Characterization and Validation of a Human 3D Cardiac Microtissue for the Assessment of Changes in Cardiac Pathology

Development of In Vitro Drug-Induced Cardiotoxicity Assay by Using Three-Dimensional Cardiac Tissues Derived from Human Induced Pluripotent Stem Cells

(2018) Maki Takeda et al.   TISSUE ENGINEERING PART C-METHODS

β-Defensin 2 is a responsive biomarker of IL-17A–driven skin pathology in patients with psoriasis

(2017) Frank Kolbinger et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

In vitro models of the cardiac microenvironment to study myocyte and non-myocyte crosstalk: bioinspired approaches beyond the polystyrene dish

(2017) Celinda M. Kofron et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cardiac spheroids as promising in vitro models to study the human heart microenvironment

(2017) Liudmila Polonchuk et al.   Scientific Reports

Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening

(2016) Yosuke K. Kurokawa et al.   ADVANCED DRUG DELIVERY REVIEWS

Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity

(2016) Hong Zhan et al.   CARDIOVASCULAR RESEARCH

Novel therapeutic strategies targeting fibroblasts and fibrosis in heart disease

(2016) Robert G. Gourdie et al.   NATURE REVIEWS DRUG DISCOVERY

From the Cover: High-Throughput Imaging of Cardiac Microtissues for the Assessment of Cardiac Contraction during Drug Discovery

(2016) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Inflammatory and fibrotic processes are involved in the cardiotoxic effect of sunitinib: Protective role of l -carnitine

(2016) Antonio J. Blanca et al.   TOXICOLOGY LETTERS

Physiological, pharmacological and toxicological considerations of drug-induced structural cardiac injury

(2015) M J Cross et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional crosstalk between cardiac fibroblasts and adult cardiomyocytes by soluble mediators

(2015) James E. Cartledge et al.   CARDIOVASCULAR RESEARCH

Global and Regional Patterns in Cardiovascular Mortality From 1990 to 2013

(2015) Gregory A. Roth et al.   CIRCULATION

An analysis of the attrition of drug candidates from four major pharmaceutical companies

(2015) Michael J. Waring et al.   NATURE REVIEWS DRUG DISCOVERY

3D Cardiac Microtissues Encapsulated with the Co-Culture of Cardiomyocytes and Cardiac Fibroblasts

(2015) Harpinder Saini et al.   Advanced Healthcare Materials

Predictivity of in vitro non-clinical cardiac contractility assays for inotropic effects in humans — A literature search

(2015) Rob Wallis et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Integrated Analysis of Contractile Kinetics, Force Generation, and Electrical Activity in Single Human Stem Cell-Derived Cardiomyocytes

(2015) Jan David Kijlstra et al.   Stem Cell Reports

Image-based evaluation of contraction–relaxation kinetics of human-induced pluripotent stem cell-derived cardiomyocytes: Correlation and complementarity with extracellular electrophysiology

(2014) Tomohiro Hayakawa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

(2014) David Cook et al.   NATURE REVIEWS DRUG DISCOVERY

Phenotypic Profiling of Structural Cardiotoxins In Vitro Reveals Dependency on Multiple Mechanisms of Toxicity

(2013) Amy Pointon et al.   TOXICOLOGICAL SCIENCES

Validation of an in vitro contractility assay using canine ventricular myocytes

(2012) A.R. Harmer et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

How can we improve our understanding of cardiovascular safety liabilities to develop safer medicines?

(2011) HG Laverty et al.   BRITISH JOURNAL OF PHARMACOLOGY

Resting heart rate: A modifiable prognostic indicator of cardiovascular risk and outcomes?

(2011) J. Malcolm Arnold et al.   CANADIAN JOURNAL OF CARDIOLOGY

Cardiotoxicity of kinase inhibitors: the prediction and translation of preclinical models to clinical outcomes

(2011) Thomas Force et al.   NATURE REVIEWS DRUG DISCOVERY

Induction of Heart Valve Lesions by Small-Molecule ALK5 Inhibitors

(2011) Mark J. Anderton et al.   TOXICOLOGIC PATHOLOGY

Evaluation of Drugs With Specific Organ Toxicities in Organ-Specific Cell Lines

(2011) Zhiwu Lin et al.   TOXICOLOGICAL SCIENCES

Intramyocardial Fibroblast Myocyte Communication

(2010) Rahul Kakkar et al.   CIRCULATION RESEARCH

Cardiotoxicity Associated with Targeting Kinase Pathways in Cancer

(2010) Howard R. Mellor et al.   TOXICOLOGICAL SCIENCES

The cardiotoxicity and myocyte damage caused by small molecule anticancer tyrosine kinase inhibitors is correlated with lack of target specificity

(2010) Brian B. Hasinoff   TOXICOLOGY AND APPLIED PHARMACOLOGY

From mechanotransduction to extracellular matrix gene expression in fibroblasts

(2009) Matthias Chiquet et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Cardiac Fibroblasts Regulate Myocardial Proliferation through β1 Integrin Signaling

(2009) Masaki Ieda et al.   DEVELOPMENTAL CELL

Cardionomics: a new integrative approach for screening cardiotoxicity of drug candidates

(2009) Judith K Gwathmey et al.   Expert Opinion on Drug Metabolism & Toxicology

Cardiovascular Complications of Cancer Therapy

(2009) Edward T.H. Yeh et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cardiotoxicity of Anticancer Drugs: The Need for Cardio-Oncology and Cardio-Oncological Prevention

(2009) Adriana Albini et al.   JNCI-Journal of the National Cancer Institute

Strategies to reduce the risk of drug-induced QT interval prolongation: a pharmaceutical company perspective

(2008) C E Pollard et al.   BRITISH JOURNAL OF PHARMACOLOGY

Effect of the Multitargeted Tyrosine Kinase Inhibitors Imatinib, Dasatinib, Sunitinib, and Sorafenib on Mitochondrial Function in Isolated Rat Heart Mitochondria and H9c2 Cells

(2008) Yvonne Will et al.   TOXICOLOGICAL SCIENCES