Protective Effect of An-Gong-Niu-Huang Wan Pre-treatment Against Experimental Cerebral Ischemia Injury via Regulating GSK-3β/HO-1 Pathway

Farrerol Directly Targets GSK-3β to Activate Nrf2-ARE Pathway and Protect EA.hy926 Cells against Oxidative Stress-Induced Injuries

(2020) Chaoqun Yan et al.   Oxidative Medicine and Cellular Longevity

Risk Factors Associated with Outcomes of Recombinant Tissue Plasminogen Activator Therapy in Patients with Acute Ischemic Stroke

(2020) Yi-Ju Tseng et al.   International Journal of Environmental Research and Public Health

Glycine Improves Ischemic Stroke Through miR-19a-3p/AMPK/GSK-3β/HO-1 Pathway

(2020) Zhongjun Chen et al.   Drug Design Development and Therapy

20(S)-protopanaxadiol and oleanolic acid ameliorate cognitive deficits in APP/PS1 transgenic mice by enhancing hippocampal neurogenesis

(2020) Kaili Lin et al.   Journal of Ginseng Research

Upregulation of Glutaredoxin 2 alleviates oxygen-glucose deprivation/reoxygenation-induced apoptosis and ROS production in neurons by enhancing Nrf2 signaling via modulation of GSK-3β

(2020) Jian Wen et al.   BRAIN RESEARCH

China Stroke Statistics 2019: A Report From the National Center for Healthcare Quality Management in Neurological Diseases, China National Clinical Research Center for Neurological Diseases, the Chinese Stroke Association, National Center for Chronic and Non-communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention and Institute for Global Neuroscience and Stroke Collaborations

(2020) Yong-Jun Wang et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Neuroprotective effect of Apelin 13 on ischemic stroke by activating AMPK/GSK-3β/Nrf2 signaling

(2019) Jialin Duan et al.   Journal of Neuroinflammation

Inhibition of GSK-3β alleviates cerebral ischemia/reperfusion injury in rats by suppressing NLRP3 inflammasome activation through autophagy

(2019) Yueting Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

(2019) Peixing Wan et al.   CELL DEATH AND DIFFERENTIATION

Neuroprotective Effects and Hepatorenal Toxicity of Angong Niuhuang Wan Against Ischemia–Reperfusion Brain Injury in Rats

(2019) Bun Tsoi et al.   Frontiers in Pharmacology

Polydatin Attenuates Neuronal Loss via Reducing Neuroinflammation and Oxidative Stress in Rat MCAO Models

(2019) Fawad Ali Shah et al.   Frontiers in Pharmacology

Effects of irisin on the dysfunction of blood–brain barrier in rats after focal cerebral ischemia/reperfusion

(2019) Peipei Guo et al.   Brain and Behavior

TGF-β2 Induces Gli1 in a Smad3-Dependent Manner Against Cerebral Ischemia/Reperfusion Injury After Isoflurane Post-conditioning in Rats

(2019) Li Peng et al.   Frontiers in Neuroscience

Icariside II, a phosphodiesterase 5 inhibitor, attenuates cerebral ischemia/reperfusion injury by inhibiting GSK‐3 β ‐mediated activation of autophagy

(2019) Jianmei Gao et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pharmacological Enhancement of Stroke Rehabilitation

(2019) Hiroki Abe et al.   STROKE

Heme oxygenase-1: clinical relevance in ischemic stroke

(2018) Daniel Bereczki et al.   CURRENT PHARMACEUTICAL DESIGN

Traditional Chinese medicine for ischaemic stroke

(2018) Tianlong Liu et al.   LANCET NEUROLOGY

The potential role of HO-1 in regulating the MLK3-MKK7-JNK3 module scaffolded by JIP1 during cerebral ischemia/reperfusion in rats

(2018) Yuan-Jian Song et al.   BEHAVIOURAL BRAIN RESEARCH

Hepatorenal protective effects of medicinal herbs in An-Gong-Niu-Huang Wan (AGNH) against cinnabar- and realgar-induced oxidative stress and inflammatory damage in mice

(2017) Ao Li et al.   FOOD AND CHEMICAL TOXICOLOGY

GSK-3β as a target for protection against transient cerebral ischemia

(2017) Wei Wang et al.   International Journal of Medical Sciences

Rhizoma Coptidis and Berberine as a Natural Drug to Combat Aging and Aging-Related Diseases via Anti-Oxidation and AMPK Activation

(2017) Zhifang Xu et al.   Aging and Disease

The Effects of Baicalin and Baicalein on Cerebral Ischemia: A Review

(2017) Wei Liang et al.   Aging and Disease

Accumulation of Arsenic Speciation and In Vivo Toxicity Following Oral Administration of a Chinese Patent Medicine Xiao-Er-Zhi-Bao-Wan in Rats

(2017) Jiaoyang Luo et al.   Frontiers in Pharmacology

A novel GSK-3β inhibitor YQ138 prevents neuronal injury induced by glutamate and brain ischemia through activation of the Nrf2 signaling pathway

(2016) Tao Pang et al.   ACTA PHARMACOLOGICA SINICA

GSK-3β downregulates Nrf2 in cultured cortical neurons and in a rat model of cerebral ischemia-reperfusion

(2016) Xi Chen et al.   Scientific Reports

Whether Metal Element-Containing Herbal Formula Angong Niuhuang Pill Is Safe for Acute Brain Disorders?

(2015) Lei Zhao et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Chikusetsu Saponin IVa Ameliorates Cerebral Ischemia Reperfusion Injury in Diabetic Mice via Adiponectin-Mediated AMPK/GSK-3β Pathway In Vivo and In Vitro

(2015) Jialin Duan et al.   MOLECULAR NEUROBIOLOGY

Cinnabar-Induced Subchronic Renal Injury Is Associated with Increased Apoptosis in Rats

(2015) Ying Wang et al.   Biomed Research International

Paeonol pretreatment attenuates cerebral ischemic injury via upregulating expression of pAkt, Nrf2, HO-1 and ameliorating BBB permeability in mice

(2014) Yuan Zhao et al.   BRAIN RESEARCH BULLETIN

Use of Angong Niuhuang in Treating Central Nervous System Diseases and Related Research

(2014) Yu Guo et al.   Evidence-based Complementary and Alternative Medicine

Therapeutic targeting of GSK3β enhances the Nrf2 antioxidant response and confers hepatic cytoprotection in hepatitis C

(2014) Yongfang Jiang et al.   GUT

An-Gong-Niu-Huang Wan protects against cerebral ischemia induced apoptosis in rats: Up-regulation of Bcl-2 and down-regulation of Bax and caspase-3

(2014) Guo-Hua Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

GSK-3 as a Target for Lithium-Induced Neuroprotection Against Excitotoxicity in Neuronal Cultures and Animal Models of Ischemic Stroke

(2011) De-Maw Chuang et al.   Frontiers in Molecular Neuroscience

Realgar- and cinnabar-containing An-Gong-Niu-Huang Wan (AGNH) is much less acutely toxic than sodium arsenite and mercuric chloride

(2010) Yuan-Fu Lu et al.   CHEMICO-BIOLOGICAL INTERACTIONS