Review
Biochemistry & Molecular Biology
Alyssa Elmore, Ali Almuntashiri, Xiaoyun Wang, Sultan Almuntashiri, Duo Zhang
Summary: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are life-threatening lung diseases. Surfactant protein-D (SP-D) has been extensively studied and found to have superior discriminatory ability for the diagnosis of ARDS. Recombinant SP-D shows potential as a drug for the treatment of ALI.
Article
Biochemistry & Molecular Biology
Alessio Filippo Peritore, Ramona D'Amico, Rosalba Siracusa, Marika Cordaro, Roberta Fusco, Enrico Gugliandolo, Tiziana Genovese, Rosalia Crupi, Rosanna Di Paola, Salvatore Cuzzocrea, Daniela Impellizzeri
Summary: The study demonstrated that ultramicronized palmitoylethanolamide (um-PEA) reduced lung damage, inflammation cell infiltration, and cytokine release in LPS-induced acute lung injury (ALI) mice. um-PEA may exert its anti-inflammatory effects possibly through the p38/NF-kappa B pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ngan Nguyen, Simin Xu, Terence Yin Weng Lam, Wupeng Liao, W. S. Fred Wong, Ruowen Ge
Summary: This study reveals that ISM1 plays an anti-inflammatory role in acute lung injury (ALI), and its deficiency leads to intensified acute lung inflammation and increased post-ALI lung fibrosis. Recombinant ISM1 effectively suppresses acute lung inflammation and ALI, and inhibits NF-κB activation in mouse alveolar macrophages.
MOLECULAR MEDICINE
(2022)
Article
Cell Biology
Jung Yeon Hong, Mi Na Kim, Eun Gyul Kim, Jae Woo Lee, Hye Rin Kim, Soo Yeon Kim, Soon Min Lee, Yoon Hee Kim, Kyung Won Kim, Myung Hyun Sohn
Summary: Exposure to high oxygen concentrations leads to excessive generation of reactive oxygen species, causing cellular injury and multiple organ dysfunctions. Clusterin (CLU) expression is increased during prolonged hyperoxia-induced lung injury, and replenishment of CLU can alleviate hyperoxia-induced cell death.
Review
Microbiology
Xin Zhou, Youxia Liao
Summary: The pathogenesis of septic ALI/ARDS is complex and multifactorial, mainly due to systemic and local inflammatory responses caused by various factors disrupting immune homeostasis, which can initiate and exacerbate ALI/ARDS.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Livia Interdonato, Ramona D'amico, Marika Cordaro, Rosalba Siracusa, Roberta Fusco, Alessio Filippo Peritore, Enrico Gugliandolo, Rosalia Crupi, Stefano Coaccioli, Tiziana Genovese, Daniela Impellizzeri, Rosanna Di Paola, Salvatore Cuzzocrea
Summary: Acute lung injury (ALI) is a common and devastating clinical disorder with a high mortality rate and no specific therapy. The aim of this study was to evaluate the protective effects of Adelmidrol (ADM) in a mice model of ALI induced by lipopolysaccharide (LPS). ADM administration reduced lung damage, airway infiltration, and oxidative stress by regulating mast cells and antioxidant enzymes. These findings suggest that ADM could be a potential candidate in the management of ALI.
Article
Plant Sciences
Yueliang Zheng, Mian Zheng, Jing Shao, Chengxing Jiang, Jian Shen, Rujia Tao, Yuqin Deng, Yingge Xu, Yuanqiang Lu
Summary: Shenfu significantly reduced the wet/dry weight ratio and inflammatory cytokine levels in a mouse model of lung injury, enhanced cell viability, inhibited cell apoptosis, and mediated protective effects by upregulating claudin-4 expression in in vitro cultured epithelial cells. Additionally, Shenfu was able to protect against both lung and intestinal epithelial damage in acute gastrointestinal injury-exacerbated ALI.
PHARMACEUTICAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Qianying Lu, Sifan Yu, Xiangyan Meng, Mingyu Shi, Siyu Huang, Junfeng Li, Jianfeng Zhang, Yangfan Liang, Mengjun Ji, Yanmei Zhao, Haojun Fan
Summary: Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is an inflammatory response that destroys lung parenchymal cells and reduces lung function. MicroRNAs play a crucial role in regulating inflammatory and immune responses in ALI/ARDS and may serve as diagnostic indicators and therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Qianying Lu, Siyu Huang, Xiangyan Meng, Jianfeng Zhang, Sifan Yu, Junfeng Li, Mingyu Shi, Haojun Fan, Yanmei Zhao
Summary: Phosgene poisoning can lead to acute respiratory distress syndrome or death, and there is currently no specific antidote for it. Further research is needed to explore treatment strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
Sedra Tibi, Garbel Zeynalvand, Hina Mohsin
Summary: This systematic review examines the role of the RAAS in the development of S-AKI in sepsis and discusses the potential use of RAAS antagonists as a therapeutic option. The findings suggest that treatment with RAAS inhibitors can decrease rates and severity of S-AKI and improve survival outcomes in septic patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Rong Chen, Chen Cao, Huimin Liu, Wanli Jiang, Rui Pan, He He, Ke Ding, Qingtao Meng
Summary: This study identifies macrophage Spry4 as a key regulator in sepsis-induced acute lung injury (ALI) and suggests that targeting Spry4 could be a potential therapeutic approach for ALI. Mechanistically, macrophage Spry4 deficiency alleviates ALI by activating the CaMKK2/AMPK pathway.
Article
Chemistry, Medicinal
Jianmin Ling, Shanshan Yu, Feng Xiong, Tingting Xu, Shusheng Li
Summary: This study found that melatonin can regulate mitophagy in sepsis-induced acute lung injury (ALI) by influencing the expression of OPTN, a mitophagy adaptor. Treatment with melatonin alleviated ALI and normalized mitophagy, thereby reducing epithelial barrier damage and inflammation. These findings suggest that manipulating mitophagy through melatonin could be a potential treatment for sepsis-associated lung injury.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Review
Medicine, General & Internal
Baisheng Sun, Mingxing Lei, Jiaqi Zhang, Hongjun Kang, Hui Liu, Feihu Zhou
Summary: Sepsis is a systemic inflammatory disease caused by severe infections, often resulting in acute lung injury (ALI). The exact pathological process of ALI caused by sepsis is not fully understood. This article reviews the research advances in the pathogenesis of ALI caused by sepsis and the treatment regimens adopted in clinical practice, providing new insights for theoretical understanding and treatment strategies.
FRONTIERS IN MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Zhong Xiao, Juan Long, Jie Zhang, Zhimin Qiu, Chen Zhang, Hongbing Liu, Xinyong Liu, Kang Wang, Yahui Tang, Longwang Chen, Zhongqiu Lu, Guangju Zhao
Summary: This study found that protopine (PTP) has a protective effect on septic acute lung injury (ALI), reducing inflammation, oxidative stress, apoptosis, and mitophagy damage, and improving survival rate. This suggests that PTP may have potential role in the treatment of sepsis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen
Summary: Infiltration of polymorphonuclear neutrophils (PMNs) is critical in acute lung injury (ALI). This study reveals that pyruvate kinase type M2 (PKM2) plays a crucial role in PMN inflammatory responses, and deletion of PKM2 in PMNs impairs their function but protects against LPS-induced ALI.
Article
Biochemistry & Molecular Biology
Binbin Chang, Zhang Wang, Hui Cheng, Tingyuan Xu, Jieyu Chen, Wan Wu, Yizhi Li, Yong Zhang
Summary: Acacetin can attenuate sepsis-induced ALI by inhibiting the inflammatory response and promoting macrophage polarization. This study is of great significance for the development of new treatments for sepsis-induced ALI.
Review
Biochemistry & Molecular Biology
Nikoleta Bizymi, Andreas M. Matthaiou, Irene Mavroudi, Aristea Batsali, Helen A. Papadaki
Summary: Myeloid-derived suppressor cells (MDSCs) are innate immune cells that have immunomodulatory properties. They interact extensively with other innate or adaptive immune cells and can either enhance or attenuate immune responses depending on the triggering conditions. However, their positive role in host defense mechanisms is rarely discussed in the literature.