Article
Chemistry, Physical
Yuhao Li, Xiaorui Jin, Xinhai Yan, Xinyu Ai, Xin Yang, Zi-Jian Zheng, Kun Huang, Gaofeng Zhao, Yongan Yang, Meiling Wu, Kai-Ge Zhou
Summary: As an alternative to organic solvents in rechargeable batteries, water possesses unique properties such as fast ionic migration, easy-processibility, economic/environmental friendliness, and flame retardancy. However, the high activity of water molecules in aqueous electrolytes leads to issues such as corrosion of the metal anode, side reactions, and poor metal electrodeposition behavior. In this study, a subnanoscale confinement strategy based on a nacre-like structure was developed to regulate the activity of water in solid electrolytes, leading to improved cycling performance and stability in aqueous energy storage devices.
Article
Chemistry, Multidisciplinary
Yi Wen, Shiang Fang, Matthew Coupin, Yang Lu, Colin Ophus, Efthimios Kaxiras, Jamie H. Warner
Summary: Four-dimensional (4D) scanning transmission electron microscopy was used to study the electric fields at the edges of 2D semiconducting monolayer MoS2. Sub-nanometer 1D features in the 2D electric field maps were observed at the outermost region along zigzag edges and also along nanowire MoS-terminated MoS2 edges. The presence of low Z number atoms terminating many of the uniform edges was revealed through electric field reconstructions, along with integrated differential phase contrast reconstructions. Density functional theory calculations supported the formation of periodic 1D edge states and indicated the enhancement of electric field magnitude for some edge terminations. The experimentally observed electric fields at the edges were attributed to the absence of an opposing electric field from a nearest neighbor atom when the electron beam propagates through the 2D monolayer and interacts. These results highlight the potential of 4D-STEM in mapping the atomic scale structure and fluctuations of electric fields around edge atoms in 2D materials.
Article
Chemistry, Physical
Haifa Jeridi, Jean de Dieu Niyonzima, Charbel Sakr, Amine Missaoui, Sharif Shahini, Alina Vlad, Alessandro Coati, Nicolas Goubet, Sebastien Royer, Ian Vickridge, Michel Goldmann, Doru Constantin, Yves Garreau, David Babonneau, Bernard Croset, Bruno Gallas, Emmanuel Lhuillier, Emmanuelle Lacaze
Summary: New collective optical properties have emerged from organized and oriented arrays of closely packed semiconducting and metallic nanoparticles. One-dimensional and two-dimensional topological defects can confine and organize the nanoparticles, leading to unique orientations. The coupling between the nanoparticles and the liquid crystal layers is necessary for fixed orientation.
Article
Chemistry, Multidisciplinary
Albert Beardo, Joshua L. Knobloch, Lluc Sendra, Javier Bafaluy, Travis D. Frazer, Weilun Chao, Jorge N. Hernandez-Charpak, Henry C. Kapteyn, Begona Abad, Margaret M. Murnane, F. Xavier Alvarez, Juan Camacho
Summary: This study combines advanced experiment and theory to show that heat transport in silicon at the nanoscale can be described using a general hydrodynamic heat transport model, contrary to traditional understanding of heat flow in bulk silicon. The research reveals the existence of two distinct time scales and heat transport mechanisms, providing an important tool for thermal management of nanoscale technologies.
Article
Chemistry, Multidisciplinary
Feiyu Yang, Pengcheng Chen, Han Jiang, Tianfa Xie, Yue Shao, Deok-Ho Kim, Bo Li, Yubing Sun
Summary: Strain gradients play a crucial role in directional cell migration. This study develops a programmable uniaxial cell stretch device to create controllable strain gradients and demonstrates that these gradients are sufficient to drive over 60% of rat embryonic fibroblasts towards the lower strain side. Focal adhesion analysis and a motor-clutch model suggest that strain-introduced traction force and integrin fibronectin pairs' catch-release dynamics are responsible for such directional migration.
