Cardiac organoid — a promising perspective of preclinical model

Probing prodrug metabolism and reciprocal toxicity with an integrated and humanized multi-tissue organ-on-a-chip platform

(2020) Shiny Amala Priya Rajan et al.   Acta Biomaterialia

Generating ring-shaped engineered heart tissues from ventricular and atrial human pluripotent stem cell-derived cardiomyocytes

(2020) Idit Goldfracht et al.   Nature Communications

Multi-lineage Human iPSC-Derived Platforms for Disease Modeling and Drug Discovery

(2020) Arun Sharma et al.   Cell Stem Cell

Infection of bat and human intestinal organoids by SARS-CoV-2

(2020) Jie Zhou et al.   NATURE MEDICINE

Human cardiac organoids for the modelling of myocardial infarction and drug cardiotoxicity

(2020) Dylan J. Richards et al.   Nature Biomedical Engineering

A Human Pluripotent Stem Cell-based Platform to Study SARS-CoV-2 Tropism and Model Virus Infection in Human Cells and Organoids

(2020) Liuliu Yang et al.   Cell Stem Cell

Single‐cell RNA sequencing analysis of SARS‐CoV‐2 entry receptors in human organoids

(2020) Rajasekaran Mahalingam et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men

(2020) Ryan M. Samuel et al.   Cell Stem Cell

Definitive hematopoietic stem/progenitor cells from human embryonic stem cells through serum/feeder-free organoid-induced differentiation

(2020) Selami Demirci et al.   Stem Cell Research & Therapy

Capturing Cardiogenesis in Gastruloids

(2020) Giuliana Rossi et al.   Cell Stem Cell

Human blood vessel organoids as a model of diabetic vasculopathy

(2019) Reiner A. Wimmer et al.   NATURE

Generation of lung organoids from human pluripotent stem cells in vitro

(2019) Alyssa J. Miller et al.   Nature Protocols

Organoids — Preclinical Models of Human Disease

(2019) Mo Li et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human-Derived Organ-on-a-Chip for Personalized Drug Development

(2019) Yasamin A. Jodat et al.   CURRENT PHARMACEUTICAL DESIGN

Human Cardiac Ventricular‐Like Organoid Chambers and Tissue Strips From Pluripotent Stem Cells as a Two‐Tiered Assay for Inotropic Responses

(2019) Wendy Keung et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Drug Screening in Human PSC-Cardiac Organoids Identifies Pro-proliferative Compounds Acting via the Mevalonate Pathway

(2019) Richard J. Mills et al.   Cell Stem Cell

A Platform for Generation of Chamber-Specific Cardiac Tissues and Disease Modeling

(2019) Yimu Zhao et al.   CELL

Modeling Cardiac Arrhythmias With Organoids

(2019) Jean-Sébastien Hulot   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Modeling Reentry in the Short QT Syndrome With Human-Induced Pluripotent Stem Cell–Derived Cardiac Cell Sheets

(2019) Rami Shinnawi et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

3D Printing of Personalized Thick and Perfusable Cardiac Patches and Hearts

(2019) Nadav Noor et al.   Advanced Science

Stem cells in tissues, organoids, and cancers

(2019) Xusheng Wang   CELLULAR AND MOLECULAR LIFE SCIENCES

2-Cl-C.OXT-A stimulates contraction through the suppression of phosphodiesterase activity in human induced pluripotent stem cell-derived cardiac organoids

(2019) Takahiro Kitsuka et al.   PLoS One

3D bioprinting of collagen to rebuild components of the human heart

(2019) A. Lee et al.   SCIENCE

MIR148A family regulates cardiomyocyte differentiation of human embryonic stem cells by inhibiting the DLL1-mediated NOTCH signaling pathway

(2019) Xing Fang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Engineering of human brain organoids with a functional vascular-like system

(2019) Bilal Cakir et al.   NATURE METHODS

Precision Medicine in the Management of Dilated Cardiomyopathy

(2019) Diane Fatkin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Bioengineering an electro-mechanically functional miniature ventricular heart chamber from human pluripotent stem cells

(2018) Ronald A. Li et al.   BIOMATERIALS

Modeling human diseases with induced pluripotent stem cells: from 2D to 3D and beyond

(2018) Chun Liu et al.   DEVELOPMENT

Generation of spatial-patterned early-developing cardiac organoids using human pluripotent stem cells

(2018) Plansky Hoang et al.   Nature Protocols

Generation of human vascularized brain organoids

(2018) Missy T. Pham et al.   NEUROREPORT

CRISPR/Cas9 Genome Editing: A Promising Tool for Therapeutic Applications of Induced Pluripotent Stem Cells

(2018) Yanli Zhang et al.   Current Stem Cell Research & Therapy

Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing

(2018) Chengzu Long et al.   Science Advances

The interstitium in cardiac repair: role of the immune–stromal cell interplay

(2018) Elvira Forte et al.   Nature Reviews Cardiology

Progress and potential in organoid research

(2018) Giuliana Rossi et al.   NATURE REVIEWS GENETICS

Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

(2018) Caroline R. Archer et al.   Scientific Reports

Modelling human cardiac diseases with 3D organoid

(2018) Bramasta Nugraha et al.   EUROPEAN HEART JOURNAL

Functional screening in human cardiac organoids reveals a metabolic mechanism for cardiomyocyte cell cycle arrest

(2017) Richard J. Mills et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human tissues in a dish: The research and ethical implications of organoid technology

(2017) Annelien L. Bredenoord et al.   SCIENCE

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Organoids: Modeling Development and the Stem Cell Niche in a Dish

(2016) Kai Kretzschmar et al.   DEVELOPMENTAL CELL

Erratum: Kidney organoids from human iPS cells contain multiple lineages and model human nephrogenesis

(2016) Minoru Takasato et al.   NATURE

Organoids as an in vitro model of human development and disease

(2016) Aliya Fatehullah et al.   NATURE CELL BIOLOGY

Personalized Cardiovascular Medicine Today

(2015) Alison Blaus et al.   CIRCULATION

Self-organizing human cardiac microchambers mediated by geometric confinement

(2015) Zhen Ma et al.   Nature Communications

Organoid Cultures Derived from Patients with Advanced Prostate Cancer

(2014) Dong Gao et al.   CELL

Microscale screening systems for 3D cellular microenvironments: platforms, advances, and challenges

(2014) Sara I. Montanez-Sauri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Tri-iodo-l-thyronine promotes the maturation of human cardiomyocytes-derived from induced pluripotent stem cells

(2014) Xiulan Yang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Matrix Rigidity-Modulated Cardiovascular Organoid Formation from Embryoid Bodies

(2014) Artem Shkumatov et al.   PLoS One

Organogenesis in a dish: Modeling development and disease using organoid technologies

(2014) M. A. Lancaster et al.   SCIENCE

Successful therapies for Alzheimer’s disease: why so many in animal models and none in humans?

(2014) Rafael Franco et al.   Frontiers in Pharmacology

In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration

(2013) Meritxell Huch et al.   NATURE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs

(2012) Tokushige Nakano et al.   Cell Stem Cell

Induced pluripotent stem cells for cardiac repair

(2012) Limor Zwi-Dantsis et al.   CELLULAR AND MOLECULAR LIFE SCIENCES