treating pressure ulcers (PUs). The results showed that PRP from young adults had higher platelet concentrations and greater production of growth factors, leading to better wound healing.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Brendin R. Beaulieu-Jones, Margaret T. Berrigan, Kortney A. Robinson, Jayson S. Marwaha, Tara S. Kent, Gabriel A. Brat
Summary: Introduction: Prescription opioids, including those prescribed after surgery, have greatly contributed to the US opioid epidemic. Educating opioid prescribers is a crucial component of ensuring the safe use of opioids among surgical patients. This study implemented an annual education curriculum for new surgical prescribers, resulting in significant improvements in knowledge and comfort levels. However, there remains a persistent knowledge and comfort gap among these prescribers.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Sneha G. Bhat, Madhuri Nagaraj, Courtney Balentine, Timothy Hogan, Jennie Meier, Hillary Prince, Kareem Abdelfattah, Herbert Zeh, Benjamin Levi
Summary: This pilot study examined the effects of a structured mental fitness program on academic surgeons and found significant improvement in Positive Intelligence (PQ) scores, as well as increased connectedness and shared language among participants. However, there were no significant changes in sleep, well-being, or teaching evaluations.
JOURNAL OF SURGICAL RESEARCH
(2024)
Article
Surgery
Kristin E. Cox, Michael A. Turner, Siamak Amirfakhri, Thinzar M. Lavin, Mojgan Hosseini, Pradipta Ghosh, Marygorret Obonyo, Takashi Murakami, Robert M. Hoffman, Paul J. Yazaki, Michael Bouvet
Summary: This study demonstrates the potential of using humanized anti-carcinoembryonic antigen (CEA) antibodies conjugated with near-infrared dyes to specifically label gastric cancers in mouse models. Orthotopic models showed bright and specific labeling with more than ten times higher tumor-to-background ratios compared to the control. This tumor-specific fluorescent antibody has promising potential as a clinical tool for improving visualization of gastric cancer margins during surgical resection.
JOURNAL OF SURGICAL RESEARCH
(2024)
Review
Surgery
Sarah Maki, Melissa Leon, Emily Glenn, Tiffany Tanner, Crystal Krause
Summary: This scoping review analyzed the literature on the use of broadband personality tests in the bariatric surgical population to optimize weight loss outcomes. The study found significant associations between personality scales and weight loss, but inconsistent reporting of outcome measures made it challenging to draw concrete conclusions. The American Society for Metabolic and Bariatric Surgery recommends standardization of outcome reporting to improve the reliability of predicting weight loss outcomes.
JOURNAL OF SURGICAL RESEARCH
(2024)