Article
Pharmacology & Pharmacy
Xiang Gao, Qingyun Wu, Xinle Zhang, Jia Tian, Dahong Liang, Yalin Min, Jiaqi Lu, Xuemei Zhang, Liao Cui, Bilian Xu, Yanzhi Liu
Summary: This study investigated the potential of salvianolate treatment in ameliorating osteopenia in prednisone-treated RA rats. The results showed that Salvianolate significantly improved bone density and bone quality.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Rheumatology
Delila Singh, Nina Hesse, Alla Skapenko, Hendrik Schulze-Koops
Summary: Methotrexate is associated with rare bone lesions that are often misdiagnosed as osteoporotic fractures. Early diagnosis is crucial for treatment and prevention of further osteopathology. This case highlights the importance of raising awareness and taking appropriate therapeutic measures, including discontinuing methotrexate.
Article
Rheumatology
Ping-Hsuan Hsieh, Claudia Geue, Olivia Wu, Emma McIntosh, Stefan Siebert
Summary: The presence of multiple long-term conditions in early rheumatoid arthritis patients significantly increases the disease burden, including direct and indirect costs. These costs increase with the number of long-term conditions, with patients with only rheumatoid arthritis incurring the lowest costs.
Article
Rheumatology
Rodrigo N. Garcia Salinas, Maria A. Lazaro, Santiago Scarafia, Alejandra Cusa, Maria V. Martire, Nieves Capozzi, Luciana Casalla, Lucia Zarate, Maria De la Vega, Maria Correa, Gustavo C. Casado, Silvia Papasidero, Silvana Perez, Oscar L. Rillo, Damaris Alvarez, Mariana Benegas, Maria P. Girard Bosch, Karin Kirmayr, Ramiro Gomez
Summary: Patients with rheumatic autoimmune diseases, especially rheumatoid arthritis, have a higher risk of serious infections compared to controls in Latin America. The RABBIT risk score showed excellent performance in predicting the risk of serious infections in these patients, with a sensitivity of 75% and specificity of 85%. This tool could be valuable for assessing infection risk in this population.
CLINICAL RHEUMATOLOGY
(2021)
Article
Chemistry, Medicinal
Xin Gao, Xuemei He, Hiroyuki Oshima, Daisuke Miyatake, Yukio Otsuka, Kota Kato, Chunxiao Cai, Tomasz Wojtkowski, Nan Song, Yuichiro Kaneko, Aixin Shi
Summary: This study investigated the pharmacokinetics and safety of peficitinib in healthy Chinese subjects. It found that peficitinib was rapidly absorbed and well tolerated at all doses.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Rheumatology
Roswitha Dietzel, Sabine Wiegmann, Diana Borucki, Christian Detzer, Kim Nikola Zeiner, Desiree Schaumburg, Bjoern Buehring, Frank Buttgereit, Gabriele Armbrecht
Summary: In patients with rheumatoid arthritis (RA), chronic inflammation can lead to muscle depletion. The study found that sarcopenia is more common in RA patients and is associated with factors such as body weight, BMI, inflammation markers, and disease duration.
Article
Rheumatology
Farzin Khosrow-Khavar, Seoyoung C. Kim, Hemin Lee, Su Been Lee, Rishi J. Desai
Summary: The study did not find evidence of increased cardiovascular risk with tofacitinib in patients with RA in a real-world setting. However, tofacitinib was associated with an increased risk of cardiovascular outcomes, although statistically non-significant, in patients with RA with cardiovascular risk factors.
ANNALS OF THE RHEUMATIC DISEASES
(2022)
Article
Medicine, General & Internal
Ewa Zelnio, Mihra Taljanovic, Malgorzata Manczak, Iwona Sudol-Szopinska
Summary: The hand and wrist are frequently involved in rheumatic diseases, and this study aimed to identify the distinguishing radiographic characteristics of psoriatic arthritis (PsA), seropositive rheumatoid arthritis (RA), and seronegative RA, especially in the early stages. The analysis of radiographic hand findings on 180 seropositive RA patients, 154 PsA patients, and 36 seronegative RA patients revealed that symmetric distribution of lesions was more suggestive of seropositive or seronegative RA, while lesions affecting PIP joints, wrist, or styloid process of the radius were more common in patients with seropositive RA. PsA was more likely to be suggested by DIP joints' involvement and proliferative bone changes. Furthermore, there were differences in the types of bone lesions and their distribution between seropositive RA, seronegative RA, and PsA, with ulnar styloid involvement more commonly seen in seronegative RA patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Oncology
Martina Valenzuela, Roberta Amato, Antonella Sgura, Antonio Antoccia, Francesco Berardinelli
Summary: The ATRX gene is emerging as one of the most important oncosuppressive genes in the human genome, with diverse activities such as regulating epigenetic stability, maintaining telomere function, responding to replicative stress, and suppressing transposable elements and viral genomes.
Review
Pharmacology & Pharmacy
Dan-na Huang, Fang-fang Wu, Ai-hua Zhang, Hui Sun, Xi-jun Wang
Summary: The study recaps the potential therapeutic effects and mechanisms of action of berberine in treating rheumatoid arthritis, as well as discusses its modulation of gut microbiota during RA. Berberine may be a promising lead drug with multi-functional activities for the therapeutic strategy of RA.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Developmental Biology
Frederic Causeret, Matthieu X. Moreau, Alessandra Pierani, Oriane Blanquie
Summary: Cajal-Retzius neurons (CRs) are among the first-formed neurons in the developing cortex, known for controlling glutamatergic neuron migration and cortical layer formation, as well as playing various additional key roles in cortical development. Recent advancements in single-cell technologies have allowed for a greater understanding of the molecular heterogeneity of CRs and their roles in different species.
Review
Immunology
Xueling Liu, Zhiguo Wang, Hua Qian, Wenhua Tao, Ying Zhang, Chunyan Hu, Weiwei Mao, Qi Guo
Summary: Rheumatoid arthritis is an autoimmune disease affecting joints, and natural medicines have shown potential therapeutic effects on RA through mechanisms such as anti-inflammation, anti-oxidation, and immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Genetics & Heredity
Patryk Slusarczyk, Katarzyna Mleczko-Sanecka
Summary: The production and breakdown of red blood cells involves significant iron recycling processes. Specialized macrophages are key in handling red blood cells, but there is still limited understanding of the mechanistic details of this process.
Article
Pharmacology & Pharmacy
Merel A. A. Opdam, Sophie Benoy, Lise M. Verhoef, Sandra Van Bijnen, Femke Lamers-Karnebeek, Rene A. M. Traksel, Petra Vos, Alfons A. den Broeder, Jasper Broen
Summary: Patients with inflammatory rheumatic diseases do not have an increased risk for COVID-19 compared to the general population. Older age and obesity are major risk factors for hospitalization for COVID-19 in patients with IRD, while the use of methotrexate may have a protective effect in reducing the risk of hospitalization.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Mei Yang, Lijuan Mao, Xingyue Yang, Xiujin Xu, Caihong Tang, Wei Wei, Jingyu Chen
Summary: This study reveals that Ginsenoside compound K (GCK) exerts its anti-inflammatory effects by targeting glucocorticoid receptor (GR). GCK can directly bind to and activate GR, which mediates its anti-inflammatory effects through transcriptional activation and transcriptional inhibition.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)