Article
Multidisciplinary Sciences
David B. Brueckner, Nicolas Arlt, Alexandra Fink, Pierre Ronceray, Joachim O. Raedler, Chase P. Broedersz
Summary: The study found that the interactions between noncancerous cells are mainly described by repulsion and friction interactions, while cancerous cells exhibit attraction and antifriction interactions. These interaction behaviors were validated in experiments and may provide a unifying theoretical description for diverse cellular interaction behaviors of different cell types.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Engineering, Biomedical
Katharina Siemsen, Sunil Rajput, Florian Rasch, Fereydoon Taheri, Rainer Adelung, Jan Lammerding, Christine Selhuber-Unkel
Summary: Cells adapt and move in response to chemical, physical, and mechanical cues from their microenvironment, highlighting the importance of developing materials that mimic human tissue physiology to control cell behavior in biomedical settings. The impact of environmental architecture is particularly significant in the context of cancer cell metastasis, where cells migrate through small constrictions to invade surrounding tissues.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Materials Science, Multidisciplinary
Qinghua Chen, Kaimo Deng, Ying Shen, Liang Li
Summary: The interface properties of organic-inorganic mixed halide perovskite solar cells are crucial for their photovoltaic performance. Researchers have successfully constructed a robust interface for perovskite films through mixed-dimensional engineering, reducing the number of defect states and increasing the lifetime of photocarriers. The introduction of a one-dimensional capping layer also acts as a diffusion barrier and protects the vulnerable perovskite against moisture. Perovskite solar cells based on stacked one-dimensional/three-dimensional structures exhibit high efficiency and stability, surpassing the performance of three-dimensional devices.
Article
Chemistry, Physical
Aleksi Isomursu, Keun-Young Park, Jay Hou, Bo Cheng, Mathilde Mathieu, Ghaidan A. Shamsan, Benjamin Fuller, Jesse Kasim, M. Mohsen Mahmoodi, Tian Jian Lu, Guy M. Genin, Feng Xu, Min Lin, Mark D. Distefano, Johanna Ivaska, David J. Odde
Summary: This study reveals that cells are capable of migrating towards substrates with decreasing stiffness, in addition to the previously known migration towards substrates with increasing stiffness. The migration direction is determined by the optimal stiffness that allows cells to generate maximal traction, rather than the changes in canonical mechanosensitive signaling or actomyosin contractility.
Article
Chemistry, Multidisciplinary
Dali Ji, Yunah Lee, Yuta Nishina, Kazuhide Kamiya, Rahman Daiyan, Dewei Chu, Xinyue Wen, Masamichi Yoshimura, Priyank Kumar, Daria V. Andreeva, Kostya S. Novoselov, Gwan-Hyoung Lee, Rakesh Joshi, Tobias Foller
Summary: This study introduces a simple electrochemical method utilizing the angstrom confinement of laminar rGO nanochannels to achieve atomically thin transition metal oxides. The method allows for sub-unit-cell growth of 2D-TMO and demonstrates a balance between high activity and stability.
ADVANCED MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Xiao-Hong Wang, Yu Liu, Bin Kang, Jing-Juan Xu, Hong-Yuan Chen
Summary: This study investigates the intercellular mechanical properties and energetic costs during cell-cell collective migration in confined microchannels. The research reveals that cells adapt to different confinement environments by regulating intercellular force, which confirms the relationship between collective cell migration and cell-cell junctions. The observations of cell orientation, actomyosin contractility, energetic costs, and glucose uptake provide a reasonable explanation for cell-force driven migration in various confined environments. The study also finds that under highly confined conditions, the intercellular force and energetic costs are greater, leading to a more orderly cell orientation during collective migration.
CHINESE CHEMICAL LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Hong Fu, Chuxiong Hu, Ming Zhang, Yu Zhu
Summary: This paper proposes an integrated optimization method that combines 3D structural optimization and magnet parameter optimization to meet the increasing demand for mechanical stiffness and electromagnetic performance of maglev planar motors. The method improves the performance more directly and comprehensively than traditional optimization methods. Experimental results show that the proposed method can significantly improve the control bandwidth and reduce current consumption in maglev planar motor systems.
MATERIALS & DESIGN
(2023)
Article
Multidisciplinary Sciences
Tsukasa Nakatoh, Takuji Osaki, Sohma Tanimoto, Md Golam Sarowar Jahan, Tomohisa Kawakami, Kentaro Chihara, Nobuyuki Sakai, Shigehiko Yumura
Summary: Two innovative methods are described for fabricating a substrate that enables the control of cell adhesion to specific areas. These methods effectively confine cells within the adhesive region and allow for the observation of new aspects of cell behavior.
Article
Cell Biology
Lauren Penfield, Denise J. Montell
Summary: During Drosophila border cell migration, the B-type lamin, Lam, maintains nuclear envelope integrity, stabilizes the lead cell protrusion, and promotes cluster invasion between nurse cells.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Shuo Jia, Pingzhao Hu
Summary: Cells from the immune system have a crucial role in detecting and killing pathogens, especially those associated with cancer tissues. The ChrNet model, incorporating gene positional information, shows superior performance in immune cell type profiling with over 90% accuracy, potentially serving as a reference architecture for other cell type classification methods.
