CircRNAs: role in human diseases and potential use as biomarkers

Wnt signaling in cancer: therapeutic targeting of Wnt signaling beyond β-catenin and the destruction complex

(2020) Youn-Sang Jung et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1α/HK2

(2020) Lili Cao et al.   Cell Death & Disease

circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway

(2020) Qiu-Shi Peng et al.   Cell Death & Disease

Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7

(2020) Ling Ma et al.   Cell Death & Disease

Guidelines and definitions for research on epithelial–mesenchymal transition

(2020) Jing Yang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circular RNA expression profile of Alzheimer’s disease and its clinical significance as biomarkers for the disease risk and progression

(2020) Yuanlong Li et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075

(2019) Tiefang Song et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Recent Development of Wnt Signaling Pathway Inhibitors for Cancer Therapeutics

(2019) Jerry Harb et al.   Current Oncology Reports

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis

(2019) Jian-Zhen Xu et al.   Cell Death & Disease

The circ RNA ‐micro RNA code: emerging implications for cancer diagnosis and treatment

(2019) Lorena Verduci et al.   Molecular Oncology

A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling

(2019) Xiao Zheng et al.   Molecular Cancer

Circular RNAs and their roles in head and neck cancers

(2019) Yang Guo et al.   Molecular Cancer

Breast Cancer Treatment

(2019) Adrienne G. Waks et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

The Landscape of Circular RNA in Cancer

(2019) Josh N. Vo et al.   CELL

Circular RNAs open a new chapter in cardiovascular biology

(2019) Simona Aufiero et al.   Nature Reviews Cardiology

Intriguing circles: Conflicts and controversies in circular RNA research

(2019) Hui‐Min Li et al.   Wiley Interdisciplinary Reviews-RNA

Exosomal circRNAs: biogenesis, effect and application in human diseases

(2019) Yangxia Wang et al.   Molecular Cancer

RNA-based diagnostic and therapeutic strategies for cardiovascular disease

(2019) Dongchao Lu et al.   Nature Reviews Cardiology

Lung cancer

(2019) Richard D Neal et al.   BMJ-British Medical Journal

Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma

(2019) Kai Zhu et al.   CARCINOGENESIS

Circular RNAs as Urinary Biomarkers

(2019) W.K. Jacky Lam et al.   CLINICAL CHEMISTRY

ERBB3 mutations in cancer: biological aspects, prevalence and therapeutics

(2019) Nicolas Kiavue et al.   ONCOGENE

Reinventing the Wheel: Synthetic Circular RNAs for Mammalian Cell Engineering

(2019) Alan Costello et al.   TRENDS IN BIOTECHNOLOGY

High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma

(2019) Dan-dan Xiong et al.   Cell Death & Disease

The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis

(2019) Zou et al.   Biomolecules

An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations

(2019) Umber Dube et al.   NATURE NEUROSCIENCE

BBCancer: an expression atlas of blood-based biomarkers in the early diagnosis of cancers

(2019) Zhixiang Zuo et al.   NUCLEIC ACIDS RESEARCH

CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression

(2019) Zhenguo Liu et al.   Cell Death & Disease

Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis

(2019) Venkata Naga Srikanth Garikipati et al.   Nature Communications

Profiling of differentially expressed circular RNAs in peripheral blood mononuclear cells from Alzheimer’s disease patients

(2019) Yanxin Li et al.   METABOLIC BRAIN DISEASE

Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation

(2018) Xiyong Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The human MAPT locus generates circular RNAs

(2018) Justin R. Welden et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis

(2018) Maolei Zhang et al.   ONCOGENE

circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression

(2018) Bo Chen et al.   Theranostics

A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer

(2018) Dong Hang et al.   Cancer Medicine

circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways

(2018) Qianru He et al.   Molecular Therapy-Nucleic Acids

Circular RNAs as novel regulators of β-cell functions in normal and disease conditions

(2018) Lisa Stoll et al.   Molecular Metabolism

Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma

(2018) Bowen Li et al.   DISEASE MARKERS

Diminished Parkin Solubility and Co-Localization with Intraneuronal Amyloid-β are Associated with Autophagic Defects in Alzheimer's Disease

(2018) Irina Lonskaya et al.   JOURNAL OF ALZHEIMERS DISEASE

CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR-4288-induced ELF3 inhibition

