Recursive feedback between matrix dissipation and chemo-mechanical signaling drives oscillatory growth of cancer cell invadopodia

Predicting confined 1D cell migration from parameters calibrated to a 2D motor-clutch model

(2020) Louis S. Prahl et al.   BIOPHYSICAL JOURNAL

Increased Stiffness Inhibits Invadopodia Formation and Cell Migration in 3D

(2020) Julie Chang et al.   BIOPHYSICAL JOURNAL

Effects of extracellular matrix viscoelasticity on cellular behaviour

(2020) Ovijit Chaudhuri et al.   NATURE

Extracellular matrix plasticity as a driver of cell spreading

(2020) Joshua M. Grolman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels

(2019) Claudia Loebel et al.   NATURE MATERIALS

Transient active force generation and stress fibre remodelling in cells under cyclic loading

(2019) Eoin McEvoy et al.   Biomechanics and Modeling in Mechanobiology

Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

(2019) Andrea Malandrino et al.   PLoS Computational Biology

Covalent cross-linking of basement membrane-like matrices physically restricts invasive protrusions in breast cancer cells

(2019) Katrina M. Wisdom et al.   MATRIX BIOLOGY

Regulation of nuclear architecture, mechanics, and nucleocytoplasmic shuttling of epigenetic factors by cell geometric constraints

(2019) Farid Alisafaei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamic fibroblast contractions attract remote macrophages in fibrillar collagen matrix

(2019) Pardis Pakshir et al.   Nature Communications

Myosin IIA and formin dependent mechanosensitivity of filopodia adhesion

(2019) N. O. Alieva et al.   Nature Communications

MT1-MMP directs force-producing proteolytic contacts that drive tumor cell invasion

(2019) Robin Ferrari et al.   Nature Communications

ECM Cross-Linking Regulates Invadopodia Dynamics

(2018) Kamyar Esmaeili Pourfarhangi et al.   BIOPHYSICAL JOURNAL

Mechanisms of Plastic Deformation in Collagen Networks Induced by Cellular Forces

(2018) Ehsan Ban et al.   BIOPHYSICAL JOURNAL

Matching material and cellular timescales maximizes cell spreading on viscoelastic substrates

(2018) Ze Gong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular clutch drives cell response to surface viscosity

(2018) Mark Bennett et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of cell morphology and differentiation by substrates with independently tunable elasticity and viscous dissipation

(2018) Elisabeth E. Charrier et al.   Nature Communications

Matrix mechanical plasticity regulates cancer cell migration through confining microenvironments

(2018) Katrina M. Wisdom et al.   Nature Communications

A minimal actomyosin-based model predicts the dynamics of filopodia on neuronal dendrites

(2017) Olena O. Marchenko et al.   MOLECULAR BIOLOGY OF THE CELL

Mechanoreciprocity in cell migration

(2017) Sjoerd van Helvert et al.   NATURE CELL BIOLOGY

mDia1 senses both force and torque during F-actin filament polymerization

(2017) Miao Yu et al.   Nature Communications

Matrix rigidity differentially regulates invadopodia activity through ROCK1 and ROCK2

(2016) Rachel J. Jerrell et al.   BIOMATERIALS

Viscoplasticity Enables Mechanical Remodeling of Matrix by Cells

(2016) Sungmin Nam et al.   BIOPHYSICAL JOURNAL

Flow-dependent myosin recruitment duringDrosophilacellularization requires zygoticdunkactivity

(2016) Bing He et al.   DEVELOPMENT

Viscoelastic response of neural cells governed by the deposition of amyloid-β peptides (Aβ)

(2016) Ze Gong et al.   JOURNAL OF APPLIED PHYSICS

Collective cell durotaxis emerges from long-range intercellular force transmission

(2016) R. Sunyer et al.   SCIENCE

Contribution of myosin II activity to cell spreading dynamics

(2016) Noam Nisenholz et al.   Soft Matter

Matrix viscoplasticity and its shielding by active mechanics in microtissue models: experiments and mathematical modeling

(2016) Alan S. Liu et al.   Scientific Reports

Actin Flows Mediate a Universal Coupling between Cell Speed and Cell Persistence

(2015) Paolo Maiuri et al.   CELL

Hydrogels with tunable stress relaxation regulate stem cell fate and activity

(2015) Ovijit Chaudhuri et al.   NATURE MATERIALS

Substrate stress relaxation regulates cell spreading

(2015) Ovijit Chaudhuri et al.   Nature Communications

A chemo-mechanical free-energy-based approach to model durotaxis and extracellular stiffness-dependent contraction and polarization of cells

(2015) Vivek B. Shenoy et al.   Interface Focus

Local Viscoelastic Properties of Live Cells Investigated Using Dynamic and Quasi-Static Atomic Force Microscopy Methods

(2014) Alexander Cartagena et al.   BIOPHYSICAL JOURNAL

Invadosomes in their natural habitat

(2014) Elisabeth Génot et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Rigidity sensing and adaptation through regulation of integrin types

(2014) Alberto Elosegui-Artola et al.   NATURE MATERIALS

Extracellular matrix stiffness and composition jointly regulate the induction of malignant phenotypes in mammary epithelium

(2014) Ovijit Chaudhuri et al.   NATURE MATERIALS

Active mechanics and dynamics of cell spreading on elastic substrates

(2014) Noam Nisenholz et al.   Soft Matter

Regulation of invadopodia by the tumor microenvironment

(2014) Christine M Gould et al.   Cell Adhesion & Migration

Master Equation-Based Analysis of a Motor-Clutch Model for Cell Traction Force

(2013) Benjamin L. Bangasser et al.   Cellular and Molecular Bioengineering

Interplay between myosin IIA-mediated contractility and actin network integrity orchestrates podosome composition and oscillations

(2013) K. van den Dries et al.   Nature Communications

Invadopodia: The leading force

(2012) Hadas Sibony-Benyamini et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

The influence of substrate creep on mesenchymal stem cell behaviour and phenotype

(2011) Andrew. R. Cameron et al.   BIOMATERIALS

Sensing and Modulation of Invadopodia across a Wide Range of Rigidities

(2011) Aron Parekh et al.   BIOPHYSICAL JOURNAL

The 'ins' and 'outs' of podosomes and invadopodia: characteristics, formation and function

(2011) Danielle A. Murphy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The structure of invadopodia in a complex 3D environment

(2010) Ondřej Tolde et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Cortactin regulates cofilin and N-WASp activities to control the stages of invadopodium assembly and maturation

(2009) Matthew Oser et al.   JOURNAL OF CELL BIOLOGY

Adhesion signaling - crosstalk between integrins, Src and Rho

(2009) S. Huveneers et al.   JOURNAL OF CELL SCIENCE

Dependence of Invadopodia Function on Collagen Fiber Spacing and Cross-Linking: Computational Modeling and Experimental Evidence

(2008) Heiko Enderling et al.   BIOPHYSICAL JOURNAL

Extracellular Matrix Rigidity Promotes Invadopodia Activity

(2008) Nelson R. Alexander et al.   CURRENT BIOLOGY

Retrograde Flow and Myosin II Activity within the Leading Cell Edge Deliver F-Actin to the Lamella to Seed the Formation of Graded Polarity Actomyosin II Filament Bundles in Migrating Fibroblasts

(2008) Tom W. Anderson et al.   MOLECULAR BIOLOGY OF THE CELL

Traction Dynamics of Filopodia on Compliant Substrates

(2008) C. E. Chan et al.   SCIENCE