Editorial Material
Virology
Basil S. Karam, Rachel S. Morris, Carolyn T. Bramante, Michael Puskarich, Emily J. Zolfaghari, Sahar Lotfi-Emran, Nicholas E. Ingraham, Anthony Charles, David J. Odde, Christopher J. Tignanelli
Summary: The mTOR pathway plays a crucial role in viral infections, with inhibiting mTOR potentially leading to suppression of virus growth and replication. Recent studies suggest the modulation of mTOR in SARS-CoV-2 infection, highlighting the potential of mTOR inhibitors as an effective treatment for coronavirus diseases.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Engineering, Biomedical
Mahya Hemmat, David J. Odde
Summary: This study uses multiscale modeling to show that GTP hydrolysis results in both longitudinal bond weakening and an outward bending preference, which together drive microtubule dynamic instability and lead to the observed microtubule tip structures. This research demonstrates the use of atomic-level structural information as the sole input to predict cellular-level dynamics without parameter adjustment.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Allergy
Miriam Gross, Carsten Speckmann, Annette May, Tania Gajardo-Carrasco, Katharina Wustrau, Sarah Lena Maier, Marcus Panning, Daniela Huzly, Abbas Agaimy, Yenan T. Bryceson, Sharon Choo, C. W. Chow, Gregor Dueckers, Anders Fasth, Sylvie Fraitag, Katja Graewe, Sabine Haxelmans, Dirk Holzinger, Ole Hudowenz, Judith M. Huebschen, Claudia Khurana, Korbinian Kienle, Roman Klifa, Klaus Korn, Heinz Kutzner, Tim Laemmermann, Svea Ledig, Dan Lipsker, Marie Meeths, Nora Naumann-Bartsch, Jelena Rascon, Anne Schaenzer, Maximilian Seidl, Bianca Tesi, Christelle Vauloup-Fellous, Beate Vollmer-Kary, Klaus Warnatz, Claudia Wehr, Benedicte Neven, Pablo Vargas, Fernando E. Sepulveda, Kai Lehmberg, Annette Schmitt-Graeff, Stephan Ehl
Summary: This study investigated the defective effector mechanism allowing rubella vaccine virus persistence in granulomas by studying patients with cytotoxicity defects and granuloma. The results suggest a critical role of T cells in rubella elimination.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Oncology
Kellen Mulford, Mariah McMahon, Andrew M. Gardeck, Matthew A. Hunt, Clark C. Chen, David J. Odde, Christopher Wilke
Summary: This study developed a non-invasive method to predict the motility of glioblastoma cells using radiomics features. It showed the feasibility of a quantitative MRI feature-based regression model in predicting the cellular motility of glioblastomas.
Article
Immunology
Carolyn T. Bramante, Jennifer L. Proper, David R. Boulware, Amy B. Karger, Thomas Murray, Via Rao, Aubrey Hagen, Christopher J. Tignanelli, Michael Puskarich, Ken Cohen, David M. Liebovitz, Nichole R. Klatt, Courtney Broedlow, Katrina M. Hartman, Jacinda Nicklas, Sherehan Ibrahim, Adnin Zaman, Hanna Saveraid, Hrishikesh Belani, Nicholas Ingraham, Grace Christensen, Lianne Siegel, Nancy E. Sherwood, Regina Fricton, Sam Lee, David J. Odde, John B. Buse, Jared D. Huling
Summary: This analysis compared baseline viral load and symptoms between vaccinated and unvaccinated adults. The results showed that vaccination within 6 months of infection was associated with a lower viral load and fewer systemic symptoms.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Marta Mastrogiovanni, Pablo Vargas, Thierry Rose, Celine Cuche, Elric Esposito, Marie Juzans, Helene Laude, Amandine Schneider, Mathilde Bernard, Sophie Goyard, Charlotte Renaudat, Marie-Noelle Ungeheuer, Jerome Delon, Andres Alcover, Vincenzo Di Bartolo
Summary: APC mutations in familial adenomatous polyposis (FAP) not only drive intestinal neoplasms but also impair T cell migration, potentially contributing to inefficient antitumor immunity.
Article
Biochemistry & Molecular Biology
Sung Hoon Lee, Jay C. Hou, Archer Hamidzadeh, M. Sulaiman Yousafzai, Visar Ajeti, Hao Chang, David J. Odde, Michael Murrell, Andre Levchenko
Summary: This study reveals that cyclic changes in the activity of the small GTPase RhoA, mediated by the RhoA guanine nucleotide exchange factor GEF-H1 and triggered by an increase in intracellular Ca2+ levels, are responsible for navigation through a dense extracellular matrix during cell migration. The cyclic changes are driven by two coupled negative feedback loops dependent on microtubule dynamics. Additionally, an increasing frequency of the molecular clock leads to faster cell migration within physically confining spaces.