(2018) Zhaoyang Ke et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer

(2018) Shuangyan Tan et al.   Molecular Cancer

PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial–Mesenchymal Transition

(2018) Xin Chen et al.   CLINICAL CANCER RESEARCH

The pro-metastasis effect of circANKS1B in breast cancer

(2018) Kaixuan Zeng et al.   Molecular Cancer

Wnt Signaling in vascular eye diseases

(2018) Zhongxiao Wang et al.   PROGRESS IN RETINAL AND EYE RESEARCH

Progress in research on the role of circular RNAs in lung cancer

(2018) Yang Chen et al.   World Journal of Surgical Oncology

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

Mutant p53 Protein and the Hippo Transducers YAP and TAZ: A Critical Oncogenic Node in Human Cancers

(2017) et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Canonical and non-canonical WNT signaling in cancer stem cells and their niches: Cellular heterogeneity, omics reprogramming, targeted therapy and tumor plasticity (Review)

(2017) Masaru Katoh   INTERNATIONAL JOURNAL OF ONCOLOGY

TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway

(2017) Jian Zheng et al.   Journal of Hematology & Oncology

Wnt signaling and podocyte dysfunction in diabetic nephropathy

(2017) Madhura Bose et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Circ-ZNF609 Is a Circular RNA that Can Be Translated and Functions in Myogenesis

(2017) Ivano Legnini et al.   MOLECULAR CELL

exoRBase: a database of circRNA, lncRNA and mRNA in human blood exosomes

(2017) Shengli Li et al.   NUCLEIC ACIDS RESEARCH

Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1

(2017) Kotb Abdelmohsen et al.   RNA Biology

Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function

(2017) Monika Piwecka et al.   SCIENCE

An emerging function of circRNA-miRNAs-mRNA axis in human diseases

(2017) Dawei Rong et al.   Oncotarget

Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b

(2017) Xiao-Wu Xu et al.   Oncotarget

Identifying and Characterizing circRNA-Protein Interaction

(2017) William W Du et al.   Theranostics

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

A circular RNA protects the heart from pathological hypertrophy and heart failure by targeting miR-223

(2016) Kun Wang et al.   EUROPEAN HEART JOURNAL

Characterization of circular RNAs in human, mouse and rat hearts

(2016) Stanislas Werfel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Myocardial Infarction-Associated Circular RNA Predicting Left Ventricular Dysfunction

(2016) Melanie Vausort et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Alzheimer's disease

(2016) Philip Scheltens et al.   LANCET

Detecting circular RNAs: bioinformatic and experimental challenges

(2016) Linda Szabo et al.   NATURE REVIEWS GENETICS

Foxo3 circular RNA retards cell cycle progression via forming ternary complexes with p21 and CDK2

(2016) William W. Du et al.   NUCLEIC ACIDS RESEARCH

Clinicopathological significance of p15 promoter hypermethylation in multiple myeloma: a meta-analysis

(2016) Yong Feng et al.   OncoTargets and Therapy

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans

(2016) Lesca M. Holdt et al.   Nature Communications

Circular RNAs and their associations with breast cancer subtypes

(2016) Asha A. Nair et al.   Oncotarget

Anti-miR-203 suppresses ER-positive breast cancer growth and stemness by targeting SOCS3

(2016) Naoshad Muhammad et al.   Oncotarget

Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/β-catenin signaling pathway

(2016) Ping Yang et al.   Oncotarget

The Biogenesis of Nascent Circular RNAs

(2016) Yang Zhang et al.   Cell Reports

Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/β-Catenin Pathway

(2016) Li Wan et al.   Biomed Research International

Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study

(2016) Marco Galasso et al.   International Journal of Genomics

The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression

(2016) Hai-Hua Geng et al.   PLoS One

The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression

(2016) Lei Yu et al.   PLoS One

PRIMA-1Met induces apoptosis in Waldenström's Macroglobulinemia cells independent of p53

(2015) Mona Sobhani et al.   CANCER BIOLOGY & THERAPY

The RNA Binding Protein Quaking Regulates Formation of circRNAs

(2015) Simon J. Conn et al.   CELL

Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis

(2015) Yan Li et al.   CELL RESEARCH

MiR-497 Suppresses YAP1 and Inhibits Tumor Growth in Non-Small Cell Lung Cancer

(2015) Chongbiao Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Using circular RNA as a novel type of biomarker in the screening of gastric cancer

(2015) Peifei Li et al.   CLINICA CHIMICA ACTA

Molecular Pathways: Hippo Signaling, a Critical Tumor Suppressor

(2015) A. Sebio et al.   CLINICAL CANCER RESEARCH

YAP enhances the pro‐proliferative transcriptional activity of mutant p53 proteins

(2015) Silvia Di Agostino et al.   EMBO REPORTS

Circular RNAs in the Mammalian Brain Are Highly Abundant, Conserved, and Dynamically Expressed

(2015) Agnieszka Rybak-Wolf et al.   MOLECULAR CELL

Neural circular RNAs are derived from synaptic genes and regulated by development and plasticity

(2015) Xintian You et al.   NATURE NEUROSCIENCE

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor

(2015) Yehoshua Enuka et al.   NUCLEIC ACIDS RESEARCH

Exon-intron circular RNAs regulate transcription in the nucleus

(2015) Zhaoyong Li et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The potent tumor suppressor miR-497 inhibits cancer phenotypes in nasopharyngeal carcinoma by targeting ANLN and HSPA4L

(2015) Shumin Wang et al.   Oncotarget

Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/β-catenin pathway

(2015) Fang Li et al.   Oncotarget

Exon Circularization Requires Canonical Splice Signals

(2015) Stefan Starke et al.   Cell Reports

Analysis of Intron Sequences Reveals Hallmarks of Circular RNA Biogenesis in Animals

(2015) Andranik Ivanov et al.   Cell Reports

Identification and Characterization of Circular RNAs As a New Class of Putative Biomarkers in Human Blood

(2015) Sebastian Memczak et al.   PLoS One

Correlation of circular RNA abundance with proliferation – exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis and normal human tissues

(2015) Anna Bachmayr-Heyda et al.   Scientific Reports

The circular RNA Cdr1as, via miR-7 and its targets, regulates insulin transcription and secretion in islet cells

(2015) Huanyu Xu et al.   Scientific Reports

Complementary Sequence-Mediated Exon Circularization

(2014) Xiao-Ou Zhang et al.   CELL

The Landscape of MicroRNA, Piwi-Interacting RNA, and Circular RNA in Human Saliva

(2014) J. H. Bahn et al.   CLINICAL CHEMISTRY

Short intronic repeat sequences facilitate circular RNA production

(2014) Dongming Liang et al.   GENES & DEVELOPMENT

circRNA Biogenesis Competes with Pre-mRNA Splicing

(2014) Reut Ashwal-Fluss et al.   MOLECULAR CELL

Detecting and characterizing circular RNAs

(2014) William R Jeck et al.   NATURE BIOTECHNOLOGY

MicroRNA-7a/b Protects against Cardiac Myocyte Injury in Ischemia/Reperfusion by Targeting Poly(ADP-Ribose) Polymerase

(2014) Bin Li et al.   PLoS One

Circular Intronic Long Noncoding RNAs

(2013) Yang Zhang et al.   MOLECULAR CELL

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

Variability in micro RNA (miRNA) abundance, speciation and complexity amongst different human populations and potential relevance to Alzheimer's disease (AD)

(2013) Walter J. Lukiw   Frontiers in Cellular Neuroscience

Cell-Type Specific Features of Circular RNA Expression

(2013) Julia Salzman et al.   PLoS Genetics

miRNA sponges: soaking up miRNAs for regulation of gene expression

(2013) Rasmus O. Bak et al.   Wiley Interdisciplinary Reviews-RNA

Diagnosis and Classification of Diabetes Mellitus

(2012)   DIABETES CARE

The E3 Ubiquitin Ligase ITCH Negatively Regulates Canonical Wnt Signaling by Targeting Dishevelled Protein

(2012) W. Wei et al.   MOLECULAR AND CELLULAR BIOLOGY

MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer

(2012) S T Guo et al.   ONCOGENE

Human papillomavirus related head and neck cancer survival: A systematic review and meta-analysis

(2012) M.A. O’Rorke et al.   ORAL ONCOLOGY

Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types

(2012) Julia Salzman et al.   PLoS One

Circular RNAs are abundant, conserved, and associated with ALU repeats

(2012) W. R. Jeck et al.   RNA

Analysis of MiR-195 and MiR-497 Expression, Regulation and Role in Breast Cancer

(2011) D. Li et al.   CLINICAL CANCER RESEARCH

miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

(2011) Thomas B Hansen et al.   EMBO JOURNAL

Canonical and noncanonical Wnts use a common mechanism to activate completely unrelated coreceptors

(2010) L. Grumolato et al.   GENES & DEVELOPMENT

Activating and resistance mutations of EGFR in non-small-cell lung cancer: role in clinical response to EGFR tyrosine kinase inhibitors

(2009) A F Gazdar   ONCOGENE