Article
Immunology
David R. Boulware, Thomas A. Murray, Jennifer L. Proper, Christopher J. Tignanelli, John B. Buse, David M. Liebovitz, Jacinda M. Nicklas, Kenneth Cohen, Michael A. Puskarich, Hrishikesh K. Belani, Lianne K. Siegel, Nichole R. Klatt, David J. Odde, Amy B. Karger, Nicholas E. Ingraham, Katrina M. Hartman, Via Rao, Aubrey A. Hagen, Barkha Patel, Sarah L. Fenno, Nandini Avula, Neha Reddy, Spencer M. Erickson, Sarah Lindberg, Regina Fricton, Samuel Lee, Adnin Zaman, Hanna G. Saveraid, Walker J. Tordsen, Matthew F. Pullen, Nancy E. Sherwood, Jared D. Huling, Carolyn T. Bramante
Summary: SARS-CoV-2 vaccine-boosted participants experienced the least severe symptoms during COVID-19, and their symptoms improved the fastest over time. Vaccination against SARS-CoV-2 was found to be associated with reduced symptom severity in a sample of low to moderate risk adults enrolled in an outpatient COVID-19 treatment trial. Booster shots further reduced symptom severity.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Bianca Cali, Mathieu Deygas, Fabio Munari, Elisabetta Marcuzzi, Antonino Cassara, Lara Toffali, Massimo Vetralla, Mathilde Bernard, Matthieu Piel, Onelia Gagliano, Marta Mastrogiovanni, Carlo Laudanna, Nicola Elvassore, Barbara Molon, Pablo Vargas, Antonella Viola
Summary: Chemical signals regulate the nuclear plasticity of migrating leukocytes to optimize their motility in restricted microenvironments.
Article
Multidisciplinary Sciences
Louis S. Prahl, Catherine M. Porter, Jiageng Liu, John M. Viola, Alex J. Hughes
Summary: Tissue boundaries and interfaces play a crucial role in morphogenesis in vivo. However, controlling cell positioning within tissue constructs is still a challenge in tissue engineering. This study presents a new approach that combines DNA velcro patterning and ECM functionalization to achieve precise control of cell placement, adhesion, and mechanics in engineered tissues.
Article
Biophysics
Roberto Alonso-Matilla, Paolo P. Provenzano, David J. Odde
Summary: This study generalized the motor-clutch analytical framework to include imbalanced motor-clutch regimes, with clutch reinforcement and catch bonding, and investigated optimality with respect to all parameters. The results found that cells could tune their clutch mechanical properties to perform a specific function and could regulate their myosin repertoire and activity to maximize force transmission. In addition, the study revealed that clutch reinforcement shifted the optimum substrate stiffness to larger values. These findings have important implications for the design of molecular tension sensors and the prediction and control of cell adhesion and migration in immunotherapy and cancer.
BIOPHYSICAL JOURNAL
(2023)
Article
Allergy
Tania Gajardo, Mathilde Bernard, Marie Lo, Elisa Turck, Claire Leveau, Marie-Therese EI-Daher, Alexandre Deslys, Patricia Panikulam, Constantin Menche, Mathieu Kurowska, Gregoire Le Lay, Lucie Barbier, Despina Moshous, Benedicte Neven, Henner F. Farin, Alain Fischer, Gael Menasche, Genevieve de Saint Basile, Pablo Vargas, Fernando E. Sepulveda
Summary: This study investigates the impact of TTC7A deficiency on immune homeostasis and reveals that TTC7A-deficient lymphocytes exhibit altered cell migration and impaired actin dynamics. These findings suggest that TTC7A plays a critical role in lymphocyte migration and is likely to contribute to the progressive immunodeficiency in patients.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Marcel S. Woo, Friederike Ufer, Jana K. Sonner, Anouar Belkacemi, Joseph Tintelnot, Pablo J. Saez, Paula F. Krieg, Christina Mayer, Lars Binkle-Ladisch, Jan Broder Engler, Simone Bauer, Nina Kursawe, Vanessa Vieira, Stefanie Mannebach, Marc Freichel, Veit Flockerzi, Pablo Vargas, Manuel A. Friese
Summary: The study identifies CACNB3 as a master regulator of ATP-dependent migDC migration, which plays a crucial role in regulating tissue-specific immune responses during injury and inflammation.
Meeting Abstract
Oncology
Rafael Hurtado, Pablo Vargas
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2023)
Meeting Abstract
Oncology
B. C. Braman, G. A. Shamsan, M. M. McMahon, D. J. Odde, C. T. Wilke